No abstract available.
Diabetes Insipidus, Nephrogenic* ; Urinary Bladder*

PURPOSE: Although there is no favoring etiology and no definitive treatment modality for interstitial cystitis(IC), the search for the cause of IC continues in hope of identifying a target for treatment. Recently nitric oxide(NO) is speculated to be associated with the pathogenesis and the treatment of IC. But, the exact mechanisms are poorly known and the experimental and clinical data about NO in IC are conflicting. We attempted to determine that urine NO level evaluated in patients with interstitial cystitis(IC) and compared with those from control patients with bacterial cystitis. MATERIALS AND METHODS: Fifty six patients were involved in this study, including control 22, patients with IC 8, patients with bacterial cystitis 17, and recovery state from bacterial cystitis 8. Urine samples were collected by clean-catch midstream in men and from urethral catheterization in women. Urinary nitrite which was considered to be an urinary NO in this study was measured by Titerek Multiscan MCC/340 ELISA reader. RESULTS: Urinary NO levels were 6.16+/-1.09 pM/mg.creatinine in control, 5.15+/-0.87 pM/mg.creatinine in IC, 79.58+/-24.69 pM/mg. creatinine in bacterial cystitis, and 32.96+/-8.38 pM/mg.creatinine in recovery state from bacterial cystitis, respectively. Urinary NO levels in bacterial cystitis and recovery state from bacterial cystitis were significantly higher than those in control and IC(p<0.0001). CONCLUSION: Urinary NO in bacterial cystitis was higher than that in control and maintained for some period. Urinary NO in IC was lower than that in bacterial cystitis.
Creatinine ; Cystitis* ; Cystitis, Interstitial ; Enzyme-Linked Immunosorbent Assay ; Female ; Hope ; Humans ; Male ; Nitric Oxide ; Urinary Catheterization ; Urinary Catheters

Percutaneous transluminal coronary angioplasty(PTCA) has been widely applied in patients with coronary artery disease since 1977. Although coronary angioplasty has beeb shown to be safe and effective treatment strategy, acute closure & restenosis remain as major limitations of PTCA. Acute occlusion due to intracoronary thrombus accumulation during or immediately after coronary angioplasty is serious complication of PTCA, also, Intracoronary urokinase has been used to treat acute occlusion by intracoronary thrombus that complicated in PTCA and proved to be effective in restoring vessel preventing acute myocardial infarction. We report a case in which embolism of left anterior descending artery was complicated during angioplasty of left circumflex artery and managed with intracoronary infusion of urokinas.
Angioplasty* ; Arteries* ; Coronary Artery Disease ; Embolism ; Humans ; Myocardial Infarction ; Thrombocytosis ; Thromboembolism* ; Thrombosis ; Urokinase-Type Plasminogen Activator

BACKGROUND AND OBJECTIVES : Microvascular integrity has been associated with the clinical outcomes in acute myocardial infarction (AMI). The present study was conducted to determine the value of many microvascular indexes assessed by an intracoronary (IC) pressure/Doppler wire in AMI following primary PCI for detecting viable myocardium by comparing with the 18F-fluorodeoxyglucose uptake rate (%FDG uptake) on positron-emission tomography (PET). SUBJECTS AND METHODS : We studied 35 patients who had their first AMI (age: 56+/-12, male: 30). After primary PCI, the TMPG (TIMI myocardial perfusion grade) was assessed. We measured the coronary flow reserve (CFR), the diastolic deceleration time (DDT), the coronary wedge pressure (Pcw), the Pcw/ Pa (mean aortic pressure) and the hyperemic microvascular resistance index (hMVRI) by an IC Doppler/ pressure wire. 18FDG PET scan was obtained at 7 days after the primary PCI; viable myocardium was defined that the %FDG uptake was more than 50% in infarct-related myocardium. RESULTS : There were significant correlations between TMPG, CFR, Pcw, Pcw/Pa, DDT, hMVRI and %FDG uptake (r=0.651, p<0.001; r=0.386, p=0.020; r=-0.388, p=0.021; r=-0.473, p=0.004; r=0.589, p<0.001; r=-0.442, p=0.008, respectively). The best cutoff values and area under curves (AUC) of the CFR, Pcw, Pcw/Pa, DDT and hMVRI for 50% FDG uptake were 1.8 (0.737), 27 mmHg (0.600), 0.33 (0.660), 600 msec (0.802) and 2.55 mmHg.cm-1.sec (0.768), respectively. The DDT had a significantly higher AUC than that of Pcw (p=0.029) and it was an independent index to predict the myocardial viability (p=0.011). CONCLUSION : DDT was the most reliable hemodynamic microvascular index that was assessed within 24 hours following primary PCI for predicting the viable myocardium in AMI patients.
Area Under Curve ; DDT ; Deceleration ; Fluorodeoxyglucose F18 ; Hemodynamics ; Humans ; Male ; Myocardial Infarction ; Myocardium ; Perfusion ; Positron-Emission Tomography ; Pulmonary Wedge Pressure

PURPOSE: We conducted this study to assess the effect of oral application of bovine colostrum on the plasma endotoxin and TNF-alpha following the abdominal surgery. METHODS: 46 patients who underwent the abdominal surgery were evenly enrolled in a prospective, randomized, double blind and placebo-controlled study. The patients were preoperatively managed by oral application of 20 g of a bovine colostrums or placebo (nonfat dried milk) per a day for 3 days. In both groups, endotoxin was sequentially determined pre-, intra- and postoperatively by a modified limulus amebocyte lysate test. TNF-alpha and CRP were also measured. The clinical course was followed and compared in both groups. RESULTS: The colostrum group showed significantly lower level of endotoxin and TNF-alpha compared to the placebo group. CRP did not differ in both groups. Clinical event did not occur in both group until the discharge. Colostrum group tends to have a lower incidence of fever and leukocytosis without statistic significance. CONCLUSION: Prophylactic preoperative oral application of bovine colostrum lower the plasma level of perioperative endotoxin and TNF-alpha. Further studies were needed for the relation of clinical effect and preoperative oral application of bovine colostrum.
Colostrum* ; Endotoxemia* ; Fever ; Horseshoe Crabs ; Humans ; Incidence ; Leukocytosis ; Plasma ; Prospective Studies ; Tumor Necrosis Factor-alpha*