1.A case of malignant histiocytosis with various skin manifestations.
Seung Ho JUNG ; Kyu Wang WHANG ; Young Keun KIM
Korean Journal of Dermatology 1992;30(5):720-726
Malignant histiocytosis(MH) is a rapidly progressive and usally fatal disorder characterized clinically fever, generalized weakness, lymphadeno athy, hepatosplenomegaly accompanied by jaundice, and purpura. The frequency of skin manifestations has been repoterd about 15% of MH patients. Papules, plaques and niidules are commonly met. Histopathologically MH shows infiltrations of atypical histiocyte; with uarious maturity in many organs including skin. We present a case of a 32-year-old female with MH involving not only lymph node, liver, spleen and bone marrow but also skin with vaorious features ; erythematous papules, annular purpuric patches, subcutaneous nodules and hemomagic nodules. Immunohist,ochemically the majority of patients atypical histiocytes in lesional skin shows a-1 antitrysin positive, but lysozyme negative. It may suggest that these are poorly differentiated atypical histiocytes rather than well differentiated ones.
Adult
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Bone Marrow
;
Female
;
Fever
;
Histiocytes
;
Histiocytic Sarcoma*
;
Humans
;
Jaundice
;
Liver
;
Lymph Nodes
;
Muramidase
;
Purpura
;
Skin Manifestations*
;
Skin*
;
Spleen
2.Detection of changes in the pylorus after pyloromyotomy .
Hee Sung WANG ; Ki Keun OH ; Choon Sik YOON ; Seung Hoon CHOI
Journal of the Korean Radiological Society 1991;27(1):151-156
No abstract available.
Pylorus*
3.One Case of Fibroma of the Testicular Tunics.
Seung Wha JUNG ; Seong Keun OH ; Jong Soon WANG
Korean Journal of Urology 1960;1(2):151-153
4.No Effect on Body Dissatisfaction of an Interaction between 5-HTTLPR Genotype and Neuroticism in a Young Adult Korean Population.
Seung Keun WANG ; Young Ho LEE ; Jeong Lan KIM ; Ik Seung CHEE
Clinical Psychopharmacology and Neuroscience 2014;12(3):229-234
OBJECTIVE: Many studies suggest an association between the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and anxiety-related personality traits (e.g., neuroticism) in healthy subjects. This study investigated the interaction of 5-HTTLPR genotype on body dissatisfaction by neuroticism and to evaluate the interaction of 5-HTTLPR genotype on self-esteem by body dissatisfaction in a young adult Korean population. METHODS: Two hundred and eighty three subjects were included in this study. The Eysenck Personality Questionnaire-Korean version was used to evaluate neuroticism, the Body Dysmorphic Disorder Examination-Self Report (BDDE-SR)-Korean version was used to evaluate body dissatisfaction, and the Self-Esteem Scale (SES)-Korean version was used to evaluate self-esteem. The 5-HTTLPR genotype by neuroticism (high : low) interaction was assessed according to the total BDDE-SR score, and 5-HTTLPR genotype by BDDE-SR (high : low) interaction was assessed according to the total SES score. RESULTS: The analysis of 5-HTTLPR genotype and neuroticism (high : low) with respect to body dissatisfaction showed no main effects of genotype whereas neuroticism did influence the BDDE-SR score and no interaction of the genotype with neuroticism. The analysis of 5-HTTLPR genotype and BDDE-SR (high : low) with respect to self-esteem score showed no main effects of genotype whereas BDDE-SR did influence the self-esteem score and no interaction of the genotype with body dissatisfaction. CONCLUSION: These results suggest that an interaction between 5-HTTPLR genotype and neuroticism does not affect body dissatisfaction and an interaction between 5-HTTPLR genotype and body dissatisfaction does not affect self-esteem in a young adult Korean population.
Body Dysmorphic Disorders
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Genotype*
;
Humans
;
Serotonin Plasma Membrane Transport Proteins
;
Young Adult*
5.Association Study between DRD2 Genetic Polymorphisms and Schizophrenia in a Korean Population.
Tae Sung KIM ; Seung Min CHA ; Seong Keun WANG ; Jeong Lan KIM ; Young Ho LEE ; Hye In CHOI ; Ik Seung CHEE
Journal of the Korean Society of Biological Psychiatry 2012;19(1):53-57
OBJECTIVES: This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. METHODS: TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. RESULTS: There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. CONCLUSIONS: These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.
Alleles
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Genotype
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Humans
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Polymorphism, Genetic
;
Receptors, Dopamine D2
;
Schizophrenia
6.Anger in Elderly Patients with Depressive Disorders.
Sengmi BAEG ; Seong Keun WANG ; Ik Seung CHEE ; Soo Yeong KIM ; Jeong Lan KIM
Psychiatry Investigation 2011;8(3):186-193
OBJECTIVE: This study was conducted to investigate anger in elderly patients with depressive disorders. METHODS: The subjects included 216 elderly patients with depression and 198 controls. All subjects were assessed by the State and Trait Anger Inventory (STAXI), Aggression Questionnaire (AQ), Reaction Inventory (RI). RESULTS: Elderly patients with depressive disorder showed lower levels of trait anger and anger expression on the STAXI, lower levels of verbal aggression and hostility on the AQ, and lower levels of anger reaction to the unpredictable disruption and disturbances factor, the embarrassing circumstances factor, and the personal disrespect factor on the RI than the controls. In the depression group, the severity of their depression was positively correlated with the trait anger, state anger, anger expression (except 'anger control') scores on the STAXI; the physical aggression, anger, and hostility scores on the AQ; and the anger reaction to unpredictable disruption and disturbances factor, the embarrassing circumstances factor, and the personal disrespect factor scores on the RI. However, the severity of depression negatively correlated with only anger control on the STAXI. In the linear logistic regression analysis, as there were higher levels of state anger seen in the STAXI, anger on the AQ, anger reaction to unpleasant factors on the RI, and therefore the likelihood of depression would be higher. CONCLUSION: Elderly depressive patients are less likely to have anger traits and to express anger than normal elderly. However, in elderly depressive patients, the higher they have severity of depressive symptoms, the higher they reported anger experience and anger expression.
Aged
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Aggression
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Anger
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Depression
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Depressive Disorder
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Hostility
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Humans
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Logistic Models
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Surveys and Questionnaires
7.Hemorrhagic cholecystitis presenting as obstructive jaundice.
Dong Keun SEOK ; Seung Seok KI ; Joon Ho WANG ; Eon Soo MOON ; Tae Ui LEE
The Korean Journal of Internal Medicine 2013;28(3):384-385
No abstract available.
Aged, 80 and over
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Cholecystitis/*complications/diagnosis
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Hemobilia/diagnosis/*etiology
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Humans
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Jaundice, Obstructive/etiology
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Male
8.No Association between 102T/C and 452His/Tyr Polymorphisms of 5-HT2A Receptor Gene and Schizophrenia in Korean Population.
Shi Kyung LEE ; Sung Keun WANG ; Ik Seung CHEE ; Young Ho LEE ; Suk Chul SHIN
Journal of Korean Neuropsychiatric Association 1999;38(1):147-155
OBJECTIVES: This study was designed to investigate the association between the silent mutation, 102T/C and the substitution of histidine by tyrosine at position 452, 452His/Tyr polymorphism of the 5HT2A receptor gene and schizophrenia in korean population. METHOD: 102T/C and 452His/Tyr polymorphism of the 5-HT2A receptor gene was typed with PCR in 93 patients with schizophrenia and 93 healthy controls. RESULTS: 1) Genotype of 102T/T, 102T/C, 102C/C were 37(40%), 34(36%), and 22(24%), res-pectively in the patients with schizophrenia. Genotype of 102T/T, 102T/C, 102C/C were 31(33%), 41(44%), and 21(23%), respectively in the controls, Allele frequencies of 102T in the patients with schizophrena was 0.58 and that in the controls was 0.55. Allele frequencies of 102C in the patients with schizophrena was 0.42 and that in controls was 0.45. There were no differencies in genotype and allele frequency of 102T/C between the patients with schizophrenia and the controls. 2) 452His/Tyr polymorphism of the 5-HT2A receptor gene was not founeded in the patients with schizophrenia and in the controls. CONCLUSION: These results suggest 102T/C and 452His/Tyr polymorphisms of the 5-HT2A receptor gene are not causally related to the development of schizophrenia in Korean population.
Gene Frequency
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Genotype
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Histidine
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Humans
;
Polymerase Chain Reaction
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Receptor, Serotonin, 5-HT2A*
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Schizophrenia*
;
Tyrosine
9.Prospective Study to Determine the Efficacy of Day Hospital Care to Improve Treatment Adherence for Hospitalized Schizophrenic Patients.
Jin Hun CHOI ; So Hyun AHN ; Seong Keun WANG ; Ik Seung CHEE ; Jung Lan KIM ; Sun Woo LEE
Journal of Korean Neuropsychiatric Association 2013;52(5):311-317
OBJECTIVES: The purpose of the study is to investigate the effects of day hospital care in hospitalized schizophrenic patients in terms of treatment adherence and treatment outcomes. METHODS: Among schizophrenic patients hospitalized between 2011 and 2012, 23 day hospital care patients and 40 control subjects were included in the study. All candidates underwent Beck Cognitive Insight Scale, Drug Attitude Inventory, WHO Quality of Life scale, and Psychological Well-Being Scale when their symptoms were stabilized during hospitalization, and after being discharged, 23 patients received day hospital care for two months and then changed to out-patient care while 40 patients received out-patient care immediately after discharge. At the point of two months of out-patient care, the treatment adherence of the two groups was evaluated ; tracking observation was performed until February, 2013, and survival rates were compared between the two groups. RESULTS: Treatment adherence was higher in the day hospital care group than in the control group. Kaplan-Meier survival analysis showed a higher survival rate for the day hospital care group compared to the control group. Levels of cognitive insight and quality of life were higher after day hospital care than before day hospital care in the day hospital care group. CONCLUSION: Through the study, it was confirmed that when hospitalized schizophrenic patients receive continuous day hospital care after being discharged, they receive further out patient care more faithfully. The study is considered to aid in the understanding regarding schizophrenic patients' treatment adherence issues and improvement of treatment outcomes.
Hospitalization
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Humans
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Outpatients
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Patient Care
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Prospective Studies*
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Quality of Life
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Schizophrenia
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Survival Rate
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Track and Field
;
Treatment Outcome
10.Early Assessment of Delirium in Elderly Patients after Hip Surgery.
Hyo Jin LEE ; Deuk Soo HWANG ; Seong Keun WANG ; Ik Seung CHEE ; Sengmi BAEG ; Jeong Lan KIM
Psychiatry Investigation 2011;8(4):340-347
OBJECTIVE: This study is intended to identify predictive factors of delirium, including risk factors and prodromal symptoms. METHODS: This study included sixty-five patients aged 65 years or older who had undergone hip surgery. Baseline assessments included age; gender; admission type (acute/elective); reason for surgery (fracture/replacement); C-reactive protein (CRP); Acute Physiology, Age, Chronic Health Evaluation (APACHE III); and the Mini-Mental State Examination (MMSE). The Korean version of the Delirium Rating Scale-Revised-98 (K-DRS-98) was used to assess prodromal symptoms daily before the onset of delirium. RESULTS: Almost 28% (n=18) of the 65 patients developed delirium after surgery. Delirium in elderly patients after hip surgery was observed more often in older patients and those with acute admission, hip fracture, higher APACHE III score, lower MMSE score, and higher CRP levels within early days after the operation. Sleep-wake cycle disturbances, thought process abnormalities, orientation, and long-term memory in symptom items of K-DRS-98 were showed significant difference on 4 days before delirium, lability of affect on 3 days before, perceptual disturbances and hallucination, and visuo-spatial ability on 2 days before, and delusion, motor agitation, and short-term memory on the day before the occurrence of delirium. CRP levels within 24 hours and 72 hours after hospitalization were significantly higher in the delirium group. CONCLUSION: Medical professionals must pay attention to behavioral, cognitive changes and risk factors in elderly patients undergoing hip surgery and to the prodromal phase of delirium. K-DRS-98 may help in identifying the prodromal symptoms of delirium in elderly patients after hip surgery.
Aged
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APACHE
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C-Reactive Protein
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Delirium
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Delusions
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Dihydroergotamine
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Hallucinations
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Hip
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Hospitalization
;
Humans
;
Memory, Long-Term
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Memory, Short-Term
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Orientation
;
Prodromal Symptoms
;
Risk Factors