No abstract available.
Sertoli-Leydig Cell Tumor*

No abstract available.
Sertoli-Leydig Cell Tumor*

No abstract available.
Sertoli-Leydig Cell Tumor*

No abstract available.
Sertoli-Leydig Cell Tumor*

A Sertoli-Leydig cell tumor (SLCT) is an extremely rare type of sex cord stromal tumor of the ovary, which mainly secretes testosterone, thus manifestations of hyperandrogenism commonly appear. This paper shall discuss a case of a postmenopausal woman who presented with pelvic organ prolapse, large left ovarian cyst and mild signs of hyperandrogenism. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, which on microscopic examination of the specimens, revealed a Mature cystic teratoma on the left ovary and an incidental finding of a well-differentiated SLCT, on the grossly normal-looking ovary. This histopathologic diagnosis of SLCT explained the patient’s hyperandrogenic characteristics. Authors likewise discussed the proper management of SLCT, including immunostaining and need for adjuvant chemotherapy.
Sertoli-Leydig Cell Tumor

No abstract available.
Puberty, Precocious* ; Sertoli-Leydig Cell Tumor*

Sertoli-Leydig cell tumor is a rare sex-cord stromal tumor of the ovary and accounts for less than 0.5% of all ovarian tumors. It is among the most fascinating from pathologic and clinical viewpoints in masculinization. We experience an unusual case of a poorly differentiated Sertoli-Leydig cell tumor in 60-year-old woman who showed masculinization and present it with brief review of literature.
Female ; Humans ; Middle Aged ; Ovary* ; Sertoli-Leydig Cell Tumor*

A case of a two and a half year old girl with a 6 month history of isosexual precocious puberty (thelarche: Tanner stage 2 breasts and menarche) secondary to an estrogenizing pure Sertoli cell tumor of the left ovary is presented. Pre-operative tumor markers AFP, BhCG and CA-125 revealed normal results. Transabdominal ultrasound with color flow mapping and Doppler interrogation revealed a solid left ovarian mass probably malignant. The patient underwent exploratory laparotomy, left salpingooophorectomy and frozen section revealing sex cord stromal tumor. Paraffin sections stained with Hematoxylin and Eosin revealed a benign Sertoli cell tumor. Immunostains of the tumor reacted positively for inhibin, calretenin and cytokeratin, but negative for epithelial membrane antigen. Total serum estradiol, prolactin, TSH and LH were elevated prior to surgical operation, with LH and prolactin substantially decreasing four weeks later into the normal prepubertal range. TSH and estradiol levels however have remained very slightly elevated. Serum FSH was at prepubertal levels. Breasts size had likewise regressed to prepubertal size four weeks postoperatively, and the menses never recurred. This is the youngest reported occurrence of this rare sex cord stromal neoplasm in the last 10 years in our institution. The prognosis of this extremely rare tumor presenting at this early juvenile stage is uncertain, and it is recommended to keep a close follow-up and regular endocrinologic investigation until prepubertal values are attained.
SERTOLI ; CELL TUMOR ; ISOSEXUAL ; PRECOCIOUS PUBERTY ; MENARCHE, ; THELARCHE

A 26-year-old woman had an ovarian Sertoli-Leydig cell tumor (SLCT) associated with an elevated level of serum alpha-fetoprotein (AFP). The tumor had a heterologous element of intestinal-type mucinous epithelium, retiform and intermediately differentiated tubules of the Sertoli cells, and AFP-producing Leydig cells. AFP was demonstrated within the Leydig cells by an immunohistochemical technique. After surgery, the serum AFP level of the patient fell to the normal range. The present case is the first documented case of AFP producing a SLCT of the ovary reported in Korea.
Adult ; alpha-Fetoproteins* ; Epithelium ; Female ; Humans ; Korea ; Leydig Cells ; Male ; Mucins ; Ovary* ; Reference Values ; Sertoli Cells ; Sertoli-Leydig Cell Tumor*

Sertoli cell tumors of the testis are very rare and are usually benign. Here we report a case of a Sertoli cell tumor of the testis in a 46-year-old man. His chief complaint was a painless, palpable testicular mass that he had for 4 years. Serum levels of tumor markers were within normal limits. Testicular ultrasonography showed a 1.5 cm sized well-demarcated nonhomogeneous echogenic mass in the left testis. Chest x-ray and abdominopelvic CT showed no metastasis. Radical orchiectomy was performed. Histopathology showed a Sertoli cell tumor with no evidence of malignancy.
Adult ; Humans ; Middle Aged ; Neoplasm Metastasis ; Orchiectomy ; Sertoli Cell Tumor ; Testis ; Thorax ; Biomarkers, Tumor