1.Comparison of Sodium Nitroprusside and Esmolol Induced Hypotension for Total Hip Arthroplasty.
Hyun Hee EUN ; Ho Yong HWANG ; Hong Hyun RYU ; Yong Woo LEE ; Seong Wan BAIK
Korean Journal of Anesthesiology 1997;33(2):324-329
BACKGROUND: Esmolol is a short acting sympathetic beta receptor antagonist, and it was successfully applied to induced hypotension. Esmolol lowers blood pressure by decreasing cardiac output, and does not cause vasodilation. This property of esmolol may help to decrease bleeding during induced hypotension. In this study, we tried to elucidate the effect of esmolol on induced hypotension for total hip arthroplasty. METHOD: Twenty patients receiving total hip arthroplasty were randomly divided to two groups. Esmolol group (10 patients) received esmolol as a hypotensive agent, and sodium nitroprusside (SNP) group (10 patients) received SNP as a hypotensive agent. We measured arterial blood gas analysis, vital sign, amounts of bleeding, amounts of transfusion and administered fluid, and various laboratory findings. RESULTS: Induced hypotension was successfully performed in either esmolol and SNP group. Heart rate increased by SNP, and decreased by esmolol. There were no statistically significant differences between the two groups in amounts of bleeding, amounts of transfusion or administered fluid, and laboratory findings. Arterial oxygen tension was relatively constant in esmolol group, but decreased in SNP group. CONCLUSION: Esmolol can be used as a single hypotensive agent during induced hypotension without significant side effects during total hip arthroplasty.
Arthroplasty, Replacement, Hip*
;
Blood Gas Analysis
;
Blood Pressure
;
Cardiac Output
;
Heart Rate
;
Hemorrhage
;
Humans
;
Hypotension*
;
Nitroprusside*
;
Oxygen
;
Sodium*
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Vasodilation
;
Vital Signs
2.A case of liposarcoma of spermatic cord.
Dae Chang RYU ; Dong Seong KIM ; Hei Young SHIM ; Han Yong CHOI
Korean Journal of Urology 1992;33(3):564-566
Liposarcoma of the spermatic cord is a rare tumor. Most are of a low-grade malignancy and recurrences tend to be localized. Preoperative diagnosis is difficult. Wide local excision with radical orchiectomy appears to be adequate treatment. A regional lymph node dissection is usually not advocated since the pattern of spread is hematogenous. We report a case of liposarcoma of the spermatic cord in 49-year-old male with brief review of the literatures.
Diagnosis
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Humans
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Liposarcoma*
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Lymph Node Excision
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Male
;
Middle Aged
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Orchiectomy
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Recurrence
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Spermatic Cord*
3.Emergency Center Ultrasonography in the Evaluation of Hemoperitoneum and solid Organ Injury.
Chu Kyeong PARK ; Jin Ho RYU ; Seong Keun KIM ; Han Deok YOON ; Tag HEO ; Suck Ju CHO ; Yong Il MIN
Journal of the Korean Society of Emergency Medicine 1997;8(2):252-257
The reliability of emergency ultrasonographic(US) detection of hemoperitoneum and solid organ injury in blunt abdominal trauma was evaluated retrospectively. From October 1,1995 to August 31,1996,90 patients were included in the study. Ultra- sonographic findings showed a sensitivity, specificity, and accuracy of 97.6%, 97.9%, and 98.1%, respectively, in detecting intraabdominal fluid collection. We believe that US in an emergency center is a quick, safe screening method in the evaluation of blunt abdominal trauma. In our department, US has replaced diagnostic peritonaeal lavage(DPL) and computed tomography(CT) as the screening study of first choice.
Emergencies*
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Hemoperitoneum*
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Humans
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Mass Screening
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Retrospective Studies
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Sensitivity and Specificity
;
Ultrasonography*
4.Ultrasonographic finding of hepatocellular carcinoma
Han Soo RYU ; Seong Ku WOO ; Jae Hoon LIM ; Young Tae KO ; Ho Kyun KIM ; Soon Yong KIM
Journal of the Korean Radiological Society 1983;19(4):753-761
With the development of gray scale ultrasonography, detection and evaluation of hepatic parenchymal diseaseincluding space occupying lesions are easitly performed and frequently used in the world. Thirty-five cases ofhistopathologically proven and ultrasonographically suggested hepatocellular carcinoma are retrospectivelystudied. The results were as follows; 1. Ultrasonographic findings of hepatocellular carcinoma show hyperechoicpattern in 22 cases (63%), hypoechoic pattern in 2 cases (6%), and mixed pattern in 11 cases (31%). 2. The marginof tumor is ill-defined in 19 cases (54%) and well defined in 16 cases (46%). 3. The size of tumor by sonographicmeasurement was larger than 5cm in diameter in 33 cases (94%). 4. The number of tumor is solitary in 19 cases andmultiple in 16 cases. The sites of involved lobe were right lobe in 22 cases (63%), left lobe in 2 cases (6%), andboth lobes in 11 cases (31%). 5. Associated sonographic findings were hepatomegaly with focal contour change in 25cases (71%), splenomegaly in 16 cases (46%), cirrhosis of liver in 15 cases (43%), ascites in 11 cases (31%) andtumoral thrombosis in portal vein in 8 cases (23%). 6. The sex ratio is 6:1 male predominence and the age rangesfrom 32 to 76 years with highest incidence in 5th and 6th decades.
Ascites
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Carcinoma, Hepatocellular
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Fibrosis
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Hepatomegaly
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Humans
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Incidence
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Liver
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Male
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Portal Vein
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Sex Ratio
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Splenomegaly
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Thrombosis
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Ultrasonography
6.Outcomes of open versus closed treatment in the management of mandibular subcondylar fractures.
Seong Yong KIM ; Jae Young RYU ; Jin Yong CHO ; Hyeon Min KIM
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2014;40(6):297-300
OBJECTIVES: To compare the clinical and radiological outcomes after closed reduction (CR) and open reduction and internal fixation (ORIF) in the management of subcondylar fractures. MATERIALS AND METHODS: Forty-eight patients presenting with subcondylar fracture between January 2010 and March 2013 were evaluated retrospectively. Fifteen patients were treated with CR and 33 patients with ORIF. The clinical and radiologic parameters were evaluated during follow-up (mean, 7.06 months; range, 3 to 36 months). RESULTS: In the CR group, no patients had any problems with regard to the clinical parameters. The average period of maxillomandibular fixation (MMF) was 5.47 days. The preoperative average tangential angulation of the fractured fragment was 3.67degrees, and loss of ramus height was 2.44 mm. In the ORIF group, no clinical problems were observed, and the average period of MMF was 6.33 days. The preoperative average tangential angulation of the subcondylar fragment was 8.66degrees, and loss of ramus height was 3.61 mm. CONCLUSION: CR provided satisfactory clinical results, though ORIF provided more accurate reduction of the fractured fragment. So there is no distinct displacement of fractured fragment, CR should be selected than ORIF because of no need for surgery.
Follow-Up Studies
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Humans
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Jaw Fixation Techniques
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Retrospective Studies
7.Udenafil, a Phosphodiesterase 5 Inhibitor, Reduces Body Weight in High-Fat-Fed Mice
Seong Yul RYU ; Yoon Jung CHOI ; So Young PARK ; Jong Yeon KIM ; Yong Dae KIM ; Yong Woon KIM
The World Journal of Men's Health 2018;36(1):41-49
PURPOSE: High-fat (HF) feeding induces hypothalamic leptin resistance via the activation of toll-like receptor 4 (TLR4). TLR4 deficiency confers resistance to diet-induced obesity. Udenafil, an anti-impotence drug, inhibits TLR4 in airway epithelial cells in vitro. In this study, we evaluated whether udenafil suppressed the hypothalamic expression of TLR4 and reduced body weight. MATERIALS AND METHODS: The hypothalamic expression of TLR4, phosphodiesterase 5 (PDE5), nuclear factor-κB (NF-κB), and myeloid differentiation primary response gene 88 (Myd88) was analyzed by real-time polymerase chain reaction after treating mice for 2 days with udenafil (0, 12, 120, or 600 µg/d). Furthermore, the hypothalamic expression of TLR4, pro-opiomelanocortin (POMC), and neuropeptide Y (NPY) was analyzed after 9 days' treatment with udenafil and/or leptin. We also measured body weight and food intake following 9 days of udenafil and/or leptin treatment in control- and HF-fed mice. RESULTS: Udenafil suppressed hypothalamic TLR4 mRNA expression dose-dependently. The changes were associated with decreased PDE5, NF-κB, and Myd88 expression. Udenafil treatment for 9 days reduced body weight and caloric intake in HF-fed mice. This may have been associated with the suppression of NPY expression that was elevated by HF feeding. POMC expression was not affected by udenafil. However, udenafil did not augment the effects of leptin on the reduction of body weight and caloric intake in HF-fed mice. CONCLUSIONS: These results suggested that udenafil reduced body weight by suppressing hypothalamic TLR4 mRNA expression in HF-fed mice and the combination effect of udenafil and leptin was additive rather than synergistic.
Animals
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Body Weight
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Cyclic Nucleotide Phosphodiesterases, Type 5
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Eating
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Energy Intake
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Epithelial Cells
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Hypothalamus
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In Vitro Techniques
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Leptin
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Mice
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Neuropeptide Y
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Obesity
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Pro-Opiomelanocortin
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Real-Time Polymerase Chain Reaction
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RNA, Messenger
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Toll-Like Receptor 4
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Toll-Like Receptors
8.Suggestion of Optimal Radiation Fields in Rectal Cancer Patients after Surgical Resection for the Development of the Patterns of Care Study.
Jong Hoon KIM ; Jin Hong PARK ; Dae Yong KIM ; Woo Cheol KIM ; Jinsil SEONG ; Yong Chan AHN ; Mi Ryeong RYU ; Mison CHUN ; Seong Eon HONG ; Do Hoon OH ; Il Han KIM
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2003;21(3):183-191
PURPOSE: To suggest the optimal radiation fields after a surgical resection based on a nationwide survey on the principles of radiotherapy for rectal cancer in the Korean Patterns of Care Study. MATERIALS AND METHODS: A consensus committee, composed of radiation oncologists from 18 hospitals in Seoul Metropolitan area, developed a survey format to analyze radiation oncologist's treatment principles for rectal cancer after a surgical resection. The survey format included 19 questions on the principles of defining field margins, and was sent to the radiation oncologists in charge of gastrointestinal malignancies in all Korean hospitals (48 hospitals). Thirty three (69%) oncologists replied. On the basis of the replies and literature review, the committee developed guidelines for the optimal radiation fields for rectal cancer. RESULTS: The following guidelines were developed: superior border between the lower tip of the L5 vertebral body and upper sacroiliac joint; inferior border 2~3 cm distal to the anastomosis in patient whose sphincter was saved, and 2~3 cm distal to the perineal scar in patients whose anal sphincter was sacrificed; anterior margin at the posterior tip of the symphysis pubis or 2~3 cm anterior to the vertebral body, to include the internal iliac lymph node and posterior margin 1.5~2 cm posterior to the anterior surface of the sacrum, to include the presacral space with enough margin. Comparison with the guidelines, the replies on the superior margin coincided in 23 cases (70%), the inferior margin after sphincter saving surgery in 13 (39%), the inferior margin after abdominoperineal resection in 32 (97%), the lateral margin in 32 (97%), the posterior margins in 32 (97%) and the anterior margin in 16 (45%). CONCLUSION: These recommendations should be tailored to each patient according to the clinical characteristics such as tumor location, pathological and operative findings, for the optimal treatment. The adequacy of these guidelines should be proved by following the Korean Patterns of Care Study.
Anal Canal
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Cicatrix
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Consensus
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Humans
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Lymph Nodes
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Radiotherapy
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Rectal Neoplasms*
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Sacroiliac Joint
;
Sacrum
;
Seoul
9.Studies on Heart Rate Variability in Patients with Acute Myocardial Infarction.
Ho Soon LEE ; Yong Seok CHOI ; Seong Woo HAN ; Woo Jung PARK ; Young Cheoul DOO ; Dong Jin OH ; Kyu Hyung RYU ; Yung LEE
Korean Circulation Journal 1997;27(11):1160-1168
BACKGROUND: Heart rate variability(HRV) represents one of the methods of examining the function of autonomic nervous system. Many patients with acute myocardial infarction show evidence of autonomic disturbance during the acute phase of the attack and reduced heart rate variability is a significant predictor of mortality in patients after acute myocardial infarction. METHOD: The study groups included 25 patients admitted to our hospital with acute myocardial infarction and 23 age matched control group. Heart rate variability(time domain measures : mean NN, SDNN, SDANN, SD, rMSSD, pNN50 and frequency domain measures : TF, LF, HF) was measured from 24 hour Holter recording and wall motion score index(WMSI)was calculated from echocardiography in both groups. Jeopardy score(JS) and ejection fraction(EF) were calculated from coronary angiogram and left ventricular cineangiogram. In patients, HRV, echocardiography and coronary angiography were taken at a mean of 9+/-4, 4.3+/-2.9, and 13+/-6 days after admission. Results: 1) HRV(time domain measures : SDNN, SDANN, SD, rMSSD, pNN50 and frequency domain measures : TF, LF, HF) except mean heart rate was significantly decreased in patients with acute myocardial infarction(AMI)(p<0.001). 2) The angiographic EF and echocardiographic WMSI showed significant negative correlation in patients with AMI(r=-0.49, p<0.05). 3) The EF was significantly related with mean heart rate(r=0.52, p<0.05), SD(r=0.45, p<0.05), TF(r=0.46, p<0.05) and LF(r=0.50, p<0.05) in patients with AMI. 4) There was no correlation among the JS, WMSI, and HRV in patients with AMI. CONCLUSIONS: These findings support that the autonomic control of the heart was pathologically changed in patients with AMI and among the HRV measurements, mean NN, SD, TF and LF were closely related with left ventricular function.
Autonomic Nervous System
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Coronary Angiography
;
Echocardiography
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Heart Rate*
;
Heart*
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Humans
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Mortality
;
Myocardial Infarction*
;
Ventricular Function, Left
10.Carotid Intima-Media Thickness and Plaque as a Predictor for Ischemic Etiology in Patients With Severe Left Ventricular Systolic Dysfunction.
Soon Yong SUH ; Seong Woo HAN ; Sung Hea KIM ; Hyun Joong KIM ; Sang Man CHUNG ; Kyu Hyung RYU
Korean Circulation Journal 2010;40(12):665-670
BACKGROUND AND OBJECTIVES: Coronary artery disease (CAD) is a major cause of heart failure associated with left ventricular systolic dysfunction (LVSD). The prognosis of LVSD is significantly influenced by the etiology of heart failure and therefore, differentiation of significant CAD from other etiologies is important. Carotid intima-media thickness (IMT) and plaque are useful predictors for cardiovascular events, including stroke and CAD. The purpose of this study was to evaluate the predictive value of carotid IMT and plaque for the diagnosis of CAD in LVSD patients. SUBJECTS AND METHODS: Seventy-three (n= 73, 47 male, 67.6+/-12.4 years) patients hospitalized for heart failure with severe LVSD were retrospectively enrolled. The severity of CAD was analyzed by the Duke Jeopardy Score system, and carotid IMT and plaque were measured according to the Mannheim Carotid IMT Consensus. RESULTS: Significant CAD was found in 41 patients (56.1%, CAD group) on coronary angiography. Mean common carotid artery (CCA) IMT (0.74+/-0.05 mm vs. 1.04+/-0.04 mm, p<0.01) was significantly higher in the CAD group. Plaque in CCA (6.25% vs. 19.5%, p<0.01) and plaque in bulb (25.0% vs. 60.9%, p<0.001) were significantly higher in the CAD group. Mean CCA IMT {odds ratio (OR) 2.61, 95% confidence interval (CI) 1.134-4.469, p<0.01} and plaque in bulb (OR 4.69, 95% CI 1.702-12.965, p<0.01) were significant predictors for the diagnosis of CAD according to multivariate logistic regression analysis. CONCLUSION: In patients with severe LVSD, mean CCA IMT and bulb plaque can be useful additional predictors for the diagnosis of CAD.
Carotid Artery, Common
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Carotid Intima-Media Thickness
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Coronary Angiography
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Coronary Artery Disease
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Heart Failure
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Humans
;
Logistic Models
;
Male
;
Prognosis
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Retrospective Studies
;
Stroke