1.The Serum Levels of Resistin and Its Relationship with Other Proinflammatory Cytokines in Patients with Alzheimer's Disease.
Seden DEMIRCI ; Ayşe AYNALI ; Kadir DEMIRCI ; Serpil DEMIRCI ; Buket Cicioğlu ARIDOĞAN
Clinical Psychopharmacology and Neuroscience 2017;15(1):59-63
OBJECTIVE: The present study aims to analyze the levels of resistin, tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-18, and C-reactive protein (CRP) in patients with Alzheimer's disease (AD) and also investigate a potential relationship between resistin levels and TNF-α, IL-1β, IL-6, IL-18, and CRP levels in patients with AD. METHODS: The study included fifty patients with AD and 30 healthy controls with normal cognitive functions. The serum resistin, TNF-α, IL-1β, IL-6, IL-18, and CRP levels were assessed. We performed a Mini-Mental State Examination (MMSE) to evaluate the general cognitive performance. RESULTS: The mean serum resistin, IL-1β, IL-18, and TNF-α levels were significantly higher in patients with AD compared with the controls (p=0.026, p=0.002, p=0.003, and p=0.038, respectively). The IL-6 and CRP levels did not differ between the groups (p=0.874 and p=0.941). The resistin levels were positively correlated with the levels of CRP and IL-18 (r=0.526, p<0.001; r=0.402, p=0.004, respectively). MMSE scores and inflammatory markers were not correlated (p>0.05 for all). CONCLUSION: Serum resistin levels were significantly increased and correlated with some inflammatory markers in AD patients, suggesting that resistin might play a role in the inflammatory process of AD.
Alzheimer Disease*
;
C-Reactive Protein
;
Cognition
;
Cytokines*
;
Humans
;
Inflammation
;
Interleukin-18
;
Interleukin-6
;
Interleukins
;
Resistin*
;
Tumor Necrosis Factor-alpha
2.Is Retinal Nerve Fiber Layer Thickness Change Related to Headache Lateralization in Migraine?.
Alime GUNES ; Seden DEMIRCI ; Levent TOK ; Ozlem TOK ; Serpil DEMIRCI ; Süleyman KUTLUHAN
Korean Journal of Ophthalmology 2016;30(2):134-139
PURPOSE: To evaluate retinal nerve fiber layer (RNFL) thickness in migraine patients with unilateral headache. METHODS: A total of 58 patients diagnosed with migraine headache consistently occurring on the same side and 58 age- and sex-matched healthy subjects were evaluated in this cross-sectional study. RNFL thickness was measured using spectral-domain optical coherence tomography, and the side with the headache was com-pared with the contralateral side as well as with the results of healthy subjects. RESULTS: The mean patient age was 33.05 ± 8.83 years, and that of the healthy subjects was 31.44 ± 8.64 years (p = 0.32). The mean duration of disease was 10.29 ± 9.03 years. The average and nasal RNFL thicknesses were significantly thinner on the side of headache and on the contralateral side compared to control eyes (p < 0.05, for all). Thinning was higher on the side of the headache compared to the contralateral side; however, this difference was not statistically significant. CONCLUSIONS: The RNFL thicknesses were thinner on the side of the headache compared to the contralateral side in the migraine patients with unilateral headache, but this difference was not statistically significant.
Cross-Sectional Studies
;
Headache*
;
Humans
;
Migraine Disorders*
;
Nerve Fibers*
;
Retinaldehyde*
;
Tomography, Optical Coherence