Purpose: This study evaluated the postoperative quality of life (QoL) after various types of gastrectomy for gastric cancer. Materials and Methods: A multicenter prospective observational study was conducted in Korea using the Korean Quality of Life in Stomach Cancer Patients Study (KOQUSS)-40, a new QoL assessment tool focusing on postgastrectomy syndrome. Overall, 496 patients with gastric cancer were enrolled, and QoL was assessed at 5 time points: preoperatively and at 1, 3, 6, and 12 months after surgery. Results: Distal gastrectomy (DG) and pylorus-preserving gastrectomy (PPG) showed significantly better outcomes than total gastrectomy (TG) and proximal gastrectomy (PG) with regard to total score, indigestion, and dysphagia. DG, PPG, and TG also showed significantly better outcomes than PG in terms of dumping syndrome and worry about cancer. Postoperative QoL did not differ significantly according to anastomosis type in DG, except for Billroth I anastomosis, which achieved better bowel habit change scores than the others. No domains differed significantly when comparing double tract reconstruction and esophagogastrostomy after PG. The total QoL score correlated significantly with postoperative body weight loss (more than 10%) and extent of resection (P<0.05 for both).Reflux as assessed by KOQUSS-40 did not correlate significantly with reflux observed on gastroscopy 1 year postoperatively (P=0.064). Conclusions Our prospective observation using KOQUSS-40 revealed that DG and PPG lead to better QoL than TG and PG. Further study is needed to compare postoperative QoL according to anastomosis type in DG and PG.

Purpose: This study evaluated the postoperative quality of life (QoL) after various types of gastrectomy for gastric cancer. Materials and Methods: A multicenter prospective observational study was conducted in Korea using the Korean Quality of Life in Stomach Cancer Patients Study (KOQUSS)-40, a new QoL assessment tool focusing on postgastrectomy syndrome. Overall, 496 patients with gastric cancer were enrolled, and QoL was assessed at 5 time points: preoperatively and at 1, 3, 6, and 12 months after surgery. Results: Distal gastrectomy (DG) and pylorus-preserving gastrectomy (PPG) showed significantly better outcomes than total gastrectomy (TG) and proximal gastrectomy (PG) with regard to total score, indigestion, and dysphagia. DG, PPG, and TG also showed significantly better outcomes than PG in terms of dumping syndrome and worry about cancer. Postoperative QoL did not differ significantly according to anastomosis type in DG, except for Billroth I anastomosis, which achieved better bowel habit change scores than the others. No domains differed significantly when comparing double tract reconstruction and esophagogastrostomy after PG. The total QoL score correlated significantly with postoperative body weight loss (more than 10%) and extent of resection (P<0.05 for both).Reflux as assessed by KOQUSS-40 did not correlate significantly with reflux observed on gastroscopy 1 year postoperatively (P=0.064). Conclusions Our prospective observation using KOQUSS-40 revealed that DG and PPG lead to better QoL than TG and PG. Further study is needed to compare postoperative QoL according to anastomosis type in DG and PG.

Purpose: This study evaluated the postoperative quality of life (QoL) after various types of gastrectomy for gastric cancer. Materials and Methods: A multicenter prospective observational study was conducted in Korea using the Korean Quality of Life in Stomach Cancer Patients Study (KOQUSS)-40, a new QoL assessment tool focusing on postgastrectomy syndrome. Overall, 496 patients with gastric cancer were enrolled, and QoL was assessed at 5 time points: preoperatively and at 1, 3, 6, and 12 months after surgery. Results: Distal gastrectomy (DG) and pylorus-preserving gastrectomy (PPG) showed significantly better outcomes than total gastrectomy (TG) and proximal gastrectomy (PG) with regard to total score, indigestion, and dysphagia. DG, PPG, and TG also showed significantly better outcomes than PG in terms of dumping syndrome and worry about cancer. Postoperative QoL did not differ significantly according to anastomosis type in DG, except for Billroth I anastomosis, which achieved better bowel habit change scores than the others. No domains differed significantly when comparing double tract reconstruction and esophagogastrostomy after PG. The total QoL score correlated significantly with postoperative body weight loss (more than 10%) and extent of resection (P<0.05 for both).Reflux as assessed by KOQUSS-40 did not correlate significantly with reflux observed on gastroscopy 1 year postoperatively (P=0.064). Conclusions Our prospective observation using KOQUSS-40 revealed that DG and PPG lead to better QoL than TG and PG. Further study is needed to compare postoperative QoL according to anastomosis type in DG and PG.

Background: Employees with depression have complex and serious health consequences, not only for them, including reduced quality of life, but also for businesses and society, leading to social costs such as reduced productivity. This study investigated the prevalence of depressive symptoms and related factors among public enterprise employees in Naju Innovation City, Korea. Methods: We investigated the sociodemographic and psychosocial characteristics of 1,061 public enterprise employees. Depression, anxiety, and occupational burnout were assessed using the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and Maslach Burnout Inventory-General Survey, respectively. Furthermore, the impact of factors on depressive symptoms was examined using a logistic regression model. Results: The prevalence of overall depressive symptoms was 11.9%. High anxiety (odds ratio [OR]=12.19; 95% confidence interval [CI]=7.17-20.76; p<0.001) and exhaustion (OR=2.79; 95% CI=1.81-4.40; p<0.001) levels were significantly associated with depressive symptoms. Conclusion Anxiety symptoms and exhaustion were the most important factors related to depressive symptoms among the public enterprise employees. Hence, when providing an employee assistance program, the psychosocial vulnerability factors of workers with depressive symptoms should be thoroughly addressed.2

Background: Employees with depression have complex and serious health consequences, not only for them, including reduced quality of life, but also for businesses and society, leading to social costs such as reduced productivity. This study investigated the prevalence of depressive symptoms and related factors among public enterprise employees in Naju Innovation City, Korea. Methods: We investigated the sociodemographic and psychosocial characteristics of 1,061 public enterprise employees. Depression, anxiety, and occupational burnout were assessed using the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and Maslach Burnout Inventory-General Survey, respectively. Furthermore, the impact of factors on depressive symptoms was examined using a logistic regression model. Results: The prevalence of overall depressive symptoms was 11.9%. High anxiety (odds ratio [OR]=12.19; 95% confidence interval [CI]=7.17-20.76; p<0.001) and exhaustion (OR=2.79; 95% CI=1.81-4.40; p<0.001) levels were significantly associated with depressive symptoms. Conclusion Anxiety symptoms and exhaustion were the most important factors related to depressive symptoms among the public enterprise employees. Hence, when providing an employee assistance program, the psychosocial vulnerability factors of workers with depressive symptoms should be thoroughly addressed.2

Background: Employees with depression have complex and serious health consequences, not only for them, including reduced quality of life, but also for businesses and society, leading to social costs such as reduced productivity. This study investigated the prevalence of depressive symptoms and related factors among public enterprise employees in Naju Innovation City, Korea. Methods: We investigated the sociodemographic and psychosocial characteristics of 1,061 public enterprise employees. Depression, anxiety, and occupational burnout were assessed using the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and Maslach Burnout Inventory-General Survey, respectively. Furthermore, the impact of factors on depressive symptoms was examined using a logistic regression model. Results: The prevalence of overall depressive symptoms was 11.9%. High anxiety (odds ratio [OR]=12.19; 95% confidence interval [CI]=7.17-20.76; p<0.001) and exhaustion (OR=2.79; 95% CI=1.81-4.40; p<0.001) levels were significantly associated with depressive symptoms. Conclusion Anxiety symptoms and exhaustion were the most important factors related to depressive symptoms among the public enterprise employees. Hence, when providing an employee assistance program, the psychosocial vulnerability factors of workers with depressive symptoms should be thoroughly addressed.2

Background: Employees with depression have complex and serious health consequences, not only for them, including reduced quality of life, but also for businesses and society, leading to social costs such as reduced productivity. This study investigated the prevalence of depressive symptoms and related factors among public enterprise employees in Naju Innovation City, Korea. Methods: We investigated the sociodemographic and psychosocial characteristics of 1,061 public enterprise employees. Depression, anxiety, and occupational burnout were assessed using the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and Maslach Burnout Inventory-General Survey, respectively. Furthermore, the impact of factors on depressive symptoms was examined using a logistic regression model. Results: The prevalence of overall depressive symptoms was 11.9%. High anxiety (odds ratio [OR]=12.19; 95% confidence interval [CI]=7.17-20.76; p<0.001) and exhaustion (OR=2.79; 95% CI=1.81-4.40; p<0.001) levels were significantly associated with depressive symptoms. Conclusion Anxiety symptoms and exhaustion were the most important factors related to depressive symptoms among the public enterprise employees. Hence, when providing an employee assistance program, the psychosocial vulnerability factors of workers with depressive symptoms should be thoroughly addressed.2

Background: Employees with depression have complex and serious health consequences, not only for them, including reduced quality of life, but also for businesses and society, leading to social costs such as reduced productivity. This study investigated the prevalence of depressive symptoms and related factors among public enterprise employees in Naju Innovation City, Korea. Methods: We investigated the sociodemographic and psychosocial characteristics of 1,061 public enterprise employees. Depression, anxiety, and occupational burnout were assessed using the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and Maslach Burnout Inventory-General Survey, respectively. Furthermore, the impact of factors on depressive symptoms was examined using a logistic regression model. Results: The prevalence of overall depressive symptoms was 11.9%. High anxiety (odds ratio [OR]=12.19; 95% confidence interval [CI]=7.17-20.76; p<0.001) and exhaustion (OR=2.79; 95% CI=1.81-4.40; p<0.001) levels were significantly associated with depressive symptoms. Conclusion Anxiety symptoms and exhaustion were the most important factors related to depressive symptoms among the public enterprise employees. Hence, when providing an employee assistance program, the psychosocial vulnerability factors of workers with depressive symptoms should be thoroughly addressed.2

Background: and Purpose: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognition and performance of daily activities. Recent studies have attempted to establish the relationship between AD and sleep. It is believed that patients with AD pathology show altered sleep characteristics years before clinical symptoms appear. This study evaluated the differences in sleep characteristics between cognitively asymptomatic patients with and without some amyloid burden. Methods: Sleep characteristics of 76 subjects aged 60 years or older who were diagnosed with subjective cognitive decline (SCD) but not mild cognitive impairment (MCI) or AD were measured using Fitbit ® Alta HR, a wristwatch-shaped wearable device. Amyloid deposition was evaluated using brain amyloid plaque load (BAPL) and global standardized uptake value ratio (SUVR) from fluorine-18 florbetaben positron emission tomography. Each component of measured sleep characteristics was analyzed for statistically significant differences between the amyloid-positive group and the amyloid-negative group. Results: Of the 76 subjects included in this study, 49 (64.5%) were female. The average age of the subjects was 70.72±6.09 years when the study started. 15 subjects were classified as amyloid-positive based on BAPL. The average global SUVR was 1.598±0.263 in the amyloidpositive group and 1.187±0.100 in the amyloid-negative group. Time spent in slow-wave sleep (SWS) was significantly lower in the amyloid-positive group (39.4±13.1 minutes) than in the amyloid-negative group (49.5±13.1 minutes) (p=0.009). Conclusions This study showed that SWS is different between the elderly SCD population with and without amyloid positivity. How SWS affects AD pathology requires further research.

Background/Aims: The prevalence and incidence of ulcerative colitis (UC) in Korea is increasing. Each patient has a different disease course and treatment response. Recently, with the development of biologic agents, histological remission has become a treatment goal. In this study, we aimed to identify the predictors of histological remission after first-line biologic agent treatment in patients with biologic agent-naïve UC. Methods: We retrospectively analyzed the medical records of 92 patients who had been diagnosed with UC and treated with first-line biologic agent treatment at our center, between 2015 and 2022. The clinical characteristics, laboratory test results, and endoscopic and biopsy findings were analyzed. Histological remission was defined as the absence of cryptitis, crypt abscesses, and inflammatory cells on histology. Univariate and multivariate logistic regression analyses were performed to identify the predictors of histological remission after first-line treatment. Results: Of the total 92 patients, 25 (27.2%) achieved histological remission. Each cohort had a varied body mass index (BMI) distribution, with a statistically significant overweight ratio, as defined by the Asian-Pacific BMI category of 23–25 kg/m2, of 48.0% in the histological remission cohort (P= 0.026). A causal correlation between the overweight category and histological remission was confirmed (odds ratio, 3.883; 95% confidence interval, 1.141–13.212; P= 0.030). Conclusions We confirmed that the overweight category was a predictor of histological remission after first-line treatment with a biological agent. However, as BMI does not account for skeletal muscle mass, future studies are required to confirm the correlation between skeletal muscle mass and histological remission.