1.The classification and the surgical management of degenerative lumbar segmental instability.
In KIM ; Kee Won RHYU ; Seong Jin PARK
The Journal of the Korean Orthopaedic Association 1992;27(1):65-77
No abstract available.
Classification*
2.Combination chemotherapy with 5-fluorouracil and cisplatin for advanced gastric cancer.
Jong Min SHIN ; Hyo Jin KIM ; Jong Seong KIM
Korean Journal of Medicine 1993;45(4):482-489
No abstract available.
Cisplatin*
;
Drug Therapy, Combination*
;
Fluorouracil*
;
Stomach Neoplasms*
3.A case of annular elastolytic giant cell granuloma.
Seong Jin JEON ; Kee Suck SUH ; Sang Tae KIM
Korean Journal of Dermatology 1991;29(1):86-90
Annular elastolytic giant cell granuloma(AEGC(3) has been called as atypical necrcibiosis lipoidica, Mieschers granuloma of the face and scalp, and actinic granu- Joma and needs differen(iation from granuloma annulare, elastosis perforans serpiginosa and nerrobiosis lipoidica. We report a case of AECCG occurring in a 53-year-old male. The patient. had an annular erythematous plaque measuring 4 cm in diameter with serpiginous raised edges and slightly atrophic centers on the right forearm for 5 years. The histopathologic finding showed patchy dermal infiltration of lymphocytes, histiocytes, and multinucleated giant cells engulfing elastic fibers. The. skin lesion cleared after intrader mal injection cf cortieosteroids.
Actins
;
Elastic Tissue
;
Forearm
;
Giant Cells*
;
Granuloma
;
Granuloma Annulare
;
Granuloma, Giant Cell*
;
Histiocytes
;
Humans
;
Lymphocytes
;
Male
;
Middle Aged
;
Scalp
;
Skin
5.The Analysis of Factors Affecting the Corneal Endothelial Cells during Vitrectomy.
Ki Seok KIM ; Jin Seong YOO ; Noh Hoon KYAK
Journal of the Korean Ophthalmological Society 2000;41(12):2598-2602
No Abstract Available.
Endothelial Cells*
;
Vitrectomy*
6.Sleep Problems in Autism Spectrum Disorder.
Young Hui YANG ; Ji Hoon KIM ; Jin Seong LEE
Sleep Medicine and Psychophysiology 2013;20(2):53-58
Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restricted, repetitive patterns of behavior and interest. Sleep problems are not uncommon in children with autism spectrum disorders. Symptoms of insomnia are the most frequent sleep problems in individuals with ASD. Sleep problems can cause significant difficulties in the daily life of children with ASD and their families. Genetic factor, deregulations of melatonin synthesis, extraneous environmental stimuli and psychiatric and medical conditions may cause sleep problems. The first line treatment of sleep problems in ASD includes managements for potential contributing factors and parent education about sleep hygiene care for child and behavioral therapy. Supplementation with melatonin may be effective before considering other medications, such as risperidone, clonidine, and mirtazapine.
Autistic Disorder*
;
Child
;
Autism Spectrum Disorder*
;
Clonidine
;
Education
;
Genetics
;
Humans
;
Hygiene
;
Melatonin
;
Parents
;
Risperidone
;
Sleep Initiation and Maintenance Disorders
7.Regulation of Human Beta-Defensin 3(hBD-3) in Human Keratinocyte(HaCaT) Cell Lines.
Yu Jin KIM ; Chang Kwun HONG ; Seong Jun SEO
Annals of Dermatology 2003;15(1):1-7
BACKGROUND: The large surfaces of the skin are often initial site of contact between microorganism and human. The skin are coated with epidermis and epithelial cells can recognize microorganism and mount a fast defense through the production of various inducible antibiotic peptides. This leads to chracteristic broad spectrum of antimicrobial activity against bacteria, fungi, and viruses. Recent studies introduce us new peptides with antimicrobial activity such as P,-defensins and cathelicidins. They are expressed on the epithelia and polymorphonuclear leukocytes, which are first lines of defence from various invasive environments. Futhermore, they are considered very interesting and important endogenous antibiotics. Our previous study has shown that the expression of human defensin(hBD-2) mRNA, which is potent antibiotic peptide against Gram-negative bacteria(P. aeruginosa), was upregulated with ultraviolet(UV) irradiation, tumor necrosis factor-α(TNF-α) and lipopolysaccharide(LPS) in HaCaT cells. A novel hBD-3, 5-kDa, nonhemolytic antimicrobial peptide, was demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes in especially, multiresistant S. aureus. We have analyzed the expression patterns of hBD-3 in HaCaT cell lines. OBJECTIVE: This research have done in order to evaluate the expression and regulation of hBD-3 mRNA in human keratinocyte cell lines. METHODS: HaCaT cell lines were used to all culture experiments. Cultured human keratinocytes were stimulated with UV irradiation or TNF-α or LPS to determine whether hBD-3 mRNA production occurred. Reverse transcription-polymerase chain reaction (RT-PCR) was per-formed to amplify hBD-3 cDNA from stimulated keratinocytes in a time dependant manner, and densitometry was used to verify the specificity of RT-PCR amplication products. RESULTS: Expression of hBD-3 was upregulated with UV irradiation, TNF-α and LPS in Ha-CaT cells compared to control CONCLUSIONS: Human keratinocytes are capable to induce hBD-3 mRNA, as well as hBD-2, in response to UV irradiation, TNF-α and LPS. suggesting that these cells could play an important role against the bacterial infection and UV light damage in human skin.
Anti-Bacterial Agents
;
Bacteria
;
Bacterial Infections
;
Cathelicidins
;
Cell Line*
;
Densitometry
;
DNA, Complementary
;
Epidermis
;
Epithelial Cells
;
Fungi
;
Humans*
;
Keratinocytes
;
Necrosis
;
Neutrophils
;
Peptides
;
RNA, Messenger
;
Sensitivity and Specificity
;
Skin
;
Ultraviolet Rays
8.Clinical effect of topical ketoconazole in seborrheic dermatitis of scalp.
Seong Jin KIM ; Young Ho WON ; Inn Ki CHUN
Korean Journal of Dermatology 1992;30(5):625-632
An etiologic agent in seborrheic dermatitis is now considered to be due to Pityrosporum ovale. The connection between the yeast and the disease has been clearly dernonstrated in a number of patients treatd with antifungal agents. However, the fact, that Pityrosporum ovale (Pityrosporum orbiculare) belongs to the normal human cutaneou. flora makes it difficult, to explain the role of the organism in seborrheic dermatitis. In this clinical study, twenty eight subjects were divided into two group by treatment regimen of topical 2% ketoconazole shampoo(TKS)and 0.3% prednisolone valerate solution (PVS). Before and during the four weeks treatment periods, the number of Pityrosporum ovale on the scalp were evaluated by scrub Giemsa staining method, which estimat,ed by score scale, under direct. microscopic examination. Also clinical symptoms including erythema, scales and itching were recorded by scores every week and compared between two treatment group. Topical application of 2% ketoconazole shampoo(TKS) is a very effective treatment regimen to reduce the yeasr cell score(from 5.8+1.3 to 1.8+1.4) than PVS(from 6.4+1.3 to 3.5+1.5), significantly(p<0.05). So the results of this study acconsistent with the view that density of Pityrosgourum ovale plays a role in the cause and course of seborcheic derrnatitis on the scalp. And antifungal agent(TKS) shows favorable effects ori tnis disease clinically and mycologically.
Antifungal Agents
;
Azure Stains
;
Dermatitis, Seborrheic*
;
Erythema
;
Humans
;
Ketoconazole*
;
Malassezia
;
Prednisolone
;
Pruritus
;
Scalp*
;
Weights and Measures
;
Yeasts
9.A clinical analysis of breast cancer.
Seong Hwan HWANG ; Jin Yong LEE ; Sang Hyo KIM
Journal of the Korean Surgical Society 1992;42(6):776-786
No abstract available.
Breast Neoplasms*
;
Breast*
10.A study of altered concentrations of plasma fibronectin in pregnancy induced hypertension.
Gil Hyeong LEE ; Wang Soo KIM ; Seong Jin OH
Korean Journal of Perinatology 1993;4(1):74-80
No abstract available.
Female
;
Fibronectins*
;
Hypertension, Pregnancy-Induced*
;
Plasma*
;
Pregnancy
;
Pregnancy*