1.Intralesional Recombinant Alpha-2a Interferon for the Treatment of Patients With Verruca.
Seung Won AHN ; Seong Joon SEO ; Chang Kwun HONG
Annals of Dermatology 2000;12(3):155-159
BACKGROUND: Interferon alpha-2a has already been shown to be effective in clinical use of virus-originated diseases such as hairy cell leukemia, condyloma acuminatum, and AIDS-related Kaposi's sarcoma. The use of recombinant alpha-interferon may allow common warts to be treated relatively atraumatically and with less incidence of recurrence. OBJECTIVE: We tried to determine the safety and effectiveness of intralesional injections of recombinant alpha-2a interferon in the treatment of patients with common warts. METHODS: A single wart on each patient was weekly injected with 0.75 to 1.5×10(5) IU/25mm2 of interferon for 8 weeks, and the response to treatment was followed up-to 6 months. RESULTS: Clearing of the treated wart at the end of treatment occurred in 5(71%) out of 7 patients and the rest showed no improvement. With evaluation for relapses up-to 6 months after treatment, warts relapsed in 2(40%) out of 5 patients. Therefore, 3(43%) out of 7 patients were completely free of warts 6 months after treatment. CONCLUSION: Intralesional recombinant interferon alpha-2a has a limited therapeutic effect, but may be considered as a therapeutic modality of recalcitrant verruca or when it can be anticipated that destructive techniques or blistering agents will not be tolerated.
Blister
;
Humans
;
Incidence
;
Injections, Intralesional
;
Interferon-alpha
;
Interferons*
;
Leukemia, Hairy Cell
;
Recurrence
;
Sarcoma, Kaposi
;
Warts*
2.A Case of Recurrent Fetal Cystic Hygroma with Polycystic Kidney.
Seong Hee KIM ; Ji Won SIN ; Hyeon Joo KIM ; Seong Sook SEO ; Hyeon Mi HA
Korean Journal of Obstetrics and Gynecology 1997;40(8):1756-1762
This is a case report of a cystic hygroma with polycystic kidney in a fetus which was suspected by ultrasonography and was confirmed by autopsy. Recently, we have experienced this case in 25-year old woman repeatedly and we report that with a brief review of relevant literature.
Adult
;
Autopsy
;
Female
;
Fetus
;
Humans
;
Lymphangioma, Cystic*
;
Polycystic Kidney Diseases*
;
Ultrasonography
3.Unusual Cutaneous Neutrophilic Infiltration in Myelodysplasia Syndrome : A Nuclear Segmentation Anomaly.
Seong Jin KIM ; Jae Jeong SEO ; Seung Chul LEE ; Young Ho WON
Annals of Dermatology 1998;10(4):270-273
We report a case of myelodysplastic syndrome (MDS) with unique histopathological findings in which numerous infiltrated neutrophils exhibited nuclear segmentation anomalies. In comparison with well-described neutrophilic dermatoses of myelodysplastic syndrome such as Sweets syndrome and pyoderma gangrenosum, this case took a rapid and aggressive clinical course. We suggest that a nuclear segmentation anomaly, pseudo Pelger-Hiiet anomaly, is likely to reflect acute transformation of MDS and can be a poor prognostic marker.
Myelodysplastic Syndromes
;
Neutrophils*
;
Pyoderma Gangrenosum
;
Skin Diseases
;
Sweet Syndrome
4.A Case of Hypereosinophilic Syndrome.
Jae Won KIM ; Seong Jun SEO ; Chang Kwun HONG ; Byung In RO
Korean Journal of Dermatology 1994;32(3):503-508
Hypereosinophilic syndrome represents a heterogenous group filisorders with the common features of idiopathic prolonged eosinophilia of undetectable cause and orgar, system dysfunction. We experienced a case af hypereosinophilic syndrome in a 58 year old man who has been suffered from fever, chilling, generelized exfoliative dermatitis, periorbital sngioedema and oral ulcer for 3 weeks duration. The blood eosinophil count was 7436/mm and skin, liver, bone marrow biopsy revealed marked infiltration of eosinophils. We treated him with co ticosteroid, but 5 months later, he died due to hepatoencephalopathy, hepatorenal syndrome, dissernimted intravascular coagulopathy and acute respiratory distress syndrome.
Biopsy
;
Bone Marrow
;
Dermatitis, Exfoliative
;
Eosinophilia
;
Eosinophils
;
Fever
;
Hepatorenal Syndrome
;
Humans
;
Hypereosinophilic Syndrome*
;
Liver
;
Middle Aged
;
Oral Ulcer
;
Respiratory Distress Syndrome, Adult
;
Skin
5.Predictive Value of Urinary Cytology in the Recurrence and the Progression of Superficial Bladder Cancer.
Seong Won SEO ; Jae Yong CHUNG ; Choong Hee NOH
Korean Journal of Urology 1997;38(12):1305-1310
A retrospective analysis was done on 68 patients with primary superficial bladder cancer between September 1989 and December 1995. We evaluated the predictive value of urine cytology in the recurrence and the progression of superficial bladder cancer. Positive cytology was shown in 52.9% (36/68) and was significantly associated with tumor grade (p=0.001). The recurrence rate in patients with negative cytology was 28.1% (9/32) compared to 77.8% (28/36) in those with positive cytology (p=0;001). No patients of negative cytology had tumor progression while 4 out of 36 (11.1%) patients of positive cytology had progression to invasive or metastatic disease. In conclusion, urinary cytology appears to be a significant prognostic factor in superficial bladder cancer.
Humans
;
Recurrence*
;
Retrospective Studies
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*
6.A case of Hypokalemic Familial Periodic Paralysis.
Seong Kuk SEO ; Gyu Ha LEE ; Han Young JEONG ; Sung Won KIM ; Kil Hyun KIM
Journal of the Korean Pediatric Society 1989;32(7):1012-1016
No abstract available.
Paralyses, Familial Periodic*
7.Keratoacanthoma in Co-existence with Nevus Sebaceus.
Seung Won AHN ; Tae Jong CHUN ; Seong Joon SEO ; Chang Kwun HONG
Annals of Dermatology 2000;12(2):138-140
Nevus sebaceus of Jadassohn has been referred to as a organoid nevus that classically evolves through three stages and may be associated with a range of skin tumors, and of these, syringocystadenoma papilliferum and basal cell carcinoma have been commonly reported to occur. The occurrence of keratoacanthoma is a very rare event in nevus sebaceus. Herein we report on a 23-year-old man with nevus sebaceus of the cheek. He represents a keratoacanthoma arising within nevus sebaceus.
Carcinoma, Basal Cell
;
Cheek
;
Humans
;
Keratoacanthoma*
;
Nevus*
;
Nevus, Sebaceous of Jadassohn
;
Organoids
;
Skin
;
Young Adult
8.Two Cases of Cellulitis on the Saphenous Venectomy Scar after a Coronary Artery Bypass Graft.
Jae Jeong SEO ; Seong Jin KIM ; Seung Chul LEE ; Inn Ki CHUN ; Young Ho WON
Korean Journal of Dermatology 1998;36(1):177-180
We report two cases of cellulitis on the saphenous venectomy scar which developed after a coronary artery bypass graft(CABG). A 68-year-old male and a 62-year-old female developed acute cellulitis in the saphenous vein donor extremity after CABG. The repeated bacterial cultures were negative in both cases. However, onychomycosis was confirmed in one patient. The intervals between CABG and the initial bout of cellulitis in the male and female patient were 10 and 22 months, respectively. Although the exact pathogenesis remains obscure, factors such as direct bacterial infection, hypersensitivity to streptococcal exotoxins, a local compromise of lymphatic and venous drainage, and fungal infection might have contributed to the development of cellulitis in these patients.
Aged
;
Bacterial Infections
;
Cellulitis*
;
Cicatrix*
;
Coronary Artery Bypass*
;
Coronary Vessels*
;
Drainage
;
Exotoxins
;
Extremities
;
Female
;
Humans
;
Hypersensitivity
;
Male
;
Middle Aged
;
Onychomycosis
;
Saphenous Vein
;
Tissue Donors
9.A Case of Hydrops Fetalis due to Rh-Incompatibility.
Seong Kuk SEO ; Han Young JEONG ; Sung Won KIM ; Kil Hyun KIM
Journal of the Korean Pediatric Society 1989;32(2):256-261
No abstract available.
Edema*
;
Hydrops Fetalis*
10.A Case of Hydrops Fetalis due to Rh-Incompatibility.
Seong Kuk SEO ; Han Young JEONG ; Sung Won KIM ; Kil Hyun KIM
Journal of the Korean Pediatric Society 1989;32(2):256-261
No abstract available.
Edema*
;
Hydrops Fetalis*