1.Ambulatory Care of the Osteoarthritis.
Journal of the Korean Medical Association 2000;43(9):839-845
No abstract available.
Ambulatory Care*
;
Osteoarthritis*
2.Superiority of modified university of Wisconsin solution in the prolonged preservation of isolated rat heart.
Jae Seong LEE ; Song Myung KIM ; Kyu Tae KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(6):427-440
No abstract available.
Animals
;
Heart*
;
Rats*
;
Wisconsin*
3.Pleomorphic Xanthoastrocytoma: A Case Report.
Seong Ki MIN ; Dong Wook KANG ; Kyu Sang SONG ; Dae Young KANG ; Seong Ho KIM
Korean Journal of Pathology 1993;27(6):666-669
Pleomorphic xanthoastrocytoma is histologically characterized by marked cellular pleomorphism of lipid-laden neoplastic astrocytes and bizarre giant cells showing mitotic figures and high cellularity. Inspite of its ominous-looking microscopic features, howerver, the prognosis is usually favorable. This tumor develops mainly in the supratentorial area of young people and frequently involves the leptomeninges. We experienced a case of pleomorphic xanthoastrocytoma in 18 year-old-male. In addition to the cellular pleomophism, the prominent reticulin fibers surround the individual tumor cells or the tumor cells nests. Immunohistochemical staining and electron microscopy revealed glial fibrillary acidic protein(GFAP) expression and pericytoplasmic basal lamina in the tumor cells.
4.Detection of Human Papillomavirus DNA by In Situ Hybridization Using Biotinylated DNA Probes in Codylomata Acuminata.
Seok Ju KIM ; Kyu Suk LEE ; Joon Young SONG ; Seong Il SUH ; Min Ho SUH
Korean Journal of Dermatology 1990;28(6):702-707
Human Papillomaviruses(HPVs) are regarded as sexually transmitable and closely associated with precancerous lesions or invasive cancers of the vulva, vagina, and cer V1X. In situ hybridization, besides showing higher sensitivity, allowed the identification of specific viral types. We studied 12 cases of condylomata accuminata for HPV typing by in situ hybridization techenique. Ten cases(83.3 % ) showed positive for HPV type 6/11, and 2 cases(16.7% ) were positive for HPV type 16/18.
DNA Probes*
;
DNA*
;
Humans*
;
In Situ Hybridization*
;
Vagina
;
Vulva
5.Recurrent Laryngeal Nerve Paralysis Associated with Cricoarytenoid Subluxation Following General Anesthesia: A case report.
Pil Oh SONG ; Hun Suck LEE ; Seong Ho LEE ; In Kyu KIM ; Myoung Keun SHIN
Korean Journal of Anesthesiology 1998;35(5):1018-1022
Arytenoid subluxation or recurrent laryngeal nerve paralysis may result from injury to the larynx following endotracheal intubation or blunt laryngeal trauma. Early diagnosis is important for appropriate treatment and better prognosis. A 62-years-old man was admitted for cholecystectomy. He was intubated without any difficulty and nasogastric tube was inserted with the help of laryngoscope and Magill forcep before surgery. He had a weak voice and hoarseness after atraumatic extubation and those symptoms did not improve even 2 days after. Indirect laryngoscopy, videolaryngotelescopy, electromyography(EMG) and computed tomographic findings revealed anterior, inferior subluxation of left cricoarytenoid cartilage associated with left thyroarytenoid muscle denervation and resultant unilateral vocal cord palsy. Conservative treatment for 40 days after the operation and follow-up examination was done. The voice quality was improved and indirect laryngoscopy examination showed that right vocal cord crossed midline in a attempt to meet its paralyzed counterpart on phonation.
Anesthesia, General*
;
Cartilage
;
Cholecystectomy
;
Denervation
;
Early Diagnosis
;
Follow-Up Studies
;
Hoarseness
;
Intubation, Intratracheal
;
Laryngeal Muscles
;
Laryngoscopes
;
Laryngoscopy
;
Larynx
;
Paralysis*
;
Phonation
;
Prognosis
;
Recurrent Laryngeal Nerve*
;
Surgical Instruments
;
Vocal Cord Paralysis
;
Vocal Cords
;
Voice
;
Voice Quality
6.Viability of calvarial bone grafts according to the contact surface.
Seong Geun PARK ; Joong Won SONG ; Ki Hwan HAN ; Jin Sung KANG ; Kwan Kyu PARK
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(3):437-447
No abstract available.
Transplants*
7.Fenretinide Induced Apoptosis in Human Neuroblastoma Cell Lines.
Jae Kyu LEE ; In Hwan SONG ; Seong Yong KIM
Korean Journal of Physical Anthropology 2007;20(4):331-342
Retinoids play an important role in growth, reproduction and differentiation. Recently, retinoids have been used to both protect and treat from various animal models of carcinogenesis. In this study the effect of N-(4-hydroxyphenyl) retinamide (fenretinide) on viability of human neuroblastoma cell lines were evaluated. For the evaluation of apoptosis of human neuroblastoma cell lines by fenretinide. MTT assay, cytoplasmic DNA fragmentation, TUNEL stain, and Western blot analysis were performed. In MTT assay, fenretinide inhibited the proliferation of CHP134, IMR32 and SH-SY5Y but not in PC12 cells. Cytoplasmic DNA fragmentation was induced by treament of fenretinide (10 micrometer) for 48 h in IMR32 cells. PARP cleavage was detected by Western blot analysis after 16 h of treatment of fenretinide in CHP134, IMR32 and SH-SY5Y. These fenretinide effects on growth inhibition and increased apoptosis followed to the time dependent manner. The fenretinide treatment did not affect the phosphorylation of MAP kinases (ERK, JNK, p38). There was no change of Bcl-x and Bad expression after treatment of fenretinide (1 micrometer) in neroblastoma cell lines. Pretreatement of PD98059, SB203580, LY294002, or genistein also did not affect fenretinide-induced PARP cleavage in neuroblastoma cell lines. From these results, the fenretinide-induced apoptosis is due to the PARP cleavage which occured MAP kinase signal cascades independently.
Animals
;
Apoptosis*
;
Blotting, Western
;
Carcinogenesis
;
Cell Line*
;
Cytoplasm
;
DNA Fragmentation
;
Fenretinide*
;
Genistein
;
Humans*
;
In Situ Nick-End Labeling
;
Models, Animal
;
Neuroblastoma*
;
PC12 Cells
;
Phosphorylation
;
Phosphotransferases
;
Reproduction
;
Retinoids
8.Pelvic Exenteration as the Treatment for Recurrent or Locally Advanced Rectal Cancer.
Seong Kyu SONG ; Yong Keun PARK ; Kwang Wook SUH
Journal of the Korean Society of Coloproctology 2005;21(5):314-319
PURPOSE: The purpose of this study is to evaluate the value of pelvic exenteration (PE) for recurrent or locally advanced rectal cancer. METHODS: This retrospective study analyzed 20 patients who underwent PE for rectal cancer from June 1994 to October 2003 in Ajou University Hospital. The surgical severity, the postoperative complications, and the survival rate were analyed based on the medical records. RESULTS: The mean operation time was 221.5+/-93.0 minutes, the mean blood loss 750.5+/-223.3 cc, and the mean transfusion amount RBC 6.5+/-4.3 units. Operative mortality was 5% (1/20). A bleeding-associated complication was noted in one patient who underwent a reoperation for hemostasis. Other minor complications were small bowel obstruction (n=3), abdominal wound infection (n=5), vesicocutaneous fistula (n=2), delayed healing of the perineal wound (n=10). The overall 5-year survival rate was 52.6% (10 of 19 patients, excluding the operative mortality case). CONCLUSIONS: Our study showed acceptable surgical severity and postoperative complications and a favorable 5-year survival rate (> or =50%) for pelvic exenteration as a treatment for recurrent or locally advanced rectal cancer. With strictly selected patients, PE may be one of the treatment options for recurrent or locally advanced rectal cancer.
Fistula
;
Hemostasis
;
Humans
;
Medical Records
;
Mortality
;
Pelvic Exenteration*
;
Postoperative Complications
;
Rectal Neoplasms*
;
Reoperation
;
Retrospective Studies
;
Survival Rate
;
Wound Infection
;
Wounds and Injuries
9.Effect of the Mixture of Thrombin Powder and Gelfoam Powder on Control of Exposed Cancellous Bone Bleeding.
Sung Wan PARK ; Ha Young CHO ; Seung Myoung LEE ; Seong Hun JEONG ; Jin Kyu SONG ; Suk Jung JANG ; Ho SHIN
Journal of Korean Neurosurgical Society 2000;29(5):664-667
No abstract available.
Gelatin Sponge, Absorbable*
;
Hemorrhage*
;
Thrombin*
10.Immumoadjuvant Activitiy of Korean Mistletoe Extract ( Viscum album coloratum ) to Enhance Humoral and Cellular Immune Response.
Taek Joon YOON ; Yung Choon YOO ; Tae Bong KANG ; Seong Kyu SONG ; Myoung Sool DOO ; Jong Bae KIM
Korean Journal of Immunology 1999;21(1):63-70
Immunoadjuvant activities of the extract (KM-110) from Korean mistletoe ( Viscum album coloratum) on the induction of humoral and cellular responses against Keyhole limpet hemocyanim (KLH) as an antigen and allogenic tumor cells were examined. When mice were immunized subcataneously (s.c.) with KLH admixed with KM-110, more than 1000-times higher antibody titers to KLH than those immunized with KLH alone was observed. KM-110 induced high level of KLH- specific IgG1, IgG2a and IgG2b antibodies. In an in vitro analysis of lymphocytes proliferation to KLH on week 4, the splenocytes of mice treated with KLH and KM- 110 exhibited significantly higher proliferating activity than those treated with KLH alone. In addition, the culture supernatnats obtained from the splenocytes of mice treated with both KLH and KM-110 showed high level of IL-2 and IL-4. In the test of cellular immune responses, KM-110 enhanced the DTH reaction to KLH in mice. Furthemore, cytotoxic T-lymphocyte (CTL) activity using an allogenic CTL induction model where C57BL/6 (H-2b) mice were injected with allogenic P815 (H-2d) mastocytoma cells admixed with or without KM-110, mice treated with P815 cells and KM-110 showed higher cytatoxic activity against allogenic tumor cells than those treated without KM-110. This results suggest that KM-110 may possess adjuvant activities to potentially enhance humoral as well as cellular immune responses against antigens.
Animals
;
Antibodies
;
B-Lymphocytes
;
Immunity, Cellular*
;
Immunoglobulin G
;
Interleukin-2
;
Interleukin-4
;
Lymphocytes
;
Mastocytoma
;
Mice
;
Mistletoe*
;
T-Lymphocytes
;
T-Lymphocytes, Cytotoxic
;
Viscum album*
;
Viscum*