"Sikmulboncho" that is quoted several times to "Donguibogam(Medical Thesaurus of Korea)" published several times in 3 countries(Korea, China & Japan) as important data of botany study. Gapjinjache "Sikmulboncho", one of the bronze metal type, that exist our country was publicated in early Seonjo(1552-1608) era. Actually there are 3 items(Korea university collection, Asami library collection, Oksan seowon collection) of Gapjinjache Naeuiwonjabon one of the wooden type seen become publication after 1607 year. Bronze metal type composes the major part for Gapjinjabon, but wood type was also mixed much. Wooden type composes the major part for Naeuiwonjabon, while bronze type was little mixed. Bronze metal type disappears by wear class gradually to during 40 years and instead of this, used wood type was used. Foundation and base of this publication have formed in itself Eulhaejache Naeeuiwonjabon that start "Donguibogam" in process that do this way. Therefore, Naeeuiwon do not publish various medical books like a Naeeuiwonjabon suddenly in early 17th century. I can speak that is caused in experience and potential power that already publish this Gapjinjabon medical book ago by medical history.
Books/*history ; Botany/*history ; China ; History, 16th Century ; History, 17th Century ; Japan ; Korea ; Literature, Modern/*history ; *Metals ; Printing/*history ; *Wood

No abstract available.

No abstract available.
Endometriosis* ; Female

No abstract available.
Animals* ; Korea* ; Yersinia pseudotuberculosis* ; Yersinia*

The task for chromosome karyotyping and diagnosis is requiring repetitive, time consuming job and high cost even it is done by well-experienced cytogenetists. Therefore an web based chromosome karyotyping instruction system has been established to be able to analyze chromosomes and obtain necessary advises from the database instead of human experts and the database is including 2 divisions with database and agent.For the first of all, database model was constructed with relational database consisting of Patient_DB, image_DB, Disease_DB and Manage_DB. As the second procedure, knowledge base by IF THEN production rule was implemented to a knowledge domain with normal and abnormal chromosomes. For the last, independent agent with the inference by knowledge base could enter the inference data into the database.Experimental data were composed of normal chromosomes of 2,736 patients' cases and abnormal chromosomes of 259 patients' cases that have been obtained from GTG-banding metaphase peripheral blood and amniotic fluid samples.The completed system provides variously morphological information by analysis of normal or abnormal chromosomes and it also makes users enable to control and search the information in a short period with learning of high amount of knowledge.
Amniotic Fluid ; Diagnosis ; Female ; Humans ; Karyotyping* ; Knowledge Bases ; Learning ; Metaphase

PURPOSE: We conducted a phase II study in previously untreated patients with unresectable stage IIIB or IV non-small cell lung cancer to evaluate the response rate and toxicity of the combination chemotherapy regimen of etoposide, ifosfamide and cisplatin. MATERIALS AND METHODS: From September 1993 to December 1996, twenty patients with advanced non-small cell lung cancer (stage IIIB 5 and IV 15) (squamous cell 8, adeno- carcinoma 12), were enrolled in this study. There were 13 (65%) males and 7 (35%) females, and median age of patients were 56 years (range: 34~66). Eighteen patients had performance status (ECOG) 0~1, two patients had performance status 2. Treatment was consisted of cisplatin (20 mg/m2 i.v., day 1~4), VP-16 (etoposide) (75 mg/m2 i.v., day 1~4), ifosfamide (1000 mg/m2 i.v., day 1~4) with mesna. This treatment was repeated every four weeks. RESULTS: The overall response rate was 25%. Complete response rate was 5% (1/20) and partial response rate was 20% (4/20). The median cycle of response was 4 (2~6) cycles. The median overall survival time was 28 weeks (9~98 weeks). The median time to progression was 10 weeks (3~50 weeks). Toxicities were evaluated by WHO criteria. Toxicity > GradeIII included: leukopenia 1.6%, thrombocytopenia 3.2%, nausea and vomiting 15%, alopecia 30%, stomatitis 10%. These toxicities were tolerable and reversible. CONCLUSION: VIP regimen was not superior to previous regimens for advanced non-small all lung cancer, and the toxicities were tolerable.
Alopecia ; Carcinoma, Non-Small-Cell Lung ; Cisplatin* ; Drug Therapy, Combination* ; Etoposide ; Female ; Humans ; Ifosfamide* ; Leukopenia ; Lung Neoplasms ; Male ; Mesna ; Nausea ; Small Cell Lung Carcinoma* ; Stomatitis ; Thrombocytopenia ; Vomiting

No abstract available.
Fistula* ; Perilymph*

No abstract available.
Animals ; Neurons* ; Neurotransmitter Agents* ; Rats*

No abstract available.
Olfactory Bulb* ; Signal Transduction*

PURPOSE: Fragile X syndrome (FXS) is the most common heritable cause of cognitive impairment. FXS is caused by hyperexpansion and hypermethylation of a polymorphic CGG trinucleotide repeat in the 5' untranslated region of the fragile X mental retadation-1(FMR1) gene. Combination of Southern blotting and simple polymerase chain reaction(PCR) amplification of the FMR1 repeat region is commonly used for diagnosis in females. To give a definite diagnosis in a female child suspected of having FXS, we carried out the molecular diagnostic test for FXS using the recently developed Abbott Molecular Fragile X PCR Kit. METHODS: The PCR amplification of the FMR1 repeat region was performed using the Abbott Mdecular Fragile X PCR Kit. The amplified products were analyzed by size-separate analysis on 1.5% agarose gels and by DNA fragment analysis using Gene scan. RESULTS: Agarose gel and Gene scan analyses of PCR products of the FMR1 repeat region showed that the patient had two heterozygous alleles with a normal 30 repeats and full mutation of >200 repeats whereas her mother had two heterozygous alleles with the normal 30 repeats and premutation of 108 repeats, suggesting that the premutation of 108 repeats in her mother may have led to the full mutation of >200 repeats in the patient. CONCLUSION: We diagnosed FXS in a female patient using a simplified molecular diagnostic test. This commercially available diagnostic test for FXS, based on PCR, may be a suitable alternative or complement method to Southern blot analysis and PCR analysis and/or methylation specific(MS)-PCR analysis for the molecular diagnosis of FXS in both males and females.
5' Untranslated Regions ; Alleles ; Blotting, Southern ; Child ; Complement System Proteins ; Diagnostic Tests, Routine ; DNA ; Female ; Fragile X Syndrome ; Gels ; Humans ; Male ; Methylation ; Mothers ; Pathology, Molecular ; Polymerase Chain Reaction ; Sepharose ; Trinucleotide Repeats