1.A case of hydroa vacciniforme with ocular involvment.
Seung Ho CHANG ; Tae Young YOON
Korean Journal of Dermatology 1993;31(4):612-615
Hydroa Vacciniforme is a rare, chronic, photosensitivity disorder witli onset in childhood that is characterized by recurrent, discrete vesiculation, necrosis and vacciniform scarring limited to sun exposed skin. We report a case of hydroa vacciniforme associated with ocular inwlvment in which vesicles could be induced only with single MED exposure to UVA.
Cicatrix
;
Hydroa Vacciniforme*
;
Necrosis
;
Photosensitivity Disorders
;
Skin
;
Solar System
2.Three Casesof Livedo Vasculitis Cleared by Combined Therapy of Acetylsalicylic Acid , Dipyridamole and Nifedipine.
Tae Young YOON ; Seung Ho CHANG
Korean Journal of Dermatology 1994;32(2):294-299
Livedo vasculitis clinically shows purpuric papules and recurrent ulcers in the lower extremities, mainly on the ankles, leaving characteristic scars called atrophie blanche after the healing of the ulcers. Its characteristic histopathologic features and clinical evolution indicate that the common pathologic event is occlusion of vessels in the middle and deep dermis. In Korean literature, seven cases of this disease have been reported but the response of the treatment was not, satisfactory. We report three cases of livedo vasculitis cleared by combined ther by of acetylsalicylic acid, dipyridamole and nifedipine, which has not been reported in Korean literatur.
Ankle
;
Aspirin*
;
Cicatrix
;
Dermis
;
Dipyridamole*
;
Lower Extremity
;
Nifedipine*
;
Ulcer
;
Vasculitis*
3.Down Syndrome with Familial Eruptive Syringoma.
Seung Ho CHANG ; Tae Young YOON
Korean Journal of Dermatology 1994;32(3):532-536
Down syndrome is the most, well known autosomal trisomy and e large number of abnormal skin features have been reported to occur in patients with Down syndromir. including syringoma. Syringomas occur with increased frequency in patients with Down syringoma, usually limited to the region around the eyes. but few cases of eruptive syringoma with Down syndrome have been reported. We reported the case of familial eruptive syringoma in a 13 years old patient with Down syndrome.
Adolescent
;
Down Syndrome*
;
Humans
;
Livedo Reticularis
;
Skin
;
Syringoma*
;
Trisomy
4.A Case of Heparin Necrosis.
Tae Young YOON ; Seung Ho CHANG
Annals of Dermatology 1994;6(1):74-77
Skin necrosis is a rare complication of heparin administration that is usually localized to injection sites. We report a case of skin necrosis that was caused by minidose intraarterial infusion of porcine heparin which had been used in a touch to prevent coagulation in percutaneous intraarterial cannula. The skin necrosis appeared 35 days after starting heparin use.
Catheters
;
Heparin*
;
Infusions, Intra-Arterial
;
Necrosis*
;
Skin
5.Sweet's Syndrome with Myelodysplastic Syndrome Progressing to Acute Myelogenous Leukemia.
Seung Ho CHANG ; Jai Il YOUN ; Yoo Shin LEE
Annals of Dermatology 1991;3(1):54-57
Sweet's syndrome is an important cutaneous sign of underlying myeloproliferative disorder. The majority of cases have occurred with acute leukemia, primarily of the myelogenous type. We described a case of Sweet's syndrome in a patient with myelodysplastic syndrome that preceded acute myelogenous leukemia by 9 months.
Humans
;
Leukemia
;
Leukemia, Myeloid, Acute*
;
Myelodysplastic Syndromes*
;
Myeloproliferative Disorders
;
Sweet Syndrome*
6.An Immunohistochemical Stain in Paget's Disease.
Hong Tak LEE ; Seung Ho CHANG ; Tae Young YOON
Korean Journal of Dermatology 1998;36(5):796-803
BACKGROUND: Generally, there are few problems in the diagnosis of Paget's disease(PD) using the H&E stain. However, the differentiation of PD from the clonal type of Bowens disease and superficial spreading melanoma in situ that shows pagetoid spreading of tumor cells, may present diagnostic difficulties. In addition, the specia1 stains used for demonstrating the presenee of Pagets cells, such as PAS and mucicarmim, are non-specific and not always sensitive. So, inenunohistochemical stains with monoclonal antibodies against various antigens may be helpful for differentiating PD from ather morphologically similar skin lesions. OBJECTIVE: The purpose of this study was to investigate the diagnostic accuracy of immunohisto- chemical staining for diagnostic use in PD. METHODS: Immunohistochemical stains used in the biotin streptavidin amplificxl technique with monoclonal antibodies to several low rnolecular weight cytokeratin(CK)s, EMA and CEA, were performed on formalin-fixed, paraffin-embedded tissue. Twelve cases of PD(10 cases of extranmmmary PD and 2 cases of mammary PD), five cases of superficial spreading melanoma in situ and five cases of Bowens disease were investigated. RESULTS: The results were as follows. 1. Positive reactions with variable intensity using CK7, CKS, CK19 were seen in all cases(100%) of PD and the. staining intensity tor CK7 or CK19 was stronger than that of CKS. 2. Of the 12 cases of PD, both CK18 and CAM5.2 staining showed positivity in 11 cases(92%). 3. EMA and CEA staining showed positivity in 10(83%) and 9(75%) of 12 cases, respectively. 4. Some Pagets cells were negative for CK8, CK18 and EMA, although other positive cells were observed in the same sections. 5. All antigens were consistently negative in all cases of Bowens disease and superficial spreading melanoma in situ. CONCLUSION: The results show that moaoclonal antibodies to low molecular weight CKs are more sensitive than EMA or CEA in the demonstration of Pagets cells. Moreover, among the low molecular weight CK series, CK7 and CK19 are most useful for their high sensitivity and intensity.
Antibodies
;
Antibodies, Monoclonal
;
Biotin
;
Bowen's Disease
;
Coloring Agents
;
Diagnosis
;
Melanoma
;
Molecular Weight
;
Skin
;
Streptavidin
7.Cutaneous Manifestations in Sepsis Caused by Methicillin-Resistant Staphylococcus aureus.
Seok Ki JUNG ; Seung Ho CHANG ; Tae Young YOON
Korean Journal of Dermatology 1998;36(2):335-340
Sepsis refers to the systemic response to serious infection. Patients with sepsis usually manifest fever, tachycardia, tachypnea, leukocytosis, and a localized site of infection. Methicillin-resistant Staphylococcus aureus(MRSA) is a gram-positive, nonmotile, aerobic, catalase- positive coccus, which is resistant to all the B -lactam antibiotics. Cutaneous manifestations in sepsis are maculopapules, nodules, petechiae, ecchymoses, purpurae, pustules, vesiculobullae, hemorrhagic bullae and ulcers. When MRSA is identified in blood cultures and skin tissue cultures, the skin lesions can be considered as cutaneous manifestations in sepsis caused by MRSA. We report two cases with erythematous pustules, petechiae, hemorrhagic bullae and maculopapules caused by MRSA sepsis. MRSA grew in blood cultures and skin tissue cultures.
Anti-Bacterial Agents
;
Ecchymosis
;
Fever
;
Humans
;
Leukocytosis
;
Methicillin Resistance*
;
Methicillin-Resistant Staphylococcus aureus*
;
Purpura
;
Sepsis*
;
Skin
;
Staphylococcus
;
Tachycardia
;
Tachypnea
;
Ulcer
8.A case of generalized lipodystrophy.
Seung Ho CHANG ; Jai Il YOUN ; Yoo Shin LEE
Korean Journal of Dermatology 1991;29(2):241-246
Generalized lipodyst,rophy is characterized by generalized loss of body fat, and is asociated vith metabolic ahnormalities, including insulin resistance, hyperglycemia., and hypertriglyceridemia. like acanthosis nigricans, generalized lipodystrophy is a cutaneous marker of insulin re.istant diabetes. We report. herein a twenty year old female witti both classic generalized lipodystripin and acanthosis nigricans, in association with insulin resistant diabetes.
Acanthosis Nigricans
;
Adipose Tissue
;
Female
;
Humans
;
Hyperglycemia
;
Hypertriglyceridemia
;
Insulin
;
Insulin Resistance
;
Lipodystrophy, Congenital Generalized*
9.Effect of N-acetylcysteine on Dapsone-Induced Methemoglobinemia.
Wen Joen CHANG ; Seung Ho KIM ; Hahn Shick LEE
Journal of the Korean Society of Emergency Medicine 1997;8(2):150-154
BACKGROUND: To determine whether N-acetylcysteine(NAC) reduces methemoglobin. METHOD: We carried out an in vivo experiment in rats, weighed about 300g. Each rat was ingested 200mg of dapsone(4,4'diaminodiphenyl sulphone) to induce methemo- globinemia. After 1 hour, 30 rats were received NAC 160mg(2ml) and another 30 rats, served as control, were received 2ml of normal saline orally,4 times hourly. Serum methemoglobin concentrations were checked 1,6, and 24 hours after dapsone ingestion. RESULT: The methemoglobin concentrations on each time were 27.1+/-5.8%,23.5+/-8.8%, 17.1+/-6.4%(mean+/-SD) in control group and 25.5+/-6.3%, 25.5+/-8.8%, 65.5+/-31.2%(mean+/-SD) in NAC group. There were no differences on methemoglobin concentrations at 1 and 6 hours between two groups(P>.05). At 24 hours, the methemoglobin concentrations of NAC group was significantly higher than those of control group(P<.01). CONCLUSION: NAC had no therapeutic effects on dapsone induced methemoglobinemia in this experimental setting.
Acetylcysteine*
;
Animals
;
Dapsone
;
Eating
;
Methemoglobin
;
Methemoglobinemia*
;
Rats
10.A Case of Infantile Myofibromatosis.
Hong Tak LEE ; Seung Ho CHANG ; Tae Young YOON
Korean Journal of Dermatology 1997;35(1):182-186
Infantile myofibromatosis is an uncornmon, benign, self-limiting, localized or generalized process, probably of hamartomatous origin, which consists to a large degree of cells having the characteristics of myofibroblasts and sometimes of pericytes. Both solitary and multicentric forms occur. Most lesions are present at birth or in early infancy, and some are familial in origin. A female newborn presented with a firm, round, red colored, 3 x 3 cm sized tumor with central necrosis on the left chest. Histological examination revealed well-circumscribed nodules consisting of short bundles of plump, spindle shaped cells displaying staining characteristics intermediate between fibroblasts and smooth muscle cells. The tumor was immunoreactive for actin but did not stain for desmin. A Follow-up examination at the age of 3 months revealed a moderate degree of spontaneous regressior of the lesion.
Actins
;
Desmin
;
Female
;
Fibroblasts
;
Follow-Up Studies
;
Humans
;
Infant, Newborn
;
Myocytes, Smooth Muscle
;
Myofibroblasts
;
Myofibromatosis*
;
Necrosis
;
Parturition
;
Pericytes
;
Thorax