No abstract available.
Child* ; Humans

A clinicopathological study was performed with 20 cases of dermatitis herpetifom is encountered at Department of Dermatology, College of Medicine, Busan National University Hospital during the period from January 1969 to August 1977. We used as criteria for diagnosis the history of chronicity and recurrence with good general health, pruritus, symmetric grouping of vesicles and papules, excoriat ions, pigmentations and ready response to DDS. The results were as folIows; 1.The age of onset was varied from 5 to 74 with most; prominent in the age group between 20 and 29 years. 2. Clinical forms included 16 cases of papulovesicular form, 1 case of papular form and, 3 cases of vesicobullous form. 3. The common predilection sites were scapular area, back, sacral area and extensor surfaces of extrernities while oral mucosa was affected in only one case. 4. Histopathological findings of 16 biopsy specimen obtained from the early vesicular lesions and surrounding erythematous areas showed subepidermal bullae in 12 cases and microabscess in 3 cases. 5. Most of the patients (80%) complained either moderate or severe pruritus.
Age of Onset ; Biopsy ; Busan ; Dermatitis Herpetiformis* ; Dermatitis* ; Dermatology ; Diagnosis ; Humans ; Ions ; Mouth Mucosa ; Pigmentation ; Pruritus ; Recurrence

A case of acne conglobata associated with hidradenitis suppurativa, dissecting cellulitis and disseminated superficial actinic porokeratosis in 44 year-old man is presented with brief review of literature. The patient had acne vulgaris for a few years during his highschool days, about 5 years prior to the development of such a typical lesions of acne conglobata as multiple comedones, papules, pustules, abscesses, cysts and draining sinnses and subsquent hypertrophic scars and keloids. We are ps,rticularly interested in association of hidradenitis suppurativa and dissecting cellulitis with ance conglobata that comprise follicular occlusion triad in tbis teint. The pstient was treztei with systemic antibiotics and corticosteroids injections and surgical interventions with considerable improvement.
Abscess ; Acne Vulgaris* ; Adrenal Cortex Hormones ; Adult ; Anti-Bacterial Agents ; Cellulitis ; Cicatrix, Hypertrophic ; Hidradenitis Suppurativa ; Humans ; Keloid ; Porokeratosis

We reviewed 23 patients of injury to the spine who were under 15 years of age and treated at Wonju Christian Hospital from January, 1978 to December, 1987. The patients were classified into 3 different categories, that were frsctures(17 cases), dislocations(3cases), and fracture-dislocation(3 cases). We analyzed the cause of injury, sexage distribution, treatment and neurological injuries. The results were as follows : l. Among the 23 cases, there were 16 boys(70%) and 7 girls(30%). The mean age was 11 years of age, and ages of active period, that is 10 to 15 years of age, were most common, 17 cases(74%). 2. The most common cause of injury was fall from a height, 13 cases(57%). The most common location of injury was cervicsl spine, 10 cases(43%) and among these cases, injury to upper cervical portion(C1–C3) was more common than lower cervical portion(C4–C7). 3. The cases of multiple compression fracture were 6 patients(26%), and all cases were located thoracic or thoraclumbar junction. 4. Most cases were stable spinal injury, 18 cases(78%), and the most common mechanism of injury were compreesion injuries due to hyperflexion, 15 cases(65%). 5. The most common associated injury was head injury, 9 cases(39%), and associated neurological complications were in 4 cases, 3 cases of these were recovered. We could ascertain that the prognosis of children spinal cord injury is better than that of adult. 6. Restoration of the height of the involved vertebral bocy occurred in all but one compression fractures of vertebral body. 7. There were 3 cases of epiphyseal injury, 2 of these were epiphyseal separations of odotoid process of atlas, the other was fracture of lumbar vertebral apphysis. 8. All but two were treated conservatively and the results were good. In stable spinal injury, we considerded that the duration of treatment was 4 to 6 weeks.
Adult ; Child ; Clinical Study ; Craniocerebral Trauma ; Fractures, Compression ; Gangwon-do ; Humans ; Prognosis ; Spinal Cord Injuries ; Spinal Injuries ; Spine

Beta-fluoroethylacetate has been extensively used as the rodenticide in Korea. In some patients with acute poisoning, beta-fluoroethylacetate caused cerebellar dysfunction as a single and persistent neurologic sequela after a period of an acute neurological disorder which is characterized by mental deterioration, seizures, and respiratory failure. But there has been no report of pathological findings to explain neurological deficit. We tried to verify the histologic changes of the central nervous systems in beta-fluoroethylacetate poisoned rats. Silver staining(Gallyas) was used to evaluate the histology. In acute intoxication experiment with LD50(7mg/Kg), beta-fluoroethylacetate elicited acute onset of consciousness deterioration, generalized tonic-clonic seizures and large amplitude tremulous activity involving whole body with full recovery after 24 hours. There was no discernible pathologic change in CNS in acutely poisoned rats. However, when poisoned with sublethal dose(5mg/Kg) daily for five days, a moderate degree of nerve cell degeneration was found selectively in dentate nucleus, Purkinie cell layer, vestibulo-cochlear nucleus and striatum. This change was not seen in hippocampus, cerebral cortex or cerebellar cortex. These findings were well correlated with the previous reports of selective pathology in human 5-FU intoxication cases. Our preliminary results suggest that beta-fluoroethylacetate, a kind of cellular metabolism inhibitor may induce selective neuropathology mainly involving cerebellar output pathway in rats.
Humans ; Rats ; Animals ; Poisons

No abstract available.
Colitis, Ulcerative* ; Humans

No abstract available.
Child* ; Down Syndrome* ; Humans ; Hypothyroidism* ; Incidence*

Carbon disulfide(CS2), a volatile solvent, has been widely used in the manufacture of the artificial silk because of its highly fat-soluble property. It has been accepted that CSz is mostly absorbed to the human beings by inhalation arld does harms mainly to the central and peripheral nervous systems and the cardiovascular system. But it is conkoversial whether the pathologic changes are due to the direct toxic effects of the CS2 or to the secondary effects of the CS2-induced arteriosclerosis. Recently the authors have observed the six patients of viscose-rayon worker with a longstanding exposure to the CS2 and obtained the results as follows:1. The ages of onset in the 6 subjects (5 males and one female) were ranged from @41 to 53 years(mean;47.1) and the duration of exposure from 11 to 18 years(mean;l4.5). 2. Three of them had no hypertension. 3. Neurologically they showed headache, dizziness, general malaise, gait difficulty, visual and memory disturbances, paresthesia of distal extremities, dementia, parkinsonian features, pseudobubar palsy, spastic gait, dysarthria, hyperreflexia, and reduced or absent ankle jerks. 4. Nerve conduction studies(N=4) revealed that three of them had polyneuropathy of axonal type.
Ankle ; Arteriosclerosis ; Axons ; Carbon* ; Cardiovascular System ; Dementia ; Dizziness ; Dysarthria ; Extremities ; Gait ; Gait Disorders, Neurologic ; Headache ; Humans ; Hypertension ; Inhalation ; Male ; Memory ; Neural Conduction ; Paralysis ; Paresthesia ; Peripheral Nervous System ; Polyneuropathies ; Reflex, Abnormal ; Silk

Characterizations of the VP4 (P type) and VP7 (G type) genes of Korean isolates of bovine rotavirus were performed using RT-PCR/RFLP and nucleotide sequencing analysis. After RT-PCR amplification of partial length (1094bp) of the VP4 and full length (1062bp) of the VP7 genes, amplified PCR products were digested with restriction endonucleases and digestion patterns were compared with those of reference rotaviruses. With the VP4 genes, four RFLP (AD) profiles were observed; three (A, B and C) were the same as those of bovine rotavirus NCDV (P[1]), IND (P[5]) and B223 (P[11]), respectively, Profile D was the same as that of porcine rotavirus OSU (p[7]). With the VP7 genes, five RFLP profiles (I-V) were observed; three of them (1, II and III) were the same as those of bovine rotavirus NCDV (G6), Cody I-801 (G8), and B223 (G10), respectively, Profile IV and V were atypical to those of reference bovine rotaviruses used in this study. These two profiles were identified as G6 and G5, respectively, after analyzing and comparing the nucleotide sequences. The G typing analysis revealed that 61.9% (26/42) were G6, which included G6 subtype; 28.6% (12/42) were G5; 7.1% (3/42) were G10; 2.4% (1/42) were G8. The P typing analysis revealed that 54.8% (23/42) were P(5); 28.6% (12/42) were P(7); 11.8% (5/42) were P(11); 4.8% (2/42) were P(1). Our results showed that G6/P(5) were the most prevalent rotaviruses in diarrheic calves in Korea. Also, this is the first report that G5P(7) rotaviruses were identified from cattle with diarrhea.
Animals ; Base Sequence ; Cattle ; Diarrhea ; Digestion ; DNA Restriction Enzymes ; Korea ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length* ; Rotavirus*

No abstract available.