1.A clinical investigation of chronic obstructive pulmonary disease patients who came to the emergency medical center.
Seung Hoi PARK ; Kwang Je BAEK ; Yun Sik HONG
Journal of the Korean Society of Emergency Medicine 1993;4(2):91-100
No abstract available.
Emergencies*
;
Humans
;
Pulmonary Disease, Chronic Obstructive*
2.Clinical efficacy of hysteroscopy.
Jung Soon PARK ; Je Seung LEE ; Sang Bok LEE ; Kyu Byung JUNG ; Seung Ho LEE
Korean Journal of Obstetrics and Gynecology 1991;34(2):237-244
No abstract available.
Hysteroscopy*
3.Clinical efficacy of hysteroscopy.
Jung Soon PARK ; Je Seung LEE ; Sang Bok LEE ; Kyu Byung JUNG ; Seung Ho LEE
Korean Journal of Obstetrics and Gynecology 1991;34(2):237-244
No abstract available.
Hysteroscopy*
4.Development and Clinical Application of the Biofeedback Anal Sphincter Control System for the Treatment of Patients with Functional Defecation Disorders Author Ung-Chae.
Ung Chae PARK ; Jong Joo KIM ; Jong Kuk LEE ; Eung Je WOO ; Seung Hun PARK
Journal of the Korean Society of Coloproctology 1998;14(3):459-466
Biofeedback is the treatment of choice for functional defecation disorders such as idiopathic chronic constipation and neurogenic fecal incontinence. The pre-existing biofeedback systems have many disadvantages. The aims of current project are, first, to develop the biofeedback system into the application software in the Windows environment, and, second, to assess the possibility of clinical usage for patients with functional defecation disorders. The hardware and software of the BASCO (Biofeedback Anal Sphincter Control) system were based on the signal measurement and signal processing of anal sphincter EMG (Electromyography). BASCO system was applied to 5 normal healthy controls and 20 patients with functional defecation disorders. Patients group was categorized as constipation group (N1=15) and incontinence group (N2=5). With use of current system, EMG-based biofeedback therapy was performed, and the outcome was analysed. Anal EMG signal data was processed by the software, and displayed in the monitor of personal computer. The software of EMG-display and database management were adequately operated. In N1 group, a paradoxical elevation or equalized activity of anal EMG pattern was shown in the simulated defecation. In N2 group, low electrical activity was shown. These findings were used for the EMG-based biofeedback therapy as a pilot study. The clinical symptoms were improved in 12 of N1 group and 3 of N2 group in the period of 3.7 (range, 1~12) months follow-up. In Conclusion, newly-developed BASCO system was adequately operated in the volunteer and patients groups. The multi-tasking and multi-processing functions were adequately shown in the real time. Current results could be used for clinical appraisal. Specifically, this system could be used for the practical application of biofeedback therapy in the patients with chronic constipation or fecal incontinence.
Anal Canal*
;
Biofeedback, Psychology*
;
Constipation
;
Defecation*
;
Fecal Incontinence
;
Follow-Up Studies
;
Humans
;
Microcomputers
;
Pilot Projects
;
Volunteers
5.A Case of MELAS Syndrome.
Ki Joong KIM ; Yong Seung HWANG ; Young In CHOI ; Sung Hye PARK ; Je Geun CHI
Journal of the Korean Pediatric Society 1990;33(11):1586-1592
No abstract available.
MELAS Syndrome*
6.Effects of a Protein Synthesis Inhibitor on Hippocampal Neuronal Damage of Rats in the Ventricular Fibrillation Cardiac Arrest Model.
Dong Rul OH ; Jang Seong CHAE ; Seung Hyun PARK ; Se Kyung KIM ; Se Min CHOI ; Je Young PARK
Journal of the Korean Society of Emergency Medicine 2000;11(4):411-420
BACKGROUND: The goal of successful resuscitation is not only to stop the process of ischemia as soon as possible but also to overcome the secondary injury process after resuscitation, which involves a complex interplay of mechanisms. Brain damage accompanying cardiac arrest and resuscitation is frequent and devastating. Cells die by one of two mechanisms: necrosis or delayed neuronal death. Delayed neuronal death may require protein synthesis. Neurons in the CA1 subfield of the hippocampus are selectively vulnerable to death after injury by ischemia and reperfusion. Death of these neurons occurs after an interval of 1 or 2 days. We assessed the effects of a protein synthesis inhibitor, cycloheximide(CHX), on hippocampal neuronal death of rats by using the ventricular fibrillation cardiac arrest(VFCA) model. METHODS: The effect of CHX(3mg/kg, s.c.) on hippocampal neuronal death was studied in two groups of 18 rats each, one group being subjected to a 2-min VFCA and the other to a 3-min VFCA. Each group was divided into three subgroups: control(group I,II) without subcutaneous injection of CHX, 'exp-12' of group I/II treated with CHX 12 hours after return of spontaneous circulation (ROSC), and 'exp-24' of group I/II treated with CHX 24 hours after ROSC. The coronal sections of the hippocampus levels were stained with hematoxylin-eosin after 72 hours of survival. The histologic damage score(HDS) was used to assign a score to the total number of damaged neurons counted in each of the hippocampal CA1 subfields. RESULTS: 1. There were not significan differences in heart rates, blood pressures, blood sugar, and blood gas in group I & II during the pre-arrest steady state or at 5 min and 30 min after ROSC. 2. In group I & II, the HDS, were significantly reduced in rats(I exp-12, 1.1+/-0.6; I exp-24, 1.3+/-0.5; II exp-12, 1.4+/-0.7; and II exp-24, 1.8+/-0.8) treated with CHX 12 hours or 24 hours after ROSC than control rats(I, 2.5+/-0.9, II, 2.9+/-0.8)(p<0.05). CONCLUSION: These results suggest that delayed hippocampal neuronal death from ischemic insult after ventricular fibrillation cardiac arrest followed by resuscitation can be prevented by a protein synthesis inhibitor, CHX. Further experimental studies of the action mechanism of protein synthesis inhibitors to delayed neuronal death and clinical applications are required.
Animals
;
Blood Glucose
;
Brain
;
Heart Arrest*
;
Heart Rate
;
Hippocampus
;
Injections, Subcutaneous
;
Ischemia
;
Necrosis
;
Neurons*
;
Protein Synthesis Inhibitors
;
Rats*
;
Reperfusion
;
Resuscitation
;
Ventricular Fibrillation*
7.Analysis of normal gait with a 3-dimensional motion analyzer.
Seung Ho YUNE ; Bong Ok KIM ; Je Woon LEE ; Sang Kyun PARK ; Cheol Joong KIM ; Sei Jin PARK
Journal of the Korean Academy of Rehabilitation Medicine 1992;16(4):399-406
No abstract available.
Gait*
8.Multifocal eosinophilic granuloma in 6th decade: a case report.
Seong Bae KIM ; Seung Ki JEONG ; Hyung Joo KIM ; Je Yo HYUN ; Eon Sub PARK ; Heung Seek PARK
The Journal of the Korean Orthopaedic Association 1991;26(3):1006-1009
No abstract available.
Eosinophilic Granuloma*
;
Eosinophils*
9.Clinical Results According to the Level and Extent of Sympathetic Block in Palmar Hyperhidrosis.
Jung Hun OH ; Seung Il PARK ; Hyoung Gon JE ; Hyun Jo KIM ; Dong Kwan KIM ; Kwang Hyun SHON ; In Cheol CHOI
The Korean Journal of Thoracic and Cardiovascular Surgery 2000;33(10):817-822
BACKGROUND: Video assisted thoracic sympathectomy or sympathicotomy is a safe and effective therapy for the treatment of palmar hyperhidrosis with immediate symptomatic imporvement. However the degree of satisfaction may diminish with time due to cmpensatory sweating or excessive hand dryness. Therefore by comparing and assessing the degree of symptomatic improvement or compensatory sweating following sympathectomy or sympathicotomy at various levels we aim to determine the optimal level of sympathetic nerve block which will result in minimal side effects and maximal benefit. MATERIAL AND METHOD: Among 194 patients having undergone video assisted thoracic sympathectomy or sympathicotomy between January 1996 and June 1999, 137 patients who responded to either telephone interview or questionnaire were included in the current study. The patients were divided into three groups. Group I(n=61) ; patients having undergone T2,3,4 sympathectomy group II(35) ; patients having undergone T2 sympathicotomy and group III(41) ; patients having undergone limited T2 sympathicotomy which consist of block of interganglionic neuronal fiber on the third rib. The parameters studied comprised of pre- and post-operative palmar temperature change treatment satisfaction the degree of compensatory sweating or discomfort from palmar dryness postoperative complication and changes in plantar sweating. RESULT: There was no difference in age and sex among the groups and the mean postoperative elevation in palmar temperature was 21.59degrees C without any differences among the groups. Patients expressing satisfaction were 65.6%, 62.9% and 90.24% in groups I, II and III, respectively(p<0.05) Moderate to severe compensatory sweating was present in 65.6% 51.4%, and 24.39%, in group I, II, and III, respectively (p<0.05) Slight but comfortable amount of palmar humidness was expressed in decreasing order group III(41.6%) group I(24.6%) and group II(5.7%) (p<0.05) Ineffectiveness or recurrence was present in 5patients in group I(8.2%) 1 patient in group II(2.9%) and none in group III. With regards to plantar sweating decrease in sweating was expressed in 43 patients(31.4%) while similar degree of sweating in 61 patients(44.5%) and increase in sweating in another 33 patinets(24.1%). CONCLUSION: Limited T2 sympathicotomy resection of the lower interganglionic neuronal fiber of the second sympathetic ganglion on the third rib showed immediate effect in palmar hyperhidrosis and caused lesser compensatory sweating and hand dryness.
Autonomic Nerve Block
;
Ganglia, Sympathetic
;
Hand
;
Humans
;
Hyperhidrosis*
;
Interviews as Topic
;
Neurons
;
Postoperative Complications
;
Surveys and Questionnaires
;
Recurrence
;
Ribs
;
Sweat
;
Sweating
;
Sympathectomy
10.Molecular Genetic Study on Human Meningiomas:Loss of Heterozygosity on Chromosome 22.
Jong Hyun KIM ; Seung Hoon LEE ; Sang Yoon PARK ; Je Ho LEE
Journal of Korean Neurosurgical Society 1991;20(4):193-198
With the methods of restriction fragment length polymorphisms(RFLPs) and Southern blot, we performed a molecular genetic study in 20 cases of intracranial meningiomas. There were four cases of invasive meningiomas, two cases of recurrent meningiomas and one case of central neurofibromatsis. Comparison of the alleles detected by DNA probes in normal versus tumor DNA revealed chromosomal alteration. The following probes were used : ESR(chromosome 6q), pYN22, pYNH37.3(chromosome 17p), cEFD52(chromosome 17q), D22S10, IGLC2(chromosome 22q). In seventeen of 20 cases(85%), constitutional heterozygosity was observed for IGLC2 probe on chromosome 22q and loss of heterozygosity was detected in nine of 17 informative cases(53%). There was no loss of heterozygosity for other probes. Three of 4 cases of invasive meningiomas and one case of central neruofibromatosis displayed loss of heterozygosity.
Alleles
;
Blotting, Southern
;
Chromosomes, Human, Pair 22*
;
DNA
;
DNA Probes
;
Genes, Suppressor
;
Humans*
;
Loss of Heterozygosity
;
Meningioma
;
Molecular Biology*
;
Polymorphism, Restriction Fragment Length