1.The effectiveness of hyaluronidase for calcium gluconate-inducing extravasation necrosis : a dose and time response.
Hong Gi LEE ; Seung Han KIM ; Moo Hyun PAIK ; Seung Hong KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(5):776-783
Extravasation necrosis due to intravenously administered fluids and drugs is an increasing problem in hospital practice. The incidence of extravasation is variable but skin necrosis is a potentially devastating complication of intravenous therapy. Local injection of hyaluronidase has been recommended for several types of infusion extravasations. The previous studies found hyaluronidase to be effective in the prevention of necrosis following intradermal nafcillin, 12% dextrose, sodium bicarbonate, aminophylline or vince alkaloids.The objectives of the study are to determine the dosage of hyaluronidase which is effective in reducing extravasation necrosis caused by 10% calcium-gluconate and to establish how soon after this extravasation it must be given to retain its effectiveness.Study I evaluated control versus only normal saline group and normal saline with hyaluronidase groups (dose:75,150,300,450 units; all in volume 2 ml, treatment delay:immediate, 15-minutes delay, half hour delay, one hour delay, three hour delay). Size and rate of eschar were compared between groups. Study II was undertaken to examine the evolution of calcium-gluconate induced soft tissue injury in the rabbit. The histologic findings of extravasation sites were compared between groups. A statistically significant protective effect was found in the treated group versus the nontreated group within 15 minutes to 30 minutes. The most effective protection was achieved by the immediate injection of 300 units dosage of hyaluronidase.In conclusion, in the 10% calcium gluconate-induced extravasation, the given data suggest that one can expect the most protective effect with a 300 units dosage of hyaluronidase and within half-hour delay in the treatment group.
Aminophylline
;
Calcium*
;
Glucose
;
Hyaluronoglucosaminidase*
;
Incidence
;
Nafcillin
;
Necrosis*
;
Skin
;
Sodium Bicarbonate
;
Soft Tissue Injuries
2.Proliferating cell nuclear antigen and nucleolar organizer region in cervical intraepithetial neoplasia.
Chang Hong KIM ; Seung Kyu HWANG ; Gi Yeon HONG ; Heung Gon KIM ; Boo Ki MIN
Korean Journal of Obstetrics and Gynecology 1993;36(7):2328-2338
No abstract available.
Nucleolus Organizer Region*
;
Proliferating Cell Nuclear Antigen*
3.Proliferating cell nuclear antigen and nucleolar organizer region in cervical intraepithetial neoplasia.
Chang Hong KIM ; Seung Kyu HWANG ; Gi Yeon HONG ; Heung Gon KIM ; Boo Ki MIN
Korean Journal of Obstetrics and Gynecology 1993;36(7):2328-2338
No abstract available.
Nucleolus Organizer Region*
;
Proliferating Cell Nuclear Antigen*
5.A Case of Dermatomyofibroma on Inguinal Area in a Middle Aged Woman.
Sung Eun SONG ; Seung Gi HONG ; Sun Young JO ; Eun Phil HEO ; Ki Woong RO
Korean Journal of Dermatology 2018;56(10):640-641
No abstract available.
Female
;
Humans
;
Middle Aged*
;
Myofibroblasts
6.A Case of Diffuse Extramammary Paget's Disease of Vulva and Anus Showing a Good Response to Radiotherapy.
Sung eun SONG ; Seung gi HONG ; Ki woong RO ; Eun phil HEO
Korean Journal of Dermatology 2018;56(4):284-300
No abstract available.
Anal Canal*
;
Paget Disease, Extramammary*
;
Radiotherapy*
;
Vulva*
8.A Case of Iatrogenic Harlequin Syndrome after Thoracic Sympathectomy
Han Him JEONG ; Seung Gi HONG ; Sun Young JO ; Jae Wan GO ; Eun Phil HEO
Korean Journal of Dermatology 2019;57(8):501-502
No abstract available.
Sympathectomy
9.Intratendinous Tophaceous Gout Mimicking Cellulitis after Achilles Tendon Repair
Woo Jin SHIN ; Sung-Ha HONG ; Seung-Pyo SUH ; Seung Gi LEE
The Journal of the Korean Orthopaedic Association 2021;56(3):261-265
A diagnosis of gout is often straightforward because gout has well known clinical presentations, laboratory analyses, and radiologic features. On the other hand, gout can mimic other diseases by showing a range of atypical clinical manifestations. This paper reports a 35-year-old male with no prior history of gout who developed tophaceous gout at his previously repaired Achilles tendon 11 years after surgery. He was initially misdiagnosed with cellulitis because of his atypical clinical features. This case is presented with a review of the relevant literature.
10.Ductal Carcinoma in Situ (DCIS) and Ductal Carcinoma in Situ with Microinvasion (DCIS-MI) of the Breast.
Gi Hong CHOI ; Seung Sang KO ; Seung Ki KIM ; Seung Il KIM ; Byeong Woo PARK ; Kyong Sik LEE
Journal of the Korean Surgical Society 2002;63(3):193-200
PURPOSE: The use of mammographic screening has led to the early detection of breast cancers as well as the increasing incidence of ductal carcinoma in situ (DCIS) and DCIS with microinvasion (MI). The biologic behaviors and management of DCIS and DCIS with MI remain uncertain and controversial. We designed this study to investigate the differences in clinical behavior and association with pathological parameter of both DCIS and DCIS with MI. METHODS: DCIS with MI was defined as DCIS with and invasive area of 1 mm or less in greatest dimension. We analyzed and compared the clinico-pathological features and treatment outcomes of 155 DCIS patients and 73 DCIS with MI patients. Chi-square test, student t-test and Kaplan-Meier method using SPSS 9.0 for MS-windows were used to verify the statistical significance. RESULTS: Both DCIS with MI and DCIS were most prevalent in women in the fifth decade, and the mean ages of the two groups were 45.0 and 46.8 years old, respectively. The primary tumors of DCIS with MI were more palpable (72.6% vs. 56.8%, P=0.032) upon physical examination and larger (3.1+/-0.21 cm vs. 2.6+/-0.12 cm, P=0.037) than those of the DCIS group. The rate of axillary lymph node metastasis was higher in the DCIS with MI group (8.3% vs. 0.7%, P=0.003). The DCIS with MI group was more commonly associated with high nuclear grade (50% vs. 28%, P=0.028). The DCIS with MI group was also linked with comedo type, although not to a statistically significant degree (67.6% vs. 52.6%, P=0.095). In terms of hormone receptor, there was no significant difference between the groups. There were three systemic metastases in DCIS patients and two DCIS with MI patients (P>0.05). There were no local-regional recurrences in either groups. The 8-year disease-free survival rates of the DCIS and DCIS with MI groups were 98.1% and 95.8% respectively (P>0.05). CONCLUSION: DCIS with MI has several clinical-pathological characterisitcs: more palpable on physical examination, larger in size, higher incidence of lesions with comedo necrosis and high nuclear grade. Examination of the axillary lymph node with less invasive techniques may be necessary in cases with suspicious invasion. Since DCIS with MI is thought to be a transitional disease entity between DCIS and invasive ductal carcinoma and has a metastatic potential, a careful histologic evaluation is necessary for the diagnosis of DCIS.
Breast Neoplasms
;
Breast*
;
Carcinoma, Ductal*
;
Carcinoma, Intraductal, Noninfiltrating*
;
Diagnosis
;
Disease-Free Survival
;
Female
;
Humans
;
Incidence
;
Lymph Nodes
;
Mass Screening
;
Necrosis
;
Neoplasm Metastasis
;
Physical Examination
;
Recurrence