BACKGROUND: Acne, one af the commonest dermatological disorders, is a disease of the pilosebaceous unit, and the primarily involved site is the face, where this structure exists in maximal density. Among the many etiologieal factors of acne, changes in the kinetics of sebum secretion in acne patients have been described, but there is no report to compare follicular density and the sebum excretion rate in different facial regions between normal and acne patients. OBJECTIVES: The purpose of this study was to compare the sebum output and follicular density in different regions of the face in women with and without acne and to evaluate the differences between the two groups. METHODS: We studied 10 normal and 14 acneic women aged 19-27. Follicular density was determined by light microscopy counting pilosebaceous units on cyanoacrylate follicular biopsy specimens. The sebum excretion rate was calculated by an image analyzer with a sebum print on Sebutape. RESULTS: 1. Follicular density was not significantly different between the normal and acne group. The number of follicles decreased from the central to the lateral aspect of the face with the highest value being on the nose tip and the lowest on the lateral forehead. 2. The total sebum excretion rate and the number of actively secreting follicles showed different patterns in the two groups. There was a decreased value in the acne group in some central regions of face. In addition, central to lateral declining pattems, shown in the normd group, were not apparent in the acne group. 3. The follicular sebum excretion rate showed large variations in both groups, without apparent central to lateral declining patterns. The confluence of adjacent follicles seemed to produce falsely low or high values compared with previous studies. CONCLUSION: Sebum production is influenced both by the number of active follicles and their individual capacity to excrete sebum, and the total sebum excretion rate was lower than normal in low grade acne in this study. Obstruction of the outflow of sebum and regression of sebaceous glands due to comnlones may account for it.
Acne Vulgaris* ; Biopsy ; Cyanoacrylates ; Female ; Forehead ; Humans ; Kinetics ; Microscopy ; Nose ; Sebaceous Glands ; Sebum*

No abstract available.
Animals ; Haloperidol* ; Mice*

The authors studied ED50 of bethanechol on the contractilities of the smooth muscles isolated from various organs of rat under the presence of atropine (a classical competitive blocker of cholinergic muscarinic receptor) or minaprine (a newly developed antidepressant drug) to investigate the peripheral anticholinergic effect of minaprine. The results were as follow: 1) There was no significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine 10⁻⁸M and 10⁻⁷M in the smooth muscles isolated from the duodenum. 2) There was no significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine 10⁻⁸M and 10⁻⁷M in the smooth muscles isolated from the ascending colon. 3) There was significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine 10⁻⁸M and 10⁻⁷M in the smooth muscles isolated from the urinary bladder (P<0.01) 4) There was significant difference between ED50 of the atropine 10⁻⁸ and minaprine (10⁻⁸M) in the smooth muscles isolated from the urinary bladder (P<0.05).
Animals ; Atropine ; Bethanechol ; Colon, Ascending ; Duodenum ; Muscle, Smooth ; Rats ; Urinary Bladder

The authors studied depression, using Zung's Self-Rating Depression Scale (SDS) in the subjects of 3,499 male and 1,335 female college freshmen of Yeungnam University. The authors collected the reports of SDS during the periods from January to February, 1986, and applied ANOVA and t-test on depression scores in order to compare them between various psychosocial factors, and sexes. The results are as follows: There was significant difference in the mean averages of total depression scores between male and female students: male students scored 35.68+7.46, female students scored 38.93+7.26 (P<0.01). The depression scores relating to the items of indecisiveness, psychomotor retardation, decreased libido, and diurnal variation were relatively higher in both groups. One hundred and sixty-one male students (4.6%) showed seriously high degree depression scores of 50 or higher, while one-hundred and seventeen female students (8.8%) showed the same scores. Female students attending in liberal arts showed higher level of depression scores (P<0.01). There was a strong tendency toward higher depression scores in the students who were dissatisfies with their home atmosphere, college, department and familiarity of parents and those who had pessimistic views of self in the past, present or future in both groups (P<0.001).
Atmosphere ; Depression* ; Female ; Humans ; Libido ; Male ; Parents ; Psychology ; Recognition (Psychology)

This study was intended to analyze the relation between the psychic traumatic experience and the psychological health of the aged. The authors carried out this study by means of the combined anxiety-depression scale (CADS) and the preadolescence traumatic experience scale (PTES) with 278 aged men and women residing in Taegu from September to October 1988. The results were as follows: 1. Based on the scores evaluated by CADS, the scores of the both groups showed that comparative group was accounted for 40.15±6.19, while the experimental group for 57.75±6.37, which showed significantly higher score in the experimental group (p<0.001). 2. The experimental group showed significantly higher early experience score than the comparative group in the dietary difficulty, alcoholism among family members, disunion between husband and wife, trouble between mother and children, early mother loss, parent's indifference and unwanted birth (p<0.001). 3. The experimental group showed higher early experience score than the comparative group by sex, age, marital status and grown location (p<0.001). 4. When the subjects were included in the unemployed and in the middle or low classes and their parents were engaged in agriculture and commercial business and believing in buddhism or no-religion, showed higher experience score (p<0.001).
Aged* ; Agriculture ; Alcoholism ; Buddhism ; Child ; Child, Unwanted ; Commerce ; Daegu ; Female ; Humans ; Male ; Marital Status ; Mental Health* ; Mothers ; Parents ; Spouses

No abstract available.
Fibroma

OBJECTIVE: We investigated the long-term outcomes of autologous peripheral blood stem cell transplantation (PBSCT) to treat refractory rheumatic diseases. METHODS: Patients who underwent PBSCT for refractory rheumatic diseases at our institution between 2002 and 2005 were assessed for outcomes including treatment response, adverse events, damage accrual, and survival at 6 months and last follow-up. RESULTS: Eleven patients, including six with systemic lupus erythematosus (SLE), four with systemic sclerosis (SSc), and one with Still's disease were treated with PBSCT. In SLE patients, two showed complete response, two partial response, and two expired. One patient who expired responded completely two months after transplantation but discontinued treatment by choice and expired at six months due to an SLE flare. Long-term, two patients went into remission without organ damage, one patient went into remission with organ damage, and one had low disease activity with organ damage. Of the four patients with SSc, two showed a complete response, one a partial response, and there was one transplantation-related death at six months. At the last record notation, two remained in remission without relapse and one was lost to follow-up. The Still's disease patient partially responded at six months and was in remission at the last record notation. CONCLUSION: The ten-year survival rate was 70% with a 40% recurrence rate and 20% treatment-related mortality rate.
Follow-Up Studies ; Humans ; Lost to Follow-Up ; Lupus Erythematosus, Systemic ; Mortality ; Peripheral Blood Stem Cell Transplantation* ; Recurrence ; Rheumatic Diseases* ; Scleroderma, Systemic ; Survival Rate

No abstract available.
Child* ; Humans ; Purpura, Thrombocytopenic, Idiopathic*

The authors studied paranoid ideation and obsession, using Derogatis' SCL-90, in the subjects of 2,564 male and 1,252 female college freshmen of Yeungnam University. The authors collected the reports of Self-Rating Paranoid ideation and Obsession Scale during the periods from January to February, 1987, and applied ANOVA and t-test on paranoid ideation and obsession scores in order to compare them between various psychosocial factors, and sexes. The results are as follows: 1. There was not significant difference in the mean averages of total paranoid ideation scores between male and female students: male students scored 4.16±3.09, female students scored 4.16±2.91. 2. High scored items were delusion and suspiciousness. 3. Fifty-nine male students (2.3%) showed high paranoid ideation scores of 12 or higher, while twenty-six female students (2.1%) showed the same scores. 4. There was strong tendency toward higher paranoid ideation scores in the students who were dissatisfied with their home atmosphere, college, department and familiarity of parents and those who had pessimistic view of self in the past, present or future in both group (respectively P<0.001). The male students who believed protestantism showed higher level of paranoid ideation scores (P<0.01). The male students who attended the department of fine art showed higher level of paranoid ideation scores (P<0.05). 5. There was significant difference in the mean averages of total obsession scores between male and female students (P<0.05): male students scored 10.40±5.43, female students scored 10.75±5.02 6. High scored items were perfectionism, indecisiveness, inattention & obsessive thoughts. 7. Thirty-eight male students (1.6%) showed high obsession scores of 25 or higher, while fifteen female students (1.2%) showed the same scores. 8. There was strong tendency toward higher obsession scores in the students who were dissatisfied with their home atmosphere, college, department and familiarity of parents and those who had pessimistic view of self in the past, present, or future in both group (respectively P<0.001). The female students who attended the department of home economic & whose educational fees were paid by her brothers & sister, showed higher level of obsession scores (respectively P<0.01).
Atmosphere ; Delusions ; Fees and Charges ; Female ; Humans ; Male ; Obsessive Behavior* ; Parents ; Protestantism ; Psychology ; Recognition (Psychology) ; Siblings

The authors studied the mental health status of the 1989 freshmen of Yeungnam University using the psychotic scale of Derogatis SCL0-90, Zung anxiety and depression scale and MMPI from January 1988 to February 1988. The subjects of this study were contained 3792 students (1206 female, 2586 male). 392 students (10.3%), out of all respondents were screened to fall on high score ranges. The authors performed a second test to 156(39.8% 47 female (30.1%), 109 male (69.9%) of the high-scored in order to clarify their mental health status and analyze various psychosocial factors; using MMPI. The MMPI results were categorized with Lachar's classification. The results were as follows: 1. By the MMPI scores, 24 respondents (15.4%) had neurotic trends, 20 (12.8%) had psychotic trends and 7 (4.5%) had trends of behavior disorder. It was about 1.4% of all 3792 freshmen. 2. On the close examination of the MMPI, 8 respondents were diagnosed for affect disorder, 6 for anxiety disorder, 9 for schizophrenia and 3 for personality disorder. It was 0.7% of all freshmen. 3. One the analysis of the psychosocial factors, the schizophrenic scores were high in the case of unsatisfy in family atmosphere, unsatisfy in marital intimacy of parents, serious in conflicts between father and I, and serious in conflicts between mother and I. 4. The hypochondriacal scores were high in the case of weak in physical condition, having hospitalization experience and physical illness.
Anxiety ; Anxiety Disorders ; Atmosphere ; Classification ; Depression ; Fathers ; Female ; Hospitalization ; Humans ; Male ; Mental Health ; MMPI* ; Mothers ; Parents ; Personality Disorders ; Psychology ; Schizophrenia ; Surveys and Questionnaires