No abstract available.
Korea*

No abstract available.
Angioplasty, Balloon, Coronary*

This study was undertaken to find out the possibility of iron-deficiency anemia by the intestinal blood loss in massive infection cases of T. trichiurus. Among the children of a community in which the whipworm infections were highly prevalent, 7 cases were selected whose E.P.G. of whipworm ova were more than 1,000. The hematological findings and estimated blood loss using (51)Cr were undertaken. The results could be summarized as follows: The E.P.G. and E.P.D. of T. trichiurus ova in studied 7 cases were 10,500-37,200/gm of feces and 0.90-5.14 million/day respectively. Findings of hematological examination were in lower limit of normal in hemoglobin content and hematocrit. And erythrocytes were neither microcytic nor hypochromic. Differential count of leucocytes showed persistently low grade of eosinophilia. Serum iron content measured by modification of Barkan method showed subnormal value in 5 out of 7 cases. Erythrocyte radioactivity half disappearance time(T1/2) and intestinal blood loss were estimated using (51)Cr-tagging erythrocytes. And the results showed that T1/2 were shortened (13-19 days ) in all cases and the blood loss was 0.94-6.54 ml/day which were correlated with worm burden (E.P.D.) significantly. From the above results, it could be concluded that intestinal blood loss of T. trichiurus heavy infection were actually occurred but the amount of losses were easily compensated.
parasitology-helminth-nematoda ; Trichocephalus trichiurus ; Trichuris trichiura ; anemia ; intestine ; hematology ; Cr(51)

No abstract available.
Korea* ; Parasitology*

No abstract available.

No abstract available.
Abstracting and Indexing as Topic*

The above article became to belatedly recognized by the editor of Journal of Korean Medical Science (JKMS) having almost same contents with an article which appeared in Korean Journal of Hospice and Palliative Care (=Hankook Hospice Wanhuaeuiryohakhoeji in Korean) 2003;6:152-63, entitled, Reliability and Validity of the Evaluation of Korean Cancer Pain Assessment Tool (K-CPAT). The 2003 article was written in Korean language, and authored by Youn Seon Choi, June young Lee, Jin No Park, Myung Ah Lee, Chang Hwan Yeom and Se Kwon Jang (with corresponding author Dr. J. Lee). Both articles shared same contents of four tables, appendix and message. The executive board for publication of the Korean Academy of Medical Sciences discussed the matter on 12 October 2006, concluded that the JKMS article was a duplicate publication, and resolved to retract the article in order to respect copy right of the Korean Society of Hospice and Palliative Care. Korean Journal of Hospice and Palliative Care have been indexed neither in PubMed nor in KoreaMed. The corresponding author of the article, Dr. Y.S. Choi, accepted the allegation of the duplicate publication.

The present study was undertaken to determine whether an analysis of the collected worms after chemotherapy with pyrantel pamoate could be used as a method measuring the amount of reinfection of Ascaris lumbricoides in a given population. A total of 398 cases from two villages and one primary school were treated with pyrantel pamoate with dose of 10 mg/kg of body weight. The whole two-day stool specimens after treatment were examined. Out of 279 followed cases, 110 cases (39.4%) were found infected with A. lumbricoides. A total of 527 worms were collected, they were in the range of 1.2 to 32.5 cm in length and 0.0004 to 7.424 gm in weight. The measurements were made on the specimens fixed with 10% formalin. The relationship between the number of worms per positive case(X) and the total weight of worms(Y) showed the positive linear regression; this was expressed by the equation, Y= 2.012X + 1.135 (Sy=4.84, r=0.92). From the above results, it seems that worms of small size may not be considered as a product of crowding effect in heavy infections. The relation between the weight(Y) and length(X) of collected A. lumbricoides was expressed as an equation, Log(e)Y=3.032 log(e)X-8.2903(S.E. of reg. coeff.= 0.040, r=0.957). In the intestinal phase of development, the first increase of the length of the worm, up to 10-12 cm was observed and this followed by the well marked increase of weight from 13 cm upto 32.5 cm in the sexually maturing phase. A total of 285 schoolchildren were treated by pyrantel pamoate, 10 mg/kg of body weight three times each in two months interval. After the second and third treatment, thirteen and fifty-four worms were collected respectively. They were measured in length and weight and were all in the range of 1.2 to 13.2 cm in length and 0.0006 to 0.436 gm in weight except 3 fully matured adults. It is assumed that these young worms, defined as those less than 0.5 gm in weight and less than 13 cm in length should be regarded as those having reinfected during the previous two months period. From this observation, it was possible to calculate the reinfected number of young worms. Therefore, it is suggested that the average number of Ascaris per month per person means the reinfection amount in a certain period of time in an endemic area of A. lumbricoides. In other words, reinfection amount may be expressed by the calculated figure of young worms reinfected in a certain period of time in a population.
parasitology-helminth-nematoda ; Ascaris lumbricoides ; ascariasis ; epidemiology-reinfection ; pyrantel pamoate

Flow cytometric analyms was performed to investigate any relationship between DNA content and clinical outcome in 32 complete hydatidiform moles (CHMs) and 12 partial hydatidiform moles (PHMs). Twenty three and nine of the 32 CHMs were diploid and aneuploid moles, respectively. Of these 23 diploid CHMs, eight (34.8%) regressed spontaneausly and 15 (65.2%) progressed to persiatent gestatiaoal trophoblastic disease (PGTD). Among nine aneuploid CHMs studied, six (66.7%) underwent spontaneous regremion and three (33.3%) required treatment for peraistent GTI). The twelve PHMs consiated of 9 diploid and 3 aneuploid moles, Three of the rune diploid moles (33.3%) remitted complelely, while the remaining 6(66.7%) progressed to PGTD. All aneuploid PHIMs underwent spontaneous remission. The S-phase of cell cycle in the CHMs studied was more frequent in those that progressed to persiatent GTDs, while G0/G1 was more frequent in those that remitted spontanemusly. The PHMs atudied failed to show any significant relationship between the phases of cell cycle and disease prognosis. Our results suggest the potentia] use of DNA ploidy and cell cycle analysis in prerlicting clinical outcome and thus in selecting cases for prophylactic chernotherapy.
Aneuploidy ; Cell Cycle ; Diploidy ; DNA* ; Female ; Flow Cytometry* ; Hydatidiform Mole* ; Ploidies ; Pregnancy ; Prognosis* ; Remission, Spontaneous ; Trophoblasts

Alzheimer's disease(AD) is associated with a characteristic neuropathology. The major hallmarks of AD are senile plaques(SPs) and neurofibrillary tangles(NFTs). beta-amyloid protein(Abeta) is derived from the proteolysis of amyloid precursor protein(APP) and then converted to SPs. Mature SPs produce cytotoxicity through direct toxic effects and activation of microglia and complement. NFTs are composed of paired helical filaments(PHFs) including abnormally phosphorylated form of the microtubule-associated protein(MAP) tau and increased tau level in cerebrospinal fluid may be observed in most AD. The aggregation of Abeta and tau formation are thought to be a final common pathway of AD. Acetycholine, dopamine, serotonin, GABA and their receptors are associated with AD. Especially, decreased nicotinic acetylcholine receptors(nAChRs) in AD are reported. Genetic lesions associated with AD are mutations in the structural genes for the APP located on chromosome 21, presenilin(PSN)1 located on chromosome 14 and PSN2 located on chromosome 1. Also, trisomy 21, Apo-E gene located on chromosome 19, PMF locus, low density lipoprotein receptor-related protein and alpha-macroglobulin increase risk of AD. In this article, we will review about the neurobioloby of AD and some newly developed research areas.
Acetylcholine ; Alzheimer Disease* ; Amyloid ; Amyloid beta-Peptides ; Apolipoproteins E ; Cerebrospinal Fluid ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 19 ; Chromosomes, Human, Pair 21 ; Complement System Proteins ; Dopamine ; Down Syndrome ; gamma-Aminobutyric Acid ; Genetics ; Lipoproteins ; Microglia ; Neurobiology* ; Proteolysis ; Serotonin