1.A Study of Phototoxicity Using the Candida Albicans Test and the Photohemolysis Test.
Seung Hyun HONG ; Hyun Chul CHOI ; Kee Chan MOON
Korean Journal of Dermatology 1995;33(2):268-274
Background: If phototoxic:ity can be predetermined in vitro, the information will aid in prognosticating whether or not caimpounds have a photosensitizing pczrlial. OBJECTIVE: For the evaluation of the phototoxic potentials of reral drugs, we performed the Candida albicans test and the photohemolysis test. METHODS: The Candida altiicans test is based on growth inhibtion of Candida albicans after application of the drug and ultraviolet light A( UVA ) irradiatior and the photohemolysis test is based on hemolysis of red blood cells caused by irradiation ir the presence of photosensitizing compounds. In the Candida albicans test, clear zones around the drug patches were evaluated, which means positive results for the phototoxic potential of the drugs. In the photohemolysis test, the amounts of hemolysis were evaluated by measuring the relar absorbance at 540nm using a spectrophotometer. RESULTS: In the Candida albicans test, ibuprofen, naldix acid, chlorpromazine and thiodiphenylamine showed positive results, whereas others did not the photohemolysis test, griseofulvin, ibuprofen and nalicdixic acid showed increased amounts hemolysis at UVA and ultraviolet light B(UVB) irracliation, and chlorpromazine, thiodiphenylaiair, chlorothiazide and piroxicam showed increased amounts of hemolysis at UVA irradiation only. CONCLUSION: The results showed that both methods were goodness screening tests for demonstrating the phototoxicity of therapeutic drugs.
Candida albicans*
;
Candida*
;
Chlorothiazide
;
Chlorpromazine
;
Dermatitis, Phototoxic*
;
Erythrocytes
;
Griseofulvin
;
Hemolysis
;
Ibuprofen
;
Mass Screening
;
Piroxicam
;
Ultraviolet Rays
2.A case of peritonitis following colonoscopy in patient on continuous ambulatory peritoneal dialysis.
Hee Seung HONG ; Seung Joon SHIN ; Byung Geun HAN ; Seung Ryul KIM ; Seung Ok CHOI ; Kwang Hoon LEE ; Hyang In KIM
Korean Journal of Nephrology 1993;12(4):711-714
No abstract available.
Colonoscopy*
;
Humans
;
Peritoneal Dialysis, Continuous Ambulatory*
;
Peritonitis*
3.The transfer system of trauma patient to emergency center.
Ok Jun KIM ; Ok Kyung CHOI ; Hong Du GOO ; Seung Whan KIM ; Seung Ho KIM
Journal of the Korean Society of Emergency Medicine 1993;4(1):112-121
No abstract available.
Emergencies*
;
Humans
4.A Case of Acute Mixed Lineage Leukemia (ANLL with TII) with neutropenic Enterocolitis.
Hyeon Joo CHOI ; Young Suk KOH ; Young Mee HONG ; Seung Joo LEE ; Kee Suk HONG ; Keum Ja CHOI
Journal of the Korean Pediatric Society 1990;33(9):1281-1287
No abstract available.
Enterocolitis, Neutropenic*
;
Leukemia*
5.The Potential Acuity Meter to Predict Postoperative Visual Acuity after Cataract Surgery.
Seung Tak OH ; Kang Ho CHOI ; Seung Jung LIM ; Hong Bok KIM
Journal of the Korean Ophthalmological Society 1996;37(4):591-595
The potential acuity meter(PAM) has been reported to be a useful instrument for predicting postoperative visual acuity after cataract extraction surgery. Forty nine eyes were tested with PAM before surgery, and the best postopertive visual acuity was obtained. The PAM accurately predicted the postoperative visual acuity to within three lines in 90.0% of the cases. When the test is in error, the tendency is for the PAM to underestimate the final acuity rather than to overestimate. Especially under undilated pupil, in dense cataracts (<20/200),and,in posterior subcapsular and cortical cataracts, the PAM tends to underestimate further.
Cataract Extraction
;
Cataract*
;
Pupil
;
Visual Acuity*
6.Successful pregnancy in a patient undergoing continuous ambulatory peritoneal dialysis.
Seung Ok CHOI ; Sung Rul KIM ; Kyong Gu YOH ; Hee Seung HONG ; Young Jun WON ; Kwang Hoon LEE ; In Bae CHEONG
Korean Journal of Medicine 1993;45(5):681-685
No abstract available.
Humans
;
Peritoneal Dialysis, Continuous Ambulatory*
;
Pregnancy*
7.Pseudo-Meigs' syndrome associateed with pedunculated subserosal myoma and elevated CA-125 level.
Seung Hyun HONG ; Youn Seok CHOI
Korean Journal of Obstetrics and Gynecology 2005;48(12):2998-3003
Pseudo-Meigs' syndrome consists of pleural effusion, ascites, and benign tumors of the ovary other than fibromas. These benign tumors include those of the fallopian tube or uterus and mature teratomas, struma ovarii, and ovarian leiomyomas. Although uterine leiomyomas are frequent gynecological finding, they are rarely cause pseudo-Meigs' syndrome with elevated serum CA 125 levels. A case of pseudo-Meigs' syndrome associated with subserosal leiomyoma is presented with a brief review of literatures.
Ascites
;
Fallopian Tubes
;
Female
;
Fibroma
;
Hydrothorax
;
Leiomyoma
;
Myoma*
;
Ovary
;
Pleural Effusion
;
Struma Ovarii
;
Teratoma
;
Uterus
8.A Case of Occult Adenocarcinoma of Cystic Duct Associated with GB Empyema.
Won Ju OH ; Seung Min LEE ; Byeng Uin CHOI ; Hyang Soon YEO ; Hong Bae PARK
Korean Journal of Gastrointestinal Endoscopy 1989;9(1):57-59
A case of adenocarcinoma of cystic duct associated with GB empyema is presented. A 72 year old male was admitted to Kwangju Christian hospital because of abdominal pain in right upper quadrant for 4 days. He underwent explolaparotomy under the impression of GB empyema or GB cancer. For seeking causative factor of GB empyema, serial sections of cystic duct and mapping were performed. We can find adenocarcinoma of cystic duct in the specimen removed at cholecystectomy. The criteria for disgnosis of cystie duct carcinoma which was outlined by Farrar. These criteria are; 1) The growth must be restricted to the cystic duct, 2) There is no neoplastic process in the gall bladder, hepatic and common bile duct. 3) Histopathological examination must be comfirm carcinoma. Here we report a case of adenocarcinoma of cystic duct associated with GB empyema with brief review of Literature.
Abdominal Pain
;
Adenocarcinoma*
;
Aged
;
Cholecystectomy
;
Common Bile Duct
;
Cystic Duct*
;
Empyema*
;
Gwangju
;
Humans
;
Male
;
Urinary Bladder
9.Studies on the Proper Dose of Estrogen for Induction of Experimental Cryptorchidism and its Histologic Changes in Rat.
Sung Joon HONG ; Seung Kang CHOI
Korean Journal of Urology 1987;28(2):173-179
For the observation of the histological changes at variable time intervals after estrogen-induced cryptorchidism, we administered different doses of depoestradiol cypionate to 1 week old Sprague-Dawley rats and determined the minimum dose at which the cryptorchidism could be induced in all the rats, and observed the histological changes from 5 weeks after birth at which time the testicular descent into the scrotum normally occurs up to 12 weeks of age, the time of complete maturation. The following results were obtained. l. In cases that the doses above O.2mg of depoestradiol cypionate for each rat were administered cryptorchidism was induced in all the rats but not induced below 0.15mg and all the induced cryptorchidism were bilateral. 2. In the rats to which O.2mg of depoestradiol cypionate was administered, the weight of the testis and the diameter of the seminiferous tubules were significantly decreased compared to those in the control group of rats until 12 weeks after birth. Nevertheless, the rate of increase in these rats was similar to that of the control group. 3. The basement membrane of the seminiferous tubules and Sertoli cells showed relatively few changes. But Leydig cells first appeared in 7 weeks after birth in the estrogen administered group while in the control group the cells continuously appeared after 5 weeks after birth. 4. For the spermatogenesis, in the normal control group, the mature sperms can be observed in 7 weeks after birth while in the estrogen administered group, 12 weeks after birth. The results reveal that the minimum dose at which the cryptorchidism could be induced in all 1 week old Sprague-Dawley rat was O.2mg depoestradiol cypionate for each rat. The spermatogenesis and Leydig cell differentiation in the estrogen administered cryptorchidism were delayed by the effect of estrogen. In addition this study indirectly ascertained that the pathogenesis of unilateral cryptorchidism was not just the deficiency of the gonadotropic hormonal stimulation only. And further observations on the estrogen-administered rats after 12 weeks of age will be required to see whether these histological changes are reversible or not.
Animals
;
Basement Membrane
;
Cell Differentiation
;
Cryptorchidism*
;
Estrogens*
;
Leydig Cells
;
Male
;
Parturition
;
Rats*
;
Rats, Sprague-Dawley
;
Scrotum
;
Seminiferous Tubules
;
Sertoli Cells
;
Spermatogenesis
;
Spermatozoa
;
Testis
10.Two Cases of Endometriosis in the Episiotomy Scar Following Vaginal Delivery.
Mee Jeong YOO ; Seung Ho HAH ; Yoon Jin JEONG ; Kyu Hong CHOI
Korean Journal of Obstetrics and Gynecology 1997;40(10):2340-2343
Endometriosis in the episiotomy scar following vaginal delivery is one of the very rare condition among the extrapelvic endometriosis. We have experienced two cases of endometriosis in the episiotomy scar following vaginal delivery. We report two cases with a brief review of the concerned literatures.
Cicatrix*
;
Endometriosis*
;
Episiotomy*
;
Female