1.Immunocytochemical study on the somatostatin,serotonin and gastrin cells in the gastrointestinal tract of the percida.
Un Bock JO ; In Jang CHOI ; Byung Tae CHOI ; Mee Suk SONG ; Seon Heui OK
Korean Journal of Anatomy 1993;26(1):65-79
No abstract available.
Gastrin-Secreting Cells*
;
Gastrins*
;
Gastrointestinal Tract*
2.DNA ploidy as a predictive index of therapeutic response in lung cancer.
In Seon CHOI ; Shin Seok LEE ; Jae Beom YANG ; Kyung Ok PARK ; Sang Woo JUNG
Tuberculosis and Respiratory Diseases 1992;39(2):150-158
No abstract available.
DNA*
;
Lung Neoplasms*
;
Lung*
;
Ploidies*
3.Detection of chromosome aberrations in interphase nuclei using fluorescence in situ hybridization technique.
Hyung Geun SONG ; Seon Ok CHOI ; In Beom KANG
Journal of Korean Medical Science 1993;8(4):257-261
We report here several experiences of interphase cytogenetics, using fluorescence in situ hybridization (FISH) technique, for the detection of chromosome aberrations. FISH, using alpha satellite specific probes of 18, X, Y chromosomes, was done in interphase nuclei from peripheral blood of patients with Edwards' syndrome, Klinefelter's syndrome and Turner's syndrome with healthy male and female controls, respectively. The distributions of fluorescent signals in 100 interphase nuclei were well correlated with metaphase findings. Nowadays FISH plays an increasingly important role in a variety of research areas, including cytogenetics, prenatal diagnosis, tumor biology, gene amplification and gene mapping.
Adolescent
;
Adult
;
Cell Nucleus/*ultrastructure
;
Child
;
Chromosome Aberrations/*physiology
;
Chromosome Banding
;
Female
;
Humans
;
In Situ Hybridization, Fluorescence
;
Infant, Newborn
;
Interphase/*physiology
;
Male
4.A Case of Palatal Myoclonus Caused by Trauma.
Seung Ok CHOI ; Seon Woo BAE ; Won Tsen KIM ; Il Saing CHOI
Journal of the Korean Neurological Association 1987;5(1):94-96
Palatal myoclonus is a rare disorder described as separable from the general group of myoclonias as a clinical and antomical entity result from lesion involving the dentato-rubro-olivary pathway and the inferior olivary nucleus. This 21-year-old man was injured in a fall from the roof. On admission to the hospital, he had cerebral contusion and occipital bone fracture with other multiple trauma. On the eleventh day after the injury, he began showing rhythmic, 150/min, bilateral contraction of the palate. This movement disorder has hitherto been considered untreatable when idiopathic origin. But several reports describe improvement of palatal myoclonus during sleep or medical treatment. In this case, palatal myoclonus was absent during sleep and it responded well to oral administration of clonazepam. We report a case of palatal myoclonus which developed after trauma for the first time in Korea.
Administration, Oral
;
Clonazepam
;
Contusions
;
Humans
;
Korea
;
Movement Disorders
;
Multiple Trauma
;
Myoclonus*
;
Occipital Bone
;
Olivary Nucleus
;
Palate
;
Young Adult
6.Nocturnal Arterial Oxygen Saturation Monitoring in Patients with Respiratory Disease.
In Seon CHOI ; Jae Beom YANG ; Young Chul KIM ; Ik Joo CHUNG ; Yu Ho KANG ; Yeoung Il KOH ; Sang Seon PARK ; Min Su LEE ; Kyung Ok PARK
Tuberculosis and Respiratory Diseases 1994;41(2):103-110
To find out the predictors of nocturnal arterial oxygen desaturation in patients with respiratory diseases, transcutaneous oxygen saturation(StcO2) monitoring studies using a pulse oximeter were performed during sleep in 20 patients. StcO2 was decreased more than 4% from the baseline value in 18 patients(90%) and more than 10%('Desaturator') in 8(40%). Five of the seven patients(71.4%) with awake PaO2<60mmHg and three of the thirteen patients(23.1%) with awake PaO2≥60mmHg were 'desaturators'. The awake PaO2/FIO2 and PaO2/PAO2 could distinguish 'desaturator' from 'nondesaturator, and PaO2, SaO2 or StcO2 could not. These results suggest that the nocturnal oxygen desaturation depends on the severity of the underlying disease rather than the baseline PaO2. Anthropomorphic and lung function factors could not separate between 'desaturator' and 'non-desaturator', and about a quarter of patients with a wake PaO2≥60mmHg developed significant desaturation. Therefore, it is necessary to monitor the nocturnal arterial oxygen saturation in patients with respiratory diseases regardless of their severity of airflow obstruction or awake PaO2.
Humans
;
Lung
;
Oxygen*
7.CT and MRI Findings of Malignant Meningiomas: Comparison with Benign Meningiomas.
Il Kwon YANG ; Kyung Sub SHINN ; Myung Hee CHUNG ; Kyu Ho CHOI ; Han Jin LEE ; Seon Ok JEONG ; Seon Kyo KIM ; Jeong Soo JEON
Journal of the Korean Radiological Society 1995;32(3):375-381
PURPOSE: The purpose is to evaluate the CT or MRI findings to help in the differentiation between benign and malignant meningiomas. MATERIAL AND METHODS: The CT and MRI findings of 8 patients with surgically proven malignant meningioma were reviewed. Four cases of 8 malignant meningiomas and 18 cases of 27 benign lesions were studied with a 1.5T or 0.5T MRI. Radiologic analysis was focused on the heterogeneity of tumor, grade of peritumoral edema, presence of cystic degeneration and calcification, tumoral enhancement pattern, dural enhancement, and tumoral border. RESULT: Histologic types of malignant meningioma were meningotheliomatous (n=4), papillary(n=1), fibroblastic(n=l), angioblastic(n=l), and sarcomatous(n=l). Tumoral Heterogeneity was seen in 8 of 8 malignant lesions(100%) and 8 of 27 benign ones(30%). (p<0.01) Marked peritumoral edema was seen in 8 of 8 malignant lesions(100%) and 2 of 27 benign ones. (7.3%)(p<0.01) Most of malignant lesions(6 of 8 cases, 75%) showed ill defined border. Calcification was not present in malignant lesions in contrast with benign ones (14 of 27 cases, 52%). (p<0.05) No statistical significance was noted in cystic degeneration, dural tail like enhancement or tumoral enhancement pattern between malignant and benign meningiomas. MRI signal intensity of malignant meningiomas was homogeneously or heterogeneously hypointense on T1WI, heterogeneously isointense or hypointense on T2WI and heterogeneous or mixed on Gd-DTPA enhancement study. CONCLUSION: The CT or MRI findings such as heterogeneity, ill defined tumoral border, marked peritumoral edema, and absence of calcification may suggest the possibility of malignancy in meningioma.
Edema
;
Gadolinium DTPA
;
Humans
;
Magnetic Resonance Imaging*
;
Meningioma*
;
Population Characteristics
8.Clinical experiences with total nutrient admixture in 26 cases.
Yong Soon KWON ; Eun Jin CHOI ; Soon Ok BYUN ; Ji Sub OH ; Hwan Seon RYU ; Charles D SANDS
Journal of the Korean Pediatric Society 1992;35(7):921-932
No abstract available.
Parenteral Nutrition, Total
9.Diagnostic Significance of TNF-alpha in Tuberculous and Non-Tuberculous Pleural Effusion.
Hyun Joo NA ; Seog Chea PARK ; Kwang Won KANG ; Hyeong Kwan PARK ; Young Chul KIM ; In Seon CHOI ; Kyung Ok PARK
Tuberculosis and Respiratory Diseases 1997;44(3):611-620
OBJECTIVES: The differentiation of tuberculous effusion from the other causes of exudative pleural effusion remained difficult even with aids of biochemical analyses and pleural biopsy. As the pathophysiology of tuberculous pleural effusion is an enhanced cell mediated immunity, Adenosine deaminase(ADA) and various cytokines including Inteferon-γ, tumor necrosis factor alpha(TNF-α) are considered as useful diagnostic tools in differentiating exudative pleural effusion The author would like to demonstrate the diagnostic usefulness of TNF-α in the differentiation of exudative pleural effusion, and compared the discriminating ability of TNF-α with ADA. METHODS: Pleural fluids obtained from 80 patients (tuberculous : 39, malignant : 31, parapneumonic : 10) with exudate pleural effusions were processed for cell counts and biochemical analysis including ADA and TNF-α RESULTS: Tuberculous pleural fluid showed higher levee of ADA and TNF-α, 48.7α 32.7U/L and 184.1±214.2pg/mL than that of non-tuberculous effusion 26.0α41.3U/L and 44.1α114.2pg/mL, respectively (ADA, TNF-α : p<0.05, p<0.01). Receiver operating characteristics(ROC) curves were generated for ADA and TNF-α, and the best cut-off value for adenosine deaminase and TNF-α were considered as 30U/L and 15pg/ml, respectively. Comparing the area under the ROC curves, there was no significant difference between ADA and TNF-α CONCLUSION: For the differential diagnosis of tuberculous pleural effusion from the other causes of exudative pleural effusions, TNF-α as well as ADA was considered as useful diagnostic method. However adding TNF-α to ADA has no further diagnotic benefit than ADA alone.
Adenosine
;
Adenosine Deaminase
;
Biopsy
;
Cell Count
;
Cytokines
;
Diagnosis, Differential
;
Exudates and Transudates
;
Humans
;
Immunity, Cellular
;
Pleural Effusion*
;
ROC Curve
;
Tuberculosis
;
Tumor Necrosis Factor-alpha*
10.A Case of Lipoid Pneumonia Caused by Aspiration of Laxatives.
Seon Ja CHO ; Kwang Min LEE ; Jin Ok CHOI ; Kang Seo PARK
Pediatric Allergy and Respiratory Disease 2000;10(1):75-80
Lipoid pneumonia is chronic, interstitial, proliferative inflammation resulting from aspiration of lipoid material. Mineral oil is a hydrocarbon that physicians often use to treat chronic constipation in children and adults. Mineral oil may not elicit a normal protective cough reflex and may impair mucociliary transport. We experienced a case of exogenous lipoid pneumonia caused by aspiration of mineral oil given as a laxatives confirmed by fiberoptic bronchoscopy with bronchoalveolar lavage and bronchial biopsy in a 9-month-old boy with chronic cough and radiologic evidence of parenchymal lung disease.We reported this case with a brief review of related literatures.
Adult
;
Biopsy
;
Bronchoalveolar Lavage
;
Bronchoscopy
;
Child
;
Constipation
;
Cough
;
Humans
;
Infant
;
Inflammation
;
Laxatives*
;
Lung
;
Male
;
Mineral Oil
;
Mucociliary Clearance
;
Pneumonia*
;
Reflex