1.T Cell Activation in Ischemic Heart Disease.
Seung Ho HUR ; Kee Sik KIM ; Seong Wook HAN ; Kyung Mok SHIN ; Yoon Nyun KIM ; Kwon Bae KIM
Korean Circulation Journal 1996;26(3):645-650
BACKGROUND: It was recently shown that human atherosclerotic plaque contains large numbers of T lymphocytes : this indicates that immune and inflammatory mechanism may be important factors in the pathogenesis of atherosclerosis. By measuring the soluble interleukin 2 receptor(sIL-2R) level we can evaluate the activation of T lymphocyte. The purpose of this study is to evaluate relationship between T cell activation and ischemic heart disease by measuring the soluble interleukin 2 receptor (sIL-2R) level in patient with ischemic heart disease. METHOD: Seventy-two patients(40 males and 32 female, mean age : 56.5+/-9.9 years) who were taken coronary angiography were included in this study. Among them, 49 patients showed abnormal coronary angiographic findings and 23 patients showed normal coronary angiographic findings. Ten mililiters of arterial blood was drawn at the time of coronary angiography. The blood was allowed to coagulate and then the serum was removed and tested in duplicate for soluble interleukin 2 receptor (sIL-2R) level by ELISA. RESULTS: 1) The soluble interleukin 2 receptor (sIL-2R) level was significantly different between abnormal coronary angiographic findings and normal coronary angiographic findings (P < 0.001). 2) According to clinical severity of ischemic heart disease (i.e. stable angina, unstable angina, acute myocardial infarction.), soluble interleukin 2 receptor (sIL-2R) level was not significantly different between single vessel disease group and multivessels disease groups (p > 0.05), but showed increasing tendency with clinical severity. 3) According to numbers of involved coronary vessels, soluble interleukin 2 receptor (sIL-2R) level was not significantly different between single vessel disease group and multivessels disease groups (p > 0.05). CONCLUSION: T lymphocyte activation, as reflected in elevated soluble interlekin 2 receptor (sIL-2R) level, is frequent in patient with ischemic heart disease. In the further we will investigate relationship between clinical diagnosis of ischemic heart disease of the numbers of involved coronary vessels and T cell activation.
Angina, Stable
;
Angina, Unstable
;
Atherosclerosis
;
Coronary Angiography
;
Coronary Vessels
;
Diagnosis
;
Enzyme-Linked Immunosorbent Assay
;
Female
;
Humans
;
Interleukin-2
;
Lymphocyte Activation
;
Lymphocytes
;
Male
;
Myocardial Ischemia*
;
Plaque, Atherosclerotic
;
Receptors, Interleukin-2
;
T-Lymphocytes
2.A Case of Right Coronary Artery Originating from Distal Left Circumflex (Single Coronary Artery).
Dae Woo HYUN ; Seung Ho HUR ; Seong Wook HAN
Korean Circulation Journal 2003;33(11):1044-1047
A single coronary artery is a rare congenital anomaly. The right coronary artery, originating from distal left circumflex, is an extremely rare variety of a single coronary artery. Our report is accompanied by a brief review of the literature.
Coronary Vessel Anomalies
;
Coronary Vessels*
3.A Case of Coronary Pseudostenosis, Diagnosed by Intravascular Ultrasound.
Hyoung Seob PARK ; Seung Ho HUR ; Seong Wook HAN
Korean Circulation Journal 2004;34(2):204-208
A coronary pseudostenosis is a characteristic angiographic image, which may appear as coronary winkles, or intussusceptions, due to a stiff guidewire during coronary interventions. Intravascular ultrasound (IVUS) plays a role in ruling out severe coronary stenosis, coronary dissections, thrombus or coronary spasm. We report a case of coronary pseudostenosis, which occurred during coronary interventions, diagnosed by intravascular ultrasound.
Coronary Stenosis
;
Intussusception
;
Spasm
;
Thrombosis
;
Ultrasonography*
4.Clinical significance of myocardial bridge.
Seong Wook HAN ; Yoon Nyun KIM ; Seung Ho HUR ; Dae Woo HYUN ; Kee Sik KIM ; Kwon Bae KIM
Korean Journal of Medicine 1998;54(6):814-819
No abstract available.
5.A Case of Bilateral Vestibular Hypofunction Following Oseltamivir Medication
Ho Yeop KIM ; Seong Ki AHN ; Dong Gu HUR
Journal of the Korean Balance Society 2013;12(1):27-30
The threat of pandemic influenza has focused attention and resources on virus surveillance, prevention, and containment. The World Health Organization has strongly recommended the use of the antiviral drug, Oseltamivir (Tamiflu(R)), to treat and prevent pandemic influenza infection. In recent years, there have been case reports of vestibulocochlear events during or after oseltamivir treatment, other countries. Oseltamivir is generally well-tolerated and its most frequent adverse effects include nausea and vomiting, diarrhea, and abdominal pain. Up to now, bilateral vestibular hypofunction after oseltamivir medication has not been reported. Herein, we report a very rare case of a 36-year-old female with bilateral vestibular hypofunction following oseltamivir medication.
Abdominal Pain
;
Containment of Biohazards
;
Diarrhea
;
Drug Toxicity
;
Female
;
Humans
;
Influenza, Human
;
Nausea
;
Oseltamivir
;
Pandemics
;
Vestibular Function Tests
;
Viruses
;
Vomiting
;
World Health Organization
6.External Ventricular Drainage System with Long Subcutaneous Tunnel.
Chang Wook HUR ; Seong Ho KIM ; Sang Woo KIM ; Chul Hun CHANG ; Byung Yon CHOI ; Soo Ho CHO
Journal of Korean Neurosurgical Society 2004;35(1):88-90
OBJECTIVE: The goal of this study is to introduce a new method of external ventricular drainage system to reduce the complications of infections by making a long subcutaneous tunnel. METHODS: Between January 2002 and March 2003, 59 cases of ventriculostomy including 44 cases of short subcutaneous tunnel and 15 cases of long subcutaneous tunnel were performed and analysed. Subarachnoid hemorrhage and intraventricular hemorrhage were major indications for ventriculostomy. RESULTS: No infection was noted in the group of 15 patients with long subcutaneous tunnel. Whereas, 6 cases(13.6%) of infection was diagnosed in the group of 44 patients with short subcutaneous tunnel. The ventriculostomy was kept maximally for 11(mean 7.4)days without infection in the patients with long subcutaneous tunnel. CONCLUSION: To reduce the infection as a complication of ventriculostomy, we devise a new drainage system that involves the long subcutaneous tunnel.
Drainage*
;
Hemorrhage
;
Humans
;
Subarachnoid Hemorrhage
;
Ventriculostomy
7.Accuracy of mitral valve area in patients with mitral stenosis measured by echocardiography : Compared with operative mitral valve area.
Chang Yeob HAN ; Kee Sik KIM ; Seong Wook HAN ; Seung Ho HUR ; Jang Ho BAE ; Yoon Nyun KIM ; Kwon Bae KIM
Korean Circulation Journal 1998;28(2):205-214
BACKGROUND: Measurement of echocardiographic mitral valve area (MVA) is an useful noninvasive method of estimating the stenotic mitral valve area. This study was undertaken to evaluate the accuracy of echocardiographic MVA measurement by comparing MVAs measured by the planimetric and pressure half-time method versus direct MVA measurement by using a cone shaped device specifically made for direct measurement of MVA. METHODS AND RESULTS: The study population consisted of 22 consecutive patients from August 1993 to February 1996. All the patients underwent 2D planimetry and Doppler echocardiographic MVA measurement before and after valve replacement surgery ; direct measurement also was performed after surgery. Five patients (22.7%) had normal sinus rhythm, and the rest of the patients had atrial fibrillation. Two-dimensional echocardiographic examinations were attempted in 22 patients, and adequate measurements were obtained in 21 of the patients studied. Mean mitral valve area were 0.99+/-0.32cm (2) ranged from 0.42 to 1.68cm (2) on 2D planimetry method, 0.93+/-0.32cm (2) ranged from 0.42 to 1.68cm (2) on Doppler pressure half-time method, 1.17+/-0.20cm (2) ranged from 0.93 to1.68cm (2) on direct measurement of mitral valve area after surgery. 2D planimetry method (r=0.621, p=0.003, SE=0.165), pressure half-time method (r=0.454, p=0.003, SE=0.187), and transmitral peak velocity (r=-0.480, p=0.026, SE=0.189) was relatively well correlate with operative mitral valve area. There was relatively good agreement between direct and 2D planimetric measurement and between direct and Dopler pressure-half time method. CONCLUSION: 2D planimetry and Doppler pressure half-time method on echocardiography are useful, noninvasive measurement method in patients with mitral stenosis.
Atrial Fibrillation
;
Echocardiography*
;
Humans
;
Mitral Valve Stenosis*
;
Mitral Valve*
10.Delayed Cerebellar Hemorrhage after Supratentorial Burr-Hole Drainage.
Chang Wook HUR ; Seong Ho KIM ; Sang Woo KIM ; Chul Hun CHANG
Journal of Korean Neurosurgical Society 2003;34(2):171-173
We report two cases with delayed cerebellar hemorrhage developed after supratentorial burr-hole drainage, and review the literature. Burr-hole drainage was performed at both sides of bilateral chronic subdural hematomas. The total amount of drainage per day was more than 300ml of hematoma mixed with cerebrospinal fluid(CSF) and the differences in doses between the two sides were significant in both cases. The symptoms improved after drainage but abrupt deterioration of neurological status occurred with the development of cerebellar hemorrhage on postoperative day 4 and 5, in each case. Although both patients were elderly, 75 and 86 years old, they did not have any coagulation defect or episode of severe increase in their blood pressures during drainage. We believe that suprate-ntorial CSF overdrainage can cause cerebellar upward shift, with resultant injury of weakened cerebellar vessels in old age.
Aged
;
Aged, 80 and over
;
Drainage*
;
Hematoma
;
Hematoma, Subdural, Chronic
;
Hemorrhage*
;
Humans