No abstract available.
Sepsis*

This study was conducted to evaluate the relations between alcohol intake and blood lipid level in a group of 1,138 Korean adult men, ages 20 to 69 years. Total number of each of a variety of drinks in the previous two weeks was obtained by questionnaire and converted into grams of alcohol consumed in a week. The levels of blood lipid such as Cholesterol, HDL-Cholesterol, Triglyceride and LDL-Cholesterol were examined by enzyme method. We also observed the effects of various variables such as age, body mass index, smoking, exercise and blood pressure on blood lipid level. The results obtained were as follows; 1. Average weekly alcohol intake was 129.0+/-167.4 gm and that of 30-39 age group was the highest as 149.3+/-170.4gm. 2. Levels of Cholesterol, Triglyceride and LDL-Cholesterol tended to increase with increasing age, but level of HDL-Cholesterol showed no significant relationship with age. 3. The positive linear regressions of alcohol intake on HDL-Cholesterol and Triglyceride were noted statistically significant. 4. Multiple regression analysis demonstrated that the effect of alcohol on HDL-Cholesterol and Triglyceride was statistically significant and the contribution rates were 5.0% and 0.8%, respectively. And, in the case of HDL-Cholesterol, the alcohol intake was the most significant independent variable.
Adult* ; Blood Pressure ; Body Mass Index ; Cholesterol ; Humans ; Linear Models ; Male ; Surveys and Questionnaires ; Smoke ; Smoking ; Triglycerides

There had been a continuous evolution of lymphoma classification and recently a Revised European-American Lymphoma Classification was proposed by the International Lymphoma Study Group. This new classification often requires information on immunophenotypic and molecular biologic markers in addition to the usual histologic findings. Recent advances in the production of commercially available monoclonal antibodies reactive on formalin-fixed paraffin-embedded tissues provide us a great help to classify the non-Hodgkin's lymphoma. We have analyzed 31 low grade B-cell lymphomas by the schemes proposed by the International Lymphoma Study Group using antibodies to CD3, CD5, CD20, CD23, CD43, cyclin D1, and bcl-2 protein, and have analyzed the immunophenotypic features. Among 31 low grade B-cell lymphomas, 8 small lymphocytic lymphomas, 5 mantle cell lymphomas, 7 follicle center lymphomas (2 grade I, 3 grade II, and 2 grade III), and 11 marginal zone B-cell lymphomas (all of which were extranodal) were identified. Among 8 small lymphocytic lymphomas, 5 cases were positive for CD5; 6 cases were positive for CD23; 7 cases were positive for CD43; all 8 cases were negative for cyclin D1; and 7 cases were positive for bcl-2. Among 5 mantle cell lymphomas, 4 cases were positive for CD5 and CD43; all five cases were negative for CD23; 4 cases were positive for cyclin D1 and bcl-2. All 7 follicle center lymphomas were negative for CD5, CD43 and cyclin D1 and 2 cases were positive for CD23; and 6 cases were positive for bcl-2. All marginal zone B-cell lymphomas were negative for CD5, CD23 and cyclin D1; 3 cases were positive for CD43 and 9 cases were positive for bcl-2. Diagnostic utility for CD5 antigen detection on paraffin embedded tissue has a limitation due to weak antigen expression in tumor cells of B-cell lymphomas; however, still be useful in differentiating small lymphocytic lymphoma and mantle cell lymphoma from other B-cell lymphomas when applied in conjunction with CD43. CD23, CD43, and cyclin D1 appear to be of great help in differentiating subgroups of low grade B-cell lymphomas. Bcl-2, as known, is found to be useful to rule out reactive follicular hyperplasia.
Antibodies ; Antibodies, Monoclonal ; Antigens, CD5 ; B-Lymphocytes* ; Biomarkers ; Classification ; Cyclin D1 ; Hyperplasia ; Immunohistochemistry* ; Leukemia, Lymphocytic, Chronic, B-Cell ; Lymphoma ; Lymphoma, B-Cell* ; Lymphoma, B-Cell, Marginal Zone ; Lymphoma, Mantle-Cell ; Lymphoma, Non-Hodgkin ; Paraffin*

The alterations in the localization of keratinocyte membrane glycoconjugates in allergic contact dermatitis were investigated in guinea pig skin treated with topical application of 2.4-dinitro-chlorobenzene. We employed the avidin-biotin complex(ABC) method for the detection of localization of 10 commercially available lectins labelled with biotin: Con-A, SBA, WGA, DBA, UEA-1, RCA-1, PNA, HP, MPA, and ECA. Staining with WGA showed a remarkably decreased intensity in basal and spinous layers of the allergic skin in comparison to those of the control skin, suggesting loss of terminal sialic acids in cell membrane glycoconjugates. The other lectins showed no remarkable difference in the staining patterns between the normal and the allergic ski. The results suggest that epidermal cell membrane glycoconjugates undergoes selective perturbations in acute allergic contact dermatitis, and that the keratinocytes might be an active part of the cutaneous immune system.

No abstract available.
Pulmonary Edema*

BACKGROUND: Histological differentiation between malignant melanoria and benign melanocytic skin lesions is at times, a difficult task for the dermatopathologist. The AgNOR staining has been regarded as a useful tool in differentiating malignant melanoma from benign rael;inocytic nevi. OBJECTIVE: We have carried out the AgNOR staining in a range of nelanocytic lesion and try to assess the value of AgNOR stairting in the identification of malignancy in melanocytic lesions. METHOD: Fifty seven melainocytic skin specimens were studied. These comprised 11 acquired melanocytic nevi, 11 congenital melanocytic nevi, 31 malignant melano nas and 4 atypical melanocytic hyperplasias. RESULT: The majority of benign nevus cells posessed one or two unifrm AgNORs, whereas marked AgNOR pleomorphism was found in some rnelanoma cells. The number of AgNORs per nucleus. averaged 1.24+0.12 in the 18 specimens of benign nevi and 2.10+0.6 in the 25 specimens of malignant melanoma. In the cases of atypical melanocytic hyperplasia it was not possible to count on an adequate number of cells to give a meaningful result because of melanin pigment. CONCLUSION: Although this study demonstrated a separation of average AgNOR counts between begnign melanocytic nevi and maligmant melanomas, there was an ovei lap in counts among individual lesions. For clinical use, there should be a standard method by which AgNORs are counted in AgNOR staining. Melanin pigment masiking the AgNORs can also be a problem.
Hyperplasia ; Melanins ; Melanoma ; Nevus ; Nevus, Pigmented ; Skin*

No abstract available.
Catheterization* ; Catheters* ; Edema* ; Subclavian Vein* ; Upper Extremity*

Japanese Encephalitis had been epidemic nationally in Korea in 1982, even it has a tendency of decrease lately. We had experienced and treated 42 patients in Han Yang University hospital and following results were obtained. 1. It is commoner in male and popular in age of 10-29. 2. Main initial symptoms are fever and headache, followed by mental change, vomiting and tightness of neck. 3. Mortality rate is 23.8% and higher in male. 4. It is noticed to be effective that therapy is focused to increased intracranial pressure by Glycerol and steroid and maintain good general care.
Asian Continental Ancestry Group* ; Encephalitis, Japanese* ; Fever ; Glycerol ; Headache ; Humans ; Intracranial Pressure ; Korea ; Male ; Mortality ; Neck ; Seoul* ; Vomiting

Tsutsugamushi disease, an infectious disease by Rickettsia(R.) tsntsugamushi, is characterized by eschar, fever and rash. Eschar caused by chigger bite, is pre sent on 47 94% of patients with documented R. tsutsugamushi. We recently noticed one case of R. tsutsugamushi infection. Patient had fever, heaclache, lymphadenopathy, erythematous maculopapules and eschar. The R. tsu tsugamushi was isolated from serum of the patient. Histopathologic findings of eschar show epidermal ulceration overlying a zone of coagulative necrosis of upper dermis and necrotizing vasculitis. E]ectron microscopic findings of endothelial cells of capillary show rickettsia with cell division.
Capillaries ; Cell Division ; Communicable Diseases ; Dermis ; Endothelial Cells ; Exanthema ; Fever ; Humans ; Lymphatic Diseases ; Necrosis ; Rickettsia ; Scrub Typhus* ; Trombiculidae ; Ulcer ; Vasculitis

To observed whether the specific IgG antibody test using ELISA was useful in diagnosis of presently ill patients of paragonimiasis, a total of 95 sera were tested. The sera were collected from 21 egg positive cases, 8 from positive reactors of intradermal test, 7 from Clonorchis infected, 9 from other parasitic diseases and 50 from apparently non-infected cases. By the result, the sensitivity of the test was 86% and the specificity was 100%. There were no cross reactions between Paragonimus antigen and other parastic infections. Specific IgG antibody test by micro-ELISA was concluded to be useful for mass screening of the presently ill paragonimiasis in the field.
parasitology-helminth-cestoda ; Spirometra sp. ; sparganum ; sparganosis ; immunology ; diagnosis ; ELISA