No abstract available.
Dermatofibrosarcoma* ; Nose*

Wolf's isotopic response is defined as the occurrence of a new skin disorder at the site of another unrelated skin disease that has already healed. In most cases of isotopic response, the initial dermatosis is herpes infection, and the most frequent second dermatoses are granulomatous reactions. Various interpretations of this phenomenon have been attempted. However, the exact mechanism has not been identified yet. Herein, we report a case in which the secondary disease was segmental vitiligo that appeared over the same dermatomes of herpes zoster. A 71-year-old woman presented with well-defined, depigmented patches on the left chest and back. She had been diagnosed with herpes zoster on the same dermatomes and treated with an antiviral agent 3 years ago. Histological examination showed decreased basal melanin pigments and melanocytes. Consequently, the patient was diagnosed with segmental vitiligo based on the clinical and histological findings.
Aged ; Female ; Herpes Zoster* ; Humans ; Melanins ; Melanocytes ; Skin ; Skin Diseases ; Thorax ; Vitiligo*

Verruca plana is a subtype of warts, which are one of the most common dermatological diseases. A 37-year-old man presented with multiple asymptomatic skin-colored, 1∼2-mm, flat-topped papules on both arms, neck, and face. The patient had ulcerative colitis, which had been treated with immunosuppressants for 15 years. After skin biopsy, verruca plana was confirmed. The patient was treated with 5% imiquimod cream for 6 months. However, only mild improvement was observed. Acitretin was then added to the treatment regimen. After 44 weeks of treatment, acitretin was stopped. Dramatic and rapid clinical improvement was achieved after 3 weeks of treatment, and no sign of recurrence after treatment cessation has been reported for 60 weeks. Consequently, the combination of oral acitretin and topical 5% imiquimod cream should be recommended for the effective and safe treatment of recalcitrant verruca plana in immunosuppressed patients.
Acitretin* ; Adult ; Arm ; Biopsy ; Colitis, Ulcerative ; Humans ; Immunosuppressive Agents ; Neck ; Recurrence ; Skin ; Warts* ; Withholding Treatment

BACKGROUND: Eyelid tumors are common neoplasms encountered in daily dermatology practices and encompass a wide variety of benign and malignant tumors, since the eyelid has many tissue types. These tumors sometimes mimic common inflammatory conditions. Nonetheless, clinical investigation of these conditions remains limited. OBJECTIVE: To investigate the clinical and histopathological characteristics of eyelid skin tumors. METHODS: We retrospectively reviewed the medical records and clinical photographs of 148 patients with eyelid skin tumors confirmed by skin biopsy examination between January 2009 and May 2016. RESULTS: The mean patient age was 50.0 years, and the male-to-female ratio was 1:1.11. Malignant eyelid skin tumors accounted for 17.3% of the total number, and older patients were more likely to be affected by malignant tumors than benign tumors (66.2 years vs. 46.4 years). Epidermal cysts (15.5%), seborrheic keratosis (14.9%), and melanocytic nevus (14.2%) were the most common benign eyelid skin tumors. Basal cell carcinoma was the most common malignant tumor (69.2%), followed by squamous cell carcinoma (11.5%). Malignant skin tumors, especially basal cell carcinoma, predominantly involved the lower eyelid. No patient showed metastasis from the malignant skin tumors, and no case of recurrence was observed after wide excision of the tumors. CONCLUSION: Our findings suggest that various tumors, including malignant ones, can affect the eyelid area. This study provides useful data on the incidence and characteristics of eyelid skin tumors. Further investigation with a large group of patients is necessary to better understand the epidemiology of eyelid skin tumors.
Biopsy ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Dermatology ; Epidemiology ; Epidermal Cyst ; Eyelids* ; Humans ; Incidence ; Keratosis, Seborrheic ; Korea* ; Medical Records ; Neoplasm Metastasis ; Nevus, Pigmented ; Recurrence ; Retrospective Studies ; Skin* ; Tertiary Care Centers*

BACKGROUND: Eyelid tumors are common neoplasms encountered in daily dermatology practices and encompass a wide variety of benign and malignant tumors, since the eyelid has many tissue types. These tumors sometimes mimic common inflammatory conditions. Nonetheless, clinical investigation of these conditions remains limited. OBJECTIVE: To investigate the clinical and histopathological characteristics of eyelid skin tumors. METHODS: We retrospectively reviewed the medical records and clinical photographs of 148 patients with eyelid skin tumors confirmed by skin biopsy examination between January 2009 and May 2016. RESULTS: The mean patient age was 50.0 years, and the male-to-female ratio was 1:1.11. Malignant eyelid skin tumors accounted for 17.3% of the total number, and older patients were more likely to be affected by malignant tumors than benign tumors (66.2 years vs. 46.4 years). Epidermal cysts (15.5%), seborrheic keratosis (14.9%), and melanocytic nevus (14.2%) were the most common benign eyelid skin tumors. Basal cell carcinoma was the most common malignant tumor (69.2%), followed by squamous cell carcinoma (11.5%). Malignant skin tumors, especially basal cell carcinoma, predominantly involved the lower eyelid. No patient showed metastasis from the malignant skin tumors, and no case of recurrence was observed after wide excision of the tumors. CONCLUSION: Our findings suggest that various tumors, including malignant ones, can affect the eyelid area. This study provides useful data on the incidence and characteristics of eyelid skin tumors. Further investigation with a large group of patients is necessary to better understand the epidemiology of eyelid skin tumors.
Biopsy ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Dermatology ; Epidemiology ; Epidermal Cyst ; Eyelids* ; Humans ; Incidence ; Keratosis, Seborrheic ; Korea* ; Medical Records ; Neoplasm Metastasis ; Nevus, Pigmented ; Recurrence ; Retrospective Studies ; Skin* ; Tertiary Care Centers*

BACKGROUND: By magnifying the scalp and structure of hair, trichoscopy enables easy differentiation among various hair loss diseases. OBJECTIVE: To measure the frequency of representative trichoscopic findings in outpatients with androgenetic alopecia and alopecia areata and the frequency of various trichoscopic findings depending on the disease severity of androgenetic alopecia. METHODS: This cross-sectional study included 87 patients with androgenetic alopecia (n=57) and alopecia areata (n=30) treated over a year (2014∼2015). Three dermatologists assessed the trichoscopic findings (hair shaft, hair follicle opening, and perifollicular epidermis) in these patients. RESULTS: Vellus hair was observed in 21 of the 30 patients (70%) with alopecia areata and 20 of the 57 patients (35%) with androgenetic alopecia. Among the patients with androgenetic alopecia, as the disease severity increased, the portion of patients with vellus hair, thickness heterogeneity, and honeycomb pigmentation also increased (p<0.05). CONCLUSION: Trichoscopy is very useful for the diagnosis of androgenetic alopecia and alopecia areata. Additionally, the severity of androgenetic alopecia can be assessed using trichoscopy.
Alopecia Areata* ; Alopecia* ; Cross-Sectional Studies ; Diagnosis ; Hair ; Hair Follicle ; Humans ; Outpatients* ; Pigmentation ; Population Characteristics ; Scalp

BACKGROUND: By magnifying the scalp and structure of hair, trichoscopy enables easy differentiation among various hair loss diseases. OBJECTIVE: To measure the frequency of representative trichoscopic findings in outpatients with androgenetic alopecia and alopecia areata and the frequency of various trichoscopic findings depending on the disease severity of androgenetic alopecia. METHODS: This cross-sectional study included 87 patients with androgenetic alopecia (n=57) and alopecia areata (n=30) treated over a year (2014∼2015). Three dermatologists assessed the trichoscopic findings (hair shaft, hair follicle opening, and perifollicular epidermis) in these patients. RESULTS: Vellus hair was observed in 21 of the 30 patients (70%) with alopecia areata and 20 of the 57 patients (35%) with androgenetic alopecia. Among the patients with androgenetic alopecia, as the disease severity increased, the portion of patients with vellus hair, thickness heterogeneity, and honeycomb pigmentation also increased (p<0.05). CONCLUSION: Trichoscopy is very useful for the diagnosis of androgenetic alopecia and alopecia areata. Additionally, the severity of androgenetic alopecia can be assessed using trichoscopy.
Alopecia Areata* ; Alopecia* ; Cross-Sectional Studies ; Diagnosis ; Hair ; Hair Follicle ; Humans ; Outpatients* ; Pigmentation ; Population Characteristics ; Scalp

No abstract available.

No abstract available.
Herpes Zoster* ; Urinary Retention*

Large cell carcinoma with a rhabdoid phenotype is very rare. We report the case of a 53-year-old man who presented with multiple nodules on the scalp, face, and trunk. A skin biopsy revealed large cell carcinoma with a rhabdoid phenotype throughout the dermis. Tumor cells had abundant cytoplasm, eccentric nuclei, and prominent nucleoli and did not adhere to each other. Immunohistochemical tests showed positive reactions for vimentin, epithelial membrane antigen (EMA), and thyroid transcription factor-1 (TTF-1) and weakly focal reactions for pan-CK, CK7, and p63. Imaging studies and a percutaneous lung biopsy were performed and the results were consistent with a large cell lung carcinoma with a rhabdoid phenotype. Based on these clinical and histopathological findings, we concluded that his condition was a cutaneous metastasis from a large cell lung carcinoma with a rhabdoid phenotype, which occurs very rarely.
Biopsy ; Carcinoma, Large Cell ; Cytoplasm ; Dermis ; Humans ; Lung* ; Middle Aged ; Mucin-1 ; Neoplasm Metastasis* ; Phenotype* ; Rhabdoid Tumor ; Scalp ; Skin ; Thyroid Gland ; Vimentin