1.Clinical Observations on 12 Children with Alport Syndreome.
Young Min BAE ; Seoung Do KIM ; Hyeonho KANG ; Byoung Soo CHO
Journal of the Korean Society of Pediatric Nephrology 2000;4(1):48-56
Pilomatricoma is a well defind and characteristic entity histologically, but this tumor may be encountered during aspiration biopsy of subcutaneous mass, and is, occasionally, confused with other neoplasms, particularly squamous cell carcinoma, basal cell carcinoma, and epidermal inclusion cyst. Recently, we have experienced a case of pilomatricoma diagnosed by aspiration biosy. The smear of the aspirate revealed anucleated "ghost" squamous cells, basaloid or basophilic squamous cells and nucleated squamous cells, which lack nuclear features of malignacy. These findings are consistent with pilomatricoma.
Basophils
;
Biopsy, Needle
;
Carcinoma, Basal Cell
;
Carcinoma, Squamous Cell
;
Child*
;
Humans
;
Pilomatrixoma
;
Uterine Cervical Neoplasms
2.Clinical experience in 200 living-donor renal transplantation.
Chung Yeob HAN ; Seoung Soo CHO ; Sung Bae PARK ; Hyun Chul KIM ; Choal Hee PARK ; Won Hyun CHO
The Journal of the Korean Society for Transplantation 1992;6(1):21-30
No abstract available.
Kidney Transplantation*
3.Steroid responsive nephrotic syndrome in mesangial IgA nephropathy.
Hyun Chul KIM ; Seoung Soo CHO ; Soo Hyeong LEE ; Sung Bae PARK ; Kwan Kyu PARK ; Eun Sook CHANG
Korean Journal of Nephrology 1993;12(1):84-90
No abstract available.
Glomerulonephritis, IGA*
;
Immunoglobulin A*
;
Nephrotic Syndrome*
4.De novo membrano-proliferative glomerulonephritis in a renal allograft.
Seoung Ho HUH ; Seong Soo CHO ; Sung Bae PARK ; Hyun Chul KIM ; Kwan Kyu PARK ; Eun Sook JNG
Korean Journal of Medicine 1993;45(1):136-140
No abstract available.
Allografts*
;
Glomerulonephritis*
5.Relationship between Metabolic Acidosis and Nutritional Parameters in Stable Hemodialysis Patients.
Kun Hoo KWON ; Jae Soo LEE ; Yong Bum CHO ; Dong Han GI ; Seoung Woo LEE ; Moon Jae KIM
Korean Journal of Nephrology 1999;18(2):301-306
To evaluate the nutritional status according to the degree of metabolic acidosis(MA) and determine that MA is a risk factor for malnutrition, we screened the laboratory data of 37 hemodialysis(HD) patients who were clinically stable for more than 6 months and taken bioelectrical impedence analysis(BIA) twice 6 months apart to check lean body mass (LBM). Mean age of patients was 49.1+/-15.0 years and sex ratio 1:2.4. Mean serum albumin level was 3.97+/-0.36g/dl and weekly Kt/V and normalized protein catabolic rate(nPCR) were 3.04+/-0.85 and 0.99+/-0.21g/kg/day. According to mean total CO2 content during the periods between BIA, the patients were divided to three groups[group 1(n=16):&18mEq/L, group 2(n=9):18< or =tCO2&21mEq/L, group 3(n=12):> or =21mEq/L). Group 1 had significantly higher body weight gain than group 2 and 3(1.82+/-1.62 vs. 0.77+/-3.13 and 1.35+/-3.85kg, P<0.05), and higher LBM gain(1.99+/-4.38 vs. 3.35+/-7.99kg, P<0.05), nPCR(1.05+/-0.20 vs. 0.91+/-0.13g/kg/day, P<0.05), intact parathyroid hormone(88.4+/-78.7 vs. 32.0+/-26.5pg/ml, P< 0.05), and phosphate(5.4+/-1.3 vs. 3.9+/-1.3mg/dl, P< 0.05) than group 3. There were no differences in age, serum albumin, BUN, creatinine and weekly Kt/V among three groups. Mean total CO2 level was inversely correlated with body weight gain and LBM gain. In conclusion, metabolic acidosis in stable HD patients may be the result of high protein intake and not related to decrease of body weight by protein catabolism.
Acidosis*
;
Body Weight
;
Creatinine
;
Humans
;
Malnutrition
;
Metabolism
;
Nutritional Status
;
Renal Dialysis*
;
Risk Factors
;
Serum Albumin
;
Sex Ratio
6.Polycystin-1 Expression in Fetal, Adult and Autosomal Dominant Polycystic Kidney.
Seoung Wan CHAE ; Eun Yoon CHO ; Moon Soo PARK ; Kyu Beck LEE ; Hyunho KIM ; Unkyung KIM
Journal of Korean Medical Science 2006;21(3):425-429
The mutation of the PKD1 gene causes autosomal dominant polycystic kidney disease (ADPKD), and the PKD1 gene encodes polycystin-1 (PC-1). PC-1 is thought to be a cell-cell/matrix adhesion receptor molecule at the cell surface that is widely expressed in the kidney. However, there are controversies about the role of PC-1 protein and its expression when using different antibodies to detect it. We used two PC-1 antibodies; C-20 (Santa Cruz, sc-10372) as the C-terminal antibody, and P-15 (Santa Cruz, sc-10307) as the N-terminal antibody. We evaluated the PC-1 expression by performing immunoblotting on the human embryonic kidney (HEK) 293 cells and the renal proximal tubular epithelial cell (RPTEC) lysates. We characterized the expression of PC-1 in the fetal, adult and polycystic kidneys tissues by performing immunohistochemistry. We confirmed the PC-1 expression in the HEK 293 cells and the RPTEC lysates, but the expression was very low. The PC-1 proteins were diffusely expressed in the tubular epithelial cells cytoplasm in the fetal and adult kidneys, and the PC-1 expression was more prominent in the proximal tubules of the fetal kidney. In the ADPKD kidney, the PC-1 proteins were heterogenously and weakly expressed in the tubular or cyst lining epithelial cells. Our data suggests that the development of the kidney may regulate the expression of PC-1, and an altered PC-1 expression may contribute to cyst formation in ADPKD.
TRPP Cation Channels/chemistry/*metabolism
;
Protein Structure, Tertiary
;
Polycystic Kidney, Autosomal Dominant/*metabolism
;
Middle Aged
;
Male
;
Kidney/*embryology/metabolism/*pathology
;
Immunohistochemistry
;
Humans
;
*Gene Expression Regulation, Developmental
;
*Gene Expression Regulation
;
Cytoplasm/metabolism
;
Cell Line
7.The Clinical Study of Stereotaxic Aspiration in Spontaneous Intraparenchymal Hematoma.
Seoung Chan BAEK ; Byung Yearn CHOI ; Oh Lyong KIM ; Yong Chul CHI ; Soo Ho CHO
Journal of Korean Neurosurgical Society 1987;16(3):695-708
In a series of 91 patients underwent stereotaxic evacuation of spontaneous intraparenchymal hematoma during last 2 years; 15 had simple aspiration and 76 had urokinase irrigation gradually through the indwelling silastic catheter. Dosage of used urokinase was average 26,000u and duration was average 2.8 days. The average removed volume percent of the hematoma was 80.1+/-15.2%, eight out of 76 cases were performed urokinase irrigation revealed rebleeding; causes were overpressure during aspiration in 4 cases, blood dyscrasia in 3 cases, and fibrinolytic effect of urokinase in one case. High incidence of rebleeding were; thalamus(4 out of 16 cases; 25%) in location, before 6 hours(4 out of 19 cases; 21.1%) in operation time interval from ictus, below 10ml(4 out of 13 cases; 30.8%) in volume of the hematoma, but not correlated with amount of used urokinase. Causes of unsatisfactory removed cases were small hematoma, brain stem and thalamic hemorrhage and malposition of the catheter. Even in cases of combined ventricular hemorrhage, we didn't experienced hydrocephalus with urokinase irrigation. In 20 cases sampled randomly, osmolality of serum and aspirated liquefied hematoma were compared; the serum osmolality was 297.6+/-12mEq and osmolality of liquefied hematoma induced by urokinase was 304.7+/-11.3mEq. These findings strongly suggest that the surrounding interstitial fluid of the hematoma was shifted into the liquefied hematoma because of 7mEq difference of osmotic pressure. Over all good result(daily living activity) on discharge was 64.5% and mortality rate was 7.9%.
Brain Stem
;
Catheters
;
Extracellular Fluid
;
Hematoma*
;
Hemorrhage
;
Humans
;
Hydrocephalus
;
Incidence
;
Mortality
;
Osmolar Concentration
;
Osmotic Pressure
;
Urokinase-Type Plasminogen Activator
8.Diffuse Nesidioblastosis of the Pancreasin Adult with Persistent Hyperinsulinemic Hypoglycemia
Seoung Ha LEE ; Kean Young HYOUNG ; Geom Seog SEO ; Bong Joo SHIN ; Chung Gu CHO ; Kwang Soo YANG ; Kwon Mook CHAE ; Ki Jung YUN
Journal of Korean Society of Endocrinology 1996;11(2):247-253
Nesidioblastosis is a term that describes multifocal hyperplasia of all panereatic cell components and is characterized primarily by their disorganization and proliferation throughout the entire panaeas. Adult onset nesidioblastosis is an extremely rare entity associated with hypersecretion of insulin. The authors have recently experieneed a case of nesidioblastosis in an adult. A 41-year old man was admitted due to interrnittenr hypoglycemic symptoms, that had been relieved by carbohydrate ingestion. Hyperinsulinemic hypoglycemia was documented during prolonged fast. Under the presumptive diagnosis of insulinoma, abdominal CT, celiac angiogram and percutaneous transhepatic portal venous sampling were done but we could not find any definitive mass. Eight-five percent of the panacas was removed. Pathologic examination of the resected pancreas revealed irregularly sized islets and scattering of small endocrine cell clusters throughout the acinar tissue and ductuloinsular complex.
Adult
;
Cellular Structures
;
Congenital Hyperinsulinism
;
Diagnosis
;
Eating
;
Endocrine Cells
;
Humans
;
Hyperplasia
;
Hypoglycemia
;
Insulin
;
Insulinoma
;
Nesidioblastosis
;
Pancreas
;
Tomography, X-Ray Computed
9.Infantile Hepatic Hemangioendothelioma in an Adult.
Ki Bae BANG ; Yong Kyun CHO ; Sang Hyuk LEE ; Eun Hye PARK ; Ji Soo SEOL ; Seoung Wan CHAE ; Sang Won JO
Korean Journal of Medicine 2013;84(2):259-264
Infantile hepatic hemangioendothelioma is a rare disorder. It is a benign entity and usually resolves spontaneously. Most patients present in infancy and early childhood. Because of its natural course and symptom onset, most cases are discovered during childhood. We experienced a rare case of infantile hepatic hemangioendothelioma in an adult.
Adult
;
Hemangioendothelioma
;
Humans
;
Liver
10.Cardiovascular Changes of Midazolam for Induction of Anesthesia.
Seoung Yong SONG ; Gyung Joon LIM ; Nam Soo CHO ; Byung Sik YU ; Chong Dal CHUNG ; Yong Il KIM ; Geum Young SO
Korean Journal of Anesthesiology 1994;27(8):909-918
The cardiovaseular response evoked by tracheal intubation was observed in 69 patients undergoing elective surgery in whom anesthesia was induced with group A, B and C induction agents. Sixty nine ASA class 1 or 2 surgical patients were divided into three groups. Group A: thiopental 5 mg/kg (control) Group B: thiopental 2 mg/kg with midazolam 0.1 mg/kg Group C: midazolam 0.2 mg/kg Systolic and diastolic blood pressure, mean arterial pressure, heart rate and loss of eyelid reflex were measured in each group. There was a little difference in the cardiovascular changes between group A and C. But there was not a significant difference between group A and B and also between group B and C. The measured time until loss of eyelid reflex of the group C (55+/-30 sec) was considerably longer than other groups (Group A: 10+/-3 sec, Group B: 37+/-13 sec). The incidence of venous complication in three groups was low. Pain on injection and posto- perative nausea and vomiting was noted in one patient of the group A and B respectively, but no patient in the group C. There was no significant difference in the incidence of the postoperative local venous complication. On the whole, these results suggest that the difference between midazolam and thiopental had no apparent hemodynamic change. From the above results, both midazolam alone and midazolam combined with thiopental may be useful agents for induction of anesthesia.
Anesthesia*
;
Arterial Pressure
;
Blood Pressure
;
Eyelids
;
Heart Rate
;
Hemodynamics
;
Humans
;
Incidence
;
Intubation
;
Midazolam*
;
Nausea
;
Reflex
;
Thiopental
;
Vomiting