No abstract available.
Diet* ; Humans ; Immunoglobulin E* ; Incidence* ; Infant*

No abstract available.
Hepatitis B* ; Hepatitis* ; Humans ; Mothers* ; Parturition*

We performed a histopathologic and immunohistochemical study of 23 cases of surgically resected large cell undifferentiated carcinoma(LCUC) of the lung. The relative incidence of LCUC was 7.6% among the total resected cases of primary lung cancer over 7 years(1987-1993). The mean age of the patients was 56 years and 21 cases were male. The mean size of the mass was 5 cm and 11 cases were located peripherally. According to the histologic features, LCUC could be divided into three groups: squamous cell carcinoma-like(6 cases), adenocarcinoma-like(13 cases), and small cell carcinoma-like(4 cases) groups. The histologic differences were related to the variations of the immunohistochemical properties, but there were no differences in prognosis among these groups. Immunoreactivity to cytokeratin(CAM 5.2) was demonstrated in 22/23(96%). Carcinoembryonic antigen was positive in 13/23(57%). Neuron specific enolase and chromogranin were positive in 11/23(48%) and 5/23(22%), respectively. Vimentin was seen in 11/23(48%). From these observations, we could subclassify them by their immunologic phenotypes; exocrine features in 6/23(26%), neuroendocrine(NE) features in 4/23(17%), both exocrine and NE phenotypes in 7/23(30%), and 6 cases(26%) showed neither phenotype. The group with NE features showed a worse prognosis(P<0.05) and immunoreactivity for vimentin was also related to a worse prognosis(P<0.05). These findings imply that the immunohistochemical properties of LCUC are closely related to the histopathologic features. The groups, subdivided by histology and immunoreactivity, showed no prognostic difference except for the NE differentiation and reaction for vimentin.
Incidence ; Lung Neoplasms

No abstract available.
Creatinine* ; Humans ; Infant, Newborn*

Intracranial tuberculomas have been reported occasionally, especially in Asia, though much decreased in recentyears. Those lesions can be diagnosed more easily and acurately using CT than conventional method, including angiography. Authors analysed CT findings of 21 cases, confirmed as tuberculoma, at Hanyang University Hospital from May 1979 to June 1983. The resuslts were as follows; 1. Of all 21 cases, multiple lesions were seen in 14 cases (67%) and single in 7(33%). 2. Of all 21 cases, lesions located only at supratentorial were in 19 cases(90%) and remained 2(10%) had lesions at both supra and infratentorial area. And temporal and parietal lobes were common location (65%) of all lesions. 3. In precontrast scan, density of tuberculoma showed largely isodense (68%)and others were slight high (29%) and low(3%). 4. All lesions were enhanced showed as homogeneous nodular (68%),ring-shaped(29%) and target shaped(3%). 5. All rings were continuous and thickness was largely uniform(67%), anddensity of center of the ring was mainly low(67%). 6. Edema was seen in 58% of all lesions: comparing with thesize of tuberculoma, edema size was smaller in 50%, lager in 33% and almost the same in 17%.
Angiography ; Asia ; Edema ; Methods ; Parietal Lobe ; Tuberculoma ; Tuberculoma, Intracranial

The importance of tick-borne diseases is increasing because of climate change, with a lack of long-term studies on tick-borne pathogens in South Korea. To understand the epidemiological characteristics of tick-borne diseases, the monthly distribution of field ticks throughout the year was studied in South Korea between May 2014 and April 2018 in a cross sectional study.

Rapid-eye-movement (REM) sleep behavior (RBD) is a form of REM sleep motor dyscontrol characterized by complex, vigorous, and frequently violent behaviors without atonia during the REM sleep. The motor dyscontrol may include not only cataplexy and sleep paralysis but alto periodic limb movements during REM and non-REM sleep. We examined two patients with charateristic episodes of behavioral manifestations during the REM sleep as well as with other sleep disorders such as narcolepsy and periodic limb movement disorder. The one patina was an 18 year-old man who had childhood-onset RBD associated with narcolepsy since 10 years old. The polysomnographic studies showed excessive augmentation of chin EMG and 6 attacks of violent behavior during REM sleep. He also complained of cataplexic symptomes. Multiple sleep latency tests (MSLT) showed four sleep onset REMs and two episodes of violent behavior during the REM sleep. The other patient was a 74 year-old man who complained of violent behaviors during the REM sleep and polysomnographic studies showed excessive augmentation of chin EMG during the REM sleep and periodic leg movements for 24min. And 14sec. During the sleep. We report two patients with RBD which were associated with narcolepsy, and periodic limb movememt disorder irrespectively, suggesting that RBD, narcolepsy and periodic limb movement disorder could occur coincidently and be understood as a motor dyscontrol during REM sleep.
Adolescent ; Aged ; Cataplexy ; Child ; Chin ; Extremities ; Humans ; Leg ; Mental Disorders* ; Narcolepsy* ; Nocturnal Myoclonus Syndrome* ; REM Sleep Behavior Disorder ; Sleep Wake Disorders ; Sleep Paralysis ; Sleep, REM*

BACKGROUND: Experimental data indicate that low-flow reperfusion following prolonged cardiocirculatory arrest may aggravate early cerebral microcirculatory repefusion disorders. We investigated the influence of cerebral repefusion flow change to the ischemic histopathologic damage of brain tissue after incomplete forebrain ischemia in rats. MATERIALS AND METHOD: Anesthetized Sprague-Dawley rats were undergone ligation of both infernal carotid artery by microvascular clamp for 10 minutes. After release of the clamp, reperfusion was started with several different flow levels (0, 10, 20, 30, 50, and 100%) of infernal carotid artery comparing to pre-clamping phase using flowmeter. After 15minutes of reperfusion, rat brains were prepared by perfusion-fixation with 3% formaldehyde. Under light microscopic examination of Hematoxylin-Eosin stained tissue slide, histopathologic damage was examined at cortex, putamen, and hippocampus regions. Categorical hisotopathologic damage scores were derived in each regions by manual counts of ischemic neurons. RESULT: The histopathologic damage scores were 0, 10. 2+/-0.5, 7.6+/-1.5, 5.9+/-1.4, 5.0+/- 2.8, 3.5+/-0.7, and 1.0+/-0.0 in control, 0, 10, 20, 30, 50, and 100% reperfusion groups, respectively(p<0.05). CONCLUSION: Our insults showed significant increment of brain histopathologic damage scores along with decreasing amount of cerebral reperfusion know after incomplete forebrain ischemia. We believe restoration of repefusion flow to pre-ischemic level would be a critical component in attenuation of brain ischemic damage.
Animals ; Brain ; Carotid Arteries ; Flowmeters ; Formaldehyde ; Hippocampus ; Ischemia* ; Ligation ; Models, Animal* ; Neurons ; Prosencephalon* ; Putamen ; Rats* ; Rats, Sprague-Dawley ; Reperfusion*

PURPOSES: To evaluate the effect of Androderm(TM) on sexual function and its safety in partially androgen-deficient aging men with erectile dysfunction. MATERIALS AND METHODS: Two Androderm patches, designed to deliver 5mg of testosterone per day, were applied daily for 4 months to the back, abdomen, upper arm, or thigh of 21 patients (mean age 52.4+/-6.76 years; range 41-63 years) with partial androgen deficiency and erectile dysfunction, The degree of symptom using the Watts (sexual arousal, desire, orgasm, and satisfaction) and Davidson (number and quality of penile erections) questionnaires, Blood levels of total and bioavailable testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin were measured monthly. The safety variables examined were lipid profiles, liver and kidney function tests, prostate specific antigen, hematologic values, body mass index, and local skin reaction. RESULTS: Blood concentrations of total and bioavailable testosterone and estradiol were significantly (p<0.05) increased, but all were within the normal range during androgen replacement with Androderm. One third of the patients reported improvement in the quality of their erections. there were no significant differences in Watts sexual function scores, number of spontaneous and morning erections, or the quality of erections compared with baseline data. No changes in blood lipid profiles, measures of liver and kidney function, PSA, hematologic values, or body mass index were noted. However, 22% of the patients dropped out of the trial because of severe skin irritation symptoms. CONCLUSION: Androderm was partially effective in improving the quality of erection in partially androgen-deficient aging men and is physiologic and safe.
Abdomen ; Aging* ; Arm ; Arousal ; Body Mass Index ; Erectile Dysfunction* ; Estradiol ; Follicle Stimulating Hormone ; Humans ; Kidney ; Kidney Function Tests ; Liver ; Luteinizing Hormone ; Male ; Orgasm ; Prostate-Specific Antigen ; Reference Values ; Sex Hormone-Binding Globulin ; Skin ; Testosterone ; Thigh ; Surveys and Questionnaires

PURPOSES: To evaluate the effect of Androderm(TM) on sexual function and its safety in partially androgen-deficient aging men with erectile dysfunction. MATERIALS AND METHODS: Two Androderm patches, designed to deliver 5mg of testosterone per day, were applied daily for 4 months to the back, abdomen, upper arm, or thigh of 21 patients (mean age 52.4+/-6.76 years; range 41-63 years) with partial androgen deficiency and erectile dysfunction, The degree of symptom using the Watts (sexual arousal, desire, orgasm, and satisfaction) and Davidson (number and quality of penile erections) questionnaires, Blood levels of total and bioavailable testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin were measured monthly. The safety variables examined were lipid profiles, liver and kidney function tests, prostate specific antigen, hematologic values, body mass index, and local skin reaction. RESULTS: Blood concentrations of total and bioavailable testosterone and estradiol were significantly (p<0.05) increased, but all were within the normal range during androgen replacement with Androderm. One third of the patients reported improvement in the quality of their erections. there were no significant differences in Watts sexual function scores, number of spontaneous and morning erections, or the quality of erections compared with baseline data. No changes in blood lipid profiles, measures of liver and kidney function, PSA, hematologic values, or body mass index were noted. However, 22% of the patients dropped out of the trial because of severe skin irritation symptoms. CONCLUSION: Androderm was partially effective in improving the quality of erection in partially androgen-deficient aging men and is physiologic and safe.
Abdomen ; Aging* ; Arm ; Arousal ; Body Mass Index ; Erectile Dysfunction* ; Estradiol ; Follicle Stimulating Hormone ; Humans ; Kidney ; Kidney Function Tests ; Liver ; Luteinizing Hormone ; Male ; Orgasm ; Prostate-Specific Antigen ; Reference Values ; Sex Hormone-Binding Globulin ; Skin ; Testosterone ; Thigh ; Surveys and Questionnaires