No abstract available.
Lipoma*

No abstract available.
Pulmonary Blastoma*

OBJECTIVE: The objective of this study is to compare the effectiveness and safety in the labor induction between the high dose oxytocin method and the new low dose oxytocin method. STUDY DESIGN: Firstly, we selected 125 pregnant women hospitalized, having the indication of labor induction from March, 1995 to August, 1996. Of them, we selected 61 pregnant women tothem the high dose oxytocin method was used, as the control group, and in- creased the quantity of 2.5 mU/min every 20 minutes with the start dose of 2.5 mU/min to them. On the other hand, with the start dose of 1.25 mU/min, we increased the quantity of 1.25 mU/min every 20 minutes to the study group of low dose oxytocin method, 64 pregnant women. RESULTS: No statistical significance was found in the time from the effective uterine contraction to the delivery in the study group, in contrast to that of the control group to them the labor induction was conducted by using the high dose oxytocin. Maximum amount used to the high dose oxytocin was significantly more than that of the low dose oxytacin, but in the total given dose, there was no significant difference between two groups. Maxi- mum uterine contraction of the control group did not show any significant. difference from that of the study group, and there was also no significant difference in the frequency of generating the complications such as fetal distress. CONCLUSION: There was no difference in the labor.induction -to delivery time, and the complications of fetus, between the existing high dose oxytocin method and the new low dose oxytocin method. Therefore it is thought the low dose oxytocin method may reduce the possibility of a complieation compared with the high dose oxytocin method. However, it is considered this matter must be investigated further in the futrre.
Female ; Fetal Distress ; Fetus ; Hand ; Humans ; Oxytocin* ; Pregnant Women ; Uterine Contraction

Invasive aspergillosis (IA) is frequent in patients with acute leukemia and results in significant morbidity and mortality among neutropenic patients. Although the lung is a common site of this disease, pneumothorax and pneumomediastinum is rare as initial manifestations of IA. A 22-year-old male was admitted to the hospital due to aggrevated dyspnea, productive cough, fever and nasal bleeding. Acute myelogenous leukemia (AML, M2) was diagnosed. His clinical course was aggrevated despite patient was treated with empirical antibiotics. Chest X-ray and high-resolution computed tomography showed pneumothorax and pneumomediastinum on the left thorax. The clinical course was improved after closed thoracostomy and empirical amphotericin B therapy for the fungal infections was started. IA was pathologically diagnosed by his sputum contained a mucus plug. His symptoms and radiological lesions were completely resolved after amphotericin B therapy alone with a total doses of 2.58g. We report a case of IA complicated by pneumothorax and pneumomediastinum in acute myelogenous leukemia with the review of literatures.
Amphotericin B ; Anti-Bacterial Agents ; Aspergillosis* ; Cough ; Dyspnea ; Epistaxis ; Fever ; Humans ; Leukemia ; Leukemia, Myeloid, Acute* ; Lung ; Male ; Mediastinal Emphysema* ; Mortality ; Mucus ; Pneumothorax* ; Sputum ; Thoracostomy ; Thorax ; Young Adult

Infectious mononucleosis(IM) is a benign self-limiting disease and result from a polyclonal B cell proliferation secondary to Epstein-Barr virus (EBV) infections. The infection is controlled by cytotoxic T cells triggered by EBV infected B cells. However, rare cases develop severe or fatal IM accompanied by hemophagocytic syndrome. We report a case of a 4-year-old girl who presented with high fever, hepatosplenomegaly, hepatic failure, pancytopenia and coagulopathy. Despite intensive treatment, the patient's condition deteriorated rapidly and died 3 days after admission. At autopsy, there was prominent infiltration of atypical lymphocytes with hemophagocytosis in multiple organs, especially liver, spleen and lymph nodes. Atypical lymphocytes were immunopositive for T cell markers and showed positive signal in EBV in situ hybridization.
Autopsy ; B-Lymphocytes ; Cell Proliferation ; Child, Preschool ; Female ; Fever ; Herpesvirus 4, Human ; Humans ; In Situ Hybridization ; Infectious Mononucleosis* ; Liver ; Liver Failure ; Lymph Nodes ; Lymphocytes ; Lymphohistiocytosis, Hemophagocytic ; Pancytopenia ; Spleen ; T-Lymphocytes

Onychomycosis is usually caused by dermatophytes, but some species of nondermatophytic molds and yeasts are also associated with nail invasion. Aspergillus niger is a nondermatophytic mold which exists as an opportunistic filamentous fungus in all environments. Here, we report a case of onychomycosis caused by A. niger in a 66-year-old female. The patient presented with a black discoloration and a milky white base and onycholysis on the proximal portion of the right thumb nail. Direct microscopic examination of scrapings after potassium hydroxide (KOH) preparation revealed dichotomous septate hyphae. Repeated cultures on Sabouraud's dextrose agar (SDA) without cycloheximide produced the same black velvety colonies. No colony growth occurred on SDA with cycloheximide slants. Biseriate phialides covering the entire vesicle with radiate conidial heads were observed on the slide culture. The DNA sequence of the internal transcribed spacer region of the clinical sample was a 100% match to that of A. niger strain ATCC 16888 (GenBank accession number AY373852). A. niger was confirmed by KOH mount, colony identification, light microscopic morphology, and DNA sequence analysis. The patient was treated orally with 250 mg terbinafine daily and topical amorolfine 5% nail lacquer for 3 months. As a result, the patient was completely cured clinically and mycologically.
Agar ; Aged ; Arthrodermataceae ; Aspergillus ; Aspergillus niger ; Base Sequence ; Cycloheximide ; Female ; Fungi ; Glucose ; Head ; Humans ; Hydroxides ; Hyphae ; Lacquer ; Light ; Morpholines ; Nails ; Naphthalenes ; Niger ; Onycholysis ; Onychomycosis ; Potassium ; Potassium Compounds ; Sequence Analysis, DNA ; Sprains and Strains ; Thumb ; Yeasts

PURPOSE: To evaluate the diagnostic value of tear film osmolarity for non-Sjogren dry eye syndrome through measuring the correlation between tear osmolarity and several conventional dry eye parameters. METHODS: In this observational cross-sectional study, 274 patients (274 eyes) with non-Sjogren dry eye syndrome were examined using tear film osmolarity and the following conventional dry eye parameters: Schirmer's test, tear film break-up time, ocular surface disease index (OSDI), and corneal staining score. The correlations between tear film osmolarity and each conventional dry eye parameter were assessed using Spearman's correlation coefficients. RESULTS: The mean tear film osmolarity of the study population was 296.34 ± 21.08 mOsm/L. The tear film osmolarity was significantly negatively correlated with the Schirmer's test value (r = -0.431, p < 0.001) and tear break-up time (r = -0.131, p = 0.031), while it was significantly positively correlated with the OSDI scores (r = 0.191, p = 0.001) and corneal staining scores (r = 0.150, p = 0.013). CONCLUSIONS: Tear film instability was significantly correlated with other conventional dry eye parameters. However, additional studies are required to determine its feasibility as a stand-alone diagnostic tool.
Cross-Sectional Studies ; Diagnosis* ; Dry Eye Syndromes ; Humans ; Osmolar Concentration* ; Tears*

Blood samples were collected from 140 institutionalized children aged 0~9 at Goyang gun. Kyunggi Do, Korea. The venous blood was taken and isolated serum was used for Haemagglutination(HA) test.1. Out of 140 samples, the positive rate of HA titer was 35.7 per cent. No significant differences was recognized by sex gropus. 2. When subdivided into the 0~4 and 5~9 years age groups, the positive rate obtained 30.4 per cent and 34.1 per cent respectively, which was no significant difference. 3. The positive rate of HA titirs in various diseases was 31.0 percent in total, being 50 per cent in mental retardation cases, 100 percent in delayed speech and hearing loss.
Child ; Child, Institutionalized* ; Gyeonggi-do ; Hearing Loss ; Humans ; Intellectual Disability ; Korea ; Toxoplasma*

Human genetic variation is represented by the genetic differences both within and among populations, and most genetic variants do not cause overt diseases but contribute to disease susceptibility and influence drug response. During the last century, various genetic variants, such as copy number variations (CNVs), have been associated with diverse human disorders. Here, we review studies on the associations between CNVs and autoimmune diseases to gain some insight. First, some CNV loci are commonly implicated in various autoimmune diseases, such as Fcgamma receptors in patients with systemic lupus erythemoatosus or idiopathic thrombocytopenic purpura and beta-defensin genes in patients with psoriasis or Crohn's disease. This means that when a CNV locus is associated with a particular autoimmune disease, we should examine its potential associations with other diseases. Second, interpopulation or interethnic differences in the effects of CNVs on phenotypes exist, including disease susceptibility, and evidence suggests that CNVs are important to understand susceptibility to and pathogenesis of autoimmune diseases. However, many findings need to be replicated in independent populations and different ethnic groups. The validity and reliability of detecting CNVs will improve quickly as genotyping technology advances, which will support the required replication.
Animals ; Autoimmune Diseases/ethnology/*genetics/immunology ; Autoimmunity/*genetics ; *DNA Copy Number Variations ; *Gene Dosage ; Genetic Association Studies ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Phenotype ; Population Groups/genetics ; Risk Factors

OBJECTIVE: To quantify magnetic resonance imaging (MRI) findings of congenital muscular torticollis (CMT) and to demonstrate the usefulness of quantitative MRI findings in the management of CMT. METHODS: This was a retrospective study of 160 subjects with CMT who had undergone neck MRI at the age of 48 months or younger at a tertiary medical center. Among the 160 subjects, 54 had undergone surgical release of CMT and 106 subjects had not undergone surgery. For the quantitative analysis, the ratios of area and intensity of the MRI findings were measured and compared between the two groups (ratio of area = the largest cross-sectional area of the SCM with CMT - the cross-sectional area of the contralateral SCM without CMT / the cross-sectional area of the contralateral SCM without CMT; ratio of intensity = the mean gray color intensity of the contralateral SCM without CMT - the lowest mean gray color intensity of the SCM with CMT / the mean gray color intensity of the contralateral SCM without CMT). Receiver operating characteristic (ROC) curve analysis was conducted for the ratios of area and intensity in order to find the optimal cutoff value for determining the need for surgery in CMT cases. RESULTS: The ratios of area and intensity were significantly higher in the surgical group than in the non-surgical group (p< or =0.001), suggesting that the sternocleidomastoid muscle (SCM) was thicker and darker in the surgical group than in the non-surgical group. The optimal cutoff value for the ratio of area was 0.17 and that for the ratio of intensity was 0.05. All subjects with a ratio of intensity less than 0.03 belonged to the non-surgical group, and all subjects with a ratio of intensity greater than 0.16 were categorized in the surgical group. CONCLUSION: The quantitative MRI findings, i.e., ratios of area and intensity, may provide a guideline for deciding the need for surgical intervention in CMT patients. Further prospective studies are required to verify these findings.
Humans ; Magnetic Resonance Imaging* ; Muscular Diseases ; Neck* ; Retrospective Studies ; ROC Curve ; Torticollis*