1.Induction of Radiation Adaptive Response in Lymphocytes of patients Undergoing Bone Scintigraphy.
Korean Journal of Nuclear Medicine 1999;33(2):172-177
PURPOSE: The purpose of this study was to ascertain whether radiation adaptive response could be induced by Tc-99m-methylene diphosphonate (Tc-99m-MDP) in peripheral lymphocytes of patients undergoing bone scintigraphy. MATERIALS AND METHODS: Lymphocytes from 22 patients (6 males, 16 females, mean age 50+/-14 years) were collected before and after bone scintigraphy using 740 MBq Tc-99m-MDP. Lymphocytes from 10 controls (6 males, 4 females, mean age 43+/-7 years) were also collected. They were exposed challenge dose of 2 Gy gamma rays using a cell irradiator Number of ring-form and dicentric chromosomal per 600 cells (chromosomal aberrations) was counted under the light microscope. RESULTS: Chromosomal aberrations in patients before bone scintigraphy (385.1+/-30.5) was not different from that of controls (367.8+/-36.6). However, chromosomal aberrations in patients after bone scintigraphy was significantly decreased 192.6+/-22.1 (p=0.0001). CONCLUSION: Low dose gamma-irradiation by Tc-99m-MDP used for bone scintigraphy induces a cytogenetic adaptive response in peripheral lymphocytes.
Chromosome Aberrations
;
Cytogenetics
;
Female
;
Gamma Rays
;
Humans
;
Lymphocytes*
;
Male
;
Radionuclide Imaging*
;
Technetium Tc 99m Medronate
2.A study on the evaluation of stress in the alcoholic patients.
Woo Sung CHO ; Jun Ha KANG ; Keun Baik JUNG ; Jong Seung JUNG ; Seung Ug YAON
Journal of the Korean Academy of Family Medicine 1993;14(3):140-146
No abstract available.
Alcoholics*
;
Humans
3.Clinical Study of Partial Agenesis of Callosum.
Seung Hwan OH ; Chang Jun COE ; Jung Ho SUH
Journal of the Korean Pediatric Society 1989;32(4):511-517
No abstract available.
4.The analysis of discharge against medical advice in the emergency department.
Seung Whan KIM ; Ok Jun KIM ; Seok Joon JANG ; Koo Young JUNG ; Seung Ho KIM
Journal of the Korean Society of Emergency Medicine 1993;4(2):116-122
No abstract available.
Emergencies*
;
Emergency Service, Hospital*
5.A case of immunologic trombocytopenic purpura in pregnancy.
Yong Eun LEE ; Seung Jin OH ; Ha Jong JANG ; Jung Sik CHO ; Huk JUNG ; Jong Il JUNG ; Sae Jun HAN
Korean Journal of Obstetrics and Gynecology 1991;34(10):1463-1469
No abstract available.
Pregnancy*
;
Purpura*
6.Sialolithiasis Mimicking Metastatic Thyroid Cancer.
Hwang Jeong JEONG ; Hee Seung BOM ; Ho Cheon SONG ; Jung Jun MIN ; Seung Min KIM ; Ji Yeul KIM
Korean Journal of Nuclear Medicine 2000;34(1):94-98
We report a false positive case of I-131 scan due to a sialolithiasis in right submandibular gland. I-131 images showed not only remnant thyroid tissues and functional metastases in the anterior neck but also a hot uptake near right submandibular gland. We confirmed the sialolithiasis by radiologic studies. Sialolithiasis should be regarded as a false positive cause when I-131 scan shows a hot spot near salivary bed.
Neck
;
Neoplasm Metastasis
;
Salivary Gland Calculi*
;
Submandibular Gland
;
Thyroid Gland*
;
Thyroid Neoplasms*
7.Prognostic Implication of Normal Myocardial Perfusion Scintigraphy in Patients with Chest Pain.
Ji Yeul KIM ; Hee Seung BOM ; Jung Jun MIN ; Ho Cheon SONG
Korean Journal of Nuclear Medicine 1997;31(1):67-72
Myocardial scintigraphy is a widely used noninvasive procedure with high sensitivity for the detection of patients with suspected coronary artery disease. The purpose of this study was to determine the prognostic value of a normal myocardial scintigraphy in 292 patients (150 males, 142 females, mean age 53+/-12 years) with chest pain who were followed from 7 to 58 (mean 25) months. Myocardial SPECT was performed with Tc-99m MIBI in 173 patients, with Tc-99m tetrofosmin in 74 patients and with T1-201 in 45 patients. During the follow-up period, there were 2 cardiac deaths and 2 nonfatal myocardial infarctions resulting in cardiac event rate of 1.37% (0.66% per year). The cardiac event rate was not different in patients with angiographically normal coronary arteries (1/30, 3.3%) and in those who had significant coronary a disease (2/27, 7.4%) (p=0.60). In conclusion, patients with chest pain and normal myocardial scintigraphy have a low cardiac event rate, and there was no significant difference of cardiac event rates between patients with normal and abnormal coronary angiograms.
Chest Pain*
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Coronary Artery Disease
;
Coronary Vessels
;
Death
;
Female
;
Follow-Up Studies
;
Humans
;
Male
;
Myocardial Infarction
;
Myocardial Perfusion Imaging
;
Perfusion Imaging*
;
Perfusion*
;
Prognosis
;
Thorax*
;
Tomography, Emission-Computed, Single-Photon
8.Comparison of Stress-rest and Rest-stress One Day Myocardial Perfusion Scintigraphies in Detecting Coronary Artery Diseases.
Ji Yeul KIM ; Hee Seung BOM ; Jung Jun MIN ; Ho Cheon SONG
Korean Journal of Nuclear Medicine 1997;31(1):30-35
It has been shown that both rest and stress myocardial perfusion imagings with technetium agents can be performed on the same day using two different doses injected within few hours. The purpose of this study was to compare the two protocols (stress-rest and rest-stress) in detecting coronary artery diseases. One hundred and sixty patients (101 males, 59 females, mean age 57+/-9 years) and 120 patients (79 males, 41 females, mean age 59+/-10 years) underwent stress-rest myocardial perfusion SPECT and rest-stress myocardial perfusion SPECT, respectively All of them underwent both myocardial perfusion SPECT and coronary angiography within 1 month. A coronary stenosis was considered significant when it compromised the luminal diameter by> or =50%. The chi square test was used to compare differences in sensitivity, specificity and accuracy between the two groups. The overall sensitivity, specificity and accuracy of stress-rest protocol were 99%, 35%and 68%, respectively. Those of rest-stress protocol were 96%, 47%, and 78%, respectively. There was no difference between the two protocols in identifying individual diseased coronary artery branches. Therefore, one day stress-rest and rest-stress myocardial SPECT using Tc-99m agents were comparable and were very sensitive tests in detecting coronary artery diseases.
Coronary Angiography
;
Coronary Artery Disease*
;
Coronary Stenosis
;
Coronary Vessels*
;
Female
;
Humans
;
Male
;
Perfusion Imaging
;
Perfusion*
;
Phenobarbital
;
Sensitivity and Specificity
;
Technetium
;
Tomography, Emission-Computed, Single-Photon
9.Development of a Noble Dosimetry Using Metaphase Analysis and Micronuclei Assay of Bone Marrow Cells in Mice.
Jung Jun MIN ; Hee Seung BOM ; Young Ho KIM ; Hyun Joong YOON ; Ji Yeul KIM
Korean Journal of Nuclear Medicine 2000;34(1):74-81
PURPOSE: The purpose of this study was to develop in vivo dosimetries using both chromosomal aberrations and micronuclei in mice to assess biological effects of radiations. MATERIALS AND METHODS: Five each mice were irradiated with 0, 1, 2, 3, 4, 5, 10 Gy of Cs-137 gamma-rays. We scored numbers of chromosomal aberrations in metaphase spreads and numbers of micronuclei in bone marrow smears under light microscope, and obtained the dose-response relationships. We also examined the relationship between the two dose-response curves. RESULTS: The frequency of both chromosomal aberrations and micronuclei increased with dose, in a linear-quadratic manner. The delta, beta, and alpha coefficients were 0.0176, 0.0324, and 0.0567 for metaphase analysis (r=1.0, p<0.001) and 0.0019, 0.0073, and 0.0506 for micronuclei assay (r=1.0, p<0.001). The frequency of chromosomal aberrations and micronuclei in diffirent radiation doses was significantly correlated (r=0.99, p<0.01). CONCLUSION: In vivo dosimetry using either metaphase analysis or micronucleus assay was feasible in mice. These methods could be useful to evaluate biological effects of radiation.
Animals
;
Bone Marrow Cells*
;
Bone Marrow*
;
Chromosome Aberrations
;
Metaphase*
;
Mice*
;
Micronucleus Tests
10.A Case of Woolly Hair.
Seok Ki JUNG ; Ok Jun LEE ; Seung Ho CHANG ; Tae Young YOON
Annals of Dermatology 1999;11(3):161-164
We report a case of woolly hair. Woolly hair is found frequently in most blacks but is unusual in individuals of non-negroid origin. A 12-year-old female patient visited our clinic complaining of a hair abnormality. It had been tightly curled, fine, light brown, short and easily broken since birth. On scanning electron microscopy, many of the hairs showed damaged cuticles with cuticular splintering, and most hair shafts were round to oval on cross sectional examination.
African Continental Ancestry Group
;
Child
;
Female
;
Hair*
;
Humans
;
Microscopy, Electron, Scanning
;
Parturition