1.The effect of continuous subcutaneous insulin infusion therapy on oxidative stress in Korean type 2 diabetic patients.
Soo Bong CHOI ; Eui Kwang CHOI ; Seung Hee ANN ; Mi Kyung CHOI ; Sun Min PARK
Korean Journal of Medicine 2000;58(5):548-559
BACKGROUND: It is known that hyperglycemia increase oxidative stress. Korean type 2 diabetic patients usually appear to be insulin deficient and insulin resistant. The blood glucose control can be normalized by the intensive insulin therapy. It has been reported that hyperinsulinemia have harmful effects on oxidative stress. The purpose of this study was to determine whether continuous subcutaneous insulin infusion (CSII) therapy by insulin pump affects the defense mechanism of oxidative stress in Korean type 2 diabetic patients. METHODS: Fasting blood from eighty three subjects was collected prior to starting CSII therapy using portable insulin pump and after hospitalization for 2 weeks. Serum and red blood cell lipid peroxide concentrations were analyzed by Yagi's methods. Serum tocopherol and vitamin C concentrations were measured by HPLC. Red blood cell glutathione peroxidase, superoxide dismutase and catalase activities were also measured. RESULTS: The mean age of subjects were 50.0+/-10.9 years, and they had diabetes for 8.4+/-5.8 years. Their average body mass index was 23.4+2.7 kg/m2. Their blood glucose levels were not controlled by oral hypoglycemic agents, diet and exercise treatment. Patients were divided into two categories according to blood glucose levels prior to CSII treatment. One category consists of patients with less than 11.1 mmol/L of average daily blood glucose levels prior to CSII treatment (the controlled group). The other category consists of patients with more than 11.1 mmol/L of average daily blood glucose levels (the uncontrolled group). Patients in the uncontrolled group had higher serum lipid peroxide levels than those in the controlled group before CSII therapy. After 2 weeks of CSII therapy, oxidative stress was not changed in controlled and uncontrolled groups. Serum insulin levels of all patients were increased after CSII treatment, but the levels before and after treatments were in the normal range, not hyperinsulinemic. Also, serum insulin levels did not correlate with serum lipid peroxide levels regardless of CSII treatment. Average serum vitamin C levels were remarkably increased after the therapy in all patients, but average serum total tocopherol levels was not altered. Also, activities of antioxidant enzymes such as glutathione peroxidase, superoxide dismutase, and catalase were not significantly changed. CONCLUSION: The blood glucose levels were normalized with the normal ranges of serum insulin levels after two weeks of CSII treatment. However, serum lipid peroxide levels were not changed even though serum vitamin C levels were increased. It is concluded that the oxidative stress of Korean type 2 diabetic patients are not changed after two weeks of CSII treatment, but there may be possibility the longer duation of CSII therapy may gradually improve oxidative stress.
Antioxidants
;
Ascorbic Acid
;
Blood Glucose
;
Body Mass Index
;
Catalase
;
Chromatography, High Pressure Liquid
;
Diet
;
Erythrocytes
;
Fasting
;
Glutathione Peroxidase
;
Hospitalization
;
Humans
;
Hyperglycemia
;
Hyperinsulinism
;
Hypoglycemic Agents
;
Insulin*
;
Oxidative Stress*
;
Reference Values
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Superoxide Dismutase
;
Tocopherols
2.Multiple Chromosomal Abnormalities Accompanying Disseminated Granulocytic Sarcoma in Recurrent Acute Myelogenous Leukemia 50,XY,+8,+10,del(15)(q13),+21,+22.
Hyun Il KIM ; Yeon Hee PARK ; Han Jin KWON ; Soo Youb CHAE ; Seung Hye ANN ; Hyo Jin LEE
Korean Journal of Hematology 2001;36(1):100-104
It is known that acute myelogenous leukemia (AML) carries chromosomal abnormalities in 55-78% of patients, and that chromosomal abnormalities were associated with pathophysiology of disease, clinical feature, and it's prognosis. Granulocytic sarcoma occurring in 2~14% of AML is especially associated with t(8;21), is common to misdiagnose as malignant lymphoma, and has poor prognosis as survival of 5.4 months due to poor response to chemotherapy. Hereby we report a case of recurrent AML occurred as granulocytic sarcoma carring multiple chromosomal aberration without accompanying t(8;21).
Chromosome Aberrations*
;
Drug Therapy
;
Humans
;
Leukemia, Myeloid, Acute*
;
Lymphoma
;
Prognosis
;
Sarcoma, Myeloid*
3.Radiation-Induced Complications after Breast Cancer Radiation Therapy: a Pictorial Review of Multimodality Imaging Findings.
Ann YI ; Hak Hee KIM ; Hee Jung SHIN ; Mi Ock HUH ; Seung Do AHN ; Bo Kyeong SEO
Korean Journal of Radiology 2009;10(5):496-507
The purpose of this pictorial essay is to illustrate the multimodality imaging findings of a wide spectrum of radiation-induced complications of breast cancer in the sequence of occurrence. We have classified radiation-induced complications into three groups based on the time sequence of occurrence. Knowledge of these findings will allow for the early detection of complications as well as the ability to differentiate tumor recurrence.
Breast Neoplasms/*radiotherapy
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*Diagnostic Imaging
;
Female
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Humans
;
Radiation Injuries/*diagnosis
;
Radiotherapy/*adverse effects
4.Classification of Metastatic versus Non-Metastatic Axillary Nodes in Breast Cancer Patients: Value of Cortex-Hilum Area Ratio with Ultrasound.
Sung Eun SONG ; Bo Kyoung SEO ; Seung Hwa LEE ; Ann YIE ; Ki Yeol LEE ; Kyu Ran CHO ; Ok Hee WOO ; Sang Hoon CHA ; Baek Hyun KIM
Journal of Breast Cancer 2012;15(1):65-70
PURPOSE: To investigate the significance of the cortex-hilum (CH) area ratio and longitudinal-transverse (LT) axis ratio and the blood flow pattern for diagnosis of metastatic axillary lymph nodes by ultrasound in breast cancer patients. METHODS: From October 2005 to July 2006, we prospectively evaluated axillary nodes with ultrasound in 205 consecutive patients who had category 4B, 4C or 5 breast lesions according to the Breast Imaging Reporting and Data System-Ultrasound (BI-RADS-Ultrasound(R)). Among the 205, there were 24 patients who had pathologic verification of breast cancer and axillary lymph node status. For a total of 80 axillary nodes we measured the areas of the cortex and hilum of lymph nodes and calculated the area ratio. We also measured the length of the longitudinal and transverse axis of the lymph nodes and calculated the length ratio. We evaluated the blood flow pattern on power Doppler imaging and classified each lymph node into a central or peripheral pattern. Diagnostic performance was analyzed according to positive criteria for lymph node metastasis (CH area ratio >2, LT axis ratio <2, peripheral type on power Doppler imaging). RESULTS: The sensitivity of the CH area ratio was superior to that of the LT axis ratio (94.1% vs. 82.3%, p=0.031) and to that of the blood flow pattern (94.1% vs. 29.4%, p=0.009). For specificity, all three evaluating parameters had high values (89.1-95.6%) and no significant differences were found (p=0.121). The CH area ratio had a better positive predictive value than the LT axis ratio (94.1% vs. 80.0%, p=0.030) and power Doppler imaging (94.1% vs. 66.6%, p=0.028). For the negative predictive value, the CH area ratio was superior to the LT axis ratio (95.6% vs. 86.6%, p=0.035) and the blood flow pattern (95.6% vs. 63.0%, p=0.027). CONCLUSION: We recommend the CH area ratio of an axillary lymph node on ultrasound as a quantitative indicator for the classification of lymph nodes. The CH area ratio can improve diagnostic performance when compared with the LT axis ratio or blood flow pattern.
Axis, Cervical Vertebra
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Breast
;
Breast Neoplasms
;
Humans
;
Lymph Nodes
;
Lymphatic Metastasis
;
Neoplasm Metastasis
;
Prospective Studies
;
Sensitivity and Specificity
5.Effects of low-dose niacin on dyslipidemia and serum phosphorus in patients with chronic kidney disease.
Hyo Jin KANG ; Do Kyong KIM ; Su Mi LEE ; Kyung Han KIM ; Seung Hee HAN ; Ki Hyun KIM ; Seong Eun KIM ; Young Ki SON ; Won Suk ANN
Kidney Research and Clinical Practice 2013;32(1):21-26
BACKGROUND: Niacin supplementation improves dyslipidemia and lowers serum phosphorus levels in patients with chronic kidney disease (CKD). We evaluated whether low-dose niacin supplementation can improve dyslipidemia, lower serum phosphorus levels, and be administered with a low frequency of adverse effects in patients with CKD. METHODS: We retrospectively analyzed the clinical records of patients with CKD who had taken niacin from January 2009 to June 2011. We excluded patients with CKD stage 1 and 5. We then enrolled 31 patients with CKD who had taken niacin at a fixed dose of 500mg/day for 6 months. We also randomly selected 30 patients with CKD who had been taking statin for 9 months as a control group. RESULTS: Among the 34 patients with CKD who were prescribed niacin, five (14%) complained of adverse effects, and three (8%) discontinued niacin. The proportion of patients in the niacin group who had been taking a statin or omega-3 fatty acids was 67.7% and 48.8%, respectively. In the niacin group, high-density lipoprotein cholesterol level was significantly increased and triglyceride level was significantly decreased at 12 and 24 weeks compared with baseline levels (P < 0.05). In the niacin group, phosphorous level (P < 0.05) was significantly decreased, and glomerular filtration rate (GFR) was significantly increased (P < 0.05) at 24 weeks compared with baseline values. CONCLUSION: Low-dose niacin had a low frequency of adverse effects and also improved dyslipidemia, lowered serum phosphorus level, and increased GFR in patients with CKD. Further studies are needed to evaluate the long-term effects of low-dose niacin for renal progression of CKD.
Cholesterol
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Dyslipidemias
;
Fatty Acids, Omega-3
;
Glomerular Filtration Rate
;
Humans
;
Hydroxymethylglutaryl-CoA Reductase Inhibitors
;
Lipoproteins
;
Niacin
;
Phosphorus
;
Renal Insufficiency, Chronic
;
Retrospective Studies
6.Effects of low-dose niacin on dyslipidemia and serum phosphorus in patients with chronic kidney disease.
Hyo Jin KANG ; Do Kyong KIM ; Su Mi LEE ; Kyung Han KIM ; Seung Hee HAN ; Ki Hyun KIM ; Seong Eun KIM ; Young Ki SON ; Won Suk ANN
Kidney Research and Clinical Practice 2013;32(1):21-26
BACKGROUND: Niacin supplementation improves dyslipidemia and lowers serum phosphorus levels in patients with chronic kidney disease (CKD). We evaluated whether low-dose niacin supplementation can improve dyslipidemia, lower serum phosphorus levels, and be administered with a low frequency of adverse effects in patients with CKD. METHODS: We retrospectively analyzed the clinical records of patients with CKD who had taken niacin from January 2009 to June 2011. We excluded patients with CKD stage 1 and 5. We then enrolled 31 patients with CKD who had taken niacin at a fixed dose of 500mg/day for 6 months. We also randomly selected 30 patients with CKD who had been taking statin for 9 months as a control group. RESULTS: Among the 34 patients with CKD who were prescribed niacin, five (14%) complained of adverse effects, and three (8%) discontinued niacin. The proportion of patients in the niacin group who had been taking a statin or omega-3 fatty acids was 67.7% and 48.8%, respectively. In the niacin group, high-density lipoprotein cholesterol level was significantly increased and triglyceride level was significantly decreased at 12 and 24 weeks compared with baseline levels (P < 0.05). In the niacin group, phosphorous level (P < 0.05) was significantly decreased, and glomerular filtration rate (GFR) was significantly increased (P < 0.05) at 24 weeks compared with baseline values. CONCLUSION: Low-dose niacin had a low frequency of adverse effects and also improved dyslipidemia, lowered serum phosphorus level, and increased GFR in patients with CKD. Further studies are needed to evaluate the long-term effects of low-dose niacin for renal progression of CKD.
Cholesterol
;
Dyslipidemias
;
Fatty Acids, Omega-3
;
Glomerular Filtration Rate
;
Humans
;
Hydroxymethylglutaryl-CoA Reductase Inhibitors
;
Lipoproteins
;
Niacin
;
Phosphorus
;
Renal Insufficiency, Chronic
;
Retrospective Studies
7.Incidence and Risk Factors for Surgical Site Infection after Gastric Surgery: A Multicenter Prospective Cohort Study.
Su Jin JEONG ; Hea Won ANN ; Jae Kyung KIM ; Heun CHOI ; Chang Oh KIM ; Sang Hoon HAN ; Jun Yong CHOI ; Kyong Ran PECK ; Cheol In KANG ; Joon Sup YEOM ; Young Hwa CHOI ; Seung Kwan LIM ; Young Goo SONG ; Hee Jung CHOI ; Hee Jung YOON ; Hyo Youl KIM ; Young Keun KIM ; Min Ja KIM ; Yoon Seon PARK ; June Myung KIM
Infection and Chemotherapy 2013;45(4):422-430
BACKGROUND: Surgical site infection (SSI) is a potentially morbid and costly complication of surgery. While gastrointestinal surgery is relatively common in Korea, few studies have evaluated SSI in the context of gastric surgery. Thus, we performed a prospective cohort study to determine the incidence and risk factors of SSI in Korean patients undergoing gastric surgery. MATERIALS AND METHODS: A prospective cohort study of 2,091 patients who underwent gastric surgery was performed in 10 hospitals with more than 500 beds (nine tertiary hospitals and one secondary hospital). Patients were recruited from an SSI surveillance program between June 1, 2010, and August 31, 2011 and followed up for 1 month after the operation. The criteria used to define SSI and a patient's risk index category were established according to the Centers for Disease Control and Prevention and the National Nosocomial Infection Surveillance System. We collected demographic data and potential perioperative risk factors including type and duration of the operation and physical status score in patients who developed SSIs based on a previous study protocol. RESULTS: A total of 71 SSIs (3.3%) were identified, with hospital rates varying from 0.0 - 15.7%. The results of multivariate analyses indicated that prolonged operation time (P = 0.002), use of a razor for preoperative hair removal (P = 0.010), and absence of laminar flow in the operating room (P = 0.024) were independent risk factors for SSI after gastric surgery. CONCLUSIONS: Longer operation times, razor use, and absence of laminar flow in operating rooms were independently associated with significant increased SSI risk after gastric surgery.
Centers for Disease Control and Prevention (U.S.)
;
Cohort Studies*
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Cross Infection
;
Hair Removal
;
Humans
;
Incidence*
;
Korea
;
Multivariate Analysis
;
Operating Rooms
;
Prospective Studies*
;
Risk Factors*
;
Tertiary Care Centers
8.Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry
Gyung-Min PARK ; Chang Hoon LEE ; Seung-Whan LEE ; Sung-Cheol YUN ; Young-Hak KIM ; Yong-Giun KIM ; Ki-Bum WON ; Soe Hee ANN ; Shin-Jae KIM ; Dong Hyun YANG ; Joon-Won KANG ; Tae-Hwan LIM ; Eun Hee KOH ; Woo Je LEE ; Min-Seon KIM ; Joong-Yeol PARK ; Hong-Kyu KIM ; Jaewon CHOE ; Sang-Gon LEE
Diabetes & Metabolism Journal 2020;44(3):470-479
There are limited data on the impact of diabetes control on the risk of subclinical coronary atherosclerosis. We analyzed 6,434 consecutive asymptomatic individuals without previous history of coronary artery disease who underwent coronary computed tomographic angiography (CCTA) (mean age, 53.7±7.6 years and 4,694 men [73.0%]). The degree and extent of subclinical coronary atherosclerosis were assessed by CCTA, and ≥50% diameter stenosis was defined as significant. A cardiac event was defined as a composite of all-cause death, myocardial infarction, unstable angina, or coronary revascularization. Study participants were categorized as normal ( Compared with normal individuals, there were no statistically significant differences in the risk of for any atherosclerotic plaque (odds ratio [OR], 1.16; 95% confidence interval [CI], 0.98 to 1.38; Asymptomatic uncontrolled diabetes was associated with significant subclinical coronary atherosclerosis with subsequent high risk for cardiac events.
9.Practice guideline for the performance of breast ultrasound elastography.
Su Hyun LEE ; Jung Min CHANG ; Nariya CHO ; Hye Ryoung KOO ; Ann YI ; Seung Ja KIM ; Ji Hyun YOUK ; Eun Ju SON ; Seon Hyeong CHOI ; Shin Ho KOOK ; Jin CHUNG ; Eun Suk CHA ; Jeong Seon PARK ; Hae Kyoung JUNG ; Kyung Hee KO ; Hye Young CHOI ; Eun Bi RYU ; Woo Kyung MOON
Ultrasonography 2014;33(1):3-10
Ultrasound (US) elastography is a valuable imaging technique for tissue characterization. Two main types of elastography, strain and shear-wave, are commonly used to image breast tissue. The use of elastography is expected to increase, particularly with the increased use of US for breast screening. Recently, the US elastographic features of breast masses have been incorporated into the 2nd edition of the Breast Imaging Reporting and Data System (BI-RADS) US lexicon as associated findings. This review suggests practical guidelines for breast US elastography in consensus with the Korean Breast Elastography Study Group, which was formed in August 2013 to perform a multicenter prospective study on the use of elastography for US breast screening. This article is focused on the role of elastography in combination with B-mode US for the evaluation of breast masses. Practical tips for adequate data acquisition and the interpretation of elastography results are also presented.
Breast*
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Consensus
;
Elasticity Imaging Techniques*
;
Information Systems
;
Mass Screening
;
Ultrasonography*