Schizophrenia is a chronic, currently incurable, and devastating syndrome. Although sleep disturbances are not primary symptoms of schizophrenia, they are important aspects of schizophrenia. Difficulties initiating or maintaining sleep are frequently encountered in patients with schizophrenia. Many schizophrenics report low subjective sleep quality. Measured by polysomnography, increased sleep latency as well as reduced total sleep time, sleep efficiency, slow wave sleep, and rapid eye movement sleep latency (REM latency), are found in most patients with schizophrenia and appear to be an important aspect of the pathophysiology of this disorder. Some literatures suggest that worsening sleep quality precedes schizophrenic exacerbations. Co-morbid sleep disorders such as obstructive sleep apnea (OSA) and restless legs syndrome (RLS), and sleep-disrupting behaviors associated with schizophrenia may lead to sleep disturbances. Clinicians should screen the patient with sleep complaints for primary sleep disorders like OSA and RLS, and carefully evaluate sleep hygiene behaviors of all patients with schizophrenia who complain of sleep disturbances.
Antipsychotic Agents ; Humans ; Hygiene ; Polysomnography ; Restless Legs Syndrome ; Schizophrenia ; Sleep Apnea, Obstructive ; Sleep Wake Disorders ; Sleep, REM

No abstract available.
Health Behavior* ; Humans

In order to investigate the main factor of pathogenicity in V. mimicus, we have studied the toxic effects of j3-hemolysin produced by V. mimicus. The purified hemolysin of V. mimicus was active erythrocytes from three animal species including mouse, rabbit and rat, but the hemolysin was most active against rabbit erythrocyte. The hemolysin lysed cultured cell and killed mouse. Rapid death of mouse was observed with rather small doses of the toxin. Intravenous injection of 20 mg of the purified toxin killed mice within 25 sec. The hemolysin also had a lethal effect on intraperitoneal injection into mice although less than on intravenous injection. Purified hemolysin injected rabbits had large morphological change in jejunum. In electron micrograph of thin sections of the human erythrocytes, cells were threated with the hemolysin at 37 C for 5 min., significant changes were not observed. But after 10 min., hemolysis was observed and after 60 min., complete degradation of human erythrocyte was observed.
Animals ; Cells, Cultured ; Erythrocytes ; Hemolysis ; Humans ; Injections, Intraperitoneal ; Injections, Intravenous ; Jejunum ; Mice ; Rabbits ; Rats ; Vibrio mimicus* ; Vibrio* ; Virulence

Serum samples from 123 males and 123 females collected by age in 1996 were analyzed for antibodies against surface antigen of Hepatitis B virus and C22-3, C200 antigens of Hepatitis C virus. Sera from the children under the age of 10 showed 30% seropositivity to the surface antigen of Hepatitis B virus, 33.3% in 10~19 year group, 20% in 20~29 year group, 17.6% in 30~39 year group, 3.3% in 40~49 year group, 5.9% in 50~59 year group, 8,3% in 60~69 year group, 2.9% in 70~79 year group, but antibody could not found in 80~86 year group. 12 out of 123 male sera were positive, 19 out of 123 female sera were positive and overall rate of positivity of antibody against surface antigen of Hepatitis B virus was 12.6%. Serum samples from peoples under the age of 30 had not antibody against C22-3, C200 antigens of Hepatitis C virus. The positivity rate was 2.9% in 30~39 year group. 5 out of 30 sera from 40~49 year age group were positive, and 3 positive sera showed extremely high titer (1:524,288) but the titers of two remaining sera were 1:32, 1:8,192 respectively. 5.9% was positive in 50~59 year group, 8.3% in 60~69 year group, 11.8% in 70~79 year group but all negative in 80~86 yea. group. 6 out of 123 male sera were positive (4.9%), 9 out of 123 female sera were positive (7.3%). Overall .ate of positivity of antibody against C22-3, C200 antigen of Hepatitis C virus was 6.1%. None out of 246 sera had both antibodies against Hepatitis B virus and Hepatitis C virus.
Antibodies* ; Antigens, Surface ; Child ; Female ; Hepacivirus* ; Hepatitis B virus* ; Hepatitis B* ; Hepatitis C* ; Hepatitis* ; Humans* ; Male

The reciprocal interaction between sleep and pain has been reported by numerous studies. Patients with acute or chronic pain often complain of difficulty falling asleep, frequent awakenings, shorter sleep duration, unrefreshing sleep, and poor sleep quality in general. According to the majority of the experimental human studies, sleep deprivation may produce hyperalgesic changes. The selective disruption of slow wave sleep has shown this effect more consistently, while results after selective REM sleep deprivation remain unclear. Patients with chronic pain have a marked alteration of sleep structure and continuity, such as frequent sleep-stage shifts, increased nocturnal awakenings, decreased slow wave sleep (SWS), decreased rapid eye movement (REM) sleep, and alpha-delta sleep. Many analgesic medications can alter sleep architecture in a manner similar to the effects of acute and chronic pain, suppressing SWS and REM sleep.
Chronic Pain ; Humans ; Sleep Deprivation ; Sleep, REM

OBJECTIVES: Obstructive sleep apnea syndrome (OSAS) not only causes respiratory disturbances during sleep but also decreases the quality of nocturnal sleep through sleep fragmentation and sleep structure change. We aimed at comparing the changes in sleep fragmentation and structure between baseline (diagnostic) nocturnal polysomnography (NPSG) and nCPAP (nasal continuous positive airway pressure) titration trial. METHODS: One hundred and three patients with a baseline night of respiratory disturbance index (RDI) of 5 or greater and reduced RDI score during nCPAP titration night were retrospectively selected for the study. Sleep fragementation and sleep structure between baseline NPSG and the NPSG during nCPAP titration were compared. Sleep fragmentation index (SFI) was defined as the total number of awakenings and shifts to stage 1 sleep divided by the total sleep time in hour. SFI and other polysomnographic parameters were statistically compared between the two nights. RESULTS: SFI during baseline NPSG and nCPAP titration nights were 29.0+/-13.8 and 15.2+/-8.8, respectively, indicating a significant SFI decrease during nCPAP titration (t=9.7, p<0.01). SFI showed significant negative correlations with sleep efficiency (r=-0.60, p<0.01) and total sleep time (r=-0.45, p<0.01) and a positive correlation with RDI (r=0.28, p<0.01). CONCLUSION: Use of nCPAP, even during the titration, significantly decreases sleep fragmentation and improves sleep structure in OSAS patients. We suggest that SFI may be utilized as a measure of assessing OSAS severity and nCPAP efficacy.
Humans ; Polysomnography ; Retrospective Studies ; Sleep Apnea, Obstructive ; Sleep Deprivation

Diet compliance is very important issue in patients with coronary artery disease(CAD). Diet compliance needs dietetic knowledge of patients and their families basically and families support. Therefore we studied about the dietetic knowledge level and educational needs of CAD patients and their families. For this study, we developed the study tool from the literature review. This tool consists of two main categories, one is about general dietary guidelines and specific food information, and the other is about educational needs of CAD patients & their families. The data were collected from 47 CAD patients and their families from June, 30 to to Semptember, 30, 1998. And they were analyzed using frequency, percentile, paired t-test, and ANOVA by SAS/ WIN. The results of this study were as follows : The results of the analysis of dietetic knowledge were as follows. In the general dietary guidelines, CAD patients knowledge level was lower than families in the importance of diet. And both patients and families had low knowledge level in the nutrition balance, protein intake, and relationship between fiber and cholesterol. In the specific food information, CAD patients knowledge level was low in protein-contained food, cholesterol -contained food, cooking method. The results of the relationship between the knowledge level and the demographic characteristics were as follows. In patients, there were significant statistical differences in the knowledge level of general dietary guidelines according to age and educational level, and the knowledge level of food information according to sex. In families, there were significant statistical differences in the knowledge level of general dietary guidelines according to age and educational level, and the knowledge level of food information according to sex and age. The results of the analysis of educational needs were as follows. Television was most common dietetic knowledge source. The highest educational needs were about recommended/restricted food and daily menu in both CAD patients and their families In th diet compliance, low-cholesterol diet was most difficult in both CAD patients and their farnilies. In conclusion, CAD patients and their families had high educational needs but insufficient concrete knowledge in such as recommended/restricted food, daily menu and cooking method. Nurses must be aware that it is necessary to establish an concrete dietetic educational program for CAD patients and their families.
Cholesterol ; Compliance ; Cooking ; Coronary Artery Disease* ; Coronary Vessels* ; Diet ; Humans ; Nutrition Policy ; Television

No abstract available.
Classification*

As most medical facilities in Korea have been concentrated in large cities, the need to improve emergency medical services in islands and mountainous areas has emerged. Consequently, the Ministry of Health and Welfare and local governments have introduced emergency medical helicopters (known as helicopter ambulances or air ambulances) with doctors in medically vulnerable areas. Having been introduced in two regions in 2011, air ambulances are operational in seven regions as of the end of 2019. The flight time is from sunrise to sunset, except in Gyeonggi province, which is open all day. Although the criteria for transport vary depending on whether an ambulance is available for operation, it is basically intended for emergency critical diseases, such as severe trauma, stroke, and acute myocardial infarction. From September 23, 2011 to December 31, 2018, a total of 10,367 transfer requests were received, which included 534 (5.2%) interruptions, 2,657 (25.6%) rejects, and 7,176 (69.2%) transfers. A total of 7,209 patients were transferred during this period, which included 1,693 (23.5%) patients of severe trauma, 1,149 (15.9%) patients of stroke, 802 (11.1%) patients of acute myocardial infarction, and 3,565 (49.5%) patients suffering from other emergency diseases. Some economic research on air ambulances in Korea has been reported to be cost-effective, but additional research should be performed. In the future, it is necessary to widen the area of operation of air ambulances and find alternative means of transporting patients during unfavorable conditions such as night or bad weather.

Impetigo herpetiformis is a rare pustular eruption that may be seen in late pregnancy. It is associated with severe maternal and fetal complications in case of misdiagnosis and delayed treatment. The patient was a 25-years-old multigravida with psoriasis in her past history. At 20weeks gestation, she had been developed erythematous scaly annular patchs with papules and pustules on inner thigh. At 37weeks' gestation, the patient was suffered from a severely pruritic pustular rash with fever and leukocytosis. The skin of the affected areas was biopsied and showed intraepidermal pustular abscess with a neutrophilic infiltrate. Treatment commenced with intravenous fluids, antibiotics, systemic prednisone, steroid creams, and phototherapy(UVB) under the careful fetal well being monitoring. Cesarean section was done due to fetal distress, and a normal healthy male infant was delivered, following which the patient's condition improved rapidly.
Abscess ; Anti-Bacterial Agents ; Cesarean Section ; Diagnostic Errors ; Exanthema ; Female ; Fetal Distress ; Fever ; Humans ; Impetigo* ; Infant ; Leukocytosis ; Male ; Neutrophils ; Prednisone ; Pregnancy* ; Psoriasis ; Skin ; Thigh