No abstract available.
Humans

OBJECTIVE: There have been several evidences that the central nervous system deflect is one of the etiologic factor in schizophrenia and minor physical anomalies can reflect these deflects indirectly. These central nervous deflects are particularly related to the negative symptoms of schizophrenia. In this study, we examined the relationship between minor physical anomalies and psychopathology in schizophrenia. METHODS: Forty-four patients(22 males, 22 females) satisfying the DSM-IV criteria for schizophrenia were measured for minor physical anomalies by using Waldrop Anomaly Scale(WS) and we used Positive and Negative Syndrome Scale(PANSS), Ulmann-Giovannoni Process-Reactive Questionnaire(PRQ), and Phillips Premorbid Adjustment Scale(PAS) for evaluating psychopathology and clinical variables. RESULTS: Schizophrenic patients had a higher group mean WS score than that found in the control group. Score of WS was correlated with PANSS and PAS score positively, and with PRQ score negatively. CONCLUSION: This study shows minor physical anomalies are associated with clinical variables with regard to symptom severity, poor premorbid adjustment and process of illness in at least some schizophrenics.
Adult* ; Central Nervous System ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Male ; Psychopathology ; Schizophrenia

Adenoid cystic carcinoma is a rare disease of which incidence is 10-15 % of bartholins gland carcinoma. The clinical presentation is characterized by a vulval mass that existed for a prolonged period to the onset of symptoms, usually infection, pain, and burningsensation Histologically, this tumor is characterized by cribriform pattern cell growing and perineural invasion. The obtaining of clear surgical margins is the most important aspect of treatment. Here we report a case of adenoid cystic carcinoma of the Bartholins gland with a brief review of literature.
Adenoids* ; Carcinoma, Adenoid Cystic* ; Incidence ; Rare Diseases

Systemic lupus erythematosus is a connective tissue disease which can affect every organ system. Neurologic abnormalities are common, occuring in approximately half of all patients at some time during the course of their illness. But symptoms of nervous system as the sole presenting symptoms occur in less than 1% of lupus patients. In patients initially presenting with neurologic symptoms and signs, differential diagnosis is difficult and sometimes it may be misdiagnosed. Therefore extensive laboratory investigations should be carried out in all patients with unusual neurological symptoms, since early diagnosis of lupus can help in providing effective treatment. We report a patient with systemic lupus erythematosus who presented with dysarthria and dysphagia resembling multiple sclerosis.
Connective Tissue Diseases ; Deglutition Disorders ; Diagnosis, Differential ; Dysarthria ; Early Diagnosis ; Humans ; Lupus Erythematosus, Systemic* ; Multiple Sclerosis* ; Nervous System ; Neurologic Manifestations

No abstract available.
Osteomyelitis*

A wide variety of cancers metastasize to the ovaries. In a majority of instances the primary site is the gastrointestinal tract, breast, or other gynecologic organs. The best known tumor of this type is signet-ring cell adenocarcinoma. The gallbladder and bile duct are rare sources of these metastases. The authors have had an experience of a case that was presented of Krukenberg tumor metastatic from the gallbladder and report the case with brief review of literature.
Adenocarcinoma ; Bile Ducts ; Breast ; Female ; Gallbladder* ; Gastrointestinal Tract ; Krukenberg Tumor* ; Neoplasm Metastasis* ; Ovary

BACKGROUND/OBJECTIVES: Artemisinin, a natural product isolated from Gaeddongssuk (artemisia annua L.) and its main active derivative, dihydroartemisinin (DHA), have long been used as antimalarial drugs. Recent studies reported that artemisinin is efficacious for curing diseases, including cancers, and for improving the immune system. Many researchers have shown the therapeutic effects of artemisinin on tumors such as breast cancer, liver cancer and kidney cancer, but there is still insufficient data regarding glioblastoma (GBM). Glioblastoma accounts for 12-15% of brain cancer, and the median survival is less than a year, despite medical treatments such as surgery, radiation therapy, and chemotherapy. In this study, we investigated the anti-cancer effects of DHA and transferrin against glioblastoma (glioblastoma multiforme, GBM). MATERIALS/METHODS: This study was performed through in vitro experiments using C6 cells. The toxicity dependence of DHA and transferrin (TF) on time and concentration was analyzed by MTT assay and cell cycle assay. Observations of cellular morphology were recorded with an optical microscope and color digital camera. The anti-cancer mechanism of DHA and TF against GBM were studied by flow cytometry with Annexin V and caspase 3/7. RESULTS: MTT assay revealed that TF enhanced the cytotoxicity of DHA against C6 cells. An Annexin V immune-precipitation assay showed that the percentages of apoptosis of cells treated with TF, DHA alone, DHA in combination with TF, and the control group were 7.15 ± 4.15%, 34.3 ± 5.15%, 66.42 ± 5.98%, and 1.2 ± 0.15%, respectively. The results of the Annexin V assay were consistent with those of the MTT assay. DHA induced apoptosis in C6 cells through DNA damage, and TF enhanced the effects of DHA. CONCLUSION: The results of this study demonstrated that DHA, the derivative of the active ingredient in Gaeddongssuk, is effective against GBM, apparently via inhibition of cancer cell proliferation by a pharmacological effect. The role of transferrin as an allosteric activator in the GBM therapeutic efficacy of DHA was also confirmed.
Annexin A5 ; Antimalarials ; Apoptosis ; Brain Neoplasms ; Breast Neoplasms ; Cell Cycle ; Cell Proliferation ; DNA Damage ; Drug Therapy ; Flow Cytometry ; Glioblastoma* ; Immune System ; In Vitro Techniques ; Kidney Neoplasms ; Liver Neoplasms ; Therapeutic Uses* ; Transferrin*

No abstract available.
Hemoptysis*

No abstract available.
Child* ; Fibroma* ; Frontal Bone* ; Humans

Oculocardiac reflex occurs frequently during strabismus surgery in children. The most common arrythmia is bradycardia, with resolution after traction of extraocular muscle is withdrawn. However, the reflex is potentially fatal as it can cause cardiac arrest. This study was undertaken to compare the effect of three muscle relaxants, succinylcholine, pancuronium and vecuronium on the oculocardiac reflex, and to determine which could prevent it during strabismus surgery in children. We compared the change of heart rate and systolic blood pressure in each muscle relaxant group before and after traction of extraocular muscle in unpremedicated children between 3 to 15 years old with atropine or glycopyrrolate undergoing strabismus surgery. The incidences of oculocardiac reflex were 31.6% in vecuronium group, 14.0% in pancuronium group and 18.4% in succinylcholine group. Overall incidence was 20.1%. Heart rate decreased significantly in vecuronium and succinylcholine group, but systolic blood pressure was unchanged. In pancuronium group, changes in heart rate and systolic blood pressure were not significant. From the above results, the use of pancuronium which does not decrease heart rate will be more protective in preventing the oculecardiac reflex during strabismus surgery in children.
Adolescent ; Arrhythmias, Cardiac ; Atropine ; Blood Pressure ; Bradycardia ; Child* ; Glycopyrrolate ; Heart Arrest ; Heart Rate ; Humans ; Incidence ; Pancuronium* ; Reflex ; Reflex, Oculocardiac* ; Strabismus ; Succinylcholine* ; Traction ; Vecuronium Bromide*