1.The measurements of ventricular size of brain CT in mood disorder.
Seung Hoon KANG ; Chul NA ; Kil Hong LEE
Journal of Korean Neuropsychiatric Association 1993;32(3):334-342
No abstract available.
Brain*
;
Mood Disorders*
2.Localized Tetanus in Legs with Abdominal Pain after Lumbar Radiculopathy Acupuncture Treatment
Yong Jae NA ; Yeo Joon YUN ; Seung Hoon HAN
Clinical Pain 2020;19(1):36-39
Tetanus is an infectious disease that causes muscle spasm with spastic paralysis and pain. Localized tetanus is rare and milder than the generalized form, however, it should be immediately treated because it may precede the onset of generalized form. The authors experienced a case of localized tetanus in both legs with abdominal pain after lumbar radiculopathy acupuncture treatment and here report this case with relevant literature reviews.
3.Localized Tetanus in Legs with Abdominal Pain after Lumbar Radiculopathy Acupuncture Treatment
Yong Jae NA ; Yeo Joon YUN ; Seung Hoon HAN
Clinical Pain 2020;19(1):36-39
Tetanus is an infectious disease that causes muscle spasm with spastic paralysis and pain. Localized tetanus is rare and milder than the generalized form, however, it should be immediately treated because it may precede the onset of generalized form. The authors experienced a case of localized tetanus in both legs with abdominal pain after lumbar radiculopathy acupuncture treatment and here report this case with relevant literature reviews.
4.Protective effect of Rhus verniciflua Stokes extract in an experimental model of post-menopausal osteoporosis.
Ji Heun JEONG ; Jong Hoon AN ; Hui YANG ; Do Kyung KIM ; Nam Seob LEE ; Young Gil JEONG ; Chun Soo NA ; Dae Seung NA ; Mi Sook DONG ; Seung Yun HAN
Anatomy & Cell Biology 2017;50(3):219-229
Post-menopausal osteoporosis (PMO) is a major global human health concern. Owing to the need for therapeutic drugs without side effects, natural extracts containing various polyphenolic compounds that may exert estrogenic effects have been studied in depth. Rhus verniciflua Stokes (RVS), which has been used as a traditional herbal medicine for centuries in Korea, was recently revealed to exert estrogenic effects attributable to its bioactive ingredients sulfuretin and butein, which have strong estrogen receptor–binding affinities. In this study, the protective potential of RVS in PMO was evaluated by using an experimental animal model of PMO, which was established by ovariectomy (OVX) of female Sprague Dawley rats. The oral administration of RVS at 20 mg/kg or 100 mg/kg for 8 weeks markedly protected against OVX-induced atrophy of the uterine tube and reversed the elevation in the ratio of serum receptor activator of nuclear factor-κB ligand to osteoprotegerin, which is a marker of disease severity. In addition, RVS inhibited OVX-induced tibia bone loss, activated osteogenic activity, and suppressed osteoclastic activity in the tibial epiphyseal plate, a region of bone remodeling. Collectively, these factors indicated that the oral intake of RVS might be beneficial for the prevention of PMO.
Administration, Oral
;
Atrophy
;
Bone Remodeling
;
Estrogens
;
Fallopian Tubes
;
Female
;
Growth Plate
;
Herbal Medicine
;
Humans
;
Korea
;
Models, Animal
;
Models, Theoretical*
;
Osteoclasts
;
Osteoporosis, Postmenopausal*
;
Osteoprotegerin
;
Ovariectomy
;
Rats, Sprague-Dawley
;
Rhus*
;
Tibia
5.Effects of Vitreomacular Traction on Ranibizumab Treatment Response in Eyes with Neovascular Age-related Macular Degeneration.
Kang Hoon LEE ; Hee Seung CHIN ; Na Rae KIM ; Yeon Sung MOON
Korean Journal of Ophthalmology 2015;29(6):396-403
PURPOSE: To investigate the effects of vitreomacular traction (VMT) on ranibizumab treatment response for neovascular age-related macular degeneration (AMD). METHODS: A retrospective review of 85 eyes of 85 patients newly diagnosed with neovascular AMD was conducted. Patients were eligible if they had received more than three consecutive monthly ranibizumab (0.50 mg) treatments and ophthalmic evaluations. Patients were classified into a VMT (+) group or VMT (-) group according to optical coherence tomography imaging. Best corrected visual acuity and central retinal thickness (CRT) measurements were obtained at three and six months after initial injection. RESULTS: One month after the third injection, mean visual acuity (VA) increases of 6.36 and 9.87 letters were observed in the VMT (+) and VMT (-) groups, respectively. The corresponding mean CRT values decreased by 70.29 microm and 121.68 microm, respectively. A total 41 eyes were identified as eligible for a subsequent fourth injection; 71.1% of patients (27 eyes) in the VMT (+) group but only 29.8% of patients in the VMT (-) group needed a subsequent fourth injection. Follow-up was extended to six months for 42 of the 85 enrolled patients (49.4%). The trends in VA and optical coherence tomography were found to be maintained at six-month follow-up. CONCLUSIONS: VA and CRT appeared to be more improved after ranibizumab treatment in the VMT (-) group compared to the VMT (+) group. VMT might antagonize the effect of ranibizumab treatment in a subpopulation of AMD patients.
Aged
;
Aged, 80 and over
;
Angiogenesis Inhibitors/*therapeutic use
;
Female
;
Follow-Up Studies
;
Humans
;
Intravitreal Injections
;
Male
;
Middle Aged
;
Ranibizumab/*therapeutic use
;
Retina/pathology
;
Retinal Diseases/*physiopathology
;
Retrospective Studies
;
Tissue Adhesions
;
Tomography, Optical Coherence
;
Vascular Endothelial Growth Factor A/antagonists & inhibitors
;
Visual Acuity/drug effects
;
Vitreous Body/*pathology
;
Wet Macular Degeneration/*drug therapy/physiopathology
6.Inhibition of ovarian carcinoma growth in nude by administration of gonadotropic hormone-releasing hormone analog.
Jin Woo KIM ; Byung Heun JEUNG ; Jong Ku NA ; Dae Hoon KIM ; Sung Eun NAMKOONG ; Seung Jo KIM ; Hun Young LEE
Korean Journal of Obstetrics and Gynecology 1992;35(12):1779-1789
No abstract available.
7.Immunolocalization of Runx2 and Osterix in the Developing Periodontal Tissues of the Mouse.
Byung In KIM ; Seung Hoon NA ; Ji Youn KIM ; Je Won SHIN ; Seong Suk JUE
International Journal of Oral Biology 2011;36(2):51-57
Runx2 and Osterix, the transcription factors for osteoblast differentiation, are known as fundamental factors to regulate the development of calcified tissues. However, the biological functions of these factors in the development of the periodontal tissues remain unclear. In this study, we investigated the distribution of Runx2 and Osterix during periodontal tissue development of the mice. Mandibles from 14-day-old mice were prepared for paraffin section. Serial sections of the mandible containing 1st molar tooth germs were obtained as a thickness of 7 microm. Some sections were stained with hematoxylin and eosin. Others were used for immunohistochemistry for PCNA, Runx2, and Osterix. Epithelial cells in growing end of Hertwig's epithelial root sheath (HERS) and mesenchymal cells adjacent to the growing end of HERS expressed PCNA. Undifferentiated mesenchymal cells and hard tissue forming cells like cementoblasts and osteoblasts in early stage of differentiation expressed Runx2. Fully differentiated cementoblasts and osteoblasts secreting matrix proteins expressed Osterix. However, the cells terminated the matrix formation did not express Osterix. Periodontal ligament cells expressed Runx2 and Osterix. Pulp cells expressed Runx2 only.These results suggest that Runx2 and Osterix might regulate the differentiation of cementoblasts in the same manner as osteoblasts. Runx2 might participate in the process of cementoblast differentiation in early stage, whether Osterix might regulate the maturation and matrix synthesis of the cells.
Animals
;
Dental Cementum
;
Eosine Yellowish-(YS)
;
Epithelial Cells
;
Hematoxylin
;
Immunohistochemistry
;
Mandible
;
Mice
;
Molar
;
Osteoblasts
;
Paraffin
;
Periodontal Ligament
;
Proliferating Cell Nuclear Antigen
;
Proteins
;
Tooth Germ
;
Transcription Factors
8.Treatment of Epiphora in Patients with Conjunctivochalasis Using Conjunctival Fixation to the Sclera.
Seung Hoon OH ; Jae Young PARK ; Hye Bin YIM ; Na Young LEE
Journal of the Korean Ophthalmological Society 2012;53(8):1063-1067
PURPOSE: To report the effects and complications of conjunctival fixation to the sclera in conjunctivochalasis patients with inferior punctal occlusion. METHODS: The authors of the present study evaluated the degree of conjunctivochalasis and performed Fluorescein Dye Disappearance Test (FDT) in 15 eyes of 8 patients diagnosed with conjunctivochalasis with inferior punctal occlusion. Under topical anesthesia, the inferior bulbar conjunctiva was attached to the sclera with 3 8-0 vicryl stitches 8 mm posterior from the limbus. After surgery, the relief of symptoms, postoperative complications and improvement of conjunctivochalasis were observed. RESULTS: One week after the surgery, all 15 eyes achieved a subjective improvement of symptoms and the degree of conjunctivochalasis and FDT showed statistical difference after surgery (p = 0.000, 0.000, respectively). A complication occurred in 1 eye which was a retinal hemorrhage due to scleral puncture. CONCLUSIONS: Conjunctival fixation to the sclera could improve epiphora in conjunctivochalasis patients with inferior punctal occlusion. However, this procedure should be performed with caution.
Anesthesia
;
Conjunctiva
;
Eye
;
Fluorescein
;
Humans
;
Lacrimal Apparatus Diseases
;
Polyglactin 910
;
Postoperative Complications
;
Retinal Hemorrhage
;
Sclera
9.Neutrophil Apoptosis and H2O2 Release by LPS in Diabetics.
Ki Hyun SEO ; Joo Ock NA ; Seung Hyug MOON ; Soo Taek UH ; Yong Hoon KIM ; Choon Sik PARK
Tuberculosis and Respiratory Diseases 2004;57(3):250-256
BACKGROUND: Bacterial infections in diabetic patients are an important cause of increased morbidity and mortality. It has been reported that bacterial infections in diabetics showed more impaired PMN functions such as reduced PMN respiratory burst and decreased microbicidal activity in inflammed tissues. Also, apoptosis(programmed cell death) is postulated to be a key mechanism for neutrophil elimination. It is very important that PMN apoptosis keeps the balance from an area of inflammation. Actuallly, as little was known about PMN apoptosis and respiratory burst in diabetes, we investigated PMN apoptosis and hydrogen peroxide production after endotoxin exposure. METHODS: Peripheral venous blood samples were collected by routine venipuncture from healthy volunteers and diabetics to harvest neutrophils. We respectively measured the PMN apoptosis, the production of hydrogen peroxide, and the cell viability. RESULTS: Normal neutrophils showed a tendency to decreased apoptosis after endotoxin treatment. In patients with diabetes, PMN apoptosis was significantly decreased compared with healthy controls. In addition, the LPS-induced neutrophils in diabetics demonstrated more decreased apoptosis. However, the production of hydrogen peroxide was not different between groups. CONCLUSION: These observations suggest that the decreased PMN apoptosis in diabetics with endotoxin exposure may also affect the increased susceptibility and severity of infections.
Apoptosis*
;
Bacterial Infections
;
Cell Survival
;
Healthy Volunteers
;
Humans
;
Hydrogen Peroxide
;
Inflammation
;
Mortality
;
Neutrophils*
;
Phlebotomy
;
Respiratory Burst
10.Thoracoscopic Removal of an Intrapulmonary Sewing Needle: A case report.
Jeong Hwan YU ; Shin Kwang KANG ; Myung Hoon NA ; Seung Pyung LIM ; Young LEE ; Jae Hyeon YU
The Korean Journal of Thoracic and Cardiovascular Surgery 2007;40(11):798-801
A 24 year old man visited our hospital, because an intrapulmonary foreign body had been found incidentally. Simple chest X-ray showed a 5 cm sized foreign body of metallic density, and chest CT confirmed the foreign body, which was like a sewing needle, in the left upper lobe. We performed a simple extraction of the foreign body using VATS (Video Assisted Thoracic Surgery). After the operation, the patient was discharged without any complications.
Foreign Bodies
;
Humans
;
Needles*
;
Thoracic Surgery, Video-Assisted
;
Thoracoscopy
;
Thorax
;
Tomography, X-Ray Computed
;
Young Adult