We report two cases of malignant schwannoma of skin in association with non-familial neurofibromatosis. Case 1, a 47 year old man, had a large subcutaneous tumor on the sacral area and case 2, a 62 year old woman, a painful, ulcerating tumor on the posterior aspect of the left arm. Both cases were histopathologically confirmed as malignant schwannomas and immunohistochemical studies showed 5-100 protein in the tumor cells. After surgical excision of the tumors, case 1 was lost to follow up, while case 2 remained without evidence of disease for more than one and half years.
Arm ; Female ; Humans ; Lost to Follow-Up ; Neurilemmoma* ; Neurofibromatoses* ; Skin ; Ulcer

No abstract available.
Female ; Ovary* ; Theca Cells* ; Thecoma*

Ultrasonographic and radiographic findings in 72 cases of pelvic masses which have been provedhistopathologically were analyzed. The results were as follows; 1. Among 72 cases, 28 cases were uterine massesand 44 cases were adnexal masses. 2. Pathologic accuracies of ultrasonographic diagnosis were 64.3% in uterinemasses, 70.5% in adnexal masses, and 68.1% in all pelvic masses. 3. Plain or IVP findings were not specific indiagnosis and showed secondary mass effects or functional disturbances. 4. Because of its high accuracy ofpathologic diagnosis and safety, ultrasonography can be regared as the most valuable and preferential study. Butin cases of cystic myomas, endometrioses, cystic missed abortions and huge masses, the accurate diagnoses weredifficult.
Abortion, Missed ; Diagnosis ; Endometriosis ; Female ; Myoma ; Pregnancy ; Ultrasonography

Uterine torsion is defined as the mtation of more than 45 degrees around the long axis of the uterus or a rotation which is severe enough to produce symptoms. Torsion of the human pregnant uterus is a very rare complication. The diagnosis is problematic and is often made during a cesrean section due to inhibited labor. Torsion of the human pregnant uterus can be caused by myoma or other uterine abnormalities, ovarian cysts, adhesions, abnormal fetal presentations, or fetal abnormalities ( though no cause can be found in about 20% of cases ). Uterine torsion produces symptoms of varying severity depending on the degree of rotation, and duration of the pregnancy. High mortality rates for both mother and infant have been reported. We experienced one case of the torsion of term pregnant uterus and report this case with a brief review of the concerned literature.
Axis, Cervical Vertebra ; Diagnosis ; Female ; Fetus* ; Humans ; Infant ; Mortality ; Mothers ; Myoma ; Ovarian Cysts ; Pregnancy ; Uterus*

BACKGROUND: Primary gastric lymphoma is a rare neoplasm that represents 1~4% of all gastric malignancies. The optimal treatment of primary gastric lymphoma remains controversial. This study was designed to examine the prognostic significance of various clinicopathologic factors in patients with gastric lymphoma and to evaluate the role of surgery in the treatment of gastric lymphoma. METHODS: Retrospective study of 71 cases of primary gastric lymphoma which had been undergone laparotomy at the Department of Surgery, Seoul National University Hospital from Jan. 1982 to Dec. 1996 was performed. The authors reviewed clinicopathologic factors of patients and evaluated their prognostic significance. RESULTS: 1) The mean age of the patients was 50 years, and the most prevalent ages occurred in the 6th & the 7th decade. The ratio of males to females was 1.3:1. 2) The presenting symptoms and signs on admission were epigastric abdominal pain & discomfort, weight loss, anorexia, indigestion, and abdominal mass in decreasing order of frequency. 3) The diagnostic accuracy of the gastrofiberscopic biopsies was 67.1% preoperatively. 4) The most common pathologic type was diffuse histiocytic type (57.1%) in Rappaport classification, and diffuse large cell type (47.1%) in NCI Working formulation classification. 5) The distribution of stages according to modified TNM classification was 47.9% stage I, 36.6% stage II, 11.3% stage III, and 4.2% stage IV. 6) Overall, a potentially curative resection was performed in 92.9% of the cases. Treatment modalities included surgery (S), chemotherapy (CT), and radiotherapy (RT) in the following proportions: 33.8% only S, 53.5% S CT, 11.3% S RT, and 1.4% S CT RT. 7) The overall 5-year survival rate was 78.9%. The 5-year survival rates according to stage were 94.1% in stage I, 80.4% in stage II, 30.0% in stage III and 0% in stage IV.
Abdominal Pain ; Anorexia ; Biopsy ; Classification ; Drug Therapy ; Dyspepsia ; Female ; Humans ; Laparotomy ; Lymphoma ; Male ; Radiotherapy ; Retrospective Studies ; Seoul ; Survival Rate ; Weight Loss

OBJECTIVE: Risperidone, one of the most widely used atypical antipsychotics, not only ameliorates the positive symptoms of the acute phase but also improves the long-term quality of life as well. To achieve sufficient therapeutic effects, it is important to readjust the treatment regimen in case of insufficient response at an appropriate time point. However, few studies have dealt with this issue in clinical settings. METHODS: We investigated the past treatment history of 51 schizophrenics treated with risperidone for more than 48 weeks by retrospective chart review. The patients were divided into responders and non-responders by predetermined criteria, and CGI-severity scores at 7 selected time points were assessed. The time pattern of therapeutic responses was analyzed, and the appropriate point of time to reliably predict the long-term efficacy was sought. RESULTS: Thirty-one (60.8%) and 20 (39.2%) patients were respectively defined as responders and non-responders by our criteria. There was no difference in the risperidone dosage between responders and non-responders, at any time point evaluated. We observed that significant differences in the pattern of CGI-severity score between the two groups emerged after the 8th week, and that the treatment response profile during this phase might predict long-term outcome. CONCLUSION: The results of this study suggest that the 8-week point may be the most appropriate time to assess the clinical response to risperidone and to decide whether to continue with the regimen or change it. However, this was a naturalistic study and the study results require further confirmative research.
Antipsychotic Agents ; Humans ; Quality of Life ; Retrospective Studies ; Risperidone* ; Schizophrenia*

OBJECTIVES: To evaluate the incidence rate and associated factors of dementia in the elderly of rural community. METHODS: This study was three and half year follow-up of Yonchon cohort, participated in a prevalence study of dementia and depression in 1996 (N=1,037). A two-phase study was conducted using the Korean version of Psychogeriatric Assessment Scale in phase I and the diagnostic interview according to DSM-IV criteria by two psychiatrists in stage II. RESULTS: Of the 968 elderly residents who had not dementia in 1996 prevalence study, 596 residents completed the incidence study. The annual incidence rate for total dementia, dementia of Alzheimer's type and vascular dementia were 1.88% (1.86% in men, 1.98% in women), 1.58% (1.39% in men, 1.80% in women) and 0.34% (0.45% in men, 0.25% in women), respectively. Increasing age was significantly associated with total dementia and dementia of Alzheimer's type (p<0.01, p<0.05, respectively). There was statistically significant difference of the three and half year mortality rate between the dementia patients who were diagnosed in prevalence study and the non-dementic elderly (chi2=28.89, df=1, p<0.001). Only the 2.8% of newly onset dementia patients sought psychiatric service in the previously year. CONCLUSIONS: The incidence of dementia among the Korean elderly in a rural community was relatively consistent with the epidemiological studies of other countries. Age was the only risk factor for total dementia and dementia of Alzheimer's type. Very few dementia patients were treated by psychiatrist.
Aged* ; Cohort Studies* ; Cross-Sectional Studies ; Dementia* ; Dementia, Vascular ; Depression ; Depressive Disorder* ; Diagnostic and Statistical Manual of Mental Disorders ; Epidemiologic Studies ; Follow-Up Studies* ; Humans ; Incidence* ; Male ; Mortality ; Prevalence* ; Psychiatry ; Risk Factors ; Rural Population

No abstract available.
Dopamine ; Parkinson Disease

PURPOSE: We performed this study to compare 1-day group using a 2nd generation cephalsporin with 3-day group for evaluating hospital acquired infection. METHODS: The patients underwent laparoscopic colorectal surgery at Korea University Medical Center Anam Hospital, from August, 2007 to June, 2008. They were randomly allocated to 2 groups: 1-day or 3-day group. A 2nd generation cephalosporin was administered within 1 hour before surgery with 12-hour intervals. In cases of suspected infection, further studies were done to identify infection. RESULTS: The study included 154 patients (1-day group - 78, vs. 3-day group - 76). No differences were noted between the 2 groups in age, body mass index, smoking, diabetes mellitus, corticosteroid-use were noted. Gender (P=0.011) and mean operative time (P=0.047) between the 2 groups were different. The preventive rates of infection were 87.18% in the 1-day group compared with 82.89% in the 3-day group (P=0.456). CONCLUSION: Our prospective randomized control study concluded that there were no differences between the 1-day and 3-day group in hospital acquired infection. We could come to the conclusion that 1-day antimicrobial agent in laparoscopic colorectal surgery would be adequate in preventing infection.
Academic Medical Centers ; Body Mass Index ; Colorectal Surgery ; Diabetes Mellitus ; Humans ; Korea ; Operative Time ; Prospective Studies ; Smoke ; Smoking

OBJECTIVES: Formal thought disorder has been regarded as an essential symptom in the diagnostic criteria for schizophrenia. The aim of our study was to present gender differences in the formal thought disorder among patients with schizophrenia. METHODS: We tested for potential gender differences in the formal thought disorder among 167 inpatients with schizophrenia (86 men and 81 women). The Scale for the Assessment of Thought, Language and Communication (TLC scale), Clinical Language Disorder Rating Scale (CLANG), Brief Psychiatric Rating Scale, Young Mania Rating Scale, and Calgary Depression Scale for Schizophrenia were used for evaluation of thought disorder, language disorder, overall symptoms, manic symptoms, and depressive symptoms, respectively. Using the analysis of covariance for continuous variables and logistic regression analysis for discrete variables, gender differences in the formal thought disorder were evaluated. RESULTS: After adjusting for the effects of marital status and religious affiliation, men showed a significantly higher score on the perseveration (TLC scale ; F=7.538, p=0.007), blocking (TLC scale ; F=8.956, p=0.003), stilted speech (TLC scale ; F=6.921, p=0.009), lack of details (CLANG ; F=7.375, p=0.007), dysfluency (CLANG ; F=21.250, p<0.0001), and dysarthria (CLANG ; F=31.198, p<0.0001) items than women. CONCLUSION: Our study has a virtue of exploring gender differences in the formal thought disorder in patients with schizophrenia. Based on our findings, further study might enlighten regarding neural correlates (namely, cerebral asymmetry/lateralization) for gender-differed patterns of the formal thought disorder in patients with schizophrenia.
Bipolar Disorder ; Brief Psychiatric Rating Scale ; Depression ; Dysarthria ; Female ; Humans ; Inpatients ; Language Disorders ; Logistic Models ; Male ; Marital Status ; Schizophrenia* ; Virtues