No abstract available.
Blood Group Incompatibility* ; Bromelains*

BACKGROUND/AIMS: Planned endoscopic submucosal dissection with snaring (ESD-S) is thought to shorten operating time spent on submucosal dissection, but may lead to uncertainty of en bloc resection or to a possible increase in tumor-positive margins. The purpose of the present study is to investigate the feasibility of ESD-S as a planned procedure for gastric adenoma. MATERIALS AND METHODS: The medical records of 99 patients who underwent ESD-S or ESD for gastric adenoma between May 2011 and May 2012 were retrospectively reviewed. We analyzed the differences between the ESD-S and the ESD groups, focusing on rates of en bloc resection and pathologic complete resection, mean operation time, and complications. RESULTS: The mean operation time was significantly lower in the ESD-S group than in the ESD group (19.9+/-11.2 vs. 33.8+/-19.9, P=0.012). Cases with an operation time under 30 minutes were more frequent in the ESD-S group (88.9% vs. 48.1%, OR=8.615, 95% CI=2.949~25.168). There were no significant differences in en bloc resection, histologic complete resection, or complication rates between the two groups. CONCLUSIONS: ESD-S has a time advantage over ESD with a comparable compete resection rate. ESD-S can be considered a planned method for available early gastric adenoma.
Adenoma* ; Endoscopy ; Focus Groups ; Humans ; Medical Records ; Retrospective Studies ; SNARE Proteins* ; Uncertainty

PURPOSE: Recently, the incidence of refractory Mycoplasma pneumoniae (MP) pneumonia has increased in Korea. Given that its early diagnosis is helpful in selection of the treatment, this study aimed at investigating the value of the antimycoplasma antibody (IgM) for early diagnosis of MP pneumonia. METHODS: A total of 315 children admitted with MP pneumonia from September 2015 to May 2016 were investigated with the IgM and polymerase chain reaction (PCR) for the diagnosis of MP pneumonia. Specifically, patients were grouped into nonrefractory respiratory MP and refractory MP groups according to their response to macrolide therapy. RESULTS: In the 44 PCR-negative seroconversed children, seroconversed IgM was more frequent in the refractory MP group compared with the nonrefractory respiratory MP group with statistical significance (P<0.001). In the 264 IgM-positive children, the time of antibody reaction was more delayed in the refractory MP group compared to the nonrefractory respiratory MP group with statistical significance (P<0.001). CONCLUSION: This study showed that there was a higher incidence of seroconversed IgM and delayed antibody reaction in the refractory MP group. In children with suspect MP pneumonia, follow-up studies of antibody are necessary, even through initial antibody and PCR showed negative findings. In addition, this result may suggest that the diagnosis of refractory MP pneunomia will be helpful in establishing the strategy of the treatment.
Child ; Diagnosis ; Early Diagnosis ; Follow-Up Studies ; Humans ; Immunoglobulin M ; Incidence ; Korea ; Mycoplasma pneumoniae ; Mycoplasma ; Pneumonia ; Pneumonia, Mycoplasma ; Polymerase Chain Reaction

PURPOSE: The incidence of renal tuberculosis has decreased considerably in recent years, but the disease still threatens public health. Childhood genitourinary tuberculosis (GUTB) has been very rare. The aim of the study was to analyze the clinical aspects and characteristics of childhood GUTB. MATERIALS AND METHODS: A total of 145 cases of GUTB were diagnosed. We analyzed retrospectively the clinical manifestations of eight patients with GUTB younger than 15 years of age. RESULTS: The age of the patients, six boys and two girls, ranged from 5 to 14 years. Follow up period ranged from 12 to 145 months. Presenting features were diverse and included gross hematuria in five cases. Rarer presenting features included one case of epididymorchitis. All had had BCG vaccination at around 1 month old. Conclusive diagnosis was made on the basis of isolation of mycobacterium tuberculosis in five patients, whereas three patients were given a therapeutic trial based on clinical manifestations. The most common site of involvement was the kidney (7 cases). Temporary urinary diversional procedures were performed in two patients for relieving ureteral obstruction. Excisional surgery was needed in three patients, whereas one underwent ureteroneocystostomy for ureteric stricture. Response to antitubercular drug therapy was gratifying. No relapse was observed during follow-up period. CONCLUSIONS: Childhood GUTB is rare, but may become serious. The importance of early diagnosis is emphasized, and aggressive treatment is needed in advanced childhood tuberculosis for preservation of renal function.
Child* ; Constriction, Pathologic ; Diagnosis ; Drug Therapy ; Early Diagnosis ; Female ; Follow-Up Studies ; Hematuria ; Humans ; Incidence ; Infant, Newborn ; Kidney ; Mycobacterium bovis ; Mycobacterium tuberculosis ; Public Health ; Recurrence ; Retrospective Studies ; Tuberculosis* ; Tuberculosis, Renal ; Ureter ; Ureteral Obstruction ; Urinary Diversion ; Vaccination

The major cause of pseudomembranous colitis is known to be Clostridium difficile (C. difficile). There are few reports that Clostridium species other than C. difficile has caused pseudomembranous colitis. We report a case of pseudomembranous colitis caused by clostridium glycolicum(C. glycolicum). A 47-year-old woman who had operational history for rectal cancer 3 months ago, was readmitted with diarrhea of 3 days duration. Seven weeks before admission, she had received ornidazole and ceftriaxone due to diarrhea and abdominal pain, and her symptoms were improved. She had received additional radiation therapy for rectal cancer during six weeks before the recent onset of diarrhea. On admission, she complained of watery diarrhea ten times a day and abdominal pain. She had tenderness on both lower abdomen. Pseudomembrane was observed by colonoscopic and histologic examination. VIDAS C. difficile toxin A II assay was positive and C. glycolicum was isolated in the stool. She recovered after receiving oral metronidazole treatment.
Abdomen ; Abdominal Pain ; Ceftriaxone ; Clostridium difficile ; Clostridium* ; Diarrhea ; Enterocolitis, Pseudomembranous* ; Female ; Humans ; Metronidazole ; Middle Aged ; Ornidazole ; Rectal Neoplasms

PURPOSE: We investigated the clinical difference between single infection and coinfection with respiratory virus in hospitalized children with acute respiratory tract infections. METHODS: We reviewed 727 patients who were admitted with the diagnosis of acute respiratory infection at the Department of Pediatrics, Bundang Jesaeng Hospital between January and December of 2014. Diagnoses were made using the multiplex reverse transcriptase polymerase chain reaction (RT-PCR) assay targeting 16 viruses in nasopharyngeal swabs. Subjects were classified as the single virus infection and coinfection groups. RESULTS: A total of 439 patients were enrolled; 359 (77.2%) under 24 months. Single virus was detected in 279 (63.6%). Coinfection with multiple virus was detected in 160 (36.4%): 126 (28.7%) with 2 viruses, 30 (6.8%), and 4 (0.9%) with 3 to 4 viruses. Viral coinfection was detected in 28 samples (17.5%), with respiratory syncytial virus (RSV) A and rhinovirus being the most dominating combination. There were no clinical differences between the single infection and coinfection groups, except sputum and the frequency of high RSV load. Sputum was significantly more frequent in the coinfection group (P=0.043), and the frequency of high RSV load was significantly higher in the single infection group (P=0.029). Disease severity (high fever, the duration of fever [≥5 days], and the length of hospital stay [≥5 days], O₂ therapy) did not differ significantly between both groups. RSV was a frequent virus of single infection during winter. Coinfection was most common in winter. CONCLUSION: There were no clinical differences between single infection and coinfection, except sputum and the frequency of high RSV load.
Child ; Child, Hospitalized ; Coinfection* ; Diagnosis ; Fever ; Humans ; Length of Stay ; Multiplex Polymerase Chain Reaction ; Pediatrics ; Respiratory Syncytial Viruses ; Respiratory Tract Infections ; Reverse Transcriptase Polymerase Chain Reaction ; Rhinovirus ; Sputum

AIMS: The purpose of this study is to analyze the characteristics of the occupational diseases compensated with the Industrial Accident Compensation Insurance that is operated by the Korea Labor Welfare Corporation (KLWC). METHODS: Using the KLWC database, we collected 4,240 cases of compensated occupational disease occurring between 1 January 2001 and 31 December 2003. We analyzed the characteristics (sex, age, type of occupational disease, exposure material, type of industry and occupation, etc.) of occupational diseases using the KLWC electronic data and compensated with the data of claimed cases investigated by the Korea Occupational Safety and Health Agency (KOSHA). RESULTS: KLWC approved 4,240 cases, including 1,199 deaths (28.3%). Men accounted for 92.6% (3,925 cases) of the approved cases. The most common age group was 50-59 years of age (n=1,433, 33.8%). The majority of diseases were respiratory diseases (2,906 cases, 68.5%), occupational hearing loss (687 cases, 16.2%), infectious disease (238 cases, 5.6%), intoxication (117 cases, 2.8%), skin diseases (111 cases, 2.6%) and cancer (41 cases, 1.0%). The causal hazardous agents were dust (2,870 cases, 67.7%), physical agents (770 cases, 18.2%), biological agents (301 cases, 7.1%), chemical agents (242 cases, 5.7%), and heavy metals (51 cases, 1.2%). The major types of industry were mining and quarrying (2,708 cases, 63.9%), manufacturing (1,112 cases, 26.2%), health and social work (159 cases, 3.8%) and construction (63 cases, 1.5%). The type of occupation included craft and related trades workers (2,622 cases, 61.8%), elementary occupations (730 cases, 17.2%), senior officials and managers (327 cases, 7.7%) and plant and machine operators and assemblers (225 cases, 5.3%). CONCLUSIONS: We were able to elucidate the kinds of occupational disease and the characteristics of workers through this study. Many compensation cases occurred among non-manufacturing and non-mining workers, especially health care workers, and there were various kinds of disease. This suggests that a management policy must be established to prevent occupational diseases occurring among workers in the above types of industry.
Accidents, Occupational* ; Biological Factors ; Communicable Diseases ; Compensation and Redress* ; Delivery of Health Care ; Dust ; Hearing Loss ; Humans ; Insurance* ; Korea ; Male ; Metals, Heavy ; Mining ; Occupational Diseases* ; Occupational Health ; Occupations ; Plants ; Skin Diseases ; Social Work

Melanoacanthoma, a rare benign variant of seborrheic keratosis, was first introduced by Mishima and Pinkus in 1960. It is a slow-growing, painless, pigmented plaque with a verrucous surface and a diameter ranging from a few millimeters to 10 cm. It tends to develop during middle-age with an equal sex incidence, and the lesion usually presents on the head, trunk, and especially the lip. It also has a histopathologic finding of mixed neoplasm composed of melanocytes scattered throughout keratinocytic lobules, and is characterized by hyperkeratosis, parakeratosis, acanthosis, papillomatosis and pseudo-horn cysts in the epidermis. We report a case of melanoacanthoma occurring in a 52-year-old female, who presented with an easily bleeding mass on her right external auditory canal, an extremely uncommon site.
Ear Canal* ; Epidermis ; Female ; Head ; Hemorrhage ; Humans ; Incidence ; Keratosis, Seborrheic ; Lip ; Melanocytes ; Middle Aged ; Papilloma ; Parakeratosis

BACKGROUND: Nitrous oxide inactivates cobalamin which is important in the folate-dependent synthesis of thymidylate. Also, methotrexate has the anti-cancer activity. The aim of this work was to determine the optimal pressure and exposure time of nitrous oxide that maximize the suppression of cancer growth, and the adequate level of methotrexate that maximize the anti-cancer activity of nitrous oxide. METHODS: Acute lymphoblastic leukemic cells and normal lymphocytes were cultured in hyperbaric chamber at 1, 2 and 3 atm of 74% nitrous oxide in 24, 48 and 72 hours at 0, 0.3, 0.5 and 0.7 micrometer of methotrexate, respectively. The results were expressed in the ratio of cell number in hyperbaric chamber to that in the incubator. RESULTS: Compared to control, the growth rates of cancer cells and lymphocytes were 0.767, 0.990 at 1 atm, 0.592, 0.880 at 2 atm and 0.718, 0.864 at 3 atm of nitrous oxide in 24 hours. The survival fraction of cancer cells and lymphocytes were 0.767, 0.894 in 24 hours, 0.800, 0.630 in 48 hours, and 0.571, 0.597 in 72 hours, at 1 atm of nitrous oxide. The growth rates of cancer cells and lymphocytes were 1.012, 0.745 at 0 micrometer, 0.912, 0.696 at 0.3 micrometer, 0.77, 0.647 at 0.5 micrometer and 1.133, 0.506 at 0.7 micrometer of methotrexate. CONCLUSIONS: The pressure increase of nitrous oxide significantly suppressed the growth of lymphocyte but not cancer cells. However, growth of cancer cells and lymphocytes were significantly reduced at high concentration of methotrexate and larger exposure time.
Cell Count ; Incubators ; Leukemia ; Lymphocytes ; Methotrexate* ; Nitrous Oxide* ; Vitamin B 12

OBJECTIVES: The purpose of this study is to analyze the characteristics of occupational diseases listed by Korea Labor Welfare Corporation(KLWC). METHODS: Using the database of the KLWC, we collected 575 approved occupational disease cases occurring between 1 January and 31 December 1999 and approved by the thirtieth June in 2000. We investigated the characteristics(sex, age, occupational history, kinds of occupational disease, exposure material, type of enterprises, etc.) of occupational disease using a mail survey and telephone interviews. RESULTS: Men accounted for 88.9 %(511 workers) of the approved cases. 56 cases(9.7%) died of occupational disease. The most common age group was 50~59 years of age(n=217, 37.7 %). The proportion of workers with grater than ten years disease related working condition exposure were 195(49.0 %). The majority of diseases were respiratory problems(211 workers, 22.4 %), occupational hearing loss(149 workers, 25.9 %), infectious disease(69 workers, 12.0 %), intoxication(60 workers, 10.4 %), skin disease(29 workers, 5.0 %) and cancer(17 workers, 3.0 %). The causal hazardous agents were dusts(209 cases, 36.3 %), physical agents(157 cases, 27.3 %), chemical agents(89 cases, 16.3 %), biological agents(82 cases, 14.3 %) and workrelated agents(34 cases, 5.9 %). The major types of enterprise were manufacturing(262 workers, 45.6 %), mining and quarrying(174 workers, 30.3 %), public administration(42 workers, 7.3 %) and the health care industry(28 workers, 4.9 %). The kinds of job included craft and related trades workers(285 workers, 49.6 %), plant or machine operators and assemblers(139 workers, 24.2 %), elementary occupations(72 workers, 12.5 %) and professionals(28 workers, 4.9 %). CONCLUSIONS: We were able to elucidate the kinds of occupational disease and the characteristics of workers through this study. Many approved cases occurred among nonmanufacturing and non-mining workers and the kinds of disease were varied. This suggests that management policy must be established to prevent occupational disease occurring among workers in the above type of industries.
Delivery of Health Care ; Hearing ; Humans ; Interviews as Topic ; Korea* ; Male ; Mining ; Occupational Diseases* ; Plants ; Postal Service ; Skin