No abstract available.
Blood Group Incompatibility* ; Bromelains*

BACKGROUND/AIMS: Planned endoscopic submucosal dissection with snaring (ESD-S) is thought to shorten operating time spent on submucosal dissection, but may lead to uncertainty of en bloc resection or to a possible increase in tumor-positive margins. The purpose of the present study is to investigate the feasibility of ESD-S as a planned procedure for gastric adenoma. MATERIALS AND METHODS: The medical records of 99 patients who underwent ESD-S or ESD for gastric adenoma between May 2011 and May 2012 were retrospectively reviewed. We analyzed the differences between the ESD-S and the ESD groups, focusing on rates of en bloc resection and pathologic complete resection, mean operation time, and complications. RESULTS: The mean operation time was significantly lower in the ESD-S group than in the ESD group (19.9+/-11.2 vs. 33.8+/-19.9, P=0.012). Cases with an operation time under 30 minutes were more frequent in the ESD-S group (88.9% vs. 48.1%, OR=8.615, 95% CI=2.949~25.168). There were no significant differences in en bloc resection, histologic complete resection, or complication rates between the two groups. CONCLUSIONS: ESD-S has a time advantage over ESD with a comparable compete resection rate. ESD-S can be considered a planned method for available early gastric adenoma.
Adenoma* ; Endoscopy ; Focus Groups ; Humans ; Medical Records ; Retrospective Studies ; SNARE Proteins* ; Uncertainty

PURPOSE: Recently, the incidence of refractory Mycoplasma pneumoniae (MP) pneumonia has increased in Korea. Given that its early diagnosis is helpful in selection of the treatment, this study aimed at investigating the value of the antimycoplasma antibody (IgM) for early diagnosis of MP pneumonia. METHODS: A total of 315 children admitted with MP pneumonia from September 2015 to May 2016 were investigated with the IgM and polymerase chain reaction (PCR) for the diagnosis of MP pneumonia. Specifically, patients were grouped into nonrefractory respiratory MP and refractory MP groups according to their response to macrolide therapy. RESULTS: In the 44 PCR-negative seroconversed children, seroconversed IgM was more frequent in the refractory MP group compared with the nonrefractory respiratory MP group with statistical significance (P<0.001). In the 264 IgM-positive children, the time of antibody reaction was more delayed in the refractory MP group compared to the nonrefractory respiratory MP group with statistical significance (P<0.001). CONCLUSION: This study showed that there was a higher incidence of seroconversed IgM and delayed antibody reaction in the refractory MP group. In children with suspect MP pneumonia, follow-up studies of antibody are necessary, even through initial antibody and PCR showed negative findings. In addition, this result may suggest that the diagnosis of refractory MP pneunomia will be helpful in establishing the strategy of the treatment.
Child ; Diagnosis ; Early Diagnosis ; Follow-Up Studies ; Humans ; Immunoglobulin M ; Incidence ; Korea ; Mycoplasma pneumoniae ; Mycoplasma ; Pneumonia ; Pneumonia, Mycoplasma ; Polymerase Chain Reaction

PURPOSE: The incidence of renal tuberculosis has decreased considerably in recent years, but the disease still threatens public health. Childhood genitourinary tuberculosis (GUTB) has been very rare. The aim of the study was to analyze the clinical aspects and characteristics of childhood GUTB. MATERIALS AND METHODS: A total of 145 cases of GUTB were diagnosed. We analyzed retrospectively the clinical manifestations of eight patients with GUTB younger than 15 years of age. RESULTS: The age of the patients, six boys and two girls, ranged from 5 to 14 years. Follow up period ranged from 12 to 145 months. Presenting features were diverse and included gross hematuria in five cases. Rarer presenting features included one case of epididymorchitis. All had had BCG vaccination at around 1 month old. Conclusive diagnosis was made on the basis of isolation of mycobacterium tuberculosis in five patients, whereas three patients were given a therapeutic trial based on clinical manifestations. The most common site of involvement was the kidney (7 cases). Temporary urinary diversional procedures were performed in two patients for relieving ureteral obstruction. Excisional surgery was needed in three patients, whereas one underwent ureteroneocystostomy for ureteric stricture. Response to antitubercular drug therapy was gratifying. No relapse was observed during follow-up period. CONCLUSIONS: Childhood GUTB is rare, but may become serious. The importance of early diagnosis is emphasized, and aggressive treatment is needed in advanced childhood tuberculosis for preservation of renal function.
Child* ; Constriction, Pathologic ; Diagnosis ; Drug Therapy ; Early Diagnosis ; Female ; Follow-Up Studies ; Hematuria ; Humans ; Incidence ; Infant, Newborn ; Kidney ; Mycobacterium bovis ; Mycobacterium tuberculosis ; Public Health ; Recurrence ; Retrospective Studies ; Tuberculosis* ; Tuberculosis, Renal ; Ureter ; Ureteral Obstruction ; Urinary Diversion ; Vaccination

Melanoacanthoma, a rare benign variant of seborrheic keratosis, was first introduced by Mishima and Pinkus in 1960. It is a slow-growing, painless, pigmented plaque with a verrucous surface and a diameter ranging from a few millimeters to 10 cm. It tends to develop during middle-age with an equal sex incidence, and the lesion usually presents on the head, trunk, and especially the lip. It also has a histopathologic finding of mixed neoplasm composed of melanocytes scattered throughout keratinocytic lobules, and is characterized by hyperkeratosis, parakeratosis, acanthosis, papillomatosis and pseudo-horn cysts in the epidermis. We report a case of melanoacanthoma occurring in a 52-year-old female, who presented with an easily bleeding mass on her right external auditory canal, an extremely uncommon site.
Ear Canal* ; Epidermis ; Female ; Head ; Hemorrhage ; Humans ; Incidence ; Keratosis, Seborrheic ; Lip ; Melanocytes ; Middle Aged ; Papilloma ; Parakeratosis

AIMS: The purpose of this study is to analyze the characteristics of the occupational diseases compensated with the Industrial Accident Compensation Insurance that is operated by the Korea Labor Welfare Corporation (KLWC). METHODS: Using the KLWC database, we collected 4,240 cases of compensated occupational disease occurring between 1 January 2001 and 31 December 2003. We analyzed the characteristics (sex, age, type of occupational disease, exposure material, type of industry and occupation, etc.) of occupational diseases using the KLWC electronic data and compensated with the data of claimed cases investigated by the Korea Occupational Safety and Health Agency (KOSHA). RESULTS: KLWC approved 4,240 cases, including 1,199 deaths (28.3%). Men accounted for 92.6% (3,925 cases) of the approved cases. The most common age group was 50-59 years of age (n=1,433, 33.8%). The majority of diseases were respiratory diseases (2,906 cases, 68.5%), occupational hearing loss (687 cases, 16.2%), infectious disease (238 cases, 5.6%), intoxication (117 cases, 2.8%), skin diseases (111 cases, 2.6%) and cancer (41 cases, 1.0%). The causal hazardous agents were dust (2,870 cases, 67.7%), physical agents (770 cases, 18.2%), biological agents (301 cases, 7.1%), chemical agents (242 cases, 5.7%), and heavy metals (51 cases, 1.2%). The major types of industry were mining and quarrying (2,708 cases, 63.9%), manufacturing (1,112 cases, 26.2%), health and social work (159 cases, 3.8%) and construction (63 cases, 1.5%). The type of occupation included craft and related trades workers (2,622 cases, 61.8%), elementary occupations (730 cases, 17.2%), senior officials and managers (327 cases, 7.7%) and plant and machine operators and assemblers (225 cases, 5.3%). CONCLUSIONS: We were able to elucidate the kinds of occupational disease and the characteristics of workers through this study. Many compensation cases occurred among non-manufacturing and non-mining workers, especially health care workers, and there were various kinds of disease. This suggests that a management policy must be established to prevent occupational diseases occurring among workers in the above types of industry.
Accidents, Occupational* ; Biological Factors ; Communicable Diseases ; Compensation and Redress* ; Delivery of Health Care ; Dust ; Hearing Loss ; Humans ; Insurance* ; Korea ; Male ; Metals, Heavy ; Mining ; Occupational Diseases* ; Occupational Health ; Occupations ; Plants ; Skin Diseases ; Social Work

OBJECTIVES: The purpose of this study is to analyze the characteristics of occupational diseases listed by Korea Labor Welfare Corporation(KLWC). METHODS: Using the database of the KLWC, we collected 575 approved occupational disease cases occurring between 1 January and 31 December 1999 and approved by the thirtieth June in 2000. We investigated the characteristics(sex, age, occupational history, kinds of occupational disease, exposure material, type of enterprises, etc.) of occupational disease using a mail survey and telephone interviews. RESULTS: Men accounted for 88.9 %(511 workers) of the approved cases. 56 cases(9.7%) died of occupational disease. The most common age group was 50~59 years of age(n=217, 37.7 %). The proportion of workers with grater than ten years disease related working condition exposure were 195(49.0 %). The majority of diseases were respiratory problems(211 workers, 22.4 %), occupational hearing loss(149 workers, 25.9 %), infectious disease(69 workers, 12.0 %), intoxication(60 workers, 10.4 %), skin disease(29 workers, 5.0 %) and cancer(17 workers, 3.0 %). The causal hazardous agents were dusts(209 cases, 36.3 %), physical agents(157 cases, 27.3 %), chemical agents(89 cases, 16.3 %), biological agents(82 cases, 14.3 %) and workrelated agents(34 cases, 5.9 %). The major types of enterprise were manufacturing(262 workers, 45.6 %), mining and quarrying(174 workers, 30.3 %), public administration(42 workers, 7.3 %) and the health care industry(28 workers, 4.9 %). The kinds of job included craft and related trades workers(285 workers, 49.6 %), plant or machine operators and assemblers(139 workers, 24.2 %), elementary occupations(72 workers, 12.5 %) and professionals(28 workers, 4.9 %). CONCLUSIONS: We were able to elucidate the kinds of occupational disease and the characteristics of workers through this study. Many approved cases occurred among nonmanufacturing and non-mining workers and the kinds of disease were varied. This suggests that management policy must be established to prevent occupational disease occurring among workers in the above type of industries.
Delivery of Health Care ; Hearing ; Humans ; Interviews as Topic ; Korea* ; Male ; Mining ; Occupational Diseases* ; Plants ; Postal Service ; Skin

The proportion of cancer as a cause of death in Korean has been continuously increasing. In 2000, 24 %(59,020 of 247,346) of deaths were caused by cancer. Occupational exposure would have contributed to the development of some cancers. It would have accounted for more than 2,000 cancers in a year if 4% of all cancer or 10% of lung cancer was regarded as arising from the work environment. However, occupational cancer has not been reported as much as expected. The first case of occupational cancer reported officially was mesothelioma caused by asbestos exposure at an asbestos textile industry in 1992. Following the report, many cases of occupational cancers have been reported such as lung cancer due to exposure to asbestos, chromium, exhaust gases, coke oven emissions, and silica, as well as leukemia due to exposure to benzene or other solvent and bladder cancer arising from exposure to benzidine salts. The Health Examination for retirees has been conducted since 1992 in order to detect occupational cancer early in workers who have been exposed to 11 carcinogenic substances. However, to date no occupational cancer has been detected through the Retirees' Health Examination. The Korea Labor Welfare Corporation(KLWC) has referred 108 claims for occupational cancer to the Korea Occupational Safety and Health Agency(KOSHA) between 1992 and 2000. Thirty-three cases were accepted, including 14 cases of lung cancer, eight cases of hematopoietic cancer and six cases of mesothelioma. KLWC has accepted the claim for primary lung cancer developed with pneumoconiosis as an occupational cancer, of which there were 31 cases in 1999 and 61 cases in 2000. In conclusion, special attention is required to detect occupational cancer due to their long latency period and the fact they are usually found after retirement.
Asbestos ; Benzene ; Cause of Death ; Chromium ; Coke ; Compensation and Redress ; Gases ; Korea* ; Latency Period (Psychology) ; Leukemia ; Lung Neoplasms ; Mesothelioma ; Occupational Exposure ; Occupational Health ; Pneumoconiosis ; Retirement ; Salts ; Silicon Dioxide ; Textile Industry ; Urinary Bladder Neoplasms

Hepatoblastoma is a rare pediatric malignancy which frequently presents at an advanced unresectable stage, but improved resectability and survival is being reported with the help of neoadjuvant chemotherapy. Twenty biopsy proven hepatoblastoma patients were diagnosed and managed during the period between January, 1987 and June, 1995. Median age at diagnosis was 13 months (2mo~7yr 10mo) with M : F = 13 : 7. The histologic profile included 13 epithelial (5 fetal, 4 mixed, 1 embryonal, 3 undetermined), and 5 mixed mesenchymal and epithelial types. Chemotherapy effectively reduced the tumor volume with statistical significance (p=0.008) and was able to convert 7 out of 9 initially unresectable cases (78%) to resectable ones. Fourteen operations were done, 12 radical and 2 palliative with or without adjuvant chemotherapy. The whole population was followed with a median duration of 33 months and the median survival in the whole group was 26 months. The curative resection group displayed a 5 year survival rate of 61.1% and none in the non-curative group survived for more than 13 months (p=0.0001). In univariate analysis for prognostic factors, large tumor size at diagnosis and absence of thrombocytopenia was associated with poor survival, but these differences were not statistically significant. Pure fetal histology was not associated with better prognosis and this may be due to a different histologic classification. In this new era of neoadjuvant chemotherapy, the optimal management strategy for hepatoblastoma is still debated with radical surgical resection at earliest possible time being the final goal. For now, individualized approach appears to be the choice.
Biopsy ; Chemotherapy, Adjuvant ; Classification ; Diagnosis ; Drug Therapy ; Hepatoblastoma* ; Humans ; Prognosis* ; Survival Rate ; Thrombocytopenia ; Tumor Burden

PURPOSE: We investigated the clinical difference between single infection and coinfection with respiratory virus in hospitalized children with acute respiratory tract infections. METHODS: We reviewed 727 patients who were admitted with the diagnosis of acute respiratory infection at the Department of Pediatrics, Bundang Jesaeng Hospital between January and December of 2014. Diagnoses were made using the multiplex reverse transcriptase polymerase chain reaction (RT-PCR) assay targeting 16 viruses in nasopharyngeal swabs. Subjects were classified as the single virus infection and coinfection groups. RESULTS: A total of 439 patients were enrolled; 359 (77.2%) under 24 months. Single virus was detected in 279 (63.6%). Coinfection with multiple virus was detected in 160 (36.4%): 126 (28.7%) with 2 viruses, 30 (6.8%), and 4 (0.9%) with 3 to 4 viruses. Viral coinfection was detected in 28 samples (17.5%), with respiratory syncytial virus (RSV) A and rhinovirus being the most dominating combination. There were no clinical differences between the single infection and coinfection groups, except sputum and the frequency of high RSV load. Sputum was significantly more frequent in the coinfection group (P=0.043), and the frequency of high RSV load was significantly higher in the single infection group (P=0.029). Disease severity (high fever, the duration of fever [≥5 days], and the length of hospital stay [≥5 days], O₂ therapy) did not differ significantly between both groups. RSV was a frequent virus of single infection during winter. Coinfection was most common in winter. CONCLUSION: There were no clinical differences between single infection and coinfection, except sputum and the frequency of high RSV load.
Child ; Child, Hospitalized ; Coinfection* ; Diagnosis ; Fever ; Humans ; Length of Stay ; Multiplex Polymerase Chain Reaction ; Pediatrics ; Respiratory Syncytial Viruses ; Respiratory Tract Infections ; Reverse Transcriptase Polymerase Chain Reaction ; Rhinovirus ; Sputum