1.The Association Between Degenerative Arthritis of the Lumbar Spine and Obesity
Woo Chun LEE ; Moon Sik HAHN ; Choon Seong LEE
The Journal of the Korean Orthopaedic Association 1982;17(6):1080-1088
Degenerative arthritis of the lumbar spine is one of the main causes of the low back pain over the fifth decade of life. Nowadays, it seems that the number of obese person increases gradually and the role of Obesity in the development of articular degeneration remains controversial. The authors studied 100 cases of the primary degenerative arthritis of the lumbar spine clinically and statistically and compared 50 cases among these with 2 control groups, with and without low back pain, from Mar. 1982 to Sep. 1982. The results were as follows: 1. Among the patients with the degenerative arthritis of the lumbar spine, the ratio of male to female was 1:4, and the age group with the highest frequency was the 6th decade (47%) 2. 44% was obese in the arthritis group and 26% in the control group with low back pain and 12% in the control group without low back pain. 3. The relative risk of the hypothesis that the arthritic patient is obeser than the patient with low back pain but without degenerative changes on X-ray was 2.3, but the hyposthesis was proved to be statistically insignificant. The relative risk of the hypothesis that the arthriticpatient was obeser than the patient without low back pain and degenerative changes on X-ray was 6.3 and proved to be statistically significant.
Arthritis
;
Female
;
Humans
;
Low Back Pain
;
Male
;
Obesity
;
Osteoarthritis
;
Spine
2.Electromicroscopic Characterization about Vibrio alginolyticus Phage Isolated from Marine Products.
Jin Woo JU ; Seong A JU ; Moon Soo HEO ; So Gyem YOON ; Joo An OK ; Byoung Gon MOON
Journal of the Korean Society for Microbiology 1997;32(1):91-101
The study of bacteriophage began by F.W. Twort in 1915 and the lytic cycle recognized by d'Herellel in 1917. It repeated about the marine bacteriophage containing Vibrio phage by Smith, Spencer and Ju. Authors isolated 2 virulent phages for the pathogenic V. alginolyticus from marine products. These 2 phages were examined their ultrastructure & host-infection by elecron microscopy and in vivo test using skin of rats. V. alginolyticus phages(VAPs) fomed plaques about 0.5 - 0.9mm in diameter and bands 50 - 60% in sucrose density gradient. VAP had 50 - 120nm tail and 40 - 90nm head in diameter. In vivo test, using rat skin, as well as in vitro test VAP had the activity to V. alginolyticus isolated.
Animals
;
Bacteriophages*
;
Coriolaceae
;
Head
;
Microscopy
;
Rats
;
Skin
;
Sucrose
;
Tail
;
Vibrio alginolyticus*
;
Vibrio*
4.Intravitreal Phacofragmentation.
Man Seong SEO ; Je Moon WOO ; In seob LIM
Journal of the Korean Ophthalmological Society 1996;37(2):244-251
We reviewed the records of seven patients who underwent pars plana vitrectomy and intravitreal phacofragmentation for removal of posteriorly dislocated lenses from September 26, 1994. to January 12, 1995. More than half volumes of crystalline lenses were dislocated during cataract extraction in four eyes, and all three eyes of dislocated lenses with intact capsules had a history of blunt trauma. Five eyes had visual acuity of 15/20 or better at 3 months after removal of intravitreal crystalline lenses. But two eyes, undergone excessive manipulation for removing intravitreal nuclear fragments via the limbus during cataract operation, had 4/20 vision with complication of retinal or choroidal detachment. These results suggest that the overall prognosis for visual recovery after pars plana vitrectomy and phacofragmentation for removal of intravitreal crystalline lens, is quite good if there were no excessive attempts to remove intravitreal lens fragment during cataract extraction.
Capsules
;
Cataract
;
Cataract Extraction
;
Choroid
;
Humans
;
Lens, Crystalline
;
Prognosis
;
Retinaldehyde
;
Visual Acuity
;
Vitrectomy
5.Purification Siderophore from Vibrio mimicus ATCC 33653 and its Effect to Bacterial Pathogenecity.
Soo Jung PARK ; Seong A JU ; Moon Soo HEO ; Cho Rock JUNG ; Jin Woo JU
Journal of the Korean Society for Microbiology 1999;34(5):461-470
Growth under conditions of iron-restriction and the production of siderophore was examined in Vibrio mimicus ATCC 33653. This strain grew and multiplied in the presence of the high-affinity iron chelators ethylenediamine-di (o-hydroxyphenylacetic acid). Chrorne azurol S (CAS) agar and solution were used to detect the production of siderophore under these condition. Siderophore could be detected in the iron-rcstricted culture supernatants. The siderophore was extracted from iron-restricted culture supernatants by phenol-chloroform-ether method and purified by Dowex ion-exchange and Sephadex G-25 gel filtracton chromatography. The purified siderophore was confirmed by paper chromatography and HPLC. The Purified siderophore enhanced the growth of V. mimicus when the bacterium was grown in iron limited medium. Injection of both the siderohore and the bacteria to mice resulted in more rapid death than that of the only bacteria. However, the siderophore did not show lethality to mice and any toxicity to cell line like HeLa and U937.
Agar
;
Animals
;
Bacteria
;
Cell Line
;
Chelating Agents
;
Chromatography
;
Chromatography, High Pressure Liquid
;
Chromatography, Paper
;
Iron
;
Mice
;
Vibrio mimicus*
;
Vibrio*
6.Characterization of a Vibrio parahaemolyticus Phage Isolated from Marine.
Sun Ok YOON ; Seong A JU ; Moon Soo HEO ; Cho Rok JUNG ; Jin Woo JU
Journal of the Korean Society for Microbiology 1999;34(5):423-433
A novel bacteriophage, designated as VPP97, that infects the strains of Vibiro parahaemolyticus (hallophilic, Gram-negative bacterium) isolated most commonly from marine environments, has been discovered, and several of its properties have been determined. The plaques were clear and sized 0.6-1.0 mm in diameter. The virion forms a single band on 70% sucrose gradient and p1.50 CsC1 gradient by sucrose gradient centrifugation and CsCI gradient centrifugation respectively. It has a hexagonal head and a relatively long tail, as shown by electron microscopy. Vibrio alginolyticus, Vibrio fluvialis and Vibrio furnissii were also sensitive to this phage It was almost totally inactivated at 70 degree C and at pH below 5 or over 10. The nucleic acid of VPP97 is composed of DNA. The VPP97 had 9 specific structural proteins sized between 21.5 kDa and 97.4 kDa on SDS-PAGE. When V. parahaemolyticus cultures were treated with either phage VPP97 or one of the several antibiotics for 2 hours, the viable number of V. parahaemolyticus treated with the phage VPP97 is lower than that treated with chloramphenicol, erythromycin or penicillin, but not lower than that treated with tetracycline. Mice that have responded to the phage treatment revealed the lower numbers of V. parahaemolyticus in small intestine and less damage on small intestine compared to the untreated mice. Therefore, we suggest that the phage treatment appears effective to the infection by V. parahaemolyticus.
Animals
;
Anti-Bacterial Agents
;
Bacteriophages*
;
Centrifugation
;
Chloramphenicol
;
DNA
;
Electrophoresis, Polyacrylamide Gel
;
Erythromycin
;
Head
;
Hydrogen-Ion Concentration
;
Intestine, Small
;
Mice
;
Microscopy, Electron
;
Penicillins
;
Sucrose
;
Tail
;
Tetracycline
;
Vibrio alginolyticus
;
Vibrio parahaemolyticus*
;
Vibrio*
;
Virion
7.Arthroscopy of the Knee Joint: A Study of 100 Knees
Sang Cheol SEONG ; Han Koo LEE ; Moon Sik HAHN ; Woo Chun LEE ; Hee Joong KIM
The Journal of the Korean Orthopaedic Association 1983;18(6):1141-1147
No abstract available in English.
Arthroscopy
;
Knee Joint
;
Knee
8.A case of abdominao-sacral resection of leiomyosarcoma of rectum combined with sacrectomy.
Bong Hwa LEE ; Kyoung Sik KIM ; Hong Moo KIM ; Seong Moon NAM ; Joon Yang NOH ; Ze Hong WOO
Journal of the Korean Society of Coloproctology 1991;7(1):71-76
No abstract available.
Leiomyosarcoma*
;
Rectum*
9.Apolipoprotein E Polymorphism in Patients with Ischemic Cerebrovascular Disease.
Moon Ho PARK ; Seong Beom KOH ; Byung Jo KIM ; Min Kyu PARK ; Kun Woo PARK ; Dae Hie LEE
Journal of the Korean Geriatrics Society 2001;5(2):151-158
BACKGROUND: The possible role of apolipoprotein E (APOE for gene, apoE for protein) allele in atherosclerotic diseases is not clearly understood. For the putative role of APOE genotypes, we examined APOE polymorphism among patients with stroke. METHODS: A total of 202 ischemic stroke patients were involved in this study. The genotype DNA was isolated from whole blood and the APOE alleles were determined by polynicrase chain reaction. RESULTS: The genotype of APOE epsilon3/3 was the most common allele in the stroke group and the control group. The frequencies of APOE epsilon2, epsilon3, epsilon4 allele in stroke group were 0.052, 0.851, and 0.097, respectively. There was no significant difference in APOE genotypes between the stroke group and the control group. No significant associations lions were found for the APOE genotypes and the serum lipid profiles. CONCLUSION: These findings suggest that APOE was not related to the stroke,
Alleles
;
Apolipoprotein E2
;
Apolipoproteins E
;
Apolipoproteins*
;
DNA
;
Genotype
;
Humans
;
Lions
;
Stroke
10.MR Imaging of Lipomatous Soft Tissue Tumor: Histopathologic Correlation.
Sung Moon LEE ; Seong Ku WOO ; Hee Jung LEE ; Mi Young HWANG ; Soo Ji SUH ; Sun Goo KIM
Journal of the Korean Radiological Society 1994;31(5):941-947
PURPOSE: The purpose of this study to access MR findings of the lipomatous soft tissue tumor based on histopathologic correlation and its predictability of the histopathologic diagnosis. MATERIALS AND METHODS: We retrospectively analyzed the MR findings and photomicrographs of 9 patients with histopathologically proven lipomatous soft tissue tumors as follows;classic lipoma(4), fibrolipoma(1), lipoblastoma(2), atypical l ipoma(1) and well-differentiated liposarcoma(1). RESULTS: All cases of lipoma showed the same signal intensities as subcutaneous fat which is composed of mature fat cells. Linear low signal intensity lesions corresponded to fibrous connective tissues within lipomas. Two cases of lipoblastoma showed heterogeneous signal intensity with areas of high signal intensity brighter than subcutaneous fat on T2WI, corresponding to myxoid matrix of cytoplasm of immature lipoblasts, and the areas of myxoid degeneration within tumors. Both atypical lipoma and liposarcoma showed heterogeneous signal intensity with ill-defined margins due to presence of lipoblasts and infiltration to adjacent muscle bundles. CONCLUSION: MR image findings were well correlated with histopathologic findings of lipomatous soft tissue tumor, especially with maturity of fat cells and the signal intensity of mesenchymal components within the tumors. MR may predict the pathologic diagnosis of lipoblastoma by presence of myxoid degeneration within Ihe tumor, but atypical lipoma and liposarcoma revealed similar MR findings.
Adipocytes
;
Connective Tissue
;
Cytoplasm
;
Diagnosis
;
Humans
;
Lipoblastoma
;
Lipoma
;
Liposarcoma
;
Magnetic Resonance Imaging*
;
Retrospective Studies
;
Subcutaneous Fat