No abstract available.
Krukenberg Tumor*

Normal micturition is usually accomplished by 3 years of age. We have experienced micturition dysfunction in neurologically and anatomically normal children, but we are embarrassed in identifying the exact cause of each case and searching for the treatment modalities. I thought there was a possibility of lower urinary tract dysfunction as an evoking factor of micturition dysfunction and so I conducted urodynamic study in neurologically and anatomically normal children with micturition dysfunction at Yonsei University Hospital from April, 1984 till December, 1986 and have come to the conclusion as follows ; 1. There was normal urodynamic findings in 9 cases(26.5%) and single abnormal findings in 18 cases(52.9%) which were composed of 6 cases(17.6%) of unstable bladder findings, 2 cases(5.9%) of hypersensitive bladder, 9 cases(26.5%) of high maximum urethral closure pressure and 1 case(2.9%) of detrusor-sphincter dyssynergia and combined abnormal findings in 7 cases(20.6%). High maximum urethral closure pressure finding, which was main abnormal one were found in 13 cases(38.2%), while unstable bladder in 12 cases(35.3%) among 34 children with micturition dysfunction. 2. Among the urodynamic parameters under anesthetic or awaken state, only the mean value of percentage of bladder capacity to normal was significantly higher in anesthetic group than awaken group. 3. Among the urodynamic parameters according to single symptom, all(percentage of bladder capacity to normal, maximum urethral closure pressure) were lower in incontinent group and maximum urethral closure pressure was higher in frequency group, but these differences were not statistically significant. 4. The satisfactory result of conservative treatment was found in 25 cases(73.5%), and was better in the group with single abnormal finding than with combined abnormal finding. In conclusion, the urodynamic study is essential to get the diagnosis and give the treatment accurately, but there should be more technical improvement doing in pediatric age group.
Ataxia ; Child* ; Diagnosis ; Humans ; Urinary Bladder ; Urinary Tract ; Urination* ; Urodynamics*

OBJECTIVE: The present study was designed to identify the acute and chronic immobilization stress-induced polyamine (putrescine) responses and their modulation by administration of melatonin in brain regions (frontal cortex and hippocampus) and gastrointestinal tract regions (GIT, gastric mucosa and duodenal mucosa). METHOD: For immobilization stress (3 or 14 days), rats (250-300 g, male Sprague-Dawley rats) were placed in restrainers once daily, for 3 h. Melatonin (10 mg/kg, i.p.) was administered once daily immediately after stress. Rats were sacrificed 2 h after the final application of stress for the measurement of putrescine levels. RESULTS: The putrescine levels of frontal cortex, hippocampus, gastric mucosa and duodenal mucosa were significantly increased by acute stress (p<0.05, p<0.05, p<0.0005 and p<0.01, respectively). The putrescine levels of frontal cortex and duodenal mucosa were significantly increased by chronic stress (p<0.05, respectively). In chronic stress group, animals showed adaptation tendency. The changes of putrescine level in gastric and duodenal mucosa induced by chronic stress were significantly lower than those by acute stress (p<0.05, respectively). The putrescine responses to acute stress in frontal cortex, hippocampus, gastric mucosa and duodenal mucosa were attenuated by administration of melatonin (p<0.01, p<0.05, p<0.05 and p<0.05, respectively). The putrescine response to chronic stress in frontal cortex was attenuated by melatonin administration (p<0.05, respectively). CONCLUSION: The results suggested that putrescine may play a role in stress response of brain regions (frontal cortex and hippocampus) and GIT regions (gastric and duodenal mucosa). Melatonin can inhibit the stress-induced putrescine responses in the brain and GIT.
Animals ; Brain* ; Gastric Mucosa ; Gastrointestinal Tract* ; Hippocampus ; Humans ; Immobilization* ; Male ; Melatonin* ; Mucous Membrane ; Putrescine ; Rats ; Rats, Sprague-Dawley

Adenoid cystic carcinoma is a rare disease of which incidence is 10-15 % of bartholins gland carcinoma. The clinical presentation is characterized by a vulval mass that existed for a prolonged period to the onset of symptoms, usually infection, pain, and burningsensation Histologically, this tumor is characterized by cribriform pattern cell growing and perineural invasion. The obtaining of clear surgical margins is the most important aspect of treatment. Here we report a case of adenoid cystic carcinoma of the Bartholins gland with a brief review of literature.
Adenoids* ; Carcinoma, Adenoid Cystic* ; Incidence ; Rare Diseases

Uterine papillary serous carcinoma is a morphologically distinct variant of endometrial carcinoma that is associated with an aggressive behavior with rapid progression and high recurrence, and poor response to salvage treatment. The most common type of malignancy developing in the uterus after radiation therapy is the malignant mixed mullerian tumor, however, the papillary serous carcinomas have rarely been reported.Here we report a case of uterine papillary serous carcinoma which had developed 7 years after radiation therapy for invasive cervical cancer.
Endometrial Neoplasms ; Female ; Recurrence ; Uterine Cervical Neoplasms ; Uterus

A retrospective study was designed to determine the diagnostic contribution of oblique view in 740 consecutive lumbar spine examinations done in adults. In 12 cases (1.62%) there was a change in the radiographic interpretation when the oblique views were used for diagnosis. Considering the significant gonadal radiation, additional cost, and limited diagnostic value, the authors feel that the oblique view should not be a routine part of the initial lumbar spine examination in adults.
Adult ; Diagnosis ; Gonads ; Humans ; Retrospective Studies ; Spine

The diagnosis of ovarian tumor has been mainly dependent on manual pelvic examination and ultrasonography. Butin case of malignant ovarian tumor, CT has more advantages over ultrasonography in assessing anatomic details,relationships to bowel loops, precise extents of tumors and follow-up examinations after surgery. Authors analyzedCT features of 46 cases of patholgocially proven ovarian tumors for recent 4 years at keimyung University DongsanHospital. The results were as follows: 1. The msot common tumor was serous cystadenocarcinoma(9 cases:20%),followed by metastases(8 cases: 17%), mucinous cystadenocarcinoma(7 ases:15%), mucinous cystadenocarcinoma(5cases:11%), teratoma(5 cases:11%), lymphoma(3 cases: 7%) and dysgerminoma(2 cases:4%). 2. The ovarian tumors werevariable in size from 2.5cm to 33cm in diameter. Most of the solid tumors were smaller than 10cm in diameter andmost of the cystic tumors were larger than 10cm in diameter. Usually mucinous tumors were much larger than seroustumors. Mucinous cystadenomas were the largest tumors. 3. Unilateral tumors(left 19,right 13 cases) were morecommon than bilateral tumors(12 cases). Bilateral tumors were seen in serous and mucinous cystadenocarcinoma,metastases and lymphoma. 4. CT features of mucinous cystadenomas were smooth margins and thin wall of the tumormasses and multiloculated cysts with internal septa in all 7 cases. 5. In contrast, CT demonstration ofbilaterality, irregular margin, thick wall, enhancing solid lesions, septal irregularity, adhesion to adjacentstructures, peritoneal/omental implantation, ascites and hydronephrosis were signs suggesting malignancy. CTfeaturs of the serous cystadenocarcinoma were mostly solid to mixed nature(83%), irregular margin(75%), enhancingsolid lesion(67%), papillary growth (75%), internal septa(58%), multilocularity (58%) and calcification (25%) indescending order of frequency. 6. On CT, mucinous cystadenocarcinoma were irregular-marginated, thick-walled,cystic tumors with enhancing solid lesion, septal irregularity and signs of metastasis, although there were somecases having similar features of benign. 7. Among the extrapelvic CT findings of malignant epithelial ovariantumor, peritoneal/omental implants(11 cases:79%) and ascites(10 cases:71%) were the most common, and indistinctuterus(6 cases:43%), bowel adehsion(5 cases:36%) and pseudomyxoma peritonei (2 cases) were descending order offrequency. 8. CT features of teratoma were diagnostic having at least three more of different tissue densitiesamong fat, water, soft tissue and calcific densities. Also there were thick wall (4 cases) and fat-fluid level(1case). 9. In 8 cases of ovarian metastases, there were solid type tumor smaller than 10cm in 4 cases and hugecystic in 2 cases. The site of primary cancer were stomach in 4 cases, colon , cervix, endometrium and unknown ineach one case. 10. In 3 cases of malignant lymphoma, the CT featurs were solid in appearance, smaller than 10cmand accompanied by lymphadenopathy in all cases.
Ascites ; Cervix Uteri ; Colon ; Cystadenocarcinoma, Mucinous ; Cystadenocarcinoma, Serous ; Cystadenoma, Mucinous ; Diagnosis ; Endometrium ; Female ; Follow-Up Studies ; Gynecological Examination ; Hydronephrosis ; Lymphatic Diseases ; Lymphoma ; Mucins ; Neoplasm Metastasis ; Pseudomyxoma Peritonei ; Stomach ; Teratoma ; Ultrasonography ; Water

PURPOSE: Matrix metalloproteinase-2 (MMP-2) and MMP-7 have been implicated in tumor growth and metastasis. This study aimed to investigate the expressions of MMP-2 and -7 in colorectal cancer and to evaluate their values as prognostic markers. METHODS: Immunohistochemical staining for MMP-2 and -7 was done in 144 resected colorectal cancer specimens. Clinicopathological data and survival results were compared with regard to the expression results. RESULTS: The expression rates of MMP-2 in tumor cells in the tumor center and the tumor border were 16.7% and 38.9%, respectively. That of MMP-2 in stromal cells was 27.8%. MMP-7 immunoreactivities of tumor cells in the tumor center and the tumor border were 6.9% and 23.6%. The expressions of MMP-2 and MMP-7 were correlated. MMP-2 expression in stromal cells was more increased in the distal part of the colorectum: 8.8% in right colon cancer, 29.5% in left colon cancer and 36.4% in rectal cancer. MMP-2 expression of tumor cells in the tumor border was correlated with T-stage. MMP-7 expression of tumor cells in the tumor border was increased in case of infiltrative cancer compared with fungating tumor. The expression patterns of MMP-2 and -7 were not correlated with other clinicopathological factors, including tumor markers, node metastasis, distant metastasis, lymphatic invasion, tumor differentiation, and recurrence. No significant associations between the overall and disease-free survival rates and the MMP-2 and -7 expression patterns were noted. CONCLUSION: The high expression rates of MMP-2 and -7 in tumor borders suggest that MMP-2 and -7 have some role in tumor invasion, but in this study, MMP-2 and -7 did not appear to be significant predictors of prognosis in colorectal cancer.
Colonic Neoplasms ; Colorectal Neoplasms ; Disease-Free Survival ; Immunohistochemistry ; Lymphatic Metastasis ; Matrix Metalloproteinase 2 ; Matrix Metalloproteinases ; Neoplasm Metastasis ; Prognosis ; Rectal Neoplasms ; Recurrence ; Stromal Cells ; Biomarkers, Tumor

No abstract available.
Anemia* ; Gastrectomy* ; Vitamin B 12 Deficiency* ; Vitamin B 12* ; Vitamins*

Priapism is a rare disease, but needs early intervention and appropriate management. We present 2 cases of ischemic low-flow priapism after intracavernosal injection of vasoactive drug. 43-year-old man and 61-year-old man visited our clinic complaining of continuous plan and erection persisting for several days after self cavernosal injection for increasing their erectile function. We performed blood gas analysis of cavernosal blood and color doppler ultrasound. And so we confirmed the diagnosis of low-flow priapism. Detumescence was finally achieved after the proximal shunt operation. Their erectile function was not recovered and they became permanent impotence.
Adult ; Blood Gas Analysis ; Diagnosis ; Early Intervention (Education) ; Erectile Dysfunction ; Humans ; Male ; Middle Aged ; Priapism* ; Rare Diseases ; Ultrasonography