Psoriasis is one of the relatively common cutaneous disorders, affecting 0.1% to 3.0% of the general population in the world. However, it is recorded that the disease is characterized by its highly variable clinical manifestations and incidence influenced by the racial, geographic and environmental factors. There is a dearth of information for the incidence and clinical manifestations of psoriasis, with the exception of two small-scale and one questionnaire surveys in Korea. This study was aimed to investigate the clinical manifestations and clinic incidence of psoriasis and was based on analysis of 301 psoriatics seen between January, 1978 and August, 1981 (3 years and 8 months) at the Department of Dermatology, Seoul National University Hospital. The results were summarized as follows; 1. In this series of 301 patients, 50.5%(152) were male and 49.5%(149) were female. No significance was attached to the sex preponderance. More than three quarters were aged between 20 and 29 years. 2. The mean age of onset in male was 25.7 years and in female it was 23.0 years, indicating a slightly earlier onset in female. The peak age of incidence in male was between 20 and 29 years and in female, between 10 and 19 years. 3. The mean duration of t.he diseases for the total sample was 7.9 years.
Female ; Male ; Humans ; Incidence

BACKGROUND: Oxygen concentrators are convenient to operate and economical for patients with chronic obstructive pulmonary disease (COPD). However, oxygen concentrators are not manufactured domestically and the COPD patients are currently treated with imported oxygen concentrators. To evaluate the efficacy and safety of domestically developed prototype oxygen concentrator before clinical application, the efficacy and safety of the domestic oxygen concentrator were evaluate by comparing with the imported one. Meterial and METHODS: The clinical tests were performed on 36 hyperhydrosis patients from April 1999 to August 1999. Domestic and imported oxygen concentrators were in turn applied to the same patient, who inspired oxygen for 60 minutes at a rate of 3 liters per minute through nasal prong. The oxygen concentrator, which was applied first, was randomly allocated. The arterial partial oxygen pressure (PaO2) was estimated to compare the efficacy; and the carboxy hemoglobin(COHb), pH, arterial CO2 partial pressure, pulse rate, blood pressure, and respiration rate to compare the safety before and after applying each oxygen concentrator. A student t-test was used to analyze the results. RESULTS: In respect to efficacy, the difference in the change of PaO2 before and after the application between two concentrators was not statistically significant. In respect to safety, the differences in the changes of COHb, pH, partial pressure of arterial CO2, pulse rate, blood pressure, respiration rate between two concentrators were also not statistically significant. CONCLUSION: The domestically developed oxygen concentrator, showed satisfactory efficacy and safety when compared with the imported one.
Blood Pressure ; Heart Rate ; Humans ; Hydrogen-Ion Concentration ; Oxygen* ; Partial Pressure ; Pulmonary Disease, Chronic Obstructive ; Respiratory Rate

Amipaque is a water soluble, non-ionic myelographic contrast media, and owing to its high diagnostic accuracy and safety, its use is gradually increasing. The authors studied the complications after Amipaque lumbermyelography in 61 patients with low back pain during the period from Jan. 1981 to Nov. 1981 in Chung Ang University Hospital. The results were as follows; 1. Total complication rate was 52%(32 of 61) and there was nosexual difference in its occurrence. 2. In total, no difference in complication rate was found between head-up positioned group with a degree of 30degrees (group I) after procedure and head-up positioned group with a degree of 70degrees (group II) but female patients had more complication rate in group I than in group II (75% vs 50%).Headache was more common in group I and nausea was more common in group II. 3. Headache was most common complicaiton (44%) and there was no sexual difference in its occurrence. 4. No significant difference in complication rate was found between patients proved to have HBP and patients to have not. 5. Complications were less common in patients with punctured level of L4-5 than in patients with L2-3 or L3-4 level puncture.
Contrast Media ; Female ; Headache ; Humans ; Low Back Pain ; Metrizamide ; Myelography ; Nausea ; Punctures ; Water

This study was carried out to investigate the ultrastructural findings of rats after administration of 0.5% lead acetate with drinking water. The Sprague-Dawley rats were divided into control and experimental groups. The control group was composed of 12 rats and was orally administered with 0.5% sodium acetate. The experimental group was composed of 36 rats and orally administered with 0.5% lead acetate. Two rats in the control group and four rats in the experimental group were sacrificed on day 2, and week 1, 2, 4, 6 and 8 after administration. The kidney was extirpated and examined by electron microscopy. The results obtained were as follows: The blood lead concentration in the experimental group began to increase from the second day after administration and it increased gradually until the 6th week and it decreased at the 8 week. The urinary excretion of delta-ALA also increased from the secondary and gradually increased up to the 8th week. On electron microscopic examination, the proximal tubular cells showed fat droplets, dilatation of the endoplasmic reticulum, mitochondrial swelling, increased numbers of secondary lysosomes and myelin figure-like residual bodies and intranuclear inclusion bodies. All these findings peaked at the eighth week after administration. Ultrastructural findings after Timm sulphide silver reaction revealed the lead granules in the proximal tubular lumen and between the microvilli of the proximal tubular cells without membrane-bounded. It can be concluded that most of the changes of micro-organelles are compatible with degenerative changes of lead exposure and passive diffusion of lead granules are involved in the proximal tubular cells.
Rats ; Animals

No abstract available.
Female ; Ovary* ; Teratoma*

No abstract available.
Pneumonectomy* ; Radiography, Thoracic* ; Thorax*

It is well established that the CT is an essential part not only in screening primary brain tumors, but alsoin staging known malignancy. This paper reports various CT findings demonstrated in 12 cases of choriocarciomawith brain metastasis. The CT findings such as the number, location and density of the metastatic lesions, thedegree of brain edema, mass effect and effect of contrast enhancement are reviewed as well as the episode ofstroke syndrome and survival duration after neurologic symptoms attacks. The results were as follows; 1. Ten ofthese cases showed solitary metastatic lesion and remaining 2 cases were multiple lesions. 2. One was isodensedensity and the others were hemorrhagic increased denstiy by CT. 3. All of these showed mass effect to thesurrounding structures along with moderate to marked brain edema. 4. The position of the metastatic lesion werelocated at the supratentorially in all cases. Most of them were at the unilateral frontal or parietal area of bothof them. One which noted multiple metastatic foci showed at the bilateral occipital regions. 5. Nine cases showedring enhancement after contrast infusion. One which noted isodense density on the noninfusion scan showed alsoring enhancement after contrast infusion. 6. Nine cases showed positive stroke syndrom. One of them was perforemdemergency craniotomy. The remainging 3 cases noted progressive neurologic symptoms. 7. Two cases were noted onlybrain metastasis but the others also had various degree of pulmonary metastasis and 2 of latter had hepaticmetastasis, too. 8. Most of the cases were treated with CHAMOCA regimen, and one of them was taken whole brainirradiation (3000 rads/2 weeks). Another one case revealed marked regression of not only metastatic brain lesionbut the pulmonary lesion after the 8th course of CHAMOCA regimen and still alive for over 460 days.
Brain Edema ; Brain Neoplasms ; Brain ; Choriocarcinoma ; Craniotomy ; Female ; Mass Screening ; Neoplasm Metastasis ; Neurologic Manifestations ; Occipital Lobe ; Pregnancy ; Rabeprazole ; Stroke

No abstract available.
Blood Glucose* ; Humans ; Infant, Newborn ; Infant, Premature*

Neurilemmomatosis is a clinical entity consisting of multiple cutaneous neurilemmomas, central nervous system tumors, and neurologic disorders. Since Shishiba et al first described the disorder in 1984, several cases have been reported. We report a Korean case of neurilemmomatosis showing multiple neurilemmomas of the skin and spinal cord, with associated motor and sonsory nerve disturbance. Histologic, immunohistopathologic and electron microscopic studies confirmed the diagnosis.
Central Nervous System Neoplasms ; Diagnosis ; Nervous System Diseases ; Neurilemmoma ; Skin ; Spinal Cord

The close similarity of acrokeratosis verruciformis(AKV) to the acral lesions of Dariers disease is well known. However, the exact relationship between the two disorders has not been satisfactorily resolved. A case of Dariers disease associated with guttate leukoderma and AKV is presented. The patient was a 17-year-old male who had dark cursted papules on the neck and lower abdomen, flat-topped keratotic papules on the dorsal surface of hoth hands, and white macules disseminated on the trunk and lower extremities of 7 years duration. The histopathologic examination of the lesion on the lower abdomen revealed parakeratotic plugs, corps ronds, and suprabasal clefts. The lesion on the dorsum of the hand showed compact hyperkeratosis, acanthosis, and papillomatosis with the pattern of church spires. The leukodermic lesion revealed decreased melanin content in the epidermal cells.
Male ; Humans