1.Effect of Curcuminoids and Natural Plants Extract Mixture on the Cardiovascular System in Rats.
Soo Hyun AHN ; Jong Ho LEE ; Ha Rim PARK ; Seoung Taek KWON ; You Seok KOH ; Young Doug SOHN ; Yang Soo JANG ; Kwang Hoe CHUNG
The Korean Journal of Nutrition 2003;36(2):101-108
Antiplatelet aggregation, anticoagulant and lipid-lowering drugs are clinically widely used for secondary preventive purpose in the cardiovascular patients, but there is no primary preventive agents to prevent these diseases. With the aim of developing effective primary agents for cardiovascular diseases, we tried to formulate an optimized mixture of natural plants extract containing Theae sinensis, Camelliae sinensis, Vitis vinifera, Gingko folium and curcuminoids from Curcuma longa and to evaluate its anti-thrombotic and anti-hypercholesterolemic effects in vivo. The inhibitory effect of curcuminoids on vascular smooth muscle cell proliferation and migration were also investigated in vitro. in the animal experiments treated with hyperlipidemic diet, oral treatment of curcuminoids and natural plants extracts mixture (100 mg/kg) into male Sprague Dawley rats for 7 week simultaneously inhibited platelet aggregation as well as improved lipid profile in the blood. Compared to control group, both of curcuminoids-treated and mixture-treated groups revealed significantly decrease of total cholesterol (24.4%, 28.6%), free cholesterol (25.1%, 24.0%), cholesterol ester (14.6%, 29.0%), LDL-cholesterol (27.0%, 32.0%) and triglyceride (15.0%, 31.0%), respectively. However, both groups showed increase of HDL-cholesterol (46.6% and 51.5%) . In particular, atherogenic index of curcuminoids and mixture treatment group was significantly decreased to 47.0% and 56.0%, respectively. Furthermore, oral treatment of curcuminoids and mixture significantly inhibited collagen-induced platelet aggregation (21.1% and 29.1%, respectively), compared to control group. The anti-thrombotic values of mixture was almost similar to that of aspirin treatment (100 mg/kg) group. These results suggest that the oral treatment of curcuminoids-based natural plant extract mixture improved cardiovascular conditions in hyperlipidemic rats.
Animal Experimentation
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Animals
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Aspirin
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Camellia sinensis
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Cardiovascular Diseases
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Cardiovascular System*
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Cell Proliferation
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Cholesterol
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Curcuma
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Diet
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Ginkgo biloba
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Humans
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Male
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Muscle, Smooth, Vascular
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Plants
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Platelet Aggregation
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Rats*
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Rats, Sprague-Dawley
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Triglycerides
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Vitis
2.Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report.
Yeun Seoung CHOI ; Jung Soo LIM ; Woocheol KWON ; Soon Hee JUNG ; Il Hwan PARK ; Myoung Kyu LEE ; Won Yeon LEE ; Suk Joong YONG ; Seok Jeong LEE ; Ye Ryung JUNG ; Jiwon CHOI ; Ji Sun CHOI ; Joon Taek JEONG ; Jin Sae YOO ; Sang Ha KIM
Tuberculosis and Respiratory Diseases 2015;78(4):463-468
Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.
Adult*
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Biopsy
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Cough
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Diabetes Insipidus
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Diabetes Insipidus, Neurogenic*
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Diabetes Mellitus*
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Diabetes Mellitus, Type 2
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Dyspnea
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Follow-Up Studies
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Histiocytosis, Langerhans-Cell*
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Humans
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Lung
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Lung Diseases
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Magnetic Resonance Imaging
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Male*
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Polydipsia
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Smoke
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Smoking
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Smoking Cessation
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Thoracic Surgery, Video-Assisted
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Water Deprivation