No Abstract Available.
Adult* ; Capsulorhexis* ; Cataract* ; Follow-Up Studies* ; Humans

No abstract available.
Meningitis, Aseptic*

We inspected reliability of A-constant of AMO SI-30NB by comparing target diopter and actual postoperative refractive status. Group 1 comprised 191 eyes which were implanted AMO PhacoFlex SI-30NB with corneal incision. Group 2 comprised 45 eyes implanted Pharmacia 812C with scleral incisions. Group 3 comprised 17 eyes implanted AMO OgaciFlex SI-30NB with corneal incision. Refraction was performed on post operative day 1, day 5, day 14, 1 month, and 3 month. It revealed hyperopic shift of 0.31 to 0.40 diopter compared to the target diopters in both Group 1 and Group 3 and no statistical difference was found between two groups(p value>0.05). On the other hand, Group 2 were statistically significant(p value<0.01). We attempted mathematical modelling of this phenomenon and the cause of hyperopylene haptics, structural weakness of haptic-optic junction, and the structure of SI-30NB itself.
Hand ; Models, Theoretical

No abstract available.
Budd-Chiari Syndrome* ; Vena Cava, Inferior*

To determine whether liposome-encapsulated tobramycin is less toxic than commercial tobramycin and the threshold dose of liposome-encapsulated tobramycin required to produce toxic reactions when it was injected intravitreally in rabbit, we used liposome-encapsulated tobramycin, tobramycin in PBS, mixture of tobramycin and liposome-encapsulated saline, liposome-encapsulated saline and normal saline respectively. After those were injected, we examined the histologic findings and the functional changes of the retina. The final results are summarized as follows; 1. When tobramycin was injected intravitreally alone, there was no toxic reaction of the retina histologically and functionally with dosage 500 micro gram of commercial tobramycin, but dosage more than 750 micro gram produced toxic reaction. 2. When liposome-encapsulated tobramycin was injected intravitreally, there was toxic reaction of the retina histologically and functionally with dosage 1500 micro gram of tobramycin. 3. When a mixture of tobramycin and liposome-encapsulated saline was injected intravitreally, there was similar toxic reaction as tobramycin used alone with dosage more than 750 micro gram of tobramycin. Liposome-encapsulated saline and normal saline did not produce toxic reaction. The above results indicate that liposome encapsulation markedly reduces the ocular toxicity of tobramycin and that as mnch as dosage 1000 micro gram of liposome-encapsulated tobramycin may be tolerated by the intravitreal route in the rabbit eye. Therefore, the results of this study offer some hope that we may use the method of intravitreal injection of liposome-encapsulated tobramycin safely and effeciently for the treatment of bacterial endophthalmitis in near future.
Endophthalmitis ; Hope ; Intravitreal Injections ; Liposomes ; Rabbits* ; Retina* ; Tobramycin*

The potential acuity meter(PAM) has been reported to be a useful instrument for predicting postoperative visual acuity after cataract extraction surgery. Forty nine eyes were tested with PAM before surgery, and the best postopertive visual acuity was obtained. The PAM accurately predicted the postoperative visual acuity to within three lines in 90.0% of the cases. When the test is in error, the tendency is for the PAM to underestimate the final acuity rather than to overestimate. Especially under undilated pupil, in dense cataracts (<20/200),and,in posterior subcapsular and cortical cataracts, the PAM tends to underestimate further.
Cataract Extraction ; Cataract* ; Pupil ; Visual Acuity*

The tear film break-up time test is a useful diagnostic test for dry eye syndrome,but it shows a wide range of results in normal subjects according to many factors, especially the methods of measuring it. We studied the factors having some influences on B.U.T. and tried to find out a standard method of measuring B.U.T. in normal subjects. The results were as follows: 1. The subjects were healthy without any ocular disease or symptoms. Total subjects were 200 persons, 400 eyes. 2. The standard method of measuring B.U.T. was as follows: a drop of 0.125% sodium fluorescein was applied into the conjunctival sac and the patient was allowed to blink for at least 1-2 minutes. The tear film was then scanned without holding the lids, using the slit lamp beam, 4-5mm in width. 3. The mean B.U.T. measured by the standard method was 20.35 +/- 6.45 sec in normal subjects. 4. The mean B.U.T. was 18.17 +/- 8.02'sec in the group using fluorescein paper, 9.68 +/- 6.19 sec in the group blinking just 4-5 times,16.54 +/- 8.32 sec in the group measured holding the lids with the fingers, and 18.36 +/- 7.95 sec in the group using a broad beam. 5. There were statistically significant decreases of B.U.T. in the group blinking just 4-5 times and in the group measured holding the lids with the fingers.
Blinking ; Diagnostic Tests, Routine ; Fingers ; Fluorescein ; Humans ; Tears*

The most common cause of blurred vision after extracapsular cataract extraction is known to be an opacification of the posterior lens capsule. The pathogenesis of posterior lens capsule opacification is primarily caused by residual lens epithelial cells. For the prevention of posterior capsular opacification, several kinds of anti-mitotic drugs is being actively investigated. But the antimitotic drugs are not clinically used due to toxicity towards the intraocular tissues. The objectives of this study is to evaluate the effect of mitomycin C and tirilazad mesylate(FREEDOX(TM)) respectively for inhibiting the proliferation of rabbit lens epithelial cells when it is administered in a short period. Lens epithelial cells from white rabbits were harvested andcultured for 4 passages. Mitomycin C was applied for 3 minutes with 0.025mg/ml and 0.05mg/ml in concentration respectively. The proliferation assay was performed by [(3)H]-thymidine uptake test. Significant decrease of lens epithelial cell proliferation appeared in both drugs.When Mitomycin-C was applied with 0.025mg/ml for 3 minutes, cell proliferation was reduced to 31.5% compared with control and in 0.05mg/ml concentration, to 12.5%. When tirilazad mesylate was applied 0.15mg/ml for 3 minutes, cell proliferation was reduced to 46.5% compared with control and in 1.5mg/ml concentration, to 7.5%. If futher investigation would show the effectives and safety of these drugs, these agents could be applied into the lens capsular bad at the time of surgery to prevent the posterior capsular opacification after cataract surgery.
Antimetabolites* ; Antimitotic Agents ; Capsule Opacification ; Cataract ; Cataract Extraction ; Cell Proliferation ; Epithelial Cells* ; Mesylates ; Mitomycin ; Rabbits

Contrast sensitivity measurements were obtained from 45 patients with noninsulin dependent diabetes mellitus(NIDDM) who had normal Snellen acuity and minimal or no visible diabetic retinopathy. Contrast sensitivity thresholds were determined with a convenient microcomputer driven display system developed by the members of Department of Ophthalmology, Yonsei University College of Medicine. The data obtained from each diabetic. patients were compared with the normal contrast sensitivity of Korean(Lee et al, 1984). We found that, 1) The patients with NIDDM and no retinopathy had abnormal contrast sensitivity at two spatial frequencies (0.4 and 27.4 LP/D). 2) The patients with NIDDM and background retinopathy had abnormal contrast sensitivity at nearly all spatial frequencies tested. We also found a dissociation of Snellen acuity and contrast sensitivity and that contrast sensitivity can be used as an early index of changes in the retina not demonstrated by measurements of visual acuity.
Contrast Sensitivity* ; Diabetes Mellitus, Type 2 ; Diabetic Retinopathy ; Humans ; Microcomputers ; Ophthalmology ; Retina ; Visual Acuity

We examined the anatomical barrier for both anterior capsular tear extension and posterior capsular rupture extension which are the most serious intraoperative complications during cataract surgery, using 28 human eyes obtained postmortem. An experimental radial tear, about 1.0 mm in size, was created on the 5.0 mm capsulorhexis margin in the 1st group(7 eyes). Lens nucleus was removed mechanically with hydrodissection and viscoexpression technique. Radial tear extension did not extend over the lens equator in six eyes, and in one eye stopped in front of Wieger's ligament. In the 2nd group(7 eyes), after making zonular rupture around 90 degrees, same procedures were performed. Radial tear extension stopped at the equator in four eyes, and in three eyes stopped in front of Wiegel's ligament. In the 3rd group(7 eyes), we performed capsulorhexis and routine phacoemulsification for lens nucleus and cortex removal. Then we created only a posterior capsule rupture with intact anterior hyaloid membrane and vitreous pressure was increased. Posterior capsular rupture extension stopped in front of Wieger's ligament in all seven eyes. In the 4th group(7 eyes), after creating the rupture of the posterior capsule including anterior hyaloid membrane, intraocular lens was inserted into the empty capsular bag as a perpendicular direction to the axis of the tear. Posterior capsular rupture extension passed Wieger's ligament in only one eye, but did not reach equator or anterior capsule. In this study, we found that zonules, equator portion of the capsular bag and Wieger's ligament act as anatomical barriers for anterior capsular teal extension as well as for posterior capsular rupture extension.
Axis, Cervical Vertebra ; Capsulorhexis ; Cataract ; Humans ; Intraoperative Complications ; Lenses, Intraocular ; Ligaments ; Membranes ; Phacoemulsification ; Rupture