No abstract available.
Proteinuria*

No abstract available.
Nephrectomy*

The toxic action of benzene on erythropoiesis and myelopciesis, has been recognized since the early years of the present century. With the advance in high civilization and modern covenience, benzene as a kind of aromatic compound has been used for industrial solvent and its longstanding use has committed a public nuisance to be overcome by medical approach. Chromosomal breakage and rearrangement may be produced by radiation, radiomimetics, virus infection and various chemicals, especially, antibiotics and antitumor agent, causing chroimosomal rearrangement in vitro, whose teratogenic action in rats was previously demonstrated. Several works hsve been published on the chromosome damage as a consequence of benzene intoxication. Recently, it was shown by certain workers that individuals who had been exposed to atmospheric benzene, even without haematological disorders, might have an elevated percentage of structural chromosome aberrations in the lymphocytes cultured from their peripheral blood. Moreover, structural and numerical chromosome aberrations were demons trated in patients with blood disorders which were believed to be due to exposure to beuzene vapors. Accordingly, much interest has been paid to its cytologic effect on the hematopoietic tissues in man and experimental animals. A high incidence of chromosomal aberrations has also been found in rabbits exposed to benzene during a period of peripheral pancytopenia and after hematologic recovery. The significance of these findings was discussed in relation to leukemic transition and to their diagnostic value in human benzene intoxication. Chromosomal anomalies can also be induced by benzene given subcutaneously to rata. A pronounced individual variation of the degree of chromosome damage was shown. The purpose of this investigation was to determine whether benzene could a direct effect on the chromosome complement of mammalian bone marrow cells in vivo and whether characteristic banding patterns might be demonstrated in rat chomosomes by a modified trypsin-Giemsa method. Four-week old Sprague-Dawley strain rats of both sexes(each weighing about 50gm) were used for this experimental study. Three groups of animals were treated-with subcutaneous infections of pure benzene. Group I received benzene, 2.0ml per kg body weight, 24 hours before sacrifice; Group II, 48 and 24 hours and Group III, 72, 48 and 24 hours. A control group was given no treatment. The animais were sacrificed in ether anesthesia. Femur and iliac bone marrow cells were suspended in medium 199 within 30 minutes and transferred to warm Hanks-distilled water(1:3) for hypotonic treatment(10 minutes). A freshly prepared solution of methanol glacial acetic acid (3:1) was used as fixative. Finally, a few drops of the cell suspension were placed on moistened, pre-cleaned slides being dried by rapid-drying technique. The slides were stained with either simple Giemsa or trypsin Giemsa banding technique. From the data obtained, this report was summarized as follows: 1. For the benzene-treated groups, chromosomal aberration rate was 13.4% in group II and 38.6% in group III, while in the controls the rate was 6.4 percent. 2. Numerical aberrations included aneuploidy, polyploidy and monoploidy. The most frequent type was hypodiploidy (5.8–9.4%) in all the treated groups. 3. Structural aberrations could be divided in gaps, ring chromosomes, breaks, deletions, exchanges and dicentrics. Among those, the majority of abnormal metaphases was gaps; 2.4%, 2.2% and 10.8% in group I, II and III respectively, and 1. 6% in control group. 4. The translocations and dicentrics were not demonstated in group I and II. 5. The normal chromosome set of the Sprague-Dawley rat was comprised of 42 chromosomes: 20 pairs of autosomes, and one pair of sex chromosomes, xx or XY chromosomes. The total number of major bands in s chromosome complement was about 40 and minor bands, 13, 6. Sucessful demonstration of banding patterns was available by proper adjustment of the concentration, temperature and duration of trypsin solution.
Acetic Acid ; Anesthesia ; Aneuploidy ; Animals ; Anti-Bacterial Agents ; Benzene ; Body Weight ; Bone Marrow Cells ; Bone Marrow ; Chromosome Aberrations ; Chromosome Breakage ; Civilization ; Complement System Proteins ; Erythropoiesis ; Ether ; Femur ; Humans ; In Vitro Techniques ; Incidence ; Lymphocytes ; Methanol ; Methods ; Pancytopenia ; Polyploidy ; Rabbits ; Rats ; Rats, Sprague-Dawley ; Ring Chromosomes ; Sex Chromosomes ; Trypsin

A case of severe osteoarthritic patient of both hip treated with McKee-Farrar total endoprosthesis on one hip is reported. The introduction, indication, procedure of the surgery and the use of the self curing acrylic cement were reviewed briefly. The hip following the surgery, even though the follow-up duration is short, showed exceIlent result.
Follow-Up Studies ; Hip ; Humans

The arthrodesis of the hip is the only certain method for eliminating pain and providing stability in young and middle aged adults. The first used arthrodesis in old congenital dislocation was reported by Heusner, Lampugnani, and Alert as early as 1885 according to Nove-Josserand. The various papers published on this operation appear to be concerned mainly with surgical methods and the frequency of bone healing, rather than with loss of function and its causes. The purpose of this study is to evaluate function of the arthrodesed hip especially the relationship between position of the hip and its daily use. The author studied arthrodesis of the hip clinically in 89 cases of arthrodesed patients, admitted to the Orthopedic Department of Severance Hospital during the 14 years from June 1957 until May 1970. The auther also studied 40 cases which confirmed sound bony ankylosis of the hip by X-ray examination. The follow-up included a careful inquiry into the patients ability to use the fixed hip in various functions of daily life. The results are as follows. 1. The average age of the patients at the time of operation was 16.9 years and tuberculosis of the hip was the most common cause 83(93%) of arthrodesis. 2. The most common type of operation in this series was intraarticular arthrodesis 67(75.3%), and the fusion rate was relatively good in intra & extraarticular arthrodesis 20(85.5%). 3. The average length of follow-up was 3.9 years. The average position of the arthrodesed hip was 37.7 degrees of flexion, 9.1 degrees of abduction and neutral rotation. Actual shortening of the leg averaged 3.8cm. 4. The gait was poor in the group which had 5cm shortening of the leg and was in 43 degrees of flexion for the arthrodesed hip. 5. The ability to sit and defecate in the ordinary toilet was satisfactory when there was 39 degrees of flexion or more for the arhrodesed hip. 6. 10 patients (25%) had back pain and 12 patients (30%) had mild scoliosis. Average Ferguson angle was 47.8 degrees and the Line of Weight Thrust showed over 40 degrees. 7. The ideal hip position of arthrodiesis in Koreans was assumed to be under 40 degrees of flexion, some degrees of abduction and no rotation.
Adult ; Ankylosis ; Arthrodesis ; Back Pain ; Dislocations ; Follow-Up Studies ; Gait ; Hip ; Humans ; Leg ; Methods ; Middle Aged ; Orthopedics ; Scoliosis ; Tuberculosis

No abstract available.
Humans ; Osteosarcoma*

The human hand is a highly sophisticated tool of sensibility and prehension, and the reconstruction of injured hands are essential to not only reconstruct of hand function but also reconstruct of body. Seven cases of tendocutaneous flap, a case of osteocutaneous flap, nine cases of thumb reconstruction with a free neurovascular wrap-around flap from the big toe, two cases of second toe-to-index trander, and a case of left ring finger to right index finger transfer were performed at the Department of Orthopedic Surgery of Hanyang University Hospital, and satisfactory results were obtained both comsmetically and functionally.
Fingers ; Hallux ; Hand ; Humans ; Microsurgery ; Orthopedics ; Thumb

Paget's disease is one of the chronic disorders of skeletal system which is frequently accompained with pathologic fractures. This disease is extremely rare in Korea and only three cases have been reported in the Journal of Korean Orthopaedic Associstion. And all these cases were not associated with pathologic fracture. We experienced a case of Paget's disease with pathologic fracture of the femur which is typical in radiologic, laboratory and histopathologic findings.
Femur ; Fractures, Spontaneous ; Korea ; Osteitis Deformans

No abstract available.
Tuberculosis, Spinal

A study was done to evaluate the diagnostic value of ultrasonography on acute scrotum patients. During the last three years, 25 patients were managed at Cheju Medical Center, eight of them were testicular torsion patients including one cryptorchid testicular torsion. one torsion of appendix testis, 11 acute epididymitis and 5 testicular rupture due to blunt scrotal trauma. Ultrasonography revealed enlarged testis and epididymis in all of the 8 testicular torsion patients and 7 of them showed inhomogeneously decreased echogenecity of the testis and epididymis. All acute epididymitis patients showed enlargement of the epididymis, and inhomogeneously decreased echogenecity was found in 8 of them. But testicular echogenecity was normal in all of the acute epididymitis patients and enlargement of the testis was found in two. All of the 5 testicular rupture patients showed irregular hypoechoic portions in the testicle and distorted testicular morphology, and linear fracture lines of the testis were found in two. We could suggest that scrotal ultrasonography is useful for the early differential diagnosis of the acute scrotum, especially when scrotal radioisotope scan is not available.
Appendix ; Diagnosis, Differential ; Epididymis ; Epididymitis ; Humans ; Jeju-do ; Male ; Rupture ; Scrotum* ; Spermatic Cord Torsion ; Testis ; Ultrasonography*