1.The Clinical Values of Metaplasia, p 53, c - erbB2 and CEA Expression in Gallbladder Carcinoma.
Seok Mo KIM ; Seong Hwan KIM ; Jeong Hwan CHANG ; Sung chul LIM ; Chae Hong SUH
Journal of the Korean Cancer Association 1999;31(6):1261-1270
PURPOSE: We evaluated the correlation between the carcinogenesis of gallbladder and the expression of lysozyme, p53, c-erbB2 and CEA in gallbladder lesions. MATERIALS AND METHODS: Thirty cases of gallbladder lesions (containing 17 cases of GB carcinoma) were examined. We analyzed the clinicopathologic findings of the early (stage I & II) and advanced carcinoma (stage III, IV & V) and those of carcinoma with or without metaplasia in the tumor. We performed p53, c-erbB2 and CEA immunohistochemical staining and compared their findings with those of normal mucosa and preneoplastic lesions. We also performed lysozyme immunohistochemical staining and compared its finding with metaplastic and non-metaplastic lesions. RESULTS: There are two distinct genetic pathways in gallbladder cacinogenesis and metaplastic carcinoma was more frequent than non-metaplastic carcinoma. Metaplasia of gallbladder did not reveal any difference of the clinicopathologic findings and depth of invasion (Nevin stage). Lysozyme expression was found in all metaplastic lesions but non-expression did not indicate non-metaplastic lesions. p53 mutations and c-erbB2 alterations may have a role in the carcinogenesis of gallbladder carcinomas, especially, in a late event, and in an early and late events, respectively. The correlation of p53 and c-erbB2 expressions was found but which did not indicate that the co-expression was needed in the carcinogenesis. CEA immunohistochemical staining may be helpful in the differential diagnosis of benign lesions and precancerous and cancerous lesions of the gallbladder. CONCLUSION: These results suggest that p53 mutations and c-erbB2 alterations may have a role in the carcinogenesis of gallbladder carcinomas, especially, in a late event, and in an early and late events, respectively.
Carcinogenesis
;
Diagnosis, Differential
;
Gallbladder*
;
Metaplasia*
;
Mucous Membrane
;
Muramidase
2.The Effects of Glutathione on Cyclosporine Induced Cytotoxicity in Cultured Insulinoma Cells.
Byung Cheol KIM ; Seong Hwan KIM ; Young Don MIN ; Jeong Hwan CHANG
The Journal of the Korean Society for Transplantation 2001;15(2):147-150
PURPOSE: Cycloporine A (CsA) is a immunosuppressive agent most widely used in organ transplanted patients for preventing immunorejection, but it has some side effects, including hypertension, nephrotoxicity, hepatotoxicity and diabetes. The mechanism of toxicity of CsA was not completely understood, but the reactive oxygen species has been proposed to be involved in the reaction of toxicity of CsA. The purpose of this study is to determine the effects of glutathione, as a physiological antioxidant on CsA induced cytotoxicity in rat insulinoma (RINm5F) cells. METHODS: RINm5F cells were incubated in the presence of CsA (105~108 M) and buthionine sulfoximine (BSO), as a inhibitor of r-glutamyl cysteine synthetase, was added to cultured media (RPMI1640). Twenty four hours of incubation with CsA and BSO, viable cells were determined by MTT method. RESULTS: CsA decreased cell viability in dose response in cultured RINm5F cells and significantly decreased according to redusing glutathione. CONCLUSION: These results suggested that CsA may induce the diabetes and glutathione have some roles in the pathogenesis of CsA-induced diabetes.
Animals
;
Buthionine Sulfoximine
;
Cell Survival
;
Cyclosporine*
;
Cysteine
;
Glutathione*
;
Humans
;
Hypertension
;
Insulinoma*
;
Ligases
;
Rats
;
Reactive Oxygen Species
3.Clinical Analysis of Endovenous Laser Treatment for Primary Varicose Vein Reflux.
Ki Hun JANG ; Jeong Hwan CHANG ; Seong Hwan KIM
Journal of the Korean Surgical Society 2007;72(5):397-402
PURPOSE: Endovenous laser treatment for incompetent great saphenous vein (GSV) has been recently proposed as an effective means of treatment. The aim of this study is to identify the complications and safety of EVLT as the main treatment for primary varicose vein incompetence when used concomitantly with miniphlebectomy and sclerotherapy. METHODS: We reviewed the records of 153 patients who underwent EVLT. Venous duplex scanning was performed 3 months after surgery in all the patients. The clinical outcomes were evaluated using questionnaires at the outpatient clinic or through phone calls. RESULTS: Considering the 97% satisfaction rate of EVLT, EVLT was an effective treatment for primary varicose vein. We observed complications such as paresthesia (20.9%), pain lasting more than 2 weeks (11.8%), ecchymosis or bruising (7.2%) that subsided spontaneously, superficial burn (5.2%) and phlebitis (2%) that was controlled by conservative treatment. The GSV recanalization rate 3 months after the procedure was 3.3%, resulting in a 96.7% success rate. CONCLUSION: The early results indicate that EVLT is an effective and safe procedure to eliminate the SFJ (sapheno-femoral junction) and obliteration of the GSV. However, long-term follow-up is necessary in our study. Better treatment outcomes are possible with accumulated experience and the establishment of strict indications for EVLT.
Ambulatory Care Facilities
;
Burns
;
Ecchymosis
;
Follow-Up Studies
;
Humans
;
Paresthesia
;
Phlebitis
;
Surveys and Questionnaires
;
Saphenous Vein
;
Sclerotherapy
;
Varicose Veins*
4.Citation Trend and Suggestions for Improvement of Impact Factor of Journal of Korean Therapeutic Radiology and Oncology.
Seong Hwan KIM ; Seong Su HWANG ; Myeong Im AHN ; Sona JEONG
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2006;24(4):309-316
PURPOSE: To analyze the recent citation trend and to find a way to improve impact factor (IF) of the Journal of Korean Therapeutic Radiology and Oncology (JKSTRO) by analysis of Korean Medical Citation Index (KoMCI) citation data of JKSTRO and comparison with that of mean citation data of all journals enlisted on KoMCI (KoMCI journals) during 2000-2005. MATERIALS AND METHODS: All citation data of entire journals enlisted on KoMCI and JKSTRO from 2000 to 2005 were obtained from KoMCI. The trend of total and annual number of published articles and reference citations, total citations and self-citations per paper, IF and impact factor excluding self-citations (ZIF) were described and compared on both KoMCI journals and JKSTRO. RESULTS: Annual number of published articles was decreased for 6 years on both KoMCI journals and JKSTRO (32% and 38% reduction rate). The number of Korean journal references per article is 1.6 papers on JKSTRO comparing to 2.0 papers on KoMCI journals. The percentage of Korean references/total references increased from 5.0% in 2000 to 7.7% in 2005 on JKSTRO and from 8.5% in 2000 to 10.1% on KoMCI journals. The number of total citations received/paper on JKSTRO (average 1.333) is smaller than that of KoMCI journals (average 1.694), there was an increased rate of 67% in 2005 comparing to 2000. The percentage of self-citations/total citations (average 72%) on JKSTRO is slightly higher than that of KoMCI journals (average 61%). IF of JKSTRO was gradually improved and 0.144, 0.125, 0.088, 0.107, 0.187, and 0.203 in 2000-2005 respectively. However, ZIF of JKSTRO is steadily decreased from 0.038 in 2000 to 0.013 in 2005 except 0.044 in 2004. CONCLUSION: IF of JKSTRO was slightly improved but had some innate problem of smaller number of citations received. To make JKSTRO as a highly cited journal, the awareness of academic status of JKSTRO and active participation of every member of JKSTRO including encouraging self-citations of papers published recent 2 years and submission of English written papers, and active academic cooperation with related academic societies.
Radiation Oncology*
5.The Prognostic Value and Reciprocity of p53 and bcl-2 Expression in Colorectal Carcinoma.
Sang Heon PARK ; Young Don MIN ; Jeong Yong KIM ; Kweon Cheon KIM ; Seong Hwan KIM ; Seong Cheol LIM
Journal of the Korean Society of Coloproctology 1998;14(4):691-700
p53 is a tumor suppressor gene product identified in a wide range of tumor including colorectal carcinoma. Genetic alterations in the p53 tumor suppressor gene are common in human colorectal carcinoma. bcl-2 is a protooncogene that inhibits apoptosis. The products of mutant p53 gene and bcl-2 have been associated with prognosis in several malignancies including colorectal carcinomas. This study was undertaken to evaluate values of p53 and bcl-2 oncoproteins as prognostic factors relative to clinicopathological factors and correlation of their expression. Analyses were made on achieval pathologic tissues of 80 patients with colorectal carcinomas including 34 patients able to follow-up over 5 years. The oncoproteins were localized using commercially available monoclonal antibodies:DO-7 for p53, clone124 for bcl-2. Expression of bcl-2 was cytoplasmic, whereas nuclear p53 expression was localized in carcinoma cells. The patients were 17 to 83 years of age. The expression of p53 and bcl-2 was determined respectively in 30 (37.5%) and 21 (26.3%)cases. The expression of p53 nuclear expression was not correlated with tumor location, size, histologic grade, Duke's classification, regional lymph node metastasis and tumor recurrence. The cytoplasmic expression of bcl-2 was not correlated with tumor location, size, histologic grade, Duke's classification, regional lymph node metastasis and recurrence. Univariate analysis showed that patients with p53 nuclear expression were not associated with poorer overall survival than patients with p53 negative, and also showed in patients with bcl-2 expression. The expression of p53 did not affect to that of bcl-2. We concluded that the p53 nuclear and bcl-2 cytoplasmic expression were not independent prognostic factors in colorectal carcinomas. Evidence of reciprocity of bcl-2 and p53 expression was not found.
Apoptosis
;
Classification
;
Colorectal Neoplasms*
;
Cytoplasm
;
Follow-Up Studies
;
Genes, p53
;
Genes, Tumor Suppressor
;
Humans
;
Lymph Nodes
;
Neoplasm Metastasis
;
Oncogene Proteins
;
Prognosis
;
Recurrence
6.The reverse lip design: a design for safe and effective abdominoplasty
Ju Young GO ; Ryuck Seong KIM ; Jae Jin OCK ; Bohrham JEONG ; Seong Hwan BAE
Archives of Aesthetic Plastic Surgery 2021;27(4):153-157
Conventional abdominoplasty includes the removal of an ellipse-shaped section of abdominal tissue between the umbilicus and mons pubis. However, this method can result in tension of the undermined flap, especially in the midline. To address this problem, we present reverse lip design as a modified method that also has aesthetic advantages. The reverse lip design entails a longer lower flap edge while preserving the triangular tissue in the vascularly stable pubis area. These markings create an image of a reverse lip shape with a cleft at the bottom of the lower markings. After typical lipoabdominoplasty is performed, redundant waist tissues can easily be pulled inward and downward. The reverse lip design abdominoplasty demonstrated no complications and required no further revisions after the procedure. Patients were generally satisfied with the aesthetic improvements in their body shape. They were also able to return to their routine activities approximately 1 week after the operation while wearing a supporting undergarment. This modified abdominoplasty using the reverse lip design reduces low midline tension of the undermined abdominal flap while enhancing body aesthetics with a slimmer waistline, leading to higher patient satisfaction.
7.A New Treatment Method of Mandibular Fracture using Acrylic Splint.
Doo Seong JEONG ; Jae Hyun PARK ; Jin Hwan KIM ; Joon CHOE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(3):482-486
As modern society becomes increasingly complex, there has been a steady increase in violence, as well as in automobile and industrial accidents. This has resulted in an increased incidence of facial injuries, including mandibular fractures. Many methods have been advocated to achieve reestablishment of normal feature and function. The choice generally depends upon such factors as location of the fractures, displacements, status of the dentition and favorability of the fracture line. Many cases of mandibular fracture are treated by intermaxillay fixation using an arch bar or bite block(acrylic splint)for rapid bone union and minimal displacement. However, there had been some problems, such as discomfort to patients, limitation to eating and weight loss, poor oral hygiene, and temporomandibular joint ankylosis. As a consequence, we have modified the shape of the acrylic splint and method of fixation for circum-mandibular fixation instead of intermaxillary fixation. Acrylic splints are rigid, strong, easily adjusted and repaired, translucent, lightweight and well tolerated by the oral mucosa. The splints are properly secured to each tooth and bind all the teeth together as a single unit. Authors have used modified acrylic splints as tools of circum-mandibular fixation in 12 cases of mandibular symphysis and body fracture from May 1997 to August 1998, achieving the results of very good occlusal relationship, oral hygiene and comfort to patients.
Accidents, Occupational
;
Ankylosis
;
Automobiles
;
Dentition
;
Eating
;
Facial Injuries
;
Humans
;
Incidence
;
Mandibular Fractures*
;
Mouth Mucosa
;
Oral Hygiene
;
Splints*
;
Temporomandibular Joint
;
Tooth
;
Violence
;
Weight Loss
8.Recurrence Rate of Herpes Zoster during the Previous Decade.
Korean Journal of Dermatology 2012;50(4):287-289
BACKGROUND: Herpes zoster recurrence, reported to be 1~5% globally, is thought to be more frequent in immunocompromised and older individuals. Data on the recurrence rate in Korea are very rare. OBJECTIVE: This study assessed the rate and affecting factors of herpes zoster recurrence, in a Korean population. METHODS: From May, 2001 to May, 2011, 2210 patients with confirmed herpes zoster episodes were enrolled. Recurrence episodes and affecting factors of herpes zoster were confirmed using telephone question and medical record review. RESULTS: The overall recurrence rate of herpes zoster was 2.31%. Recurrences were significantly more likely in persons with zoster-associated pain of 30 days or longer, at the initial episode, and in immunocmpromised patients. Women and anyone aged between 50 and 70 years, at the index episode, had a greater likelihood of recurrence. CONCLUSION: Recurrence of herpes zoster is more common in women and is associated with pain duration and immune status.
Aged
;
Female
;
Herpes Zoster
;
Humans
;
Korea
;
Medical Records
;
Recurrence
;
Telephone
9.Effectiveness of the PRISM III Score for Predicting Mortality in Pediatric Intensive Care Neurologic Patients.
Jung Seo PARK ; Sung Hwan KIM ; Seung Soo SHEEN ; Seong Mi JEONG ; Young Joo LEE
Journal of the Korean Child Neurology Society 1998;5(2):271-281
PURPOSE: The Pediatric Risk of Mortality(PRISM) III score was developed from the Physiologic Stability Index(PSI) to assess pediatric ICU mortality and Provide an objective data as a severity index. Although the PRISM score has been applied to many comparisions and analyses in previous studies, there are few reports applied to pediatric intensive care patients in Korea. To evaluate the effectiveness of the PRISM III score as a severity index for expecting mortality and find important variables influencing mortality, we applied this scoring scale to pediatric neurologic patients admitted to the ICU and analyzed the data statistically. METHODS: Data collection was done by careful review of medical records and scored each clinical variable. The outcome at discharge was determined as non-survival, survival, and hopeless discharge. Determination of mortality in the hopeless discharge group was done within 48 hours after discharge by telephone interview. The study populations were classified into four groups; CNS infection(26 patients), acute encephalopathy(31 patients), status epilepticus(35 patients) and cerebrovascular disorder(4 patients). The difference of the PRISM III score between the survival group and non-survival group was compared by using the nonparametric Mann~Whitney test in the entire study population and for each diagnostic group. To confirm the degree of fitness between the actual mortality and Predicted mortality, the Hosmer-Lemeshow goodness-of-fit test, a multiple logistic regression model was used. All clinical variables used for scoring were compared for survivals and non-survivals by the Chi-square test. f values <0.05 were considered significant. RESULTS: The PRISM III score was significantly higher in the non-survival groups than in the survival group. Predicted mortality from the PRISM III score has fitted to actual mortality According to the results of analyses in each diagnostic groups, the PRISM III score was higher in non-survivals of the acute encephalopathy and CNS infection groups, but statistically insignificant in the cerebrovascular disorders and status epilepticus groups. The important variables of the PRISM III score associated with mortality were mental state, Pupil reflex, systolic blood pressure, acidosis, blood sodium level blood creatinine level, blood glucose level, and PT/PTT. , CONCLUSION: The PRISM III score is helpful in predicting mortality in pediatric intensive care neurologic patients, especially those in the acute encephalopathy or the CNS infection groups. However, this score was not useful in the status epilepticus group, and insignificant in cerebrovascular group. Due to the smallness of the study group, more massive and comprehensive studies are needed as a follow up to this study.
Acidosis
;
Blood Glucose
;
Blood Pressure
;
Cerebrovascular Disorders
;
Creatinine
;
Data Collection
;
Follow-Up Studies
;
Humans
;
Critical Care*
;
Interviews as Topic
;
Korea
;
Logistic Models
;
Medical Records
;
Mortality*
;
Pupil
;
Reflex
;
Sodium
;
Status Epilepticus
10.Choroidal Metastasis of Adenocarcinoma of the Lung: A case report.
Seong Hwan PARK ; Ju Han LEE ; Jeong Seok MOON ; Jong Sang CHOI
Korean Journal of Pathology 1999;33(6):471-473
Choroidal metastatic carcinoma is very rare. We recently experienced a case of lung adenocarcinoma which presented to the clinic with ocular symptoms. This 57-year-old Korean male patient visited the department of ophthalmology due to decreased visual acuity and pain of the left eye. On MRI scan, a nodule was attached to the retina of the left eyeball. On simple chest radiograph, a large amount of pleural effusion was noted in the left pleural cavity. Emergency enucleation of the left eyeball was done with an impression of malignant melanoma causing an intractable ocular pain. Grossly, the lesion in the eyeball was rising from the choroid. On histologic examination, tumor cells formed many irregular, small gland-like structures. The tumor cells showed alcian blue-positive mucin in the cytoplasm and glandular lumens and were positive for CEA. Chest CT scan was performed postoperatively and showed a huge mass in the left lower lobe and multiple nodular opacities in both lung fields. Bronchoscopic biopsy revealed moderately differentiated adenocarcinoma similar to that of the eyeball.
Adenocarcinoma*
;
Biopsy
;
Choroid*
;
Cytoplasm
;
Emergencies
;
Humans
;
Lung Neoplasms
;
Lung*
;
Magnetic Resonance Imaging
;
Male
;
Melanoma
;
Middle Aged
;
Mucins
;
Neoplasm Metastasis*
;
Ophthalmology
;
Pleural Cavity
;
Pleural Effusion
;
Radiography, Thoracic
;
Retina
;
Tomography, X-Ray Computed
;
Visual Acuity