No abstract available.

Acromioclavicular joint dislocations are frequently seen with industrial accident, sports activity and traffic accident. Various operative treatment modalities have been suggested. The purpose of this study is to compare the clinical results of two operative methods in young patients with acromioclavicular dislocation. The authors analyzed the clinical and radiological results of 30 patients with acromioclavicular dislocation, in whom 15 patients were treated by acromioclavicular reduction & fixation with K-wire(Phemister procedure) and 15 patients by acromioclavicular reduction & coracoclavicular fixation by cancellous screw with coracoclavicular ligament repair(Bosworth procedure) from March 1989 to September 1993 at Ansan Hospital, Korea University. They were followed up more than 12 months. The results obtained were as follows: 1. The difference of coracoclavicular distance compared with normal side after operation was 2.6mm in Phemister operations and 1.6 mm in Bosworth operations. And these differences were not changed at follow up significantly. 2. The complications were two K-wire migrations, one superficial infection, and one recurred gross deformity after pin removal in Phemister operations and two mild upward migrations of screw after Bosworth operations. 3. We obtained similar good results after Phemister and Bosworth operations. But less complications were visible, and anatomical reduction and early ROM exercise were possible after Bosworth operations.
Accidents, Occupational ; Accidents, Traffic ; Acromioclavicular Joint ; Congenital Abnormalities ; Dislocations ; Follow-Up Studies ; Gyeonggi-do ; Humans ; Korea ; Ligaments ; Methods ; Sports

No abstract available.
Thyroiditis, Autoimmune ; Turner Syndrome

PURPOSE: To evaluate the MR imaging of Mullerian duct anomalies (MDA) and analyze its diagnostic accuracy associated gynecologic diseases and effect on treatment plan. MATERIALS AND METHODS: Twelve patients with suspected MDA and three with incidentally-found MDA were included. Axial, sagittal and coronal images of T1-, FSET2- or T2-, proton density- and Gadolinium-enhanced T1-weighted images were obtained with 1.5T (n=13) and 0.5T (n=2) MR machines. On the basis of Buttram and Gibbons' classification, MR images were analyzed and classified as laparotomy (n=7), hysteroscopy (n=7), laparoscopy (n=3) or hystersalpingography (n=2). These were analyzed in terms of external contour of the uterus, intercornual distance, signal intensity of the uterus and septum, associated genitourinary diseases, and the influence of MR imaging on treatment plan. RESULTS: A total of 15 cases of MDA were accurately classified by MR imaging, as follows: didelphyses (n=6: 40%); ageneses (n=3: 20%); septate uteri (n=3: 20%); bicornuate uteri(n=2: 13%) and unicornuate uterus(n=1: 7%). In 14 cases (93%) findings corresponded with those of other examinations. The external contour of the uterus was banana-shaped in the didelphyc and unicornuate uterus, a fundal cleft in the bicornuate, and normal in the septate; intercornual distance was greater in didelphyc and bicornuate uteri. Except in three cases of agenesis, the signal intensity of the uterus was normal; in the septum, on T2WI, this was isosignal in the bicornuate uterus and low in the septate, as compared with that of the myometrium. In four of five cases, associated gynecologic diseases were found on MR imaging; in five cases (33%), there were associated urologic anomalies, and in six (40%), MR imaging influenced the treatment plan. CONCLUSION: MR imaging was valuable for the diagnosis of MDA and the determination of associated gynecologic diseases, and also influenced the treatment plan.
Animals ; Classification ; Diagnosis ; Female ; Genital Diseases, Female ; Humans ; Hysteroscopy ; Laparoscopy ; Laparotomy ; Magnetic Resonance Imaging* ; Mice ; Myometrium ; Protons ; Uterus

OBJECTIVE: The aim of this study is to ascertain the differences in NF-kappaB (Nuclear Factor-kappa B : p50) activity between the placental tissues of preeclampsia and normal pregnancy, and to certify that the circulating lipid peroxides is increased in preeclamptic women. METHODS: Placental tissues were obtained from preeclamptic (n=33) and normal pregnancies (n=21) with no other medico-surgical illness or obstetric complications, delivered by cesarean section without labor. The activities of NF-kappaB and IkappaBalpha (Inhibitory factor kappaBalpha) on syncytiotrophoblast, cytotrophoblast, endothelium, extravillous cytotrophoblast, and decidua were separately measured by immunohistochemical staining using tissue microarray technique. Malondialdehyde assay was used to evaluate the oxidative stress, measuring lipid peroxide levels on each sample. Mann-Whitney test was done for statistical analysis of the data. RESULTS: Nuclear staining of NF-kappaB (p50) was seen more intensively within the extravillous cytotrophoblast of preeclampsia group compared with the control group (p<0.05). The immunoreactivity of NF-kappaB (p50) was also detected in cytotrophoblasts, syncytiotrophoblasts, endothelium, and decidua, but showing no statistical difference between two groups. IkappaBalpha was strongly expressed in both groups but there was no statistically significant between two gropups. Preeclamptic group showed significantly increased circulating lipid peroxide levels compared to normal pregnancy group (1.22+/-0.79 nmol/mL vs 0.41+/-0.12 nmol/mL, p<0.05). CONCLUSION: The expression of NF-kappaB is significantly increased in extravillous cytotrophoblast of preeclamptic women compared to normal pregnancy, and may be associated with increased levels of circulating lipid peroxide. These findings might help us to understand the pathologic mechanism of preeclampsia and further study should be done for effects of NF-kappaB on implantation.
Cesarean Section ; Decidua ; Endothelium ; Female ; Humans ; Lipid Peroxides ; Malondialdehyde ; NF-kappa B ; Oxidative Stress ; Placenta ; Pre-Eclampsia* ; Pregnancy ; Trophoblasts

PURPOSE: The purpose is to correlate computed tomographic findings classified according to the degree of disease severity(grading A-E) with clinical course of acute pancreatitis. MATERIALS AND METHODS: in a retrospective review of 42 patients with acute pancreatitis, computed tomographic scans were classifed according to the degree of disease severity, and were correlatd with the clinical course. RESULTS: Pancreatic abscesses were seen in 14.3% and occured in 35.7% of grade D and E patients. Three patients with abscess died. Fatty infiltration of the liver was noted in 16.7%, pleural effusion in 21.4%.. stones and thickened wall of the gallbladder were present in 7.1% and in 9.5%, respectively. CONCLUSION: Our data indicate that phlegmonous extrapancreatic spread on initial CT scan had a high predictive value of the patients, prognosis.
Abscess ; Cellulitis ; Gallbladder ; Humans ; Liver ; Pancreatitis* ; Pleural Effusion ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed

PURPOSE: Radiofrequency ablation (RFA) of lung cancer in animals and humans has been described in previously published reports. The aim of this study was to present our preliminary experience of treatment of lung cancer involving this approach. MATERIALS AND METHODS: Eight patients with lung malignancies [stage IIIB or IV bronchogenic adenocarcinoma (n=6), metastatic squamous cell carcinoma (n=1), metastatic hepatocellular carcinoma (n=1)] underwent RFA treatment. In all cases LeVeen-type electrodes were employed and CT was used to monitor the procedure. One-day and one-month follow-up CT scans were obtained and analyzed. RESULTS: Prior to treatment, tumor diameter ranged from 2.5 to 5 cm; afterwards, low attenuation consistent with coagulative necrosis was observed. Complications included a small amount of pneumothorax (n=4), pleural effusion (n=8), and subcutaneous emphysema (n=1). Tumor size decreased in five patients, was unchanged in two, and increased in one. CONCLUSION: Radiofrequency ablation of lung cancer is safe and may result in a reduced tumor burden.
Adenocarcinoma ; Animals ; Carcinoma, Hepatocellular ; Carcinoma, Squamous Cell ; Catheter Ablation* ; Electrodes ; Follow-Up Studies ; Humans ; Lung Neoplasms* ; Lung* ; Necrosis ; Pleural Effusion ; Pneumothorax ; Subcutaneous Emphysema ; Tomography, X-Ray Computed ; Tumor Burden

The development of renal glomerular lesions secondary to severe visceral infection (pulmonary, pleural, retroperitoneal or hepatic abscess) is not generally appreciated. Such patients resemble those with infective endocarditis. The suggested pathogenetic mechanisms by which infection can cause glomerular damage are immunologic interaction, direct toxicity of a bacterial products, and some other triggering factors; However, direct correlation between the infectious and immunologic events has not been demonstrated. The histopathologic findings of infectious glomerulonephritis are variable, and these findings, as well as the clinical abnormalities, may resolve with effective antimicrobial therapy or abscess drainage. We experienced a case of glomerulonephritis and acute renal failure due to staphylococcal retroperitoneal abscess. The patient was a 58-year-old man who presented with abdominal and back pain. We performed an abdominal CT scan which showed a retroperitoneal abscess which was proven to be a staphylococcal infection upon percutaneous abscess drainage. Furthermore, we performed a renal biopsy in order to investigate hematuria, RBC casts, and proteinuria. Pathologic findings revealed postinfectious glomerulonephritis. Abscess drainage and sensitive antibiotics were administered, after which his symptoms and urinary abnormalities disappeared, and the retroperitoneal abscess subsided. Here, we report a case of a staphylococcal retroperitoneal abscess which led to postinfectious glomerulonephritis and acute renal failure along with a brief review of the literatures.
Abscess* ; Acute Kidney Injury ; Anti-Bacterial Agents ; Back Pain ; Biopsy ; Drainage ; Endocarditis ; Glomerulonephritis* ; Hematuria ; Humans ; Middle Aged ; Proteinuria ; Staphylococcal Infections ; Tomography, X-Ray Computed

BACKGROUND AND OBJECTIVES: Alterations of olfactory function among patients with cirrhosis of the liver, acute viral hepatitis or alcoholic liver disease have been reported. The goal of this study is to evaluate the alteration of olfactory function among chronic viral hepatitis patients. MATERIALS AND METHODS: The study group consisted of 21 patients with chronic active viral hepatitis and 32 normal subjects. Between December 2006 and January 2008, olfactory function among the study groups was evaluated using the Connecticut Chemosensory Clinical Research Center and the Cross Cultural Smell Identification Test. Then, correlations between the olfactory function test scores and serological data were analyzed. RESULTS: Hepatitis patients had significantly lower smell identification test scores. Only serum total bilirubin level had negative correlation with smell identification test scores. CONCLUSION: Chronic viral hepatitis appears to influence olfactory function.
Bilirubin ; Connecticut ; Fibrosis ; Hepatitis ; Humans ; Liver ; Liver Diseases ; Liver Diseases, Alcoholic ; Smell

Purpose: HOX transcript antisense intergenic RNA (HOTAIR), as a long non-coding RNA, has been reported to regulate carcinogenesis by epigenetic mechanism in various cancers. Protocadherin 10 (PCDH10) is one of the well-known tumor suppressor genes, and is frequently methylated in gastric cancers (GC). We aimed to investigate the detailed pathway of how HOTAIR contributes to the target gene in gastric carcinogenesis. Materials and Methods: We investigated the mechanism of HOTAIR on carcinogenesis and metastasis of GC. Methylation-specific PCR was performed to identify the interaction between HOTAIR and PCDH10. In addition, we investigated the interaction between miR-148b and HOTAIR by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. Results: The expression of HOTAIR was significantly upregulated in GC tissues (p<0.05) and GC cell lines (p<0.01), while PCDH10 was downregulated in GC tissues (p<0.05). The knockdown of HOTAIR (si-HOTAIR1 and 2) significantly upregulated the mRNA/protein expression of PCDH10 and reduced the methylation of PCDH10 compared to the control in MKN 28 and MKN 74. Si-HOTAIR1 and 2 significantly reduced DNA methyltransferase 1 (DNMT1) expression, and overexpression of HOTAIR increased DNMT1 expression. In RIP, we found that miR-148b interacted with HOTAIR. Si-HOTAIRs increased miR-148b expression, and miR-148b mimic inversely reduced HOTAIR expression. Si-HOTAIRs and miR-148b mimic reduced DNMT1 expression and increased PCDH10 expression compared to the control. Conclusion This study demonstrated that HOTAIR interacts with miR-148b and DNMT1, eventually leading to PCDH10 methylation, which contributes to the progression of GC. Our findings provide a better understanding for detailed pathway of HOTAIR in epigenetic mechanism of GC.