1.A case of fetal atrial flutter with hydrops fetalis.
Seong Hang CHOI ; Kee Hyoung LEE ; Chang Sung SOHN ; Ju Won LEE ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1993;36(8):1165-1170
Fetal hydrops is often serious and associated with a high perinatal motality rate. Cardiac causes of fetal hydrops include congenital heart diseases and rhythm disturbances. An irregular fetal heart rate may indicate atrial fibrillation and atrial flutter with variable AV conduction. Fetal atrial flutter is characterized by the pressence of flutter waves which are regular sawtooth undulations in the baseline that are larger than p waves. Authors experienced a case of fetal atrial flutter with hydrops fetalis at 30 week's gestation which was confirmed by fetal M-mode echocardiogram and electrocardiography. A new born infant had shown to have atrial flutter in utero and after delivery was successfully converted to normal sinus rhythm with digoxin and quinidene.
Atrial Fibrillation
;
Atrial Flutter*
;
Digoxin
;
Edema*
;
Electrocardiography
;
Female
;
Heart Diseases
;
Heart Rate, Fetal
;
Humans
;
Hydrops Fetalis*
;
Infant
;
Pregnancy
2.The study of serum lipids in grossly obese elementary school students in Seoul.
Seong Hang CHOI ; Kyoung Bum KIM ; Se Geun PARK ; Ji Tae CHUNG ; Chang Sung SON ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1993;36(1):73-80
Our study surveded 418 obese first grade elementary school children(279 male and 139 female), in seoul, and measured levels of serum total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride were measured in addition to the measurement of body weight and height. The following results were obtained. 1) Obesity index was catergorized into mild, moderate, and severe, and the percentage of mild was 6.8%, moderate 48%, severe 45.7% respectively in surveyed children. 2) The average level of total cholesterol was 1.66.60 27.63mg/dl, HDL cholesterol 50.22+/-0.68mg/dl, LDL cholesterol 82.23+/-1.26mg/dl. 3) Atherogenic index was calculated, and obtained value was 2.45+/-0.48. It showed higher statstical significance in boys than in girls(p<0.05). 4) There was no significant difference in average level of total cholesterol, LDL cholesterol, and triglyceride in accordance of the severity of obesity. 5) Statistical significance was found in different average ievels of HDL cholesterol and atherogenic index according to obesity index (p<0.05). 6) There was a statistical significance in the average values of Kaup index and Rohrer index in accordance with obesity index (p<0.000). 7) There was no correlation between abnormal levels of total cholesterol, HDL cholesterol, and LDL cholesterol and the severity of obesity. 8) Abnormal levels of triglyceride, atherogenic index, Rohrer index and Kaup index had a statistical significance since their levels. 9) There was a correlation between atherogenic index and body measurement. Total cholesterol level showed correlation with obesity index, and HDL cholesterol with Kaup index and arm circum ference.
Arm
;
Body Weight
;
Child
;
Cholesterol
;
Cholesterol, HDL
;
Cholesterol, LDL
;
Humans
;
Male
;
Obesity
;
Seoul*
;
Triglycerides
3.Infectivity of Orientia tsutsugamushi to Various Eukaryotic Cells and Their Cellular Invasion Mechanism.
Kyung Soo IHN ; Seung Hoon HAN ; Hang Rae KIM ; Seung Yong SEONG ; Ik Sang KIM ; Myung Sik CHOI
Journal of the Korean Society for Microbiology 1999;34(5):435-443
Orientia tsutsugamushi is obligate intracellular bacterium that grows within the cytoplasm of the eukaryotic host cells. Therefore capability of the attachment, entry into the host cell and intracellular survival should be critical process for oriential infection. In this study we investigated the cellular invasion mechanism of Orientia tsutsugamushi and the role of transmembrane heparan sulfate proteoglycan, which binds diverse components at the cellular microenvironment and is implicated as host cell receptors for a variety of microbial pathogens. First of all Orientia tsutsugamushi can invade a wide range of nonprofessional phagocytic cells including fibroblast, epithelial cells a#nd endothelial cells of various host species, including B and T lymphocytes. Thus, it was postulated that the attachment of O. tsutsugamushi requires the recognition of ubiquitous surface structures of many kinds of host cells. Treatments with heparan sulfate and heparin inhibited the infection of Orientia tsutsugamushi in dose-dependent manner for L cell, mouse fibroblast, whereas other glycosaminoglycans such as chondroitin sulfate had no effect. Collectively, these findings provide strong evidence that initial interaction with heparan sulfate proteoglycan is required for the oriential invasion into host cells.
Animals
;
Cellular Microenvironment
;
Chondroitin Sulfates
;
Cytoplasm
;
Endothelial Cells
;
Epithelial Cells
;
Eukaryotic Cells*
;
Fibroblasts
;
Glycosaminoglycans
;
Heparan Sulfate Proteoglycans
;
Heparin
;
Heparitin Sulfate
;
Mice
;
Orientia tsutsugamushi*
;
Phagocytes
;
T-Lymphocytes
4.The Effect of Irradiation on the Expression of PCNA and Apoptosis Induction during the DMBA Induced Carcinogenesis in Hamster Buccal Pouch.
In Seong JEON ; Min Suk HEO ; Hang Moon CHOI ; Sam Sun LEE ; Soon Chul CHOI
Korean Journal of Oral and Maxillofacial Radiology 2000;30(3):207-216
PURPOSE: This study was carried out to investigate the effect of irradiation on the expression of proliferating cell nuclear antigen (PCNA) and apoptosis induction during the carcinogenesis in hamster buccal pouch. MATERIALS AND METHODS: Three months old Syrian golden hamsters were divided into control and 2 experimental groups. Hamsters in control group were left untreated on buccal pouchs. Twenty four hamsters were treated with 0.5% DMBA tri-weekly on the right buccal pouch. Forty eight hamsters were treated with 0.5% DMBA tri-weekly and irradiated with the dose of 5 Gy and 10 Gy at 6, 9, 12, 15 weeks after DMBA application. Resected buccal pouches were sectioned and examined for potential expression pattern of PCNA and apoptosis. RESULTS: The PCNA index was increased with the stages of buccal pouch epithelium carcinogenesis except the hyperplasia stage in control group (p<0.05). The irradiation did not effect on the PCNA index in the dysplasia and the carcinoma in situ stage, but in the hyperplasia stage, the PCNA index was increased with 10 Gy radiation and decreased in the carcinoma stage (p<0.05). The apoptotic index was significantly decreased from the carcinoma in situ stage and the lowest in the carcinoma stage. The apoptotic index was significantly decreased in the hyperplasia and dysplasia stage with the 5 Gy irradiation and significantly increased only in the carcinoma stage with the 10 Gy irradiation (p<0.05). CONCLUSION: The PCNA and apoptotic index were varied according to the irradiation period and dosage in each carcinogenesis stage.
9,10-Dimethyl-1,2-benzanthracene*
;
Animals
;
Apoptosis*
;
Carcinogenesis*
;
Carcinoma in Situ
;
Cricetinae*
;
Epithelium
;
Hyperplasia
;
Mesocricetus
;
Proliferating Cell Nuclear Antigen*
;
Radiation Dosage
5.Seroepidemiological Survey of Hemorrhagic Fever with Renal Syndrome in Korea , 1994 - 1996.
Ik Sang KIM ; Myong Sik CHOI ; Won Jong JANG ; Hang Rae KIM ; Sae Gwang PARK ; Myung Suk HUH ; Seung Yong SEONG
Journal of the Korean Society for Microbiology 1999;34(3):245-251
To understand the seroepidemiological patterns of haemorrhagic fever with renal syndrome in Korea, a nation-wide survey collaborated with fourteen clinics was carried out from 1994 to 1996. Sera of 4,547 patients with acute febrile episodes were tested by indirect immunofluorescent antibody test and the seroepidemiological analysis including sex, age, seasonal and regional distributions were performed. According to the results obtained in this study, the epidemiological characteristics of haemorrhagic fever with renal syndrome in Korea were summarized as follows: 1. Seropositive rate of hemorrhagic fever with renal syndrome among the patients with acute febrile episodes was 6.4% by the cut-off point of 1:40. 2. Among the seropositives, male outnumbered female and the ratio of males to females was 2.0:1.0. 3. Seventy six % of the seropositive patients were 21-60 years old. 4. The number of seropositive cases increased from October and reached maximum in December and began to decrease gradually from January. 5. The geographical distribution of the seropositives cover most areas including Cheju province in Korea.
Female
;
Fever
;
Hemorrhagic Fever with Renal Syndrome*
;
Humans
;
Jeju-do
;
Korea*
;
Male
;
Seasons
6.Do Helper T Cell Subtypes in Lymphocytic Thyroiditis Play a Role in the Antitumor Effect?.
Seok Woo YANG ; Seong Ho KANG ; Kyung Rae KIM ; In Hong CHOI ; Hang Seok CHANG ; Young Lyun OH ; Soon Won HONG
Journal of Pathology and Translational Medicine 2016;50(5):377-384
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently accompanied by lymphocytic thyroiditis (LT). Some reports claim that Hashimoto's thyroiditis (the clinical form of LT) enhances the likelihood of PTC; however, others suggest that LT has antitumor activity. This study was aimed to find out the relationship between the patterns of helper T cell (Th) cytokines in thyroid tissue of PTC with or without LT and the clinicopathological manifestation of PTC. METHODS: Fresh surgical samples of PTC with (13 cases) or without (10 cases) LT were used. The prognostic parameters (tumor size, extra-thyroidal extension of PTC, and lymph node metastasis) were analyzed. The mRNA levels of two subtypes of Th cytokines, Th1 (tumor necrosis factor α [TNF-α], interferon γ [IFN-γ ], and interleukin [IL] 2) and Th2 (IL-4 and IL-10), were analyzed. Because most PTC cases were microcarcinomas and recent cases without clinical follow-up, negative or faint p27 immunoreactivity was used as a surrogate marker for lymph node metastasis. RESULTS: PTC with LT cases showed significantly higher expression of TNF-α (p = .043), IFN-γ (p < .010), IL-4 (p = .015) than those without LT cases. Although the data were not statistically significant, all analyzed cytokines (except for IL-4) were highly expressed in the cases with higher expression of p27 surrogate marker. CONCLUSIONS: These results indicate that mixed Th1 (TNF-α, IFN-γ , and IL-2) and Th2 (IL-10) immunity might play a role in the antitumor effect in terms of lymph node metastasis.
Biomarkers
;
Cyclin-Dependent Kinase Inhibitor p27
;
Cytokines
;
Follow-Up Studies
;
Interferons
;
Interleukin-4
;
Interleukins
;
Lymph Nodes
;
Necrosis
;
Neoplasm Metastasis
;
RNA, Messenger
;
T-Lymphocytes, Helper-Inducer
;
Thyroid Gland
;
Thyroid Neoplasms
;
Thyroiditis
;
Thyroiditis, Autoimmune*
7.Radiation-induced apoptosis, necrosis and G2 arrest in Fadu and Hep2 cells.
Sam Sun LEE ; Beom Hyun KANG ; Hang Moon CHOI ; In Seong JEON ; Min Suk HEO ; Soon Chul CHOI
Korean Journal of Oral and Maxillofacial Radiology 2000;30(4):275-279
PURPOSE: Radiation damage is produced and viable cell number is reduced. We need to know the type of cell death by the ionizing radiation and the amount and duration of cell cycle arrest. In this study, we want to identified the main cause of the cellular damage in the oral cancer cells and normal keratinocytes with clinical useful radiation dosage. MATERIALS AND METHODS: Human gingival tissue specimens obtained from healthy volunteers were used for primary culture of the normal human oral keratinocytes(NHOK). Primary NHOK were prepared from separated epithelial tissue and maintained in keratinocyte growth medium containing 0.15 mM calcium and a supplementary growth factor bullet kit as described previously. Fadu and Hep-2 cell lines were obtained from KCLB. Cells were irradiated in a (137)Cs gamma-irradiator at the dose of 10 Gy. The dose rate was 5.38 Gy/min. The necrotic cell death was examined with Lactate Dehydrogenase(LDH) activity in the culture medium. Every 4 day after irradiation, LDH activities were read and compared control group. Cell cycle phase distribution and preG1-incidence after radiation was analyzed by flow cytometry using Propidium Iodine(PI) staining. Cell cycle analysis were carried out with a FAC Star plus flowcytometry(FACS, Becton Dickinson, USA) and DNA histograms were processed with CELLFIT software(Becton Dickinson, USA). RESULTS: LDH activity increased in all of the experimental cells by the times. This pattern could be seen in the non-irradiated cells, and there was no difference between the non-irradiated cells and irradiated cells. We detected an induction of apoptosis after irradiation with a single dose of 10 Gy. The maximal rate of apoptosis ranged from 4.0% to 8.o% 4 days after irradiation. In all experimental cells, we detected G2/M arrest after irradiation with a single dose of 10 Gy. Yet there were differences in the number of G2/M arrested cells. The maximal rate of the G2/M ranges from 60.0% to 80.0% 24h after irradiation. There is no significant changes on the rate of the G0/G1 phase. CONCLUSION: Radiation sensitivity was not related with necrosis but cell cycle arrest and apoptosis. These data suggested that more arrested cell is correlated with more apoptosis.
Apoptosis*
;
Calcium
;
Cell Count
;
Cell Cycle
;
Cell Cycle Checkpoints
;
Cell Death
;
Cell Line
;
DNA
;
Flow Cytometry
;
Healthy Volunteers
;
Humans
;
Keratinocytes
;
Lactic Acid
;
Mouth Neoplasms
;
Necrosis*
;
Propidium
;
Radiation Dosage
;
Radiation Tolerance
;
Radiation, Ionizing
8.Study of the relationship between the indication rod of stent on implant CT and the real path of implant fixture insertion considering residual ridge.
Do Hoon KIM ; Min Suk HEO ; Sam Sun LEE ; Sung Ook OH ; Hang Moon CHOI ; In Seong JEON ; Soon Chul CHOI
Korean Journal of Oral and Maxillofacial Radiology 2003;33(2):79-83
PURPOSE: To assess the relationship between the direction of the indicating rod of the radiographic stent for ideal prosthetic design and the actual possible path of implant fixture placement when residual ridge resorption is considered. MATERIALS AND METHODS: The study materials consisted of 326 implant sites (male 214 cases and female 112 cases) from a total of 106 patients (male 65 patients and female 41 patients) who desired implant prostheses. Computed tomography of patients were taken and reformatted using ToothPix (R) software. Bony defects, bony sclerosis, the change of the direction of indicating rod, and root proximity of the adjacent teeth were examined on the CT-derived images. RESULTS: The rate of the irregular crestal cortex was relatively high on premolar and molar area of maxilla. Mandibular molar area showed relatively high rate of focal sclerosis on the area of implant fixture insertion. The position of the indicating rods were relatively acceptable on the molar areas of both jaws. However, the position of the indicating rods should be shifted to buccal side with lingual rotation of the apical end on maxillary anterior teeth and premolar area. CONCLUSION: Clinically determined rod direction and position of the indicating rod for implant placement was not always acceptable for insertion according to the reformatted CT images. The pre-operative treatment plan for implant should be determined carefully, considering the state of the alveolar bone using the reformatted CT images.
Bicuspid
;
Dental Implants
;
Female
;
Humans
;
Jaw
;
Maxilla
;
Molar
;
Prostheses and Implants
;
Sclerosis
;
Stents*
;
Tooth
9.Severe bony ankylosis of the temporomandibular joint on one side and contralateral adhesion: A case report.
Ji Young SONG ; Seong Gon KIM ; Hang Moon CHOI ; Hyun Jung KIM
Imaging Science in Dentistry 2015;45(2):103-108
Bony fusion between the mandibular condyle and skull base involves temporomandibular joint (TMJ) bony ankylosis. This condition might originate from trauma, infection, or systemic disease. TMJ adhesion can develop after synovial damage. Both TMJ ankylosis and adhesion lead to functional impairment and pain. Here, we present a case of a 50-year-old female who had bony ankylosis of the right TMJ and adhesion of the left TMJ. She had otitis media in the right ear. A large mass in the right TMJ was observed on computed tomograph. Magnetic resonance image showed a large fused bone mass with normal bone marrow in the right TMJ and flattening of the condyle with a thin disk in the left TMJ. Gap arthroplasty with temporal fascia was performed on the right TMJ, and discectomy, high condylectomy, and coronoidectomy were performed on the left TMJ. During a 2-year follow-up after surgery, the patient had no recurrence.
Ankylosis*
;
Arthroplasty
;
Bone Marrow
;
Diskectomy
;
Ear
;
Fascia
;
Female
;
Follow-Up Studies
;
Humans
;
Mandibular Condyle
;
Middle Aged
;
Mouth Rehabilitation
;
Otitis Media
;
Recurrence
;
Skull Base
;
Temporomandibular Joint*
10.Intravaginal Misoprostol for the Termination of Second and Third Trimester Pregnancy.
Hang Jae LEE ; Hae Hyeog LEE ; Seok Min LEE ; Seong Yun JEONG ; Ji Yeon LEE ; Seog Beom YOON ; Kyu Hong CHOI ; Jeong Jae LEE ; Im Soon LEE ; Kwon Hae LEE
Korean Journal of Perinatology 1999;10(4):460-464
OBJECTIVE: The purpose was to evaluate the effect of the intravaginal misoprostol(prostaglandin E1,) for termination after second trimester. METHODS: Thirty pregnant women with intrauterine fetal death and with indications for therapeutic termination of intrauterine pregnancy at least fourteen weeks of gestation were recruited. They were evaluated the mean time from induction to termination, maternal side effects, and total dose of the powdered 100ug misoprostol adminstered in the posterior vaginal fornix every six hours. RESULTS: The mean time from induction to termination was 21.1+/-8.2 hours after administration of the intravaginal misoprostol. Only two patients had not been delivered within 48hours. Vomiting, diarrhea, and fever were not accompanied except nausea. The total dosage of misoprostol was 412.5+/-156.1ug. CONCLUSION: This study shows that intravaginal misoprostol appears to be safe, effective and inexpensive method for the labor induction for termination of pregnancy in the second or third trimester of pregnancy.
Diarrhea
;
Female
;
Fetal Death
;
Fever
;
Humans
;
Misoprostol*
;
Nausea
;
Pregnancy
;
Pregnancy Trimester, Second
;
Pregnancy Trimester, Third*
;
Pregnant Women
;
Vomiting