1.A Case of Pulsating Exophthalmos.
Journal of the Korean Ophthalmological Society 1972;13(2):95-98
A case of pulsating exophthalmos is reported in a 50 years old Korean Woman. The complaints of this case were exophthalmos, chemosis on Rt. eye and intracranial bruit. The etiology of this case is considered due to toxemia of pregnancy and hypertension without trauma. A brief review of the literatures related with the etiology, symptom and therapy is made.
Exophthalmos*
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Female
;
Humans
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Hypertension
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Middle Aged
;
Pre-Eclampsia
2.Correlation of Ki-67, p53 and bcl-2 Expression with Grade and Behavior of Ependymoma.
Korean Journal of Pathology 1999;33(9):723-728
Ependymomas constitute no more than 5 to 7% of all primary CNS neoplasm and their biologic behavior is difficult to predict by microscopic appearances. Recently, many studies have attempted to correlate biologic behavior with tumor proliferation index, tumor suppressor gene and oncogene using immunohistochemical stains. We evaluated 25 cases of surgically resected intracranial ependymomas for the proliferation activity using Ki-67, and expression of p53 and bcl-2 protein with regard to the prognosis. The cases were divided into 17 ependymomas (WHO Grade II), 3 papillary ependymomas (WHO Grade II), and 5 anaplastic ependymomas. Clinically, the patients were divided into two groups, recurrent (18 cases) or non-recurrent (7 cases). The Ki-67 proliferation index was significantly higher in the recurrent group (p<0.05) and in the younger ages (correlation index=0.534). Although Ki-67 proliferation index was higher in anaplastic ependymoma, it was not significant statistically (p>0.05). p53 protein expression tended to increase in the patients who had anaplastic ependymoma and in the recurrent group. bcl-2 expression was not correlated with histologic grade or recurrence of the tumor. We conclude that Ki-67 proliferation index and p53 expression are important markers for predicting biologic behavior of ependymoma.
Coloring Agents
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Ependymoma*
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Genes, Tumor Suppressor
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Humans
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Oncogenes
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Prognosis
;
Recurrence
3.The Endocrine Manifestations and Growth of the Patients with 22q11.2 Microdeletion Syndrome.
Jong Seung LEE ; Jin Ho CHOI ; Han Wook YOO
Journal of Korean Society of Pediatric Endocrinology 2004;9(1):66-71
PURPOSE:Varying clinical phenotypes are associated with the chromosome 22q11.2 microdeletion syndrome. The endocrine manifestation are latent or overt hypoparathyroidism, thyroid dysfunction and short stature. This study was undertaken to investigate frequencies of endocrine abnormalities and short stature in patients with the chromosome 22q11.2 microdeletion syndrome. METHODS:Forty three unrelated patients were diagnosed having chromosome 22q11.2 microdeletion syndrome. Chromosomal microdeletion was confirmed by fluorescent in situ hybridation (FISH) with DNA probe (22q11.2 LSI TUPLE1 from Vysis). Serum total calcium and intact parathyroid hormone (PTH) were measured in all patients. Thyroid function tests including free thyroxine(T4), thyroid stimulating hormone (TSH) and thyroid autoantibodies were performed in all patients. Insulin-like growth factor-1 (IGF-1) was measured in 10 patients. Height, weight and body mass index were compared with chronological age in all patients. RESULTS:Seven patients (16%) had an overt hypoparathyroidism, presenting with hypocalcemic tetany. Thirteen patients (31%) showing hypocalcemia with normal PTH were regarded as having latent hypoparathyroidism since their PTH secretion response was blunted. Out of 2 patients with thyroid diseases, one patient had Graves disease and the other had Hashimoto thyroiditis. Five patients (12%) were below the 3rd percentile in height at evaluation. The BMI was below the 5th percentile in 23% of patients. CONCLUSION: Twenty patients (47%) presented with overt and latent hypoparathyroidism. Interestingly, autoimmune thyroid diseases such as Graves disease and Hashimoto thyroiditis were associated in patients with chromosome 22q11.2 microdeletion, indicating predisposition to autoimmune disorders. Therefore, a careful endocrine and growth evaluation is needed in these patients.
Autoantibodies
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Body Mass Index
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Calcium
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DNA
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Graves Disease
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Hashimoto Disease
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Humans
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Hypocalcemia
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Hypoparathyroidism
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Parathyroid Hormone
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Phenotype
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Tetany
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Thyroid Diseases
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Thyroid Function Tests
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Thyroid Gland
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Thyrotropin
4.Prognostic Implications of Ki-67 Labelling Index and p53, bcl-2 Protein Expression in the Primary Central Nervous System Lymphoma.
Jae Ho HAN ; Woo Ick YANG ; Tai Seung KIM
Korean Journal of Pathology 2000;34(6):456-464
It has been claimed that CNS lymphoma, a rare neoplasm accounting for only a small fraction of malignant brain tumors, occurs with increasing frequency in immunologically normal as well as immunocompromised individuals. We investigated the prognostic value of Ki-67 index, p53, and bcl-2 oncoprotein expression in relation to the clinicopathological parameters in the primary CNS lymphoma patients. The tumors were graded by Kiel classification and the Working formulation and included 33 high-grade, 4 intermediate-grade, and 5 low-grade lymphomas. The phenotype was determined in 38 cases: 30 were B cell type and 8 were T cell type. All cases displayed variable degrees of nuclear Ki-67 staining from 1.0% to 92.0% (mean 51.1%). A highly significant correlation was established between the proportion of Ki-67 positive cells and the classification into grades (p=0.0002) and phenotypes (p=0.0002). Overexpression of p53 and bcl-2 protein was found in 37.1% and 51.4% of 35 patients, respectively. And p53 expression was significantly increased in B cell type (p=0.02). On Kaplan-Meier survival curve, the phenotype, grade of tumors, and p53 and bcl-2 protein expression were not correlated with overall survival. On multivariate analyses, overall survival was independently influenced by Ki-67 index. In conclusion, it is suggested that Ki-67 proliferating index is the most important marker for predicting biologic behavior of the primary CNS lymphoma.
Brain Neoplasms
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Central Nervous System*
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Classification
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Humans
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Lymphoma*
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Lymphoma, Non-Hodgkin
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Multivariate Analysis
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Phenotype
5.A Statistical study on Urolithiasis.
Korean Journal of Urology 1973;14(2):77-82
A Statistical analysis was made on 275 cases of urinary calculi During the period from Jan.. 1963 to Aug. 1972, on the Department of Urology of Han-il Hospital and the results were obtained as following; 1. The incidence of urinary calculi was 3.09 % of out-patients. 2. The age of the patients ranged from 20 to 30 years in approximately 70 percent. 3. A seasonal occurrence was highest during summer on 31 percent. 4. The locational distribution of urinary calculi was 71.6 percent in ureter, 18.2 percent in kidney, 7.5 percent in bladder, 2. 7 percent in urethra. 5. The locational distribution of ureter calculi was 66 percent in lower, 22 percent in middle and 12 percent in upper portion. 6. In a number of urinary calculi, 89. 8 percent was single and 5.8 percent was double and 4.4 % was more than 2. 7. The ureterolithotomy was performed on 74 of 197cases requiring surgical intervention. Cystoscopic manipulation (Spontaneous Expelled) and conservative treatment were 120 cases of 197 cases. Other manner on 3 cases. 8. The results of qualitative analysis of 240 urinary calculi showed cal. Phosphate + oxalate in 53.7 percent, Cal phosphate in 13.7 percent, Calcium phosphate + ammonate in 7.5 percent, Ca phosphate +carbonate in 7.1 percent, Ca carbonate in 5.O percent. Ca oxalate in' 4.2 percent. etc.
Calcium
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Calculi
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Carbon
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Humans
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Incidence
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Kidney
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Outpatients
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Seasons
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Statistics as Topic*
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Ureter
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Urethra
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Urinary Bladder
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Urinary Calculi
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Urolithiasis*
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Urology
6.The effects of long-term lithium treatment on the parathyroid hormone and calcium level.
In Joon PARK ; Seung Hyun KIM ; Sun Ho HAN
Journal of Korean Neuropsychiatric Association 1991;30(6):974-981
No abstract available.
Calcium*
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Lithium*
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Parathyroid Hormone*
7.Hypokalemic Familial Periodic Paralysis: A Report of 4 members in a family
Kwang Jin RHEE ; Seung Ho YUNE ; Han Kee CHAE
The Journal of the Korean Orthopaedic Association 1977;12(2):241-246
Hypokalemic familial periodic paralysis is one of the rare familial disease characterized by recurrent and transient attacks of weakness or paralysis of the somatic musculature. Also, this disease is usually inherited as an autosomal dominant trait in most cases. During an attack, the plasma potassium falls as a rasults of shift of potassium from the extracellular to the intracelluar compartment, but there is no loss of total potassium from the body. We have experienced hypokalemic familial periodic paralysis recently which affected 4 members in a family,and report this disorder.
Accidental Falls
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Humans
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Paralyses, Familial Periodic
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Paralysis
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Plasma
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Potassium
8.A Case of Primary Cutaneous Plasmacytoma.
Han Seung LEE ; Ho Jung LEE ; Jung Bin KIM ; Woo Ick YANG ; Seung Kyung HANN
Annals of Dermatology 1996;8(4):287-290
A 66-year-old female patient had a firm, non-tender, dome shaped mass on the scalp. The lesion had enlarged slowly for 2 years, and measured about 4 × 6 cm. The histologic finding of the skin biopsy specimen demonstrated an infiltration of immature plasma cells in the dermis, which express monoclonal cytoplasmic lambda light chain by immunohistochemical stainings, and staging work-up after the biopsy revealed no evidence of disease in other foci. The mass on the scalp was treated successfully by radiation therapy, with the diagnosis of primary cutaneous plasmacytoma.
Aged
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Biopsy
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Cytoplasm
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Dermis
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Diagnosis
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Female
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Humans
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Plasma Cells
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Plasmacytoma*
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Scalp
;
Skin
9.CHONDROBLSTOMA ON TEMPOROMANDIBULAR JOINT, A CASE REPORT.
Hyun Ho CHANG ; Seung Yun HAN ; Hyung Mo AHN ; Won Jong CHOI ; Jae Seung KIM
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1997;23(4):756-762
Chondroblastoma is a rare primary bone tumor which originates from cartilage, and represents approximate 1% af all bone tumor. The chondroblastoma arises most frequently from the epiphysis of the long bones with the humerus being the commonest site. It afflicts usually the young under 25 years with greater incidence in male. As there is no cartilage cell on craniofacial bone which is mainly fromed by intramembranous ossification, the chondroblastoma on the craniofacial bone is extremely rare. But the chondroblastoma recurred frequently in craniofacial bone when the mass is excised incompletely or curretted and, as the tumor has the outstanding ability of local invasiveness, it destructs the adjacent bone. In addition, it is difficult to diagnose differentially from sarcoma or giant cell tumor histopathologically. Due to the entities described above, it is necessary to remove the entire tumor mass as complete as possible, to treat with radiation pre or postoperatively for preventing from recurrence, and to observe for a long time. The chondroblastoma on temporal bone is rare and is difficult to diagnose and treat successfully. So we'd like to present a case of chondroblastoma which was originated from temporal side of TMJ with literatural review.
Cartilage
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Chondroblastoma
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Epiphyses
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Giant Cell Tumors
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Humans
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Humerus
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Incidence
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Male
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Recurrence
;
Sarcoma
;
Temporal Bone
;
Temporomandibular Joint*
10.Comparisons of Early MRI Patterns with Arthroscopic Findings of Possible Acute ACL Tears.
Kyoung Ho YOON ; Jin Hwan AHN ; Seung Ho KIM ; Kye Young HAN ; Kwon Ick HA
The Journal of the Korean Orthopaedic Association 1998;33(1):68-74
Early MRI and arthroscopic findings were compared to evaluate the efficacy of the former for patients, who upon physical examination, were diagnosed with possihle acute ACL tears. MRI, taken between 1-21 days after injury, had to reveal complete ACL tears and arthroscopic surgery should have taken place 3-12 weeks after the injury for patients of this prospective study. Fifty such cases were initially catagorized according to five MRI patterns. Types I to V were separated by the following ACL tear characteristics: Enlarged and diffusely increased in signal, horizontally oriented, non-visualized, discontinuous and vertically oriented. The cases were then divided into two groups of arthroscopic findings; Group A included cases of complete ACL tearing and group B included those with intact or minimally torn ACLs. Of MRI types I through V, there were 31, 9, 5, 4, and I cases of each respectively. 37 cases resulted in complete ACL tears (21 type I, 6 type II, 5 type III, 4 type IV and 1 type V) and 13 cases were catagorized into group B, 10 of which had pattern type I and 3 of which had pattern type II. As result, types III, IV and V had a 100% Positive Predictive Value (PPV) whereas types I and II together had a 67% PPV vaiue. Division of the cases into the five pattern types in early MRI proved valuble for possible cases of acute ACL tears. MRI pattern types III, IV and V were correlated with definite complete ACL tears. However, caution must be taken for types I and II, the majority of the cases, for which there exists a significant possibility for misdiagnosis and consequently unnecessary arthroscopic surgery.
Arthroscopy
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Diagnostic Errors
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Humans
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Knee
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Magnetic Resonance Imaging*
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Physical Examination
;
Prospective Studies