No abstract available.
Child* ; Humans

Nevus flammeus is benign but cosmetically devastating congenital vascular malformation whose past treaments have been marred by unacceptable complication or by unacceptable ineffectiveness. Argon laser is a therapeutic device which has been newly applied to this condition with fairly good result. However, all lesions do not show good response and it depends on the clinical and histopathological types. Therefore, it is very important to select patients who will show good response to argon laser therapy. Histological pattern was indicated as the most important prognostic factor. However, it is not always possible to get the histological data. This study was undertaken to evaluate whether it is possible to anticipate histologic patterns of nevus flammeus from color and clinical morphology of the lesions when biopsy is difficult to be taken. Color and clinical morphology of the lesions were recorded, and 4-mm punch biopsies were performed in 74 patients who visited the Laser Clinic in our dermatologic department during past 2 years, The study results were as follows. Eleven pink cases were all patch form morphologically but 8 cases(72, 7%) were constricted type and 8 cases(27 Q%) were intermediate type histopathologically. In 28 red cases, 27 cases(96 4gp) were patch form and only 1 case was smooth elevated form morphologically. And 2p cases(74, l%) were dilated or intermediate type and 7 cases(25 9%) were constricted or deep located type histologically.
Argon ; Biopsy ; Humans ; Laser Therapy ; Nevus* ; Port-Wine Stain* ; Vascular Malformations

Statisticsl observation was made on 404 patients who had been referred for consultation to the Department of Dermatology during their admission in Seoul National University Children's Hospital from October 1985 to March 1987. The results were as follows : 1. The consulted pstients were 404 among 126,622 inpatients(0.32%). 2. The most frequent age group was below 1 year(25.0%). 3. Pediatrics was the most importnat department in the number, as well as in the rate of consulted patients to inpatients. 4. The most common 10 dermatoses were contact dermatitis, atopic dermatitis, drug eruption, fungal infection, viral infection, infantile eczema, benign tumor, miliaria, urticaria, and skin manifestation of systemic diseases in order of frequency. 5. The frequent causes of consultation were as follows ; the dermatologic diseases or conditions 67.6%, the diseases related to the trestment 13.4%, the skin lesions of systemic diseases 10.8%, the dermatologic tests 3.6%, and admitted to other departments with dermatologic diseases 1.2% respectively.
Dermatitis, Atopic ; Dermatitis, Contact ; Dermatology* ; Drug Eruptions ; Humans ; Inpatients* ; Miliaria ; Pediatrics ; Seoul ; Skin ; Skin Diseases ; Skin Manifestations ; Urticaria

No abstract available.

No abstract available.
Humans

Atopic dermatitis is characterized by many signs of immunodeficiency. We have performed this experiment to know whether there are reduced respiratoty burst of neutrophils in patients with atopic dermatitis in response to stimulants such as zymosan activated serum(ZAS), phorbol myristate cetate(PMA) and for- mylmethionylleucylphenylalanine(FMLP). The atopic derrqatitis group consisted of 27 patients(5 are severe, 22 are mild) and the control group consisted of 10 persons. Superoxide anion generation of neutrophils in response to stimulants was measured as nmol of reriuced cytochrome C by spectrophotometer(at 550nm, molar extinction coefficient of cytochrome C=21.lmM 1cm ). We compared the superoxide anion generation according to the severity of atopie dermatitis, total serum IgE level and eosinophil count. Results were as follows. 1. After stimulation by PMA and FMLP, superoxide anion generation in severe atopic dermatitis group decreased compared with the control and mild atopic dermatitis group. After stimulation by ZAS there was a decreasing tendency in severe atopic dermatitis group, however it was not statistically significant. 2. Superoxide anion generation had no correlation with the total serum IgE level. 3. Superoxide anion generation had no correlation with the eosinophil count. Our data suggested that some physiologic stimulants of respiratory hurst may be generated during the course of atopic dermatitis. Possible physiologic stimulants include C5a, bacterial chemotactic factors, certain arachidonate metabolites such as leukotriene B4, as well as phagocytosis. We think that these physiologic stimulants can desensitize neutrophils of atopic dermatitis in vivo specifically or onspecifically so that superoxide anion generation may be reduced in response tostimulants in vitro.
Chemotactic Factors ; Cytochromes ; Cytochromes c ; Dermatitis ; Dermatitis, Atopic* ; Eosinophils ; Humans ; Immunoglobulin E ; Leukotriene B4 ; Molar ; Myristic Acid ; Neutrophils* ; Phagocytosis ; Superoxides* ; Zymosan

No abstract available.

Although port-wine stains present as macular patches generally, some patients show considerable overgrowth of angiomatous tissue and show different results of laser therapy according to their histologic patterns. We observed 337 port-wine stain patients clinically, and tried to classify clinical morphology of port-wine stains and analyze with other features such as color, age and size. The results were as follows: Most of the lesions were located on the face, followed by neck, upper extremity, lower extremity and trunk in order. 2, On the face, the left lower part was the most frequent area of the lesions. The difference of the distribution between right and left side was not found, but the lesions were significantly more frequent on the lower part than the upper one. 3. The morphology was classified into patch, hypertrophic, cavernous and papular form according to therapeutic purpose. 4 When the color is darker, the others than the patch form appeared. 5, In old patients the color was darker and the papular form increased. 6. When the size enlarged, the hypertrophic form. increased. 7. Among ten patients who got the lesions at both the upper and lower eyelids, two showed ocular problems.
Coloring Agents* ; Eyelids ; Humans ; Laser Therapy ; Lower Extremity ; Neck ; Port-Wine Stain ; Upper Extremity ; Wine*

No abstract available.
Temporomandibular Joint*

Dermographism is an exaggerated triple response of Lewis and appears as a lineat wheal with a flare at a site in which skin is briskIy stroked with a firm object. The etiology and pathogenesis of dermographism are uncertain but passive transfer tests are sometimes poeitive. The active serum factor has been characteiized as Ig E in some patients. In this experimental study, we tried passive transfer of dermographism with the sera of the patients with dermographism. Twelve dermographic patients' sera were tested to fourteen normal healthy persons and two asymptomatic dermographic persons, total number of thirty nine cases. Only two recipients were passively transferred but they showed positive responses to all sera tested, two and three respectively. This result suggests that not only serum factor but also recipient's factor(s) may be concerned in passive transfer of dermographism.
Humans ; Intradermal Tests ; Skin ; Stroke