1.Exchange Transfusion Using Percutaneous Femoral Vein Catheterization in Neonates: Comparison with Umbilical Vein Catheterization.
Song Ja KIM ; Hyang Ok WOO ; Seung Hwan KIM ; Mi Ryeong KIM ; Sun Kyeong SIN ; Hee Shang YOUN
Journal of the Korean Pediatric Society 1994;37(2):180-184
Traditionally umbilical vein has been used for exchange transfusion in neonates. This method is relatively safe and effective but with a few complications. So via percutaneous femoral vein catheters we tried exchange transfusions in 30 patients with neonatal hyperbilirubinemia admitted to GNUH from September 1990 to August 1992. Femoral vein catheterization succeeded in 2~3 trials, In all cases high bilirubin level was lowered by half at the end of exchange transfusion. Transient microscopic hematuria by bladder puncture occurred in one neonate. Exchange transfusion via femoral vein catheter is a sage, easy and effective method.
Bilirubin
;
Catheterization*
;
Catheters*
;
Femoral Vein*
;
Hematuria
;
Humans
;
Hyperbilirubinemia, Neonatal
;
Infant, Newborn*
;
Punctures
;
Umbilical Veins*
;
Urinary Bladder
2.96 Survey of Korean Society of Cataract and Refractive Surgery Members.
Kyung Hwan SHYN ; Jae Ki SHIM ; Seung Hwan SIN ; Sang Woo PARK
Journal of the Korean Ophthalmological Society 1999;40(2):403-408
The second survey which was composed of questionnaires on a variety of ophthalmic topics was made up and sent to members of the Korean Society of Cataract and Refractive Surgery(KSCRS) in March, 1997. The second survey was composed of 80 items, including 8 additional items compare to the first survey in 1996. Forty-three percent(65/150) responded and the results were compared to these of the first survey.Over half of the respondents(64%) were in their forties. Catarct operation accounted for over 60% of the total operations in 75% of KSCRS members which was increased compared to previous survey(45%). The 0-2 days of admission in the cataract surgery was 56% of respondents that was increased than previous survey(36%). Increased preference to 3.5mm incision and 5.5mm incision in cataract operation and increased use of 5.5mm optic size IOL(47%) in phacoemulsification surgery compare to previous survey in that 6.0mm optic size IOL was mostly used were shown which indicate increase of small incision cataract surgery.For radial keratotomy as a means of correcting myopia, 97% of the respondents were not performing the procedure. Fortu-six percent of the respondents have been doing excimer laser photorefractive keratectomy which was decreased than previous survey(54%).For use of foldable IOL. which was one of new question items, 50% of respondents answered they use it in less than 20% of cataract surgery which indicates foldable IOL is not popularly used.These results reflect the present trends of cataract and refractive surgeries in Korea.
Cataract*
;
Surveys and Questionnaires
;
Keratotomy, Radial
;
Korea
;
Lasers, Excimer
;
Myopia
;
Phacoemulsification
;
Photorefractive Keratectomy
;
Refractive Surgical Procedures*
3.Effects of Immunostimulatory CpG-Oligodeoxynucleotides of Bronchial Asthma in Rat.
Sin Hyung LEE ; Je Hyeong KIM ; Hye cheol JEONG ; Kyung Kyu KIM ; Ki Hwan JUNG ; Byung Gyu KIM ; Seung Heon LEE ; Sang Myun PARK ; Cheol SIN ; Jae Youn CHO ; Jae Jeong SHIM ; Kwang Ho IN ; Se Hwa YOO ; Kyung Ho KANG
Tuberculosis and Respiratory Diseases 2001;50(1):12-28
BACKGROUND AND OBJECT: Immunostimulatory CpG-oligodeoxynucleotides (ISS CpG-ODN) up-regulate the TH1-type immune response and down-regulate the TH2-type response. This study was performed to investigate the immune response changes resulting from ISS CpG-ODN on bronchial hyperrestponsiveness, eosinophilic inflammation and mucus hypersecretion in rat asthma. MATERIALS AND METHODS: 10 normal controls(NC) and 26 asthmatic rats, which were generated by ovallbumin(OVA) sensitization and challenge, were studied. The asthmatic rats were randomized into 11 asthma controls(AC) and 15 in the asthma-CpG treatment group(CpG). The CpG group was administered ISS CpG-ODN intramuscularly and the AC group was administered a placebo(0.9% NaCl)on day 15 and 20. After CpG-ODN or placebo administration, we measured the IFN-(TH1-type cytokine) and IL-4(TH2-type cytokine) levels in the bronchoalveolar lavage fluid(BALF), the specific airway resistance(sRaw), eosinophilic fraction in BALF, eosinophilic infiltration, goblet cell dysplasia and MUC5AC gene expression in the lung tissue. RESULTS: In the BALF of the CpG group, the IFN-γ concentration was significantly high and the IL-4 concentration was significantly low when compared with the AC group. Both the sRaw and eosinophilic fraction, and infiltration into the BALF and lung tissue significantly lower in the CpG group when compared with the AC group. However, little difference in goblet cell dysplasia and MUC5Ac gene expression was observed between the CpG group and the Ac group. CONCLUSION: ISS CpG-ODN decreases bronchial hyperresponsiveness and eosinophilic inflammation in the rat asthma model through the up-regulation of the TH1-type immune response with the down-regulation of the TH2-type response. However, the effect of these immune response changes on mucus hypersecretion was is not remarkable in this study.
Animals
;
Asthma*
;
Bronchoalveolar Lavage
;
Down-Regulation
;
Eosinophils
;
Gene Expression
;
Goblet Cells
;
Inflammation
;
Interleukin-4
;
Lung
;
Mucus
;
Rats*
;
Up-Regulation
4.Expression of cyclooxygenase-1, -2 in human uterine cervix during gestational period.
Joon Hwan OH ; Haeng Soo KIM ; Jung In YANG ; Myung Sin KIM ; Sung Chun YANG ; Gee Soo HAN ; Seung Sub KEUM ; Gee Suk OH
Korean Journal of Obstetrics and Gynecology 2000;43(11):2014-2019
OBJECTIVE: To determine whether cyclooxygenase (COX)-1 and COX-2 are expressed differentially during the whole gestational period in the pregnant human uterine cervix and if they are involved in the process of labor. METHODS: Nine patients were matched for obstetrical history and maternal age were divided into an abortion group who aborted between 13 and 16 weeks(n=3), a preterm group who delivered between 20 and 37 weeks(n=3), and a term group who delivered between 37 and 42 weeks of gestation(n=3). Immediately after vaginal delivery cervical biopsy samples were obtained and immunohistochemically stained for COX-1 and COX-2 and the degree of staining was evaluated by H-scoring system. RESULTS: Expression of COX-1 and COX-2 was found in epithelial and stromal cells of uterine cervical tissues of preterm and term group. The immunohistochemical expression of COX-1 and COX-2 was strongest in the term group compared to the preterm group in stromal cells(HSCORE : 2.0 vs. 4.0 ; 2.0 vs. 3.0), and in epithelial cells(HSCORE : 1.0 vs. 3.0 ; 1.0 vs. 3.0). CONCLUSION: Although small amount of the groups were investigated, in the pregnant human uterine cervix, COX-1 and COX-2 are found to be expressed, and both shows the strongest expression in term cervical tissue. It is suggested that the uterine cervix, under the control of prostaglandins, is actively involved in the process of labor, and it is thought that the role of COX-1 and COX-2 is more important in parturition process with advancing gestational age.
Biopsy
;
Cervix Uteri*
;
Cyclooxygenase 1*
;
Cyclooxygenase 2
;
Female
;
Gestational Age
;
Humans*
;
Maternal Age
;
Parturition
;
Pregnancy
;
Prostaglandin-Endoperoxide Synthases
;
Prostaglandins
;
Stromal Cells
5.A Case of Huge Empyema Caused by Pulmonary Actinomycosis.
Duck Ryung KIM ; Yoon Hee CHOI ; Seung Whan LEE ; Jong Sin LEE ; Min Jae KIM ; Seung Sook LEE ; Du Hwan CHOE ; Cheol Hyeon KIM ; Jae Cheol LEE
Tuberculosis and Respiratory Diseases 2004;57(6):579-583
Actinomycosis is an indolent infectious disease characterized by pyogenic response and necrosis, followed by intense fibrosis. The main forms of human actinomycosis are cervicofacial, pulmonary, and abdominopelvic type. Pulmonary actinomycosis accounts for 15% to 20% of total cases and unfortunately, clinical manifestations and radiologic findings are nonspecific. Small pleural effusion or empyema may develop in advanced disease but massive empyema is infrequent and rarely reported. We report a case of huge empyema caused by pulmonary actinomycosis in a 55 year-old man, presented with one-month history of productive cough and fever. The CT scan revealed a huge cavity with air-fluid level occupying the left hemithorax. Empyema caused by actinomycosis was confirmed microscopically by demonstration of sulfur granules in empyema sac through thracotomy. Decortication and surgical resection of empyema sac and destructed lung was accomplished and followed by intravenous infusion of penicillin G.
Actinomycosis*
;
Communicable Diseases
;
Cough
;
Empyema*
;
Fever
;
Fibrosis
;
Humans
;
Infusions, Intravenous
;
Lung
;
Middle Aged
;
Necrosis
;
Penicillin G
;
Pleural Effusion
;
Sulfur
;
Tomography, X-Ray Computed
6.A Case of Transvaginal Expulsion of Intramural Leiomyoma after Uterine Artery Embolization.
Seung Jun PARK ; Gi Young KIM ; Sang Hwak HAN ; Jeong Bum CHOI ; Sin Hye KIM ; Ji Hoon YOO ; Hwan Sung JOE ; Hyo Sang HAN ; In Cheul HWANG ; Seung Boo YANG
Korean Journal of Obstetrics and Gynecology 2006;49(11):2438-2444
Uterine artery embolization for the treatment of uterine leiomyomas is gaining acceptance as an effective alternative to surgical treatment in preserving uterus and reducing symptoms. Vaginal expulsion of leiomyomas after UAE is uncommon, and has been regarded as a side effect of the procedure, as well as a natural phenomenon of treatment response. A-28-year-old unmarried woman who has been suffered from menorrhagia underwent UAE. MRI revealed the remnant leiomyomas were reduced in size and volume and also symptoms of leiomyomas were much improved. After 6 month, We've made sure about non-visualization of leiomyoma on follow-up pelvic dynamic MRI. We report this rare case of vaginal expusion of intramural leoimyoma with a brief literature.
Female
;
Follow-Up Studies
;
Humans
;
Leiomyoma*
;
Magnetic Resonance Imaging
;
Menorrhagia
;
Single Person
;
Uterine Artery Embolization*
;
Uterine Artery*
;
Uterus
7.A Case of Mycobacterium kansasii Pulmonary Disease Presenting as Endobronchial Lesions in HIV-Infected Patient.
Moon Sung KIM ; Ji Won HAN ; Su Sin JIN ; Jong Min LEE ; Jick Hwan HAH ; Youn Jeong KIM ; Seung Joon KIM ; Moon Won KANG ; Ji Young KANG
Tuberculosis and Respiratory Diseases 2013;75(4):157-160
Incidence of nontuberculous mycobacterium (NTM) pulmonary disease is increasing with the wider recognition and development of diagnostic technology. Mycobacterium kansasii is the second most common pathogen of NTM pulmonary disease in human immunodeficiency virus (HIV)-infected patients. However in Korea, the incidence of M. kansasii pulmonary disease is relatively low, and there has been no report of M. kansasii pulmonary disease with bronchial involvement in HIV patients, to the best of our knowledge. We report a case of M. kansasii pulmonary disease presenting with endobronchial lesions in an HIV-infected patient complaining of chronic cough with bilateral enlargements of hilar lymph nodes on chest X-ray.
Bronchial Diseases
;
Cough
;
HIV
;
Humans
;
Incidence
;
Korea
;
Lung Diseases*
;
Lymph Nodes
;
Mycobacterium kansasii*
;
Mycobacterium*
;
Nontuberculous Mycobacteria
;
Thorax
8.The Effectiveness of 6-month Treatment with Citalopram in Korean Panic Disorder Patients: A Prospective, Open-labeled, Multi-Center Trial.
In Soo LEE ; Jong Chul YANG ; Young Hee CHOI ; Jung Bum KIM ; Sang Yeol LEE ; Seung Hwan LEE ; Kang Seob OH ; Bum Hee YU
Korean Journal of Psychopharmacology 2006;17(2):203-211
OBJECTIVE: The authors examined the efficacy of citalopram, and its effect on the quality of life in patients with panic disorder. METHOD: Seventy three patients who had panic disorder were recruited for this study. They did not have major depression and other axis I diseases. They were scheduled to be examined 4 times (at baseline, 4, 12 and 24 weeks) and took citalopram for 24 weeks with a flexible dosing schedule. The primary efficacy variables were the response and remission rates (response: HAMA total score decreased by at least 50% from baseline; remission: HAMA total score < or = 7). Other variables included the Hamilton Rating Scale for Depression, Panic Disorder Severity Scale (PDSS), Acute Panic Inventory, Clinical Global Impression Scale and Sheehan Disabilities Scale (SDS). RESULTS: The number of patients who completed 24 weeks of treatment was 33 (45.2%). Forty patients who were dropped out consisted of 4 patients with symptom improvement and 36 patients with failure to return. Response/remission rates were 56.2/31.5% in the last-observation-carried-forward methods and 87.9/69.7% in the observed case data. Treatment with citalopram improved anxiety and depressive symptoms during 24 weeks on all efficacy measures. By a completed patient analysis, citalopram also significantly improved the disability scores on SDS. In this study, any serious adverse effects were not observed. CONCLUSION: Treatment with citalopram was effective and well-tolerated for the patients with panic disorder, and also improved quality of life in the patients.
Anxiety
;
Appointments and Schedules
;
Axis, Cervical Vertebra
;
Citalopram*
;
Depression
;
Humans
;
Panic Disorder*
;
Panic*
;
Prospective Studies*
;
Quality of Life
;
Treatment Outcome
9.The Effect of Concentration of Nitrous Oxide on Bispectral Index and Sedation Score.
Ho Yeong KIL ; Bong Soo CHAE ; Seong Ik LEE ; Yeong Hwan CHOI ; Seung Joon LEE ; Sung Woo LEE ; Yong Sin KIM ; Dae Woo KIM
Korean Journal of Anesthesiology 2000;38(2):220-224
BACKGROUND: Bispectral index (BIS) has been designed to measure objectively the degree of sedation and hypnosis for several anesthetics. It is predicted that sedation and hypnosis during nitrous oxide inhalation affect BIS in an unusual manner due to a different mechanism compared to usual hypnotics. The aim of this study was to evaluate the effect of different concentration of nitrous oxide inhalation on BIS and sedation score. METHODS: Forty unpremedicated ASA physical status I or II patients scheduled for lower extremity surgery were studied. After performing epidural anesthesia, patients inhaled gradually increasing concentrations of nitrous oxide from 0 to 67% (15 minutes for each concentration) via a tightly sealed face mask. At the end of each inhalation, BIS and OAA/S scale (Observers's Assessment of Alertness/ Sedation scale) were assessed. RESULTS: The increasing concentrations of inhaled nitrous oxide resulted in significant reduction of the OAA/S scale but in no change of BIS. Concentrations of nitrous oxide exceeding 50% affected behavior or emotion of the patients. CONCLUSIONS: Following increasing concentrations of inhaled nitrous oxide, sedation score was reduced significantly but BIS was not affected.
Anesthesia, Epidural
;
Anesthetics
;
Humans
;
Hypnosis
;
Hypnotics and Sedatives
;
Inhalation
;
Lower Extremity
;
Masks
;
Nitrous Oxide*
10.Pulmonary Cryptococcosis Mimicking Primary Lung Cancer with Multiple Lung Metastases.
Yu Seung KIM ; In Hee LEE ; Hyun Seon KIM ; Su Sin JIN ; Jong Hwan LEE ; Sung Kyoung KIM ; So Hyang SONG ; Jinyoung YOO ; Chi Hong KIM ; Soon Seog KWON
Tuberculosis and Respiratory Diseases 2012;73(3):182-186
Cryptococcosis is an invasive fungal infection, which is more common in immunocompromised patients. However, pulmonary cryptococcosis can occur in immunocompetent patients and should be considered on a differential diagnosis for nodular or mass-like lesions in chest radiograph. Recently, we experienced a patient with pulmonary cryptococcosis, successfully treated with oral fluconazole therapy. A 74-year-old female patient was referred for an evaluation of abnormal images, a large consolidative mass with multiple nodular consolidations and small nodules that mimics primary lung cancer with multiple lung to lung metastases. Computed tomography-guided lung biopsy confirmed the diagnosis of pulmonary cryptococcosis. The follow-up image taken after 4 months with oral fluconazole treatment showed marked improvement.
Aged
;
Biopsy
;
Cryptococcosis
;
Diagnosis, Differential
;
Female
;
Fluconazole
;
Follow-Up Studies
;
Humans
;
Immunocompromised Host
;
Lung
;
Lung Neoplasms
;
Multiple Pulmonary Nodules
;
Neoplasm Metastasis
;
Thorax