1.A Case of Congenital Lymphatic Dysplasia Complicated by Hydrops Fetalis.
Young Mi YOON ; Seon Nyo KIM ; Hye Rim KIM ; Young Hwa JUNG ; Chang Won CHOI ; Beyong Il KIM
Neonatal Medicine 2017;24(1):40-44
Congenital lymphatic dysplasia is a rare congenital maldevelopment of the lymphatic system, in which dysfunction of the lymphatic system may cause leakage of lymph fluid into the limbs and the pleural, pericardial, or peritoneal cavity. We experienced a case of hydrops fetalis with subcutaneous lymphedema, chylothorax, chylous ascites and pericardial effusion. Lymphangiography revealed a critical defect of lymphatic system. Here, we report the first case of premature infant with congenital lymphatic dysplasia confirmed by lymphangiography, which is the first reported in Korea.
Chylothorax
;
Chylous Ascites
;
Edema*
;
Extremities
;
Humans
;
Hydrops Fetalis*
;
Infant, Newborn
;
Infant, Premature
;
Korea
;
Lymphatic System
;
Lymphedema
;
Lymphography
;
Pericardial Effusion
;
Peritoneal Cavity
2.Clinical Characteristics of Hypospadias and Its Association with Very Low Birth Weight Infants with Small for Gestational Age
Seon Nyo KIM ; Seung Hyun KIM ; Chan KIM ; Hanna KIM ; Jieun HWANG ; Misun YANG ; So Yoon AHN ; Se In SUNG ; Yun Sil CHANG ; Hyeseon KIM
Neonatal Medicine 2024;31(2):17-23
Purpose:
To investigate the risk factors associated with hypospadias in very low birth weight (VLBW) infants (VLBWIs).
Methods:
We retrospectively analyzed 729 infants born at ≥24 weeks of gestational age and weighing <1,500 g from January 2012 to December 2022. We assessed the prevalence of hypospadias by birth weight percentiles and also compared the demographics and placental histopathology of the infants with hypospadias (n=52) and those without hypospadias (n=677).
Results:
Of the 729 patients analysed, hypospadias was recorded in 26 (20.3%), 14 (26.9%), and 12 (2.5%) infants in the <3rd, ≥3rd–<10th, and ≥10th–<90th percentiles, respectively. Of all of the patients with hypospadias, 50% had birth weights <3rd percentile (p<0.001). The hypospadias group demonstrated a longer mean gestational age (30.1 weeks vs. 27.9 weeks, p<0.001), lower incidence of maternal pregnancy-induced hypertension (48.1% vs. 17.3%, p<0.001), lower incidence of premature rupture of membrane (11.5% vs. 27.1%, p=0.013), lower acute chorioamniotic maternal response (9.1% vs. 35.2%, p<0.001), and higher maternal underperfusion (95.5% vs. 71.9%, p<0.001).
Conclusion
The frequency of hypospadias was found to be the highest among VBLWIs <3rd percentile, who were severely small for their gestational age (SGA). Additionally, the incidence increased with a decreasing birth weight. Physical examination is necessary at birth for VLBWIs classified as SGA. Moreover, the data on the incidence of hypospadias among VLBWIs in neonatal intensive care units can assist in tracking counseling from the prenatal to the postnatal period for patients born <3rd percentile.
3.Clinical Manifestations of Capillary Hemangiomas in Preterm Infants.
Seon Nyo KIM ; Juyoung LEE ; Seung Han SHIN ; Chang Won CHOI ; Ee Kyung KIM ; Han Suk KIM ; Beyong Il KIM ; Jung Hwan CHOI
Korean Journal of Perinatology 2015;26(3):222-228
PURPOSE: Capillary hemangiomas occur more frequently in preterm infants. We aimed to describe the clinical course of capillary hemangiomas in preterm infants. METHODS: The records of preterm infants with a gestational age (GA) of <35 weeks who were admitted to two tertiary neonatal intensive care units from January 2004 to December 2013 and had capillary hemangiomas were reviewed retrospectively. Subgroup analysis of between infants of GA <30 weeks and GA 30-34+6 weeks were done and ad hoc analysis comparing study population and matched preterm infants without hemangioma for investigation of differences in clinical characteristics. RESULTS: Of the 2,772 preterm infants, 112 (4%) infants developed capillary hemangiomas. The majority (91.9 %) of them had a solitary hemangiomas with the trunk was the most commonly involved site (43%). Three quarters of the patients were treated with topical corticosteroid, propranolol or laser treatment. When we divided this population as who were born before or after GA 30 weeks, there was no difference at postmenstrual age (PMA) of onset of capillary hemangiomas (median [IQR], 36(+4) [30(+5)-40(+5)] vs. 36+2 [33(+6)-41(+1)] weeks, P = 0.275). The age at involution of capillary hemangiomas was also not differ between two groups (median [IQR], 7.75 [3.75-12.25] vs. 7.5 [4-13.75] months, P=0.425). There were no statistical differences between preterm infants with capillary hemangiomas and their age, weight and sex matched control preterm infants without hemangiomas in the neonatal and maternal factors. CONCLUSION: The development of capillary hemangiomas occurred at approximately 36 to 37 weeks of PMA regardless of prematurity in preterm infants. Capillary hemangiomas of preterm infants resolved spontaneously and disappear completely by around 7 months of corrected age.
Capillaries*
;
Gestational Age
;
Hemangioma
;
Hemangioma, Capillary*
;
Humans
;
Infant
;
Infant, Newborn
;
Infant, Premature*
;
Intensive Care Units, Neonatal
;
Propranolol
;
Retrospective Studies
4.A Serial Echocardiograhic Obesrvation of Acute Myocardial Injury Associated with Pheoechromocytoma Crisis.
Gyung Hwa HWANG ; Jung Hoon SUNG ; Seon Nyo CHU ; Hong Hoon PAKR ; Sun Hye JUNG ; In Jai KIM ; Tae Young KIM ; Sang Wook LIM ; Dong Hoon CHA
Journal of the Korean Society of Echocardiography 2002;10(1):65-68
Pheochromocytoma may cause anatomic and functional cardiac abnormalities. Various echocardiographic abnormalities have been observed, including systolic anterior movement, global hypokinesis as well as hypokinesis of the base and the apex of LV. There are no previous reports of serial echocardiographic finding in patients with pheochromocytoma. We experienced a 38-year-old woman with pheochromocytoma who suffered from acute myocardial injury. Echocardiography revealed that the acute myocardial injury started in the base in the early phase and subsequently extended to the mid-portion of left ventricule. The injury persisted longer in the base than the mid-portion. than 1.5 times the adjacent normal coronary artery.
Adult
;
Coronary Vessels
;
Echocardiography
;
Female
;
Humans
;
Pheochromocytoma
5.The Usefulness of Birth Weight Z-Score as a Predictor of Catch Up Growth in Preterm Infants.
Huee Jin PARK ; Hae Yun LEE ; Hae Kyung WOO ; Seon Nyo KIM ; Juyoung LEE ; Hye Ran YANG ; Beyong Il KIM ; Chang Won CHOI
Neonatal Medicine 2015;22(3):142-149
PURPOSE: The aim of the study was to examine whether the degree of fetal smallness in small for gestational age (SGA) infants would increase the risk of catch-up-growth failure at 12 and 24 months corrected age (CA), and whether the high-calorie nutritional support would improve catch-up growth between 12 and 24 months CA. METHODS: We conducted a retrospective cohort study on 103 preterm infants born between January 2010 and December 2011. Logistic regression analysis was performed to investigate whether the birth weight z-score would be an independent risk factor for catch-up growth failure at 12 or 24 months CA. Among the 46 infants with failed catch-up growth at 12 months CA, 16 infants were provided high-calorie nutritional support, including nutritional supplements and medium chain triglyceride (MCT) oil at the pediatric gastroenterology clinic. RESULTS: Of 103 preterm infants, 34 infants (33%) were SGA and 69 infants (67%) were appropriate for gestational age (AGA). One birth weight z-score decrement increased the odds for catch-up growth failure 2.9 times at 12 months CA and 3.0 times at 24 months CA after adjustment for major neonatal morbidities. The increase in z-score between 12 and 24 months CA was significantly greater in the infants provided nutritional support than in the infants who were not provided nutritional support. CONCLUSION: The birth weight z-score can be used as a predictor of catch-up growth failure. High-calorie nutritional support may improve weight gain during the second year in preterm infants with failed catch-up growth at 12 months CA.
Birth Weight*
;
Cohort Studies
;
Gastroenterology
;
Gestational Age
;
Humans
;
Infant
;
Infant, Newborn
;
Infant, Premature*
;
Logistic Models
;
Nutritional Support
;
Parturition*
;
Retrospective Studies
;
Risk Factors
;
Triglycerides
;
Weight Gain
6.A Case of Transient Granulocytopenia during Treatment of a Patient with Graves' Disease and Type 1 Diabetes Mellitus - Differential Diagnosis from Agranulocytosis by a Single Injection of G-CSF.
Jin Kyeong PARK ; Jeong Hun SEONG ; Jun LEE ; Seon Nyo CHU ; Hun JEONG ; Yoo Lee KIM ; Seok Won PARK ; Yong Wook CHO ; Sang Jong LEE
Journal of Korean Society of Endocrinology 2002;17(2):280-285
Granulocytopenia, which can be seen in patients with Graves' disease during treatment with antithyroid agents, could be a self resolving transient episode or can imply the beginning of life threatening agranulocytosis requiring a change in treatment modality. Transient granulocytopenia could be a manifestation of hyperthyroidism itself, or a mild side effect of antithyroid drugs. Aganulocytosis is a rare, but major complications of the termination drug, propylthiouracil (PTU), requiring prompt termination of the medication, and intensive care. Therefore, differentiation of agranulocytosis and transient granulocytopenia, is important, but is not practically easy. We introduce a case of transient granulocytopenia, which was detected in a patient with Graves'Disease, accompanied by underlying type 1 diabetes mellitus, during treatment with PTU. Diagnosis of transient granulocytopenia was made by a normal granulocyte count following a single injection of G-SCF, and the patient was treated with conservative therapy. This case confirms a diagnostic tool for differentiating transient granulocytopenia and PTU-induced agranulocytosis.
Agranulocytosis*
;
Antithyroid Agents
;
Beginning of Human Life
;
Diabetes Mellitus, Type 1*
;
Diagnosis
;
Diagnosis, Differential*
;
Granulocyte Colony-Stimulating Factor*
;
Granulocytes
;
Graves Disease*
;
Humans
;
Hyperthyroidism
;
Critical Care
;
Propylthiouracil
7.A Case of Lactobacillus Bacteremia during Probiotic Supplementation in a Very Preterm Infant with Short Bowel Syndrome.
Seon Nyo KIM ; Hae Yun LEE ; Saeyun KIM ; Byung kook LEE ; Young Hwa JUNG ; Joosun HUH ; Jae Gu SEO ; Seung Han SHIN ; Ee Kyung KIM ; Han Suk KIM ; Jung Hwan CHOI
Neonatal Medicine 2015;22(3):173-176
Probiotics are living micro-organisms that beneficially affect the composition of the host intestinal microflora. In very preterm infants, probiotics reportedly help reduce necrotizing enterocolitis (NEC), invasive fugal colonization and sepsis, and enable the establishment of complete enteral feeding at an earlier stage. However, emerging evidence has indicated the risk of potential side effects of probiotic use, such as gut organism translocation, including probiotic organisms, in infants that are more premature. In the present report, we describe a case of Lactobacillus bacteremia in a very preterm infant with short bowel syndrome. Lactobacillus sepsis developed during the therapeutic use of this organism for diarrhea and diarrhea-related malabsorption. The organism isolated from the blood sample was found to be of the same strain as that administered, by using molecular techniques. The findings of the present case suggest that probiotics should be carefully used, particularly in very preterm infants with altered intestinal permeability such as short bowel syndrome.
Bacteremia*
;
Colon
;
Diarrhea
;
Enteral Nutrition
;
Enterocolitis, Necrotizing
;
Humans
;
Infant
;
Infant, Newborn
;
Infant, Premature*
;
Lactobacillus*
;
Permeability
;
Probiotics*
;
Sepsis
;
Short Bowel Syndrome*
8.Alternative Isoforms of TonEBP with Variable N-termini are Expressed in Mammalian Cells.
Hyo Shin KIM ; Sook Jin SON ; Seon Nyo KIM ; Yong Duk KIM ; Kwang Jin KIM ; Byeong Hwa JEON ; Jin Bong PARK ; Sang Do LEE
The Korean Journal of Physiology and Pharmacology 2007;11(3):135-138
Hypertonicity imposes a great deal of stress to cells since it causes rise in cellular ionic strength, which can be reduced by the accumulation of compatible osmolytes. TonEBP plays a central role in the cellular accumulation of compatible osmolytes via transcriptional stimulation of membrane transporters and aldose reductase. Alternatively spliced forms of TonEBP mRNA have previously been reported and two of them showed different transcriptional activity. In the present study, isoform-specific antibodies were produced to confirm the translation of the spliced mRNA to protein. TonEBP was immunoprecipitated by using anti-TonEBP antibody and then immunoblotted using anti-TonEBP or isoform specific antibodies to find out the expression profile of TonEBP isoforms in basal or stimulated condition. From these results, we conclude that all TonEBP isoforms are expressed in mammalian cells and their expression patterns are not same in every cells.
Aldehyde Reductase
;
Alternative Splicing
;
Antibodies
;
Membrane Transport Proteins
;
Osmolar Concentration
;
Protein Isoforms*
;
RNA, Messenger