Cotylaspis coreensis sp. n., Cotylaspis sinensis Faust et Tang, 1936, Phyllodistomum parasiluri Yamaguti, 1934, Kaurma orientalis Yamaguti, 1937, Astiotrema reniferum (Looss, 1898), Astiotrema odhneri Bhalerao, 1936, Astiotrema sp. and Cephalogonimus japonicus Ogata, 1936 were collected from the intestine of freshwater mud-turtle, Amyda sinensis Wiegmann in Korea which were purchased at Namdaemoon Market of Seoul on October 1968 and May 1977. Cotylaspis coreensis differs from other members of the genus in relatively large size of pharynx, the number and distribution of vitelline follicles, size of testis, length of intestine and position of genital opening. Distribution of Cotylaspis sinensis was firstly recorded in Korea. Phyllodistomum parasiluri collected in this study was considered to be the first to recover from the reptilian host although the collected worms were still immatured. The genus Astiotrema collected in this study were divided into three species, A. reniferum which is hitherto unrecorded in Korea, A. odhneri which had been described as A. orientale, A. amydae and A. fukuii and another Astiotrema sp. which differs from the former two species in minor differences in size of suckers, size of ova and size of cirrus pouch. The distribution of Cephalogonimus japonicus was firstly recorded in Korea.
parasitology-helminth-trematoda ; Cotylaspis coreensis ; Phyllodistomum parasiluri ; Kaurma orientalis ; Astiotrema reniferum ; Astiotrema odhneri ; Astiotrema sp. ; Cephalogonimus japonicus ; turtle-Amyda sinensis ; epidemiology

BACKGROUND: Acne, one af the commonest dermatological disorders, is a disease of the pilosebaceous unit, and the primarily involved site is the face, where this structure exists in maximal density. Among the many etiologieal factors of acne, changes in the kinetics of sebum secretion in acne patients have been described, but there is no report to compare follicular density and the sebum excretion rate in different facial regions between normal and acne patients. OBJECTIVES: The purpose of this study was to compare the sebum output and follicular density in different regions of the face in women with and without acne and to evaluate the differences between the two groups. METHODS: We studied 10 normal and 14 acneic women aged 19-27. Follicular density was determined by light microscopy counting pilosebaceous units on cyanoacrylate follicular biopsy specimens. The sebum excretion rate was calculated by an image analyzer with a sebum print on Sebutape. RESULTS: 1. Follicular density was not significantly different between the normal and acne group. The number of follicles decreased from the central to the lateral aspect of the face with the highest value being on the nose tip and the lowest on the lateral forehead. 2. The total sebum excretion rate and the number of actively secreting follicles showed different patterns in the two groups. There was a decreased value in the acne group in some central regions of face. In addition, central to lateral declining pattems, shown in the normd group, were not apparent in the acne group. 3. The follicular sebum excretion rate showed large variations in both groups, without apparent central to lateral declining patterns. The confluence of adjacent follicles seemed to produce falsely low or high values compared with previous studies. CONCLUSION: Sebum production is influenced both by the number of active follicles and their individual capacity to excrete sebum, and the total sebum excretion rate was lower than normal in low grade acne in this study. Obstruction of the outflow of sebum and regression of sebaceous glands due to comnlones may account for it.
Acne Vulgaris* ; Biopsy ; Cyanoacrylates ; Female ; Forehead ; Humans ; Kinetics ; Microscopy ; Nose ; Sebaceous Glands ; Sebum*

Alzheimer's disease(AD) is associated with a characteristic neuropathology. The major hallmarks of AD are senile plaques(SPs) and neurofibrillary tangles(NFTs). beta-amyloid protein(Abeta) is derived from the proteolysis of amyloid precursor protein(APP) and then converted to SPs. Mature SPs produce cytotoxicity through direct toxic effects and activation of microglia and complement. NFTs are composed of paired helical filaments(PHFs) including abnormally phosphorylated form of the microtubule-associated protein(MAP) tau and increased tau level in cerebrospinal fluid may be observed in most AD. The aggregation of Abeta and tau formation are thought to be a final common pathway of AD. Acetycholine, dopamine, serotonin, GABA and their receptors are associated with AD. Especially, decreased nicotinic acetylcholine receptors(nAChRs) in AD are reported. Genetic lesions associated with AD are mutations in the structural genes for the APP located on chromosome 21, presenilin(PSN)1 located on chromosome 14 and PSN2 located on chromosome 1. Also, trisomy 21, Apo-E gene located on chromosome 19, PMF locus, low density lipoprotein receptor-related protein and alpha-macroglobulin increase risk of AD. In this article, we will review about the neurobioloby of AD and some newly developed research areas.
Acetylcholine ; Alzheimer Disease* ; Amyloid ; Amyloid beta-Peptides ; Apolipoproteins E ; Cerebrospinal Fluid ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 19 ; Chromosomes, Human, Pair 21 ; Complement System Proteins ; Dopamine ; Down Syndrome ; gamma-Aminobutyric Acid ; Genetics ; Lipoproteins ; Microglia ; Neurobiology* ; Proteolysis ; Serotonin

No abstract available.
Poisoning*

No abstract available.
Hepatitis B* ; Hepatitis* ; Humans ; Mothers* ; Parturition*

This study was undertaken to estimate the reinfection incidence of Ascaris lumbricoides after biannual blanket mass chemotherapy and to figure out the characteristic seasonal fluctuation pattern in a Korean rural village. A total of 612 residents from 4 Ri's of Hwasung Gun, Kyunggi Do, Korea was selected and divided into 6 groups according to hamlets, each of which consisted of about 100 inhabitants. Each group received blanket biannual mass chemotherapy with 10 mg/kg of pyrantel pamoate respectively in each month, during the period from April 1977 to September 1978 (Group A-April and October 1977 and April 1978, Group B-May and November 1977 and May l978, and so on). Beforehand Ascaris infection status was evaluated by examining eggs and worms expelled exactly after the first mass chemotherapy checked during the first 6 months and the reinfection incidences were estimated in follow-up examinations during next l2 months by the above two kinds of methods and by detection of young Ascaris positive cases. Young Ascaris was defined as worm shorter than l3 cm and lighter than 500 mg and considered to have introduced to human host during the period from the previous 2 months to 2 weeks. The results were summarized as follows: Beforehand infection rate with Ascaris were 42.3 percent (34.4-50.6 percent by group) by egg detection and 46.2 percent (36.2-51.9 percent by group) by worm detection methods in average. Number of worms per infected case was 2.7 (1.5-4.2 by group) in average. Reinfection rates estimated by egg detection ranged from 8.0 to 3l.5 percent (l6.9 percent in average) in the first follow-up period and from 14.0 to 20.0 percent (l7.5 percent in average) in the second follow-up. Seasonal fluctuation was found marked and there were roughly two peaks, of which the larger appeared from February to March and the smaller from August to September. Reinfection rates by worm detection method ranged from 20.6 to 34.9 percent(25.7 percent in average) and from 14.3 to 21.9 percent (19.6 percent in average) in respective follow-up examinations. Seasonal fluctuation was also observed and the peak incidence appeared one month earlier than those made by egg positive conversion. Number of worms per infected case decreased to 1.6 in average in both follow-up. Young Ascaris detection rates ranged from 6.0 to 12.9 percent (9.4 percent in average) and from 2.3 to 5.8 percent (3.8 percent in average) in respective follow-up. Seasonal fluctuation was also observed. From January to February, the positive rates were up to 12.9 percent and 12.7 percent respectively, which formed the higher peak. Lower one was observed during July to August. From the above results, the actual time of Ascaris reinfection were November to December for the higher peak and May to June for the lower one in Korean population. Pickled vegetable was suggested as a most probable source of Ascaris reinfection during late autumn to winter season.
parasitology-helminth-nematoda ; Ascaris lumbricoides ; reinfection ; epidemiology

A status survey on Metagonimus yokogawai infection along the Tamjin River basin, South Cholla Do, Korea was conducted from September to November 1977. The snail intermediate host, Semisulcospira sp., the fish host, Plecoglossus altivelis and the inhabitants in three villages in Jangheung and Kangjin Guns were examined for detection of this trematode infection respectively. The results could be summarized as follows: Out of 452 snails, Semisulcospira sp., 105 (23.2%) were found positive for rediae and/or cercariae of M. yokogawai in Jangheung Gun. All of 20 sweetfishes, P. altivelis were infected with metacercariae of M. yokogawai and the mean number per fish was 15,688 and per gram of fish muscle, 234. Out of 606 inhabitants in three villages, 160(26.4%) persons were found infected with M. yokogawai and the mean E.P.G counts per infected cases were 2,078. Sixty cases (9.8%) were positive for ova of Clonorchis sinensis with mean E.P.G., 846, frequently mixed-infected with M. yokogawai. From the above results, it was turned out that the Tamjin River basin is one of the endimic foci of metagonimiasis in Korea. The relatively low infection rate of human host in spite of much higher infection of intermediate hosts were considered to be due to the less population of sweetfishes in the Tamjin River than in the Sumjin River basin.
parasitology-helminth-trematoda ; Metagonimus yokogawai ; epidemiolgy

Mathematical models such as the negative binomial, Poisson and Polya-Eggenberger distributions were applied to the observed data of the number of metacercariae of Paragonimus iloktsuenensis in crab hosts, Sesarma dehaani which were collected in Hadong, South Kyong-sang Do, Korea. From the above analysis, it was found that the pattern of density of metacercariae of this lungfluke among the crab hosts was well fitted to the negative binomial distribution, rather than to the Poisson or Polya-Eggenberger distribution.
parasitology-helminth-trematode ; Paragonimus iloktsuenensis ; epidemiology ; mathematics ; metacercaria ; crab ; Sesarma dehaani

Direct contact method of autoradiography was applied in order to know in Eurytrema pancreaticum which was incubated at various intervals such as 60, 120, 240, and 360 minutes in the vitro media added with radioactive succinic acid, C(14)-succinate. The distribution of the radioactive succinate was clarified by this technique and possible explanation was presented. The autoradiographic procedures were essentially the same as those reported previously by Yoon et al. (1964). The most distinct autoradiograms were obtained after 240 minutes incubation. The radioactivity of this labelled succinic acid chiefly concentrated in reproductive organs, such as testes, ovary, egg containing uterine tubules and vitelline follicles.
paraisology-helminth-trematoda-Eurytrema pancreaticum ; autoradiography ; metabolism-succinic acid ; succinic acid

No abstract available.
Keratinocytes*