The malignant neoplasm of thyroglossal duct cyst (TGDC) is a rare tumor and is mostly revealed accidently in the course of histologic examinations after surgery. The most common histopathologic type is a papillary carcinoma. We experience a 25-year-old young woman of papillary carcinoma in thyroglossal duct cyst and the position of pyramidal lobe was unusual. She was treated by Sistrunk's operation with total thyroidectomy. We report this case with a review of literature.
Adult ; Carcinoma, Papillary ; Female ; Humans ; Thyroglossal Cyst ; Thyroidectomy

The malignant neoplasm of thyroglossal duct cyst (TGDC) is a rare tumor and is mostly revealed accidently in the course of histologic examinations after surgery. The most common histopathologic type is a papillary carcinoma. We experience a 25-year-old young woman of papillary carcinoma in thyroglossal duct cyst and the position of pyramidal lobe was unusual. She was treated by Sistrunk's operation with total thyroidectomy. We report this case with a review of literature.
Adult ; Carcinoma, Papillary ; Female ; Humans ; Thyroglossal Cyst ; Thyroidectomy

No abstract available.
Adrenoleukodystrophy*

The vertebral artery is infrequently injured because it lies deep in the neck, surrounded for the most part by bony foramina. Vertebral artery injuries are caused by penetrating traumas, blunt traumas and iatrogenic injuries. Sequela of vertebral artery injury include arteriovenous (AV) fistulae, and pseudoaneurysms may appear months after injury. Angiography is currently the gold standard for evaluating vascular injuries, such as vertebral artery injuries, and can be therapeutic. A vertebral artery fistula can also be treated by operative ligation. We experienced a rare case of a vertebro-jugular AV fistula secondary to a cervical stab wound. In this case, the patient was successfully treated by coil embolization and glue injection during angiography, which was confirmed by a postangiograpy operation.
Adhesives ; Aneurysm, False ; Angiography ; Arteriovenous Fistula* ; Embolization, Therapeutic ; Fistula ; Humans ; Ligation ; Neck ; Vascular System Injuries ; Vertebral Artery ; Wounds, Stab

No abstract available.
Eosinophils* ; Mouth Mucosa* ; Ulcer*

No abstract available.
Granuloma* ; Syphilis, Cutaneous*

Primary squamous cell carcinoma (SCC) of the thyroid is an unusual neoplasm. Recently, a new theory has been expounded suggesting that papillary thyroid carcinoma has an SCC component, as squamous differentiation is detected in only a portion of papillary thyroid carcinomas. We experienced two cases of primary squamous cell carcinoma of the thyroid. One case was an 82-year-old woman who underwent a total thyroidectomy. Histopathologic findings revealed that the squamous cell carcinoma was extended to the soft tissue. The woman was treated with postoperative radiotherapy, but her prognosis was poor. On the other hand, the case of a 31-year-old woman who was diagnosed with squamous cell carcinoma and papillary carcinoma within the thyroid displayed good prognosis. We review the literature and discuss these two cases that bring into focus the different prognoses.
Carcinoma ; Carcinoma, Papillary ; Carcinoma, Squamous Cell ; Female ; Hand ; Humans ; Prognosis ; Thyroid Gland ; Thyroid Neoplasms ; Thyroidectomy

Primary cutaneous adenosquamous carcinomas are very rare with only few published reports. The histopathologic finding consists of two different components - mucin secreting cells (adenocarcinoma) and squamous cells (squamous cell carcinoma). We experienced a case of occipital scalp adenosquamous carcinoma, which is an extremely rare neoplasm in scalp. The lesion is histologically distinctive because of the presence of mixed areas of unequivocal adenocarcinoma and squamous cell carcinoma. It is found that combined surgery and additional radiation therapy is necessary because the biological behavior and prognosis of this neoplasm are considered as more aggressive and worse than that of conventional squamous cell carcinoma.
Adenocarcinoma ; Carcinoma, Adenosquamous ; Carcinoma, Squamous Cell ; Mucins ; Prognosis ; Scalp ; Skin Neoplasms

BACKGROUND: QT dispersion(QTd) has been shown to be ventricular electrical instability, especially predictor of ventricular arrythmia and indicator of antiarrythmic effect. It was reported that there was a relationship between acute myocardial infarction and increased QTd in that QTd is dependent of the degree of reperfusion as well as the site and size of infarction. In this study, we intended to verify a significant association between myocardial ischemia and QTd by comparing the changes in QTd with or without chest pain in patients with unstable angina who had proven myocardial ischemic changes. METHOD: We studied 20 patients (12 men and 8 women : mean age, 58+/-3.4 years) with unstable angina who had proven myocardial ischemic changes and perfusion defect by 24 hour Holter monitoring, Treadmill test, or coronary angiography. Each case was measured QTd during chest patin and resting state 24 hours after chest pain. All standard 12-lead ECGs were recorded at a speed of 25 mm/sec and examined retrospectively by one observer. QTd corrected for heart rate (QTcd) was calculated by Bazett's formula. The difference of QTd was assessed by comparing by paired t-test. RESULTS: The mean values of QTd were 117.9+/-49.9 msec and 69.7+/-30.2 msec with existence and the absence of chest pain. There was significant increment of QTd when the paients with unstable angina had chest pain(p<0.01). QTcd also significantly increased with the mean value of 119.7+/-57.1 and 74.9+/-36.6 msec (p=0.015). CONCLUSIONS: The results of this study clarified the change of QTd with myocardial ischemia. We expect QTd using a single, noninvasive method to indicate that the chest pain is induced by myocardial ischemic changes. For the furture, it may be possible to study as to the significance of QTd as a predictor of cardiovascular accidents in patients with unstable angina by measuring the serial QTd.
Angina, Unstable ; Arrhythmias, Cardiac ; Chest Pain ; Coronary Angiography* ; Coronary Stenosis* ; Coronary Vessels* ; Electrocardiography ; Electrocardiography, Ambulatory ; Exercise Test ; Female ; Heart Rate ; Humans ; Infarction ; Male ; Myocardial Infarction ; Myocardial Ischemia ; Perfusion ; Reperfusion ; Retrospective Studies ; Thorax

Purpose: To investigate the effect of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, on inflammatory cytokines of urogenital tissue in a rat model of type 2 diabetes (T2DM) to infer pharmaceutical influence of dapagliflozin on genitourinary infection or inflammation. Methods: Study animals were divided into the following 4 groups of 10 animals each: (1) the Otsuka Long-Evans Tokushima Fatty (OLETF)-DA group treated with dapagliflozin at 1.0 mg/kg/day, (2) the OLETF-VO group treated with voglibose at 0.6 mg/kg/day, (3) the control group (OLETF-CO) given water, and (4) the Long-Evans Tokushima Otsuka (LETO) rats were included as nondiabetic control group. Changes in blood glucose, 24-hour urine volume, and urine glucose were measured. The interleukin-1β (IL-1β) and interleukin-18 (IL-18) levels in the bladder and the urethra were quantified, respectively. Results: The urine glucose level and the 24-hour urine volume at 12 weeks of treatment were significantly higher in the OLETF-DA group than that in any other group (P<0.05). The cytokine analysis of the bladder and urethra showed higher IL18 and IL-1β in the OLETF-DA and the OLETF-CO groups than that in the OLETF-VO and LETO groups (P<0.05). The cytokine levels did not differ between the OLETF-DA and the OLETF-CO groups, and the level of IL-18 in the OLETF-DA group was higher in the urethra than in the bladder. Conclusions This study revealed that dapagliflozin increased the urine glucose concentration, resulting in an inflammatory response remain in the urogenital tract as the untreated diabetic rats. Therefore, when treating patients with T2DM with dapagliflozin, careful attention should be paid to genitourinary infection or inflammation.