1.Pancreatic islet-cell adenoma.
Ji Hong KIM ; Ho Seong KIM ; Duk Hi KIM ; Hyun Yee IM ; Chan Il PARK
Journal of the Korean Pediatric Society 1993;36(6):870-876
Pancreatic islet cell adenoma is a benign tumor of pancreatic beta-cell and a rare cause of hyperinsulinemic hypoglycemia in children. The authors experienced a case of pancreatic islet cell adenoma(Insulinoma)in a 11 year and 8 month old male who had frequent loss of consciousness and seizure. Enucleation was done after localization of tumor by selective celiac artery angiography and abdominal computed tomography. Diagnosis was confirmed by histologic findings as pancreatic-adenoma, gyriform growth pattern. A brief review of related literature was made.
Adenoma*
;
Angiography
;
Celiac Artery
;
Child
;
Diagnosis
;
Humans
;
Hyperinsulinism
;
Hypoglycemia
;
Infant
;
Islets of Langerhans
;
Male
;
Seizures
;
Unconsciousness
2.Partial remission with transarterial embolization in a case of metastatic adrenal cortical carcinoma.
Moon Soo KOH ; Myung Shik LEE ; Seong Woon HONG ; Duk LIM
Journal of Korean Medical Science 1991;6(2):173-176
A case of metastatic adrenal cortical carcinoma in which partial remission was achieved with transarterial embolization is presented as probably the first reported case in the literature to date. A 29-year-old woman was admitted because of adrenal cortical carcinoma which had not responded to mitotane. A left adrenalectomy with segmentectomy of the involved liver had been done previously. Abdominal computerized tomography demonstrated multiple large metastatic tumors in the liver. Transarterial embolization with Gelfoam and 20 mCi of 131I-labeled lipiodol was performed and resulted in a decrease in tumor size and biochemical parameters. Transarterial embolization can be one of the therapeutic modalities for metastatic adrenal cortical carcinomas.
Adrenal Cortex Neoplasms/metabolism/*therapy
;
Adult
;
*Embolization, Therapeutic
;
Female
;
Gelatin Sponge, Absorbable
;
Hepatic Artery
;
Humans
;
Hydrocortisone/metabolism
;
Iodine Radioisotopes
;
Iodized Oil
;
Liver Neoplasms/metabolism/*secondary/*therapy
3.Nuclear DNA content measured by flow cytometry as a predictor of gestational trophoblastic disease outcome.
Seong Duk HONG ; Sang Kyun HAN ; Woong Shick AHN ; Jae Keun JUNG ; Hun Young LEE ; Seung Jo KIM
Korean Journal of Obstetrics and Gynecology 1991;34(6):838-847
No abstract available.
DNA*
;
Flow Cytometry*
;
Gestational Trophoblastic Disease*
4.A prospective study of totally implanted venous access system in 19 children with cancer.
Kyung Duk PARK ; Eun Sil DONG ; Seong Hoon HA ; Hong Hoe KOO ; Hee Young SHIN ; Hyo Seop AHN ; Seong Eun JUNG ; Gui Won PARK
Journal of the Korean Pediatric Society 1993;36(5):687-692
A totally implanted venous access system was inserted in 19 children with cancer. The devices were utilized for the administration of antineoplastic drugs, parenteral fluids, antibiotics, and blood products. Total duration of implantation was 4,046 days for 23 implanted system (range 7-445 days). Complications included cather infection (0.247/100 catheter days), occlusion (0.692/100 catheter days), and dislodgement of needle (0.643/100 catheter days). There were major complications that necessitated removal of catheters, including systemic infections (0.09/100 catheter days) and complete occlusions (0.09/100 catheter days). The system was thought to be safe and convenient in chemotherapy, and permitted full physical activity.
Anti-Bacterial Agents
;
Antineoplastic Agents
;
Catheters
;
Child*
;
Drug Therapy
;
Humans
;
Motor Activity
;
Needles
;
Prospective Studies*
5.Prognostic Value of Elactrophysiologic Tests in Bell's Palsy.
Duk Hong MOON ; Eun Hi SA ; Young Jin YUN ; Dong Jo LEE ; Seong Uk HONG
Journal of the Korean Neurological Association 1996;14(3):781-788
Bell's palsy is a relatively common, unilateral facial paralysis of unknown etiology. The purpose of this study was to evaluate the prognostic value of several electrophysiologic tests in Bell's palsy. Blink reflex (BR), side-to-side compound muscle action potential (CMAP) amplitude comparison, and side-to-side nerve excitability test (NET) threshold differ once have been studied during the first 2 weeks in 66 patients with Bell's palsy. According to the early response of BR(Rl), the patients were divided into 3 groups: Rl< or = 13ms(17cases) ; Rl>13ms(22cases), and absent BR(27cases). There was a remarkable tendency towards a satisfactory recovery from paralysis if BR occurred during the first 2 weeks from onset(p<0.001). In patients with normal BR, 88.2% had a satisfactory recovery, when the reflex was absent a bad prognosis was given in 59.3% of the patients. According to side-to-side CMAP amplitude comparison, the patients were divided into 2 groups; CMAP amplitude comparison > or = 25% (35cases), and CMAP amplitude comparison <25% (31cases). There was a tendency towards a satisfactory recovery from paralysis if side-to-side CMAP amplitude comparison was more than 25% (p < 0,003). In patients with more than 25% of CMAP amplitude comparison, 82.9% of the patients had a satisfactory recovery, but in patients with less than 25% of CMAP amplitude comparison, 51.6% of the patients had a bad prognosis. According to side-to-side NET threshold difference, the patients were divided into 2 groups, NET threshold difference < or = 3.5mA(43cases), and NET threshold difference >3.5mA (23cases). When the threshold of electrical excitability on both sides differs 3.5mA or more an unsatisfactory recovery has strongly to expected(p<0.001). In patients with less than 3.5mA of NET threshold, 81.4% had a satisfactory recovery, but in patients with more than 3.5mA of NET threshold, 60.9% had a bad prognosis. BR, side-to-side CMAP amplitude comparison, and side-to-side NET threshold difference seem to be useful independent indices for predicting the prognosis an early stage of the paralysis.
Action Potentials
;
Bell Palsy*
;
Blinking
;
Facial Paralysis
;
Humans
;
Paralysis
;
Prognosis
;
Reflex
6.A Case of Hereditary Spastic Ataxia.
Young Jin YUN ; Duk Hong MOON ; Dong Jo LEE ; Seon Chool HWANG ; Seong Uk HONG
Journal of the Korean Neurological Association 1995;13(2):396-400
Hereditary spastic ataxia is a familial neurological disorder which exhibit the features of a progressive combined pyramidal tract and cerebellar deficiency. The main features are progressive gait disturbance, incoordination, nystagmus, visual impairment, hyperreflexia, extensor plantar response, peripheral neuropathy, and pes cavus. A 27-year-old male patient with spastic ataxic gait was evaluated. He showed characteristic features of hereditary spastic ataxia. There were another twelve affected members in four generations of his family which may be inherited by autosomal dominant pattern. One of them is reported with review of the literature on familial spastic ataxia.
Adult
;
Ataxia*
;
Family Characteristics
;
Foot Deformities
;
Gait
;
Humans
;
Male
;
Muscle Spasticity*
;
Nervous System Diseases
;
Peripheral Nervous System Diseases
;
Pyramidal Tracts
;
Reflex, Abnormal
;
Reflex, Babinski
;
Vision Disorders
7.A case Report of a Spontaneous cervical Hematomyelia.
Dong Jo LEE ; Young Jin YUN ; Duk Hong MOON ; Eun Hi SA ; Seon Chool HWANG ; Seong Uk HONG
Journal of the Korean Neurological Association 1995;13(2):383-386
The spontaneous hematomyelia is an uncommon event and its predisposing conditions are vascular malformation, syringomyelia, pregnancy and delivery, angioma, hemophilia, anticoagulant therapy, etc. We have recently experienced the patient with spontaneous onset and resolving hematomyelia in the cervical spinal cord. A 30-year-old male patient with non-traumatic spinal shock was evaluated. On MRI, a hematomyelia along cervical spi-nal cord was revealed. A suspicious AV malformation was noticed at C3-4 level. Fol-low-up MRIs showed spontaneous resolution of the hematoma.
Adult
;
Hemangioma
;
Hematoma
;
Hemophilia A
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Pregnancy
;
Shock
;
Spinal Cord
;
Spinal Cord Vascular Diseases*
;
Syringomyelia
;
Vascular Malformations
8.Long-term Clinical Outcome and Echocardiographic Restenosis after Successful Percutaneous Transmitral Commissurotomy.
Young Hak KIM ; Duk Hyun KANG ; Jae Kwan SONG ; Kee Joon CHOI ; Cheol Whan LEE ; Myeong Ki HONG ; Jae Joong KIM ; Seong Wook PARK ; Seung Jung PARK
Korean Circulation Journal 1998;28(2):194-204
BACKGROUND: The purpose of this study was to assess the clinical outcome and echocardiographic incidence of restenosis after successful percutaneous transmitral commissurotomy (PTMC) and to identify predictors of restenosis. METHODS: Between 1989 and 1992, Inoue PTM (n=73) and double balloon technique (n=85) were used in 158 consecutive patients (male 52, age; 41+/-11 year) with mitral stenosis. Clinical and echocardiographic examinations were performed annually in 137 patients who exhibited good initial result with PTMC (mitral valve area 1.5cm (2) and mitral regurgitation[MR] 2+). Restenosis was defined as a mitral valve area< (MVA) 1.5cm (2) or more than 50% loss of the initial gain in MVA. Commissural mitral regurgitation (CMR) was defined as MR originating from medical or lateral commissure on color flow imaging and regarded as an index of complete commissural splitting. RESULTS: Immediately after PTMC, MVA increased from 0.9+/-0.2cm (2) to 1.8+/-0.3cm (2) and functional class improved up to NYHA class 1 or 2 in all patients. Annual echocardiographic follow-ups were completed in 129 (94%) patients and mean follow-up duration was 54+/-21 months. Adverse events occurred in 16 (13%) patients (1 death, 3 mitral valve replacement, 3 re-PTMCs, 9 deterioration of the NYHA class), and restenosis occurred in 41 (32%) patients. Event-free and restenosis-free survival rates at 7 years were 776 % and 586 %, respectively. According to multivariate Cox analysis, restenosis (p=0.0017, relative risk[r.r]=2.82) was the only predictor of adverse events ; smaller increase ( 1.0cm (2)) of MVA (p=0.0001, r.r=4.8) and the absence of CMR (p=0.0000, r.r=4.8) were independent predictors of restenosis. CONCLUSION: Long-term clinical outcomes and restenosis rates after PTMC are favorable and immediate results after PTMC can predict late restenosis better than baseline clinical and echocardiographic characteristics.
Echocardiography*
;
Follow-Up Studies
;
Humans
;
Incidence
;
Mitral Valve
;
Mitral Valve Insufficiency
;
Mitral Valve Stenosis
;
Survival Rate
9.A Study on the Electroencephalographic Characteristics at Each Anesthetic Steps.
Tae Kyun KIM ; Jung Min HONG ; Seong Wan BAIK ; Jong Duk PARK ; Gye Rock JEON
Korean Journal of Anesthesiology 2006;50(2):132-139
BACKGROUND: Bispectrum and bicoherence analysis that is the frequency domain methods of EEG analysis was examined to elucidate the correlation with the depth of anesthesia. METHODS: 25 patients under the gynecological surgery were studied. EEG was surveyed by PhysioLab 400. Analysis of EEG was done according to the progress of anesthesia, normal state before anesthesia, before incision of skin, operation 1, operation 2, awake and post-anesthesia. EEG is applied to filtering of signal, base line correction, linear detrend removal to get more reliable analysis. The appearance rate of bispectrum peaks are calculated by bispectrum operation. And bicoherences are calculated by bispectrum and power spectrum of AR model. RESULTS: In awaking state of patient in pre-anesthesia and post anesthesia, appearance rate of bispectral coupling was observed that a strong appearance rate was represented in all area (0-35 Hz). During the anesthesia, the low frequency area (3-15 Hz) revealed a strong appearance. Also the 2D map of a appearance rate is divided into four sections for more objectivity. Of four sections Bipara#4 is considered that the best parameter which showed progress of anesthesia (P < 0.01). In bicoherence study, in awake state which patient is in pre-anesthesia and post anesthesia, appearance rate of bicoherence value was observed that a strong appearance rate was represented in high frequency range (15-30 Hz). However, under the anesthesia of patients, the low frequency area (0-10 Hz) revealed a strong appearance. And, of four sections Bicpara#2 and Bicpara#4 are considered that the best parameter which showed progress of anesthesia effectively (P < 0.01). CONCLUSIONS: The analysis of the peak appearance of bispectrum and bicoherence is useful monitoring for the depth of anesthesia.
Anesthesia
;
Electroencephalography
;
Female
;
Gynecologic Surgical Procedures
;
Humans
;
Skin
10.Increased Basal Coronary Artery Tone and Hyperresponsiveness to Acetylcholine and Ergonovine in Spasm Related Coronary Artery in Patient with Variant Angina.
Seung Jung PARK ; Seong Wook PARK ; Jae Joong KIM ; Jae Kwan SONG ; Myeong Ki HONG ; Duk Hyun KANG ; Sang Sig CHEONG ; Jong Koo LEE
Korean Circulation Journal 1994;24(6):928-936
BACKGROUND: In patients with variant angina, previous data have been inconclusive as to whether basal coronary artery tone is elevated at the spastic sites and nonspastic sites. The purpose of this study was to assess the basal coronary artery tone and to evaluate the responsiveness to acetylcholine and ergonovine in patients with variant angina. METHODS: Basal coronary artery tone was assessed by obtaining the percent increase in coronary artery diameter induced by nitroglycerin in 66 patients with variant angina and 26 control subjects. We also compared the basal coronary tone and the constrictive responses to acetylcholine and ergonovine between the 31 patients with variant angina whom spasm was provoked by the low doses of acetylcholine(Ach; intracoronary, 20microg) or ergonovine(Erg; intravenous, 50microg)(Group 1) and the 35 patients provoked by higher doses of acetylcholine(intracoronary, 100microg) or ergonovine(intravenous cumulative dose of 350microg)(Group 2). RESULTS: Patients with variant angina whom spasm was provoked by low doses of acetylcoline and ergonovine, have a more tendency of combine fixed disease(mix disease), multivessel spasm and high disease activity. Basal coronary artery tone at the spastic sites was significantly elevated in the Group 1 in whom spasm was provoked by low doses of acetycholine and ergonovine than that in Group 2(44+/-17 vs 13+/-11%, respectively, p<0.05). Basal coronary artery tone of spasm-related artery, but not nonspasm related artery, at the non spastic site was greater in the Group 1 than that in Group 2 (26+/-14 vs 16+/-10%, respectively, p<0.05). In the patients with variant angina in whom spasm was provoked by higher dose of acetylcholine or ergonovine, basal coronary artery was comparable at the spastic and nonspastic sites and was not different from that in the control subjects. The magnitude of vasoconstrictive responses to acetylcoline and ergonovine, at the nonspastic sites, were also greater in Group 1 than those in Group 2 and the control groups(Ach; 40+/-20 vs 26+/-11. 27+/-12% : Erg ; 37+/-18 vs 12+/-8, 13+/-10%, respectively, p<0.05). CONCLUSION: These findings suggest that elevated basal coronary artery tone of the spastic sites and nonspastic sites of spasm-related artery in patients with variant angina may be related to occurrence of coronary spasm.
Acetylcholine*
;
Arteries
;
Coronary Vessels*
;
Ergonovine*
;
Humans
;
Muscle Spasticity
;
Nitroglycerin
;
Spasm*