1.Biochemical Characteristics and Antibiotic Susceptibilities of Serratia marcescens Isolated from Clinical Specimens.
Yunsop CHONG ; Kui Nyung YI ; Samuel Y LEE
Yonsei Medical Journal 1978;19(1):32-38
A minimal test scheme, consisting of deoxyribonuclease (DNase) and tween 80 hydrolysis (TEH) together with a few other biochemical tests, was used to make tentative identification of Serratia marcescens from clinical specimens. The identifications were reevaluated by testing comprehensive biochemical characteristics of 52 isolates, and all were found to be correct. The biochemical reactions of the isolates were very homogenous, showing typical characteristics of the species except in the urease test and acid production from sucrose, adonitol and inositol. These facts support the feasibility of the use of the minimal identification scheme. Pigment production was noted only in 7 isolates invalidating the value of this characteristic for the identification. Fifty-seven isolates were tested for their antibiotic susceptibility. They were found most frequently susceptible to gentamicin (47.4%), chloramphenicol (35.0%) and kanamycin (28.1%). Many isolates (49.1%) were multiply resistant to ampicillin, chloramphenicol, gentamicin, kanamycin, streptomycin and tetracycline.
Antibiotics/pharmacology*
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Cells, Cultured
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Drug Resistance, Microbial
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Human
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Microbial Sensitivity Tests
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Serratia marcescens/drug effects
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Serratia marcescens/isolation & purification
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Serratia marcescens/metabolism*
2.Discovery of a Fluoroquinolone-Resistant Serratia marcescens Clinical Isolate without Quinolone Resistance-Determining Region Mutations.
Haifei YANG ; Guosheng CHEN ; Jun CHENG ; Yanyan LIU ; Lifen HU ; Ying YE ; Jiabin LI
Annals of Laboratory Medicine 2014;34(6):487-488
No abstract available.
Aged
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Anti-Bacterial Agents/*pharmacology
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Bacterial Proteins/genetics
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Drug Resistance, Bacterial/*genetics
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Fluoroquinolones/*pharmacology
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Humans
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Male
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Microbial Sensitivity Tests
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Mutation
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Serratia Infections/*diagnosis/microbiology
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Serratia marcescens/*drug effects/genetics/isolation & purification
3.The Emergence of the 16S rRNA Methyltransferase RmtB in a Multidrug-Resistant Serratia marcescens Isolate in China.
Xue Jiao MA ; Hai Fei YANG ; Yan Yan LIU ; Qing MEI ; Ying YE ; Hong Ru LI ; Jun CHENG ; Jia Bin LI
Annals of Laboratory Medicine 2015;35(1):172-174
No abstract available.
Aged, 80 and over
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Anti-Bacterial Agents/pharmacology
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Bacterial Proteins/*genetics
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China
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Drug Resistance, Multiple, Bacterial
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Humans
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Male
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Methyltransferases/*genetics
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Microbial Sensitivity Tests
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RNA, Ribosomal, 16S/genetics/metabolism
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Serratia marcescens/drug effects/*enzymology/*genetics/isolation & purification
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Urinary Tract Infections/diagnosis/microbiology
4.Comparison of Antimicrobial Effect of Alcohol Gel according to the Amount and Drying Time in Health Personnel Hand Hygiene.
Journal of Korean Academy of Nursing 2013;43(3):305-311
PURPOSE: The purpose of this study was to compare the effect of alcohol gel according to the amount and drying time in health personnel hand hygiene and to promote in their practice adequate and effective hand hygiene. METHODS: The cross-over experimental study was performed with 14 volunteers. Hands were artificially contaminated with 5 mL of 10(8) CFU/mL of Serratia marcescens (ATCC 14756) and four different alcohol gel hand hygiene methods varying by the amount of alcohol gel (2 mL vs. 1 mL) and drying time (complete vs. incomplete) were compared. Samples were collected by glove juice sampling procedures. RESULTS: Mean log reduction values of the four different hand hygiene methods were 2.22+/-0.36, 1.26+/-0.53, 1.49+/-0.60, 0.89+/-0.47 respectively for the 4 groups: adequate amount (2mL) and complete dry (30 seconds rubbing followed by 2 min air-dry), inadequate amount (1 mL) and complete dry, adequate amount and incomplete dry (15 seconds rubbing and no air-dry), and inadequate amount and incomplete dry. The difference was statistically significant in the adequate amount and complete dry group compared to other three groups (p<.001). CONCLUSION: Only alcohol gel hand hygiene with adequate amount and complete drying was satisfactory by U.S. FDA-TFM efficacy requirements for antiseptic hand hygiene products.
Adolescent
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Adult
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Anti-Infective Agents, Local/*pharmacology
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Cross-Over Studies
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Ethanol/chemistry/*pharmacology
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Gels/*chemistry
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Hand Hygiene/*methods
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Humans
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Middle Aged
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Serratia marcescens/*drug effects
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Time Factors
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Young Adult
5.Risk Factors for Mortality in Patients with Serratia marcescens Bacteremia.
Sun Bean KIM ; Yong Duk JEON ; Jung Ho KIM ; Jae Kyoung KIM ; Hea Won ANN ; Heun CHOI ; Min Hyung KIM ; Je Eun SONG ; Jin Young AHN ; Su Jin JEONG ; Nam Su KU ; Sang Hoon HAN ; Jun Yong CHOI ; Young Goo SONG ; June Myung KIM
Yonsei Medical Journal 2015;56(2):348-354
PURPOSE: Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia. MATERIALS AND METHODS: We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality. RESULTS: The 28-day mortality was 22.4% (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95% confidential interval (CI) 0.044-0.960, p=0.040, and adjusted OR 1.474, 95% CI 1.200-1.810, p<0.001, respectively]. CONCLUSION: Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.
Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents/therapeutic use
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Bacteremia/drug therapy/microbiology/*mortality
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Cross Infection/mortality
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Female
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Humans
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Intensive Care Units
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Male
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Middle Aged
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Multiple Organ Failure
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Republic of Korea/epidemiology
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Retrospective Studies
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Risk Factors
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Serratia Infections/diagnosis/drug therapy/*mortality
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Serratia marcescens/drug effects/*isolation & purification
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Severity of Illness Index
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Survival Rate
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Time Factors
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Treatment Outcome
6.Serratia marcescens vaccine in the treatment of malignant pleural effusion.
Heling SHI ; Yunzhong ZHU ; Liyan XU ; Zhe LIU ; Yonghong YOU ; Qiyi MENG ; Xinyong ZHANG ; Juntao XU
Chinese Journal of Oncology 2002;24(2):188-190
OBJECTIVETo evaluate the efficacy and toxicity of Serratia marcescens (S311) vaccine in the treatment of malignant pleural effusion.
METHODSThirty-four patients with malignant pleural effusion were given S311 as intrapleural injection with a dose of 10(9) U (0.32 mg) on D 1, 8 and 15, and observed for four weeks.
RESULTSThe overall response rate (CR + PR) was 97.1% (CR in 12 patients and PR in 21 patients). The systemic toxicity was mild, including fever (82.4%), pleuritic pain (50.7%), nansea (26.5%), dyspnea (17.5%) and chills (5.9%).
CONCLUSIONSerratia marcescens vaccine is effective for malignant pleural effusion, with tolerable toxic effects. Further study is warranted.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacterial Vaccines ; adverse effects ; immunology ; therapeutic use ; Chest Pain ; chemically induced ; Dose-Response Relationship, Drug ; Female ; Fever ; chemically induced ; Humans ; Male ; Middle Aged ; Pleural Effusion ; drug therapy ; immunology ; Serratia marcescens ; immunology ; Time Factors ; Treatment Outcome