1.Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity.
Chen YAN ; Qun LONG ; Yun-Dong ZHANG ; Gajendran BABU ; Madhu Varier KRISHNAPRIYA ; Jian-Fei QIU ; Jing-Rui SONG ; Qing RAO ; Ping YI ; Mao SUN ; Yan-Mei LI
Chinese Journal of Natural Medicines (English Ed.) 2021;19(7):528-535
In this study, three new germacranolide sesquiterpenes (1-3), together with six related known analogues (4-9) were isolated from the whole plant of Carpesium cernuum. Their structures were established by a combination of extensive NMR spectroscopic analysis, HR-ESIMS data, and ECD calculations. The anti-leukemia activities of all compounds towards three cell lines (HEL, KG-1a, and K562) were evaluated in vitro. Compounds 1-3 exhibited moderate cytotoxicity with IC
Antineoplastic Agents, Phytogenic/pharmacology*
;
Asteraceae/chemistry*
;
Drug Screening Assays, Antitumor
;
Humans
;
K562 Cells
;
Phytochemicals/pharmacology*
;
Sesquiterpenes, Germacrane/pharmacology*
2.Study on effect of Hypericum perforatum on pharmacokinetics of zedoary turmeric oil in compound antiviral preparation.
Yin-Yu LI ; Yu BEI ; Hui ZHANG ; Jian-An LI ; Wen ZHAO ; Qiao-Xue XIAO ; Min-Jing ZHANG ; Ya-Dong HUANG ; Qi XIANG
China Journal of Chinese Materia Medica 2013;38(7):1083-1086
OBJECTIVETo study zedoary turmeric oil (ZTO) and the pharmacokinetics of its homemade compound antiviral preparation in New Zealand rabbits.
METHODRP-HPLC was used to determinate the content of germacrone in rabbit plasma after oral administration.
RESULTAfter oral administration of ZTO and its homemade compound antiviral preparation, the plasma concentration-time curve of germacrone is in conformity to two-compartment open model. The pharmacokinetic parameters of ZTO: t1/2alpha, t1/2beta, Vd, CL, AUC and Ka were (1.52 +/- 0.59), (1.97 +/- 0.27) h, (47.59 +/- 2.29) L x kg(-1), (176.77 +/- 7.65) L x h(-1) x kg(-1), (5.70 +/- 0.70) mg x h x L(-1) and (0.97 +/- 0.11) h(-1), respectively, while those of compound preparation were (0.41 +/- 0.03), (1.47 +/- 0.35) h, (75.21 +/- 5.21) L x kg(-1), (287.79 +/- 6.39) L x h(-1) x kg(-1), (3.91 +/- 0.53) mg x h x L(-1) and (5.14 +/- 1.26) h(-1), respectively. There was no significant difference between the above two groups of pharmacokinetic parameters, expect that Ka of compound preparation was significantly higher than that of ZTO (P < 0.05).
CONCLUSIONHypericum perforatum in compound preparation doesn't impact the distribution and elimination of active ingredients of ZTO in New Zealand rabbits, but it improves the absorption speed, and shortens the time of drug absorption, which contributes to rapid efficacy of ZTO in rabbits.
Animals ; Antiviral Agents ; pharmacokinetics ; Curcuma ; chemistry ; Drug Compounding ; Drug Interactions ; Drugs, Chinese Herbal ; pharmacology ; Hypericum ; chemistry ; Male ; Plant Oils ; pharmacokinetics ; Rabbits ; Sesquiterpenes, Germacrane ; pharmacokinetics
Result Analysis
Print
Save
E-mail