1.Toward angiogenesis of implanted bio-artificial liver using scaffolds with type I collagen and adipose tissue-derived stem cells.
Jae Geun LEE ; Seon Young BAK ; Ji Hae NAHM ; Sang Woo LEE ; Seon Ok MIN ; Kyung Sik KIM
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2015;19(2):47-58
BACKGROUNDS/AIMS: Stem cell therapies for liver disease are being studied by many researchers worldwide, but scientific evidence to demonstrate the endocrinologic effects of implanted cells is insufficient, and it is unknown whether implanted cells can function as liver cells. Achieving angiogenesis, arguably the most important characteristic of the liver, is known to be quite difficult, and no practical attempts have been made to achieve this outcome. We carried out this study to observe the possibility of angiogenesis of implanted bio-artificial liver using scaffolds. METHODS: This study used adipose tissue-derived stem cells that were collected from adult patients with liver diseases with conditions similar to the liver parenchyma. Specifically, microfilaments were used to create an artificial membrane and maintain the structure of an artificial organ. After scratching the stomach surface of severe combined immunocompromised (SCID) mice (n=4), artificial scaffolds with adipose tissue-derived stem cells and type I collagen were implanted. Expression levels of angiogenesis markers including vascular endothelial growth factor (VEGF), CD34, and CD105 were immunohistochemically assessed after 30 days. RESULTS: Grossly, the artificial scaffolds showed adhesion to the stomach and surrounding organs; however, there was no evidence of angiogenesis within the scaffolds; and VEGF, CD34, and CD105 expressions were not detected after 30 days. CONCLUSIONS: Although implantation of cells into artificial scaffolds did not facilitate angiogenesis, the artificial scaffolds made with type I collagen helped maintain implanted cells, and surrounding tissue reactions were rare. Our findings indicate that type I collagen artificial scaffolds can be considered as a possible implantable biomaterial.
Actin Cytoskeleton
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Adult
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Animals
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Artificial Organs
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Biocompatible Materials
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Collagen Type I*
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Humans
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Liver Diseases
;
Liver*
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Membranes, Artificial
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Mice
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Stem Cells*
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Stomach
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Tissue Scaffolds
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Vascular Endothelial Growth Factor A
2.Pneumatosis coli.
Beom Jae LEE ; Sehe Dong LEE ; Jong Jae PARK ; Jae Seon KIM ; Young Tae BAK
Korean Journal of Medicine 2008;74(3):342-343
No abstract available.
3.Two Cases of Primary Sclerosing Cholangitis.
Chang Hong LEE ; Jae Seon KIM ; Young Tae BAK ; Jin Ho KIM ; Jong Guk KIM ; Kwan Soo BYUN ; Jong Eun YEON ; Kyoung Min KIM ; Ie Byung PARK
Korean Journal of Gastrointestinal Endoscopy 1995;15(4):788-795
Prirnary sclerosing cholangitis, a chronic progressive cholestatic hepatobiliary disorder of unknown etiology, is characterized by inflammation, scarring and obliteration of bile duct leading to biliary cirrhosis and liver failure. Because histologic finding has only a limited role in the diagnosis, the gold standard for establishing the diagnosis is cholangiographic demonstration of typical diffuse biliary stricutre or beading. The natural history is extremely variable. We report two cases of primary sclerosing cholangitis diagnosed by repeated endoscopic retrograde cholangiographies. They were followed up for 7 and 2 years, respectively.
Bile Ducts
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Cholangiography
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Cholangitis, Sclerosing*
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Cicatrix
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Diagnosis
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Inflammation
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Liver Cirrhosis, Biliary
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Liver Failure
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Natural History
4.Esophageal motility disorder suspected during endoscopy.
Byung Gyu KIM ; Ji Hyun KIM ; Jong Jae PARK ; Jae Seon KIM ; Young Tae BAK
Korean Journal of Medicine 2006;71(2):235-236
No abstract available.
Endoscopy*
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Esophageal Motility Disorders*
5.Butterfly in the Esophagus: What Is Wrong?.
Jin Ki HWANG ; Seung Goun HONG ; Moon Kyung JOO ; Jong Jae PARK ; Jae Seon KIM ; Young Tae BAK
Journal of Neurogastroenterology and Motility 2010;16(1):94-95
No abstract available.
Butterflies
6.A Case of Collagenous Colitis.
Jae Seon KIM ; Chul Weon CHOI ; Gwan Gyu SONG ; Jae Myung YU ; Young Tae BAK ; Jin Ho KIM ; Jong Guk KIM ; Chang Hong LEE ; Nam Hee WON
Korean Journal of Gastrointestinal Endoscopy 1993;13(2):405-409
Collagenous colitis is an uncommon condition charaeterized clinically by diarrhea and weight loss and histologically by thickening of the subepithelial collagen band with chromic inflammation. Laboratory tests of blood, urine and stool, and colonscopic findings are usually normal. The etiology of collagenous colitis is unknown. We report a case of collagenous colitis improved after treatment with sulfasalazine with review of literatures.
Colitis, Collagenous*
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Collagen*
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Diarrhea
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Inflammation
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Sulfasalazine
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Weight Loss
7.An Automated Cell Detection Method for TH-positive Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease Using Convolutional Neural Networks
Doyun KIM ; Myeong Seong BAK ; Haney PARK ; In Seon BAEK ; Geehoon CHUNG ; Jae Hyun PARK ; Sora AHN ; Seon-Young PARK ; Hyunsu BAE ; Hi-Joon PARK ; Sun Kwang KIM
Experimental Neurobiology 2023;32(3):181-194
Quantification of tyrosine hydroxylase (TH)-positive neurons is essential for the preclinical study of Parkinson’s disease (PD). However, manual analysis of immunohistochemical (IHC) images is labor-intensive and has less reproducibility due to the lack of objectivity. Therefore, several automated methods of IHC image analysis have been proposed, although they have limitations of low accuracy and difficulties in practical use. Here, we developed a convolutional neural network-based machine learning algorithm for TH+ cell counting. The developed analytical tool showed higher accuracy than the conventional methods and could be used under diverse experimental conditions of image staining intensity, brightness, and contrast. Our automated cell detection algorithm is available for free and has an intelligible graphical user interface for cell counting to assist practical applications. Overall, we expect that the proposed TH+ cell counting tool will promote preclinical PD research by saving time and enabling objective analysis of IHC images.
8.Small Bowel Metastatic Cancer Observed With Double Balloon Enteroscopy in a Patient With a Past History of Multiple Cancers.
Ji Young SONG ; Beom Jae LEE ; Eun Sang YU ; Young Ju NA ; Jong Jae PARK ; Jae Seon KIM ; Young Tae BAK
Intestinal Research 2015;13(4):350-354
Small bowel tumors are very rare and generally malignant. As a result of the anatomical location and nonspecific manifestations of small bowel tumors, they are very difficult to diagnose. Balloon-assisted enteroscopy is a relatively noninvasive method compared to surgical resection, and allows for real-time observation, tissue confirmation with biopsy, and interventional procedures. Here, we report the case of a 69-year-old woman with a small bowel metastatic carcinoma observed with double balloon enteroscopy (DBE). She had a history of multiple cancers including ovarian cancer, bladder cancer, and breast cancer. The antegrade DBE procedure was performed before surgery for biopsy tissue confirmation. The patient underwent small bowel resection, and the final diagnosis was the same as that determined by preoperative biopsy. The final diagnosis was metastatic small bowel cancer originating from a cancer of the breast. This is the first detailed report of the preoperative diagnosis of small intestinal metastatic breast cancer by DBE.
Aged
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Biopsy
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Breast Neoplasms
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Diagnosis
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Double-Balloon Enteroscopy*
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Female
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Humans
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Ovarian Neoplasms
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Urinary Bladder Neoplasms
9.A Case of a Submucosal Ganglioneuroma of the Ampulla of Vater That Was Treated by Endoscopic Resection.
Hye Jin CHO ; Jae Seon KIM ; Tae Jung YUN ; Seok Bae YOON ; Hyun Seok KANG ; Jae Young MOON ; Jong Jae PARK ; Young Tae BAK
Korean Journal of Gastrointestinal Endoscopy 2009;39(6):393-397
Submucosal tumors in the gastrointestinal tract are covered with a mucous membrane such as the surrounding tissue. Therefore, the use of endoscopic biopsy to diagnose submucosal tumors is not as effective as that for epithelial tumors. Although imaging tools such as ultrasonography or computed tomography have made great advances, it is still difficult to diagnose submucosal tumors before resection. The surgical resection of tumors is the most accurate diagnostic method, yet less invasive endoscopic resection has been preferred in recent years. We report herein on a rare case of ganglionueroma arising from the Ampulla of Vater and this lesion was incidentally found during performance of routine esohagogastroduodenoscopy. The lesion was diagnosed as a ganglioneuroma, and it was successfully removed through endoscopic resection.
Ampulla of Vater
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Biopsy
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Ganglioneuroma
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Gastrointestinal Tract
;
Mucous Membrane
10.A Case of Endoscopic Stenting for Anastomotic Leakage after Total Gastrectomy.
Ja In PARK ; Jong Jae PARK ; Joo Yeon OH ; Won Woo LEE ; Hye Jin CHO ; Jae Young MOON ; Jae Seon KIM ; Young Tae BAK
Korean Journal of Gastrointestinal Endoscopy 2009;39(6):369-373
Anastomotic leakage after gastrectomy has significant morbidity and mortality, and the mortality rate has been reported to be over 60%. There have been very few reports concerning endoscopic stenting for the management of anastomotic leakage. Successful treatment of anastomotic leakage with covered self-expanding metallic stents (stent) has recently been reported. A 62-year-old man with melena was diagnosed with advanced gastric cancer and he underwent total gastrectomy. At the 3rd day after surgery, anastomotic leakage was found by an upper gastrointestinal series (UGI). He underwent laparoscopic primary repair on the 5th day after surgery. The leakage resumed thereafter. At the 12th day after the primary repair, the leakage was successfully managed by stent insertion and the patient improved thereafter. At the 11th week after stent insertion, the stent was removed without complications and the leakage was completely closed. At 1 year after stent removal, no stricture has been found on the anastomosis site. We report here on a case of anastomotic leakage after gastrectomy, and this was completely managed by stent insertion.
Anastomotic Leak
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Constriction, Pathologic
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Gastrectomy
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Humans
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Melena
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Middle Aged
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Postoperative Complications
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Stents
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Stomach Neoplasms